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张业旺 教授

基本情况:

男,教授,硕士生导师。江苏大学天智绿业药物研究所所长。从事生物工程和制药工程方向的研究。主持及参与国家自然科学基金等多项基金项目。已经发表SCI论文50余篇,作为第一作者和通讯作者共发表SCI检索文章30余篇。2008年9月受Brain Pool项目资助,赴韩国Konkuk University做博士后研究,在2009年3月至2010年8月在该校受聘担任Assistant Professor。Email: zhangyewang@ujs.edu.cn; 药学院2211室。

教育经历

2002.09-2006.03,华东理工大学,博士,生物化工

1997.09-2000.06,大连理工大学,硕士,生物化工

1993.09-1997.06,武汉工程大学,学士,有机化工

工作经历:

2015.07至今,教授,江苏大学

2008.09-2010.08,Postdoc,Assistant professor,Konkuk University, 韩国

2006.06-2015.07,讲师,副教授,江苏大学

2000.06-2002.08,研发工程师,石家庄制药集团

研究方向:

生物催化与转化,制药过程工程。主要包括: (1) 重要药物中间体的生物法生产新技术开发; (2) 重要生物催化剂的筛选与制备; (3) 制药过程集成化技术。招收药学学术型研究生和制药工程专业学位研究生,欢迎制药工程,药学,化学,化学工程,生物工程以及分子生物学等相关专业的学生报考!

在研项目:

1.国家自然科学基金面上项目,主持,编号:21376110。

2.江苏大学天智绿业药物研究所项目,主持,编号:20150266。

3.国家自然科学基金面上项目,(第2),编号:31370184。

4.江苏省功能材料绿色合成重点实验室开放课题,主持,编号:201310。

5.江苏省大气污染与环境检测重点实验室开放课题,主持,编号:kHK1109。

获得奖励

1.先后获得镇江市2009年,2011年优秀科技论文二等奖。

2.获得2011年广西省优秀科技论文二等奖。

学术兼职

担任Journal of Microbiology and Biotechnology (IF2014=1.525)的编委(Editorial Board)。

担任Applied Microbiology and Biotechnology, Process Biochemistry,Enzyme and Microbial Technology, Applied Biochemistry and Biotechnology, Spectroscopy Letters, Preparative Biochemistry and Biotechnology, Instrumentation Science and Technology, International Journal of Nanomedicine, Journal of Scientific and Industrial Research, Nanoscience and Nanotechnology Letters, Journal of Nanoscience and Nanotechnology, Journal of Nanoparticle Research, Journal of Molecular Catalysis B: Enzymatic等SCI期刊的审稿人。

代表性论文:

1.Meng-Yao Zhuang, Qian-Liu Zhou, Xiang-Yu Wang, Jun-Xi Zhang, Lan Xue, Ru Wang, Jiu-Xun Zhang, Ye-Wang Zhang*. Immobilization of lipase onto dopamine functionalized magnetic nanoparticles. Nanoscience and Nanotechnology Letters, 2016, In press, DOI: 10.1166/nnl.2016.2127

2.Xiao-Ping Jiang, Ting-Ting Lu, Cai-Hong Liu, Xiao-Ming Ling, Meng-Yao Zhuang, Jiu-Xun Zhang, Ye-Wang Zhang*. Immobilization of alcohol dehydrogenase onto epoxy-functionalized Fe3O4@SiO2 nanoparticles for synthesis of (R)-mandelic acid. International Journal of Biological Macromolecules. 2016, 88: 9-17. DOI: 10.1016/j.ijbiomac.2016.03.031.

3.Cai-Hong Liu, Xiao-Qian Li, Xiao-Ping Jiang, Meng-Yao Zhuang, Xiao-Min Ling, Jiu-Xun Zhang, Chun-Hai Bao, Ye-Wang Zhang*. Preparation of functionalized graphene oxide nanocomposites for covalent immobilization of NADH oxidase. Nanoscience and Nanotechnology Letters. 2016, In press, DOI: 10.1166/nnl.2016.2102.

4.Xiao-Min Ling, Xiang-Yu Wang, Ping Ma, Yi Yang, Jie-Mei Qin, Xue-Jun Zhang, Ye-Wang Zhang*. Covalent Immobilization of Penicillin G Acylase onto Fe3O4@Chitosan Magnetic Particles. Journal of Microbiology and Biotechnology, 2016, In press. DOI: 104014/jmb.1511.11052.

5.Guo-Hua Xia, Wei Liu, Xiao-Ping Jiang, Xiang-Yu Wang, Ye-Wang Zhang*, Jianyong Guo. Modification of Fe3O4@SiO2 magnetic nanoparticles for immobilization of lipase. Journal of Nanoscience and Nanotechnology. 2016, In press. DOI: 10.1166/jnn.2015.10964

6.Qing-Lan Tao, Yue Li, Ying Shi, Rui-Jiang Liu, Ye-Wang Zhang*, Jianyong Guo. Application of Molecular Imprinted Magnetic Fe3O4@SiO2 Nanoparticles for Selective Immobilization of Cellulase. Journal of Nanoscience and Nanotechnology. 2016, 16:6055-6060. DOI: 10.1166/jnn.2015.10853

7.Ying Shi, Wei Liu, Qing-Lan Tao, Xiao-Ping Jiang, Cai-Hong Liu, Sha Zeng, Ye-Wang Zhang*. Immobilization of lipase by adsorption onto magnetic nanoparticles in organic solvents. Journal of Nanoscience and Nanotechnology. 2016, 16: 601-607 DOI: 10.1166/jnn.2015.10694.

8.Xiaoyun Zhang, Ye-Wang Zhang*, Hongyin Zhang, Qiya Yang, Haiying Wang, Guochao Zhang. Preparation, characterization and antibacterial activity of octenyl succinic anhydride modified inulin. International Journal of Biological Macromolecules. 2015, 78: 79-86. DOI: 10.1016/j.ijbiomac.2015.03.067

9.Xingbo shi, Suli Dong, Minmin Li, Xiaojun Liu, Yewang Zhang, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong and Hongwei Gai*. Counting quantum dots in aggregates for the detection of biotinylated proteins. Chemical Communications. 2015, 51, 2353-2356. DOI: 10.1039/C4CC02918F.

10.Xiang-Yu Wang, Xiao-Ping Jiang, Yue Li, Sha Zeng, Ye-Wang Zhang*. Preparation Fe3O4@Chitosan Magnetic Particles for Covalent Immobilization of Lipase from Thermomyces lanuginosus. International Journal of Biological Macromolecules. 2015, 75: 44-50. DOI: 10.1016/j.ijbiomac.2015.01.020.

11.Yue Li, Xiang-Yu Wang, Xiao-Ping Jiang, Jing-Jing Ye, Ye-Wang Zhang*, Xiao-Yun Zhang. Fabrication of graphene oxide decorated with Fe3O4@SiO2 for immobilization of cellulase. Journal of Nanoparticle Research, 2015, 17: 8. DOI: 10.1007/s11051-014-2826-z.

12.Xiao-Yun Zhang, Xiang-Yu Wang, Xiao-Ping Jiang, Shun-Yi Fan, Ye-Wang Zhang*. Enhanced enzymatic synthesis of amoxicillin by addition of organic cosolvents with response surface methodology. BioTechnology: An Indian Journal. 2015, 11(5): 161-169.

13.Yue Li, Xiang-Yu Wang, Rui-Zhuo Zhang, Xiao-Yun Zhang, Xi-Ming Xu, Ye-Wang Zhang*. Molecular Imprinting and Immobilization of Cellulase onto Magnetic Fe3O4@SiO2 Nanoparticles. Journal of Nanoscience and Nanotechnology. 2014, 14: 2931-2936. DOI:10.1166/jnn.2013.8625.

14.Wei Liu, Fang Zhou, Xiao-Yun Zhang, Yue Li, Xiang-Yu Wang, Xi-Ming Xu, Ye-Wang Zhang*. Preparation of magnetic Fe3O4@SiO2 nanoparticles for immobilization of lipase. Journal of Nanoscience and Nanotechnology. 2014, 14: 3068-3072. DOI:10.1166/jnn.2013.8567.

15.Jianfeng Wang, Wei Liu, Baoquan Liu, Shengdi Fan, Ye-Wang Zhang*. Analyzing increased fluorescence of single quantum dots on dehydrated agarose by single-molecular imaging. Spectroscopy Letters. 2013, 46: 195-200. DOI: 10.1080/00387010.2012.700544.

16.Ye-Wang Zhang, Manish Kumar Tiwarri, Hui Gao, Marimuthu Jeya, Jung-kul Lee*. Cloning and characterization of a thermostable H2O-forming NADH oxidase from Lactobacillus rhamnosus. Enzyme and Microbial Technology. 2012, 50: 255-262. DOI: 10.1016/j.enzmictec.2012.01.009.

17.Qiang Tan, Yewang Zhang, Dongzhi Wei. Characterization and stability of D-amino acid oxidase and catalase within the permeabilized recombinant Pichia pastoris cells. African Journal of Biotechnology. 2011, 10: 19153-19160. DOI: 10.5897/AJB11.554

18.Ye-Wang Zhang, Manish Kumar Tiwarri, Marimuthu Jeya, Jung-kul Lee*. Covalent immobilization of recombinant Rhizobium etli CFN42 xylitol dehydrogenase onto modified silica nanoparticles. Applied Microbiology and Biotechnology. 2011, 90: 499-507. DOI: 10.1007/s00253-011-3094-9.

19.Ye-Wang Zhang, Marimuthu Jeya, Jung-Kul Lee*. Enhanced activity and stability of L-arabinose isomerase by immobilization on aminopropyl glass. Applied Microbiology and Biotechnology. 2011, 89: 1435-1442. DOI: 10.1007/s00253-010-2966-8.

20.Raushan Kumar Singh, Ye-Wang Zhang, Ngoc-Phuong-Thao Nguyen, Marimuthu Jeya, Jung-Kul Lee*. Covalent immobilization of β-1,4-glucosidase from Agaricus arvensis onto functionalized silicon oxide nanoparticles. Applied Microbiology and Biotechnology, 2011, 89: 337-344. DOI: 10.1007/s00253-010-2768-z

21.Ye-Wang Zhang*, Rui-Jiang Liu, Xi-Ming Xu*. One-pot, two-step enzymatic synthesis of amoxicillin by complexing with Zn2+. Applied Microbiology and Biotechnology, 2010, 88:49-55. DOI: 10.1007/s00253-010-2727-8

22.Ye-Wang Zhang, Marimuthu Jeya, Jung-Kul Lee*. L-Ribulose production by an Escherichia coli harboring L-arabinose isomerase from Bacillus licheniformis. Applied Microbiology and Biotechnology, 2010, 87: 1993-1999. DOI: 10.1007/s00253-010-2600-9

23.Ye-Wang Zhang, Ponnandy Prabhu, Jung-Kul Lee*. Alginate immobilization of recombinant Escherichia coli whole cells harboring L-arabinose isomerase for L-ribulose production. Bioprocess and Biosystems Engineering, 2010, 33: 741-748. DOI: 10.1007/s00449-009-0397-7

24.张业旺*,刘瑞江,闻崇炜,徐希明。青霉素酰化酶促合成-内酰胺抗生素的过程优化研究进展。中国抗生素杂志,2010, 35(10), 721-726.

25.Ye-Wang Zhang, Ponnandy Prabhu, Jung-Kul Lee, In-Won Kim*. Enhanced stability of Bacillus licheniformis L-arabinose isomerase by immobilization with alginate. Preparative Biochemistry and Biotechnology, 2010, 40: 65-75. DOI: 10.1080/10826060903400567

26.Qiang Tan, Yewang Zhang, Qingxun Song, Dongzhi Wei. Single-pot conversion of cephalosporin C to 7-aminocephalosporanic acid in the absence of hydrogen peroxide. World Journal of Microbiology and Biotechnology. 2010, 26: 145-152. DOI: 10.1007/s11274-009-0153-9

27.Shu-Guang Fang, Tan Qiang, Rui-Jiang Liu, Xi-Ming Xu, Ye-Wang Zhang*. Enhanced production of 6-aminopenicillanic acid in aqueous-methyl isobutyl ketone system with immobilized penicillin G acylase. Preparative Biochemistry and Biotechnology. 2010, 40(1):38-45. DOI: 10.1080/10826060903389489

28.Ye-Wang Zhang, Ponnandy Prabhu, Jung-kul Lee*. Immobilization of Bacillus licheniformis L-arabinose isomerase for semi-continuous L-ribulose production. Bioscience, Biotechnology and Biochemistry. 2009, 73: 2234-2239. DOI: 10.1271/bbb.90330

29.Hyung-Moo Jung, Marimuthu Jeya, Sang-Yong Kim, Hee-Jung Moon, Raushan Kumar Singh, Ye-Wang Zhang, Jung-Kul Lee*. Biosynthesis, biotechnological production, and application of teicoplanin: current state and perspectives. Applied Microbiology and Biotechnology, 2009, 84:417-428. DOI: 10.1007/s00253-009-2107-4

30.Suk-Jin Ha, Sang-Yong Kim, Jin-Ho Seo, Marimuthu Jeya, Ye-Wang Zhang, In-Won Kim, and Jung-Kul Lee. Ca2+ increases the specific coenzyme Q10 content in Agrobacterium tumefaciens. Bioprocess and Biosystem Engineering.2009, 32: 697-700.  DOI: 10.1007/s00449-009-0318-9

31.Marimuthu Jeya, Ye-Wang Zhang, In-Won Kim, Jung-Kul Lee*. Enhanced saccharification of alkali treated rice straw by cellulase of Trametes hirsuta and statistical optimization of hydrolysis condition by RSM. Bioresource Technology, 2009, 100 (21): 5155-5161. DOI: 10.1016/j.biortech.2009.05.040

32.Yewang Zhang, Dongzhi Wei*. Enzymatic preparation of cefaclor with immobilized penicillin acylase. Preparative Biochemistry and Biotechnology. 2008, 38: 136-145. DOI: 10.1080/10826060701884046

33.Yewang Zhang, Shulai Liu, Dongzhi Wei*, Ruijiang Liu, Ximing Xu. Kinetically controlled synthesis of cefaclor with immobilized penicillin acylase in the presence of organic cosolvents. Chemical and Biochemical Engineering Quarterly. 2008, 22: 349-354.

34.张业旺*,谭强,刘瑞江,徐秀泉,徐希明。青霉素酰化酶制备6-APA研究进展。中国抗生素杂志。2008, 33: 385-391。

35.Dengchao Li, Yewang Zhang, Dongzhi Wei*, Qingxun Song, Shiwei Cheng. Enzymatic synthesis cephalexin at high substrates concentration with in situ product removal. Food Technology and Biotechnology. 2008, 46: 461-466

36.Rui Han, Yewang Zhang, Xiuling Dong, Hongwei Gai* and Edward S. Yeung. Spectral imaging of single molecules by transmission grating based epi-fluorescence microscopy. Analytica Chimica Acta.2008, 619: 209-214. DOI: 10.1016/j.aca.2008.05.017

37.Yewang. Zhang, Dongzhi Wei*, Dengchao Li, Shulai Liu, Qingxun Song. Optimisation of enzymatic synthesis of cefaclor with in situ product removal and continuous acyl donor feeding. Biocatalysis and Biotransformation. 2007, 25: 59-64. DOI: 10.1080/10242420601141762

38.Yewang Zhang*, Ruijiang Liu, Xiaoyu Wu. The proteolytic systems and heterologous proteins degradation in the methylotrophic yeast Pichia pastoris. Annals of Microbiology. 2007, 37, 553-560. DOI: 10.1007/BF03175354

39.Qiang Tan, Qingxun Song, Yewang Zhang, Dongzhi Wei*. Characterization and application of D-amino acid oxidase and catalase within permeabilized Pichia pastoris cells in bioconversions. Applied Biochemistry and Biotechnology. 2007, 136: 279-289. DOI: 10.1007/s12010-007-9026-6

40.Yewang Zhang, Dengchao Li, Qingxun Song, Dongzhi Wei*. Effects of substrate concentration on the enzymatic synthesis of cefaclor by penicillin acylase with in situ product removal. Chemical and Biochemical Engineering Quarterly. 2006, 20: 183-188.

41.Liu Yang, Dongzhi Wei, Yewang Zhang. Semi-continuous enzymatic synthesis of cefaclor enhanced by in situ product removal, Journal of Chemical Technology and Biotechnology. 2004, 79: 480-485. DOI: 10.1002/jctb.1003

 

申请专利

1.Lee JK, Jeya M , Zhang YW, Tiwari MK, Moon HJ. Novel xylitol dehydrogenase, and method for producing L-xylulose using same. WO 2011/099657 A1

2.张业旺,李越,江晓萍,刘彩虹。一种功能化氧化石墨烯载体的制备方法及其应用,申请号:201510035161.9,公开号:CN104650240A。

3.张业旺,王进,王香玉,庄孟瑶,凌小敏。一种多巴胺功能化磁性纳米载体的制备方法及其应用。申请号:201510899079.0。

 

参编书籍

第十章 药物制剂工艺学,《制药工艺学》,国家卫生和计划生育委员会“十二五”规划教材,全国高等医药教材建设研究会“十二五”规划教材,全国高等学校制药工程专业、药物制剂专业卫生部“十二五”规划教材,人民卫生出版社,北京,2014。ISBN: 9787117187039。