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魏渊 副教授

学位:博士
职称:副教授

工作经历:

2010年3月至今江苏大学药学院

2004年5月—2010年2月美国纽约州卫生部Wadsworth研究中心研究助理(博士生)

教育背景:
1999年9月—2003年7月南京大学生物化学专业学士
2003年9月—2010年2月美国纽约州立大学Albany分校公共卫生学院毒理学专业博士

研究方向:
细胞色素 P450 酶系相关的药物代谢与毒理,药物基因组学

学术兼职:

国际药物代谢学会(ISSX)会员

中华中医药学会会员

基金项目(主持):

1.2014-2017  国家自然科学基金 (面上项目)    项目名称:基于TALEN技术的细胞色素P450基因敲除大鼠模型的构建与应用项目代码:81373480

2.2012-2014  国家自然科学基金(青年项目)项目名称:基于XH-CL基因敲除小鼠模型的雷公藤内酯醇肝外组织代谢与毒理研究

项目代码:81102522

3.2012-2014   江苏省自然科学基金项目名称:肝外细胞色素P450代谢在雷公藤内酯醇多系统毒性中的作用研究

项目代码:BK2011473

4.江苏省“青蓝工程”青年骨干教师

5.江苏省博士后科研资助计划(1201081C)

6.江苏大学高级人才基金

代表性论文:

1.Wei Y*, Sui Danjuan, Xu Haimiao, Ouyang Zhen,Wu Na, et al.Roles of Atractylodeslancea rhizome water extract in reducing the triptolide-induced toxicities and enhancing the anti-inflammatory effect[J].Chinese Journal of Natural Medicines in press

2.Wang D, Wang K, Sui D, Ouyang Z, Wei Y*. Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice[J]. Chemico-Biological Interactions, 2017, 268: 47-52.

3.Li L, Megaraj V, Wei Y, et al. Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse[J]. Carcinogenesis, 2014, 35(11): 2584-2591.

4.Wei Y, Li L, Zhou X, Zhang QY, Dunbar A, Liu F, Kluetzman K, Yang W, Ding X.Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug MetabDispos. 2013 Jan;41(1):132-40.

5.Li L, Wei Y, Zhou X, et al. Characterization of a Cyp2a (4/5) bgs-null Mouse Model: Role of CYP2A and CYP2B in Nicotine Metabolism[J]. The FASEB Journal, 2012, 26(1 Supplement): 1052.3-1052.3.

6.Wei Y, Wu H, Li L, Liu Z, Zhou X, Weng Y, D'Agostino J, Ling G, Zhang L, Kluetzman K, Yao Y, Zhang QY, and Ding X Generation and characterization of a CYP 2A 13/2B6/ 2F 1 -transgenic mouse model. Drug MetabDispos. 2012 Jun;40(6):1144-50.

7.Cao X, Deng W, Wei Y, Yang Y, Su W, Wei Y, Xu X, Yu J.IncorporatingpTGF-β1/calcium phosphate nanoparticles with fibronectin into 3-dimensional collagen/chitosan scaffolds: efficient, sustained gene delivery to stem cells for chondrogenicdifferentiation.Eur Cell Mater. 2012 Feb 7;23:81-93.

8.Li L*, Wei Y *, Van Winkle L, Zhang QY, Zhou X, Hu J, Xie F, Kluetzman K, Ding X. Generation and characterization of a Cyp 2f 2-null mouse and studies on the role of CYP 2F 2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa. J PharmacolExpTher.2011 Oct;339(1):62-71. (* 并列第一作者 ).

9.Tong S, Chu C , Wei Y , Wang L, Gao X, Xu X, Yu J.Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger. J Pharm Pharmacol.2011 Feb;63(2):238-44.

10.Zhou X, Wei Y, Xie F, Laukaitis CM, Karn RC, Kluetzman K, Gu J, Zhang QY, Roberts DW, Ding X. A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP 2A 5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. MolPharmacol.2011 Apr;79(4):710-23.

11.Wei Y , Zhou X, Fang C, Li L, Kluetzman K, Yang W, Zhang QY, Ding X.Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. J PharmacolExpTher.2010 Jul;334(1):69-77.

12.Ling G, Wei Y , and Ding X. Transcriptional regulation of human CYP 2A 13 expression in the respiratory tract by CCAAT/enhancer binding protein and epigenetic modulation. MolPharmacol.2007, 71(3): 807-16;

13.Gu J, Chen CS, Wei Y , Fang C, Xie F, Kannan K, Yang W, Waxman DJ, and Ding X. A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition. J PharmacolExpTher.2007, 321(1): 9-17;

14.Wei Y , Zhou X, Ling GY, Zhang L, D'Agostino J, Kluetzman K, and Ding X Generation and characterization of a human CYP 2A 13 transgenic mouse model. DRUG METABOLISM REVIEWS 2006, 38(S2) 54-54

15. Zhao SW, Shen PP, Zhou Y, Wei Y , Xin XB, and Hua ZC. Selecting peptide ligands of microcystin-LR from phage displayed random libraries. Environ Int. 2005,31(4): 535-41.

 

16. 王笃军, 王硕, 严峰, 王国斌, 许海玉, 欧阳臻,  魏渊. (2017). 欧前胡素和异欧前胡素对小鼠肝 CYP450 的影响. 中成药, 39(1), 14-20.    (通讯作者)

17. 袁媛, 魏渊, 于军, 等. 表观遗传与药材道地性研究探讨[J]. 中国中药杂志, 2015, 40(13): 2679-2683.

18.王凯, 眭丹娟, 王长锁, 杨丽, 欧阳臻, 陈乃富, 韩邦兴, 魏渊. (2017). 5 种石斛对四氯化碳致小鼠急性肝损伤的保护作用. 中国中药杂志, 42(10), 1945-1950.  (通讯作者)

19.吴娜, 刘星雨, 王笃军, 罗盼, 吴瑶,  魏渊. (2014). 雷公藤内酯醇对 C57BL/6 小鼠亚慢性毒性作用的研究. 中成药, 36(5), 904-908.      (通讯作者)

20. 刘星雨, 吴娜, 张娇, 吴瑶, 罗盼, 王伟男, 魏渊. (2014). 生, 炙甘草对小鼠 CYP3As 及对雷公藤内酯醇解毒的比较. 中成药, 36(12), 2451-2457.    (通讯作者)

 

中国发明专利(授权)

吸烟人群肺癌风险相关细胞色素P450基因检测芯片(专利号:ZL201110123137.2)