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万瑾毅 副教授

        女,副教授,硕士生导师。 近年来主持及参与国家自然科学基金等多项科研项目,在J Chromatogr A, J Chromatogr B, Am J Chinese Med, J Pharmaceut Biomed等国际学术期刊发表SCI论文20余篇,国家授权专利2项。担任 Am J Chinese MedJ Chromatogr B等期刊审稿人。

 

【联系方式】

办公室:江苏大学药学院2507室

Email: wanjinyi@ujs.edu.cn

 

【教育及工作经历】

2005/09—2009/06  南京中医药大学中药学专业,学士

2009/09—2014/06  中国药科大学生药学专业,博士(硕博连读)

2014/06—2018/04  江苏大学药学院,讲师

2016/12—2017/12  美国芝加哥大学医学院,博士后

2018/04—至今     江苏大学药学院副教授

 

【研究方向】

1. 基于功能代谢组学的中药菌群代谢与药效研究

2. 基于现代质谱技术的中药质量控制与评价研究

3. 基于系统生物学评价的中药药效物质基础研究

 

【招生方向】

1. 生药学学术型学位研究生

2. 制药工程专业型学位研究生

 

【科研项目】

目前主持国家自然科学基金(81603378)、江苏省自然科学基金(BK2060545)、江苏大学高级专业人才基金(15JDG069)等,作为主要参与人参与完成多项国家级、省级科研项目。

 

【代表性论文】

1. Jin-Yi Wan, Wei-Hua Huang*, Wei Zheng, Chan Woong Park, Su Hwan Kim, Dae Bang Seo, Kwang-Soon Shin, Jinxiang Zeng, Haiqiang Yao, Clara Sava-Segal, Chong-Zhi Wang, Chun-Su Yuan. Multiple effects of ginseng berry polysaccharides: plasma cholesterol level reduction and enteric neoplasm prevention. Am J Chinese Med. 2017, 45(6):1-15.

2. Jin-Yi Wan*, Chong-Zhi Wang*, Qi-Hui Zhang, Zhi Liu, Mark W. Musch, Marc Bissonnette, Eugene B. Chang, Ping Li, Lian-Wen Qi, Chun-Su Yuan. Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota. Biomed Chromatogr. 2017, 31(4): e3851.

3. Jin-Yi Wan1, Yu-Zhen Zhang1, Jin-Bin Yuan, Feng-Qing Yang, Yan Chen, Lian-Di Zhou*, Qi-Hui Zhang*. Biotransformation and metabolic profile of anemoside B4 with rat small and large intestine microflora by ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. Biomed Chromatogr. 2017, 31(5): e3873.

4. Jing Sun*, Da-Dui Ren, Jin-Yi Wan, Chen Chen, Dong Chen, Huan Yang, Chun-Lai Feng, Jing Gao*. Desensitizing Mitochondrial Permeability Transition by ERK-Cyclophilin D Axis Contributes to the Neuroprotective Effect of Gallic Acid against Cerebral Ischemia/Reperfusion Injury. Front Pharmacol. 2017, 8:184.

5. Zhi Liu, Chong-Zhi Wang, Xing-You Zhu, Jin-Yi Wan, Jing Zhang, Wei Li*, Chang-Chun Ruan*, Chun-Su Yuan. Dynamic Changes in Neutral and Acidic Ginsenosides with Different Cultivation Ages and Harvest Seasons: Identification of Chemical Characteristics for Panax ginseng Quality Control. Molecules. 2017, 22(5):734.

6. Jin-Yi Wan, Chong-Zhi Wang, Zhi Liu, Qi-Hui Zhang, Mark W. Musch, Marc Bissonnette, Eugene B. Chang, Ping Li, Lian-Wen Qi*, Chun-Su Yuan*. Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B. 2016, 1015: 62-73.

7. Yingshu Feng1, Congyong Sun1, Yangyang Yuan1, Yuan Zhu, Jin-Yi Wan, Caleb Kesse Firempong, Emmanuel Omari-Siaw, Yang Xu, Zunqin Pu, Jiangnan Yu*, Ximing Xu*. Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation. Int J Pharm. 2016, 501: 342-349.

8. Jin-Yi Wan1, Yong Fan1, Qing-Tao Yu, Ya-Zhong Ge, Chen-Pu Yan, Raphael N. Alolga, Ping Li*, Zhong-Hua Ma*, Lian-Wen Qi*. Integrated evaluation of malonyl ginsenosides, amino acids andpolysaccharides in fresh and processed ginseng. J Pharmaceut Biomed. 2015, 107: 89-97.

9. Kai Quan1, Qun Liu1, Jin-Yi Wan1, Yi-Jing Zhao, Ru-Zhou Guo, Raphael N. Alolga, Ping Li*, Lian-Wen Qi*. Rapid preparation of rare ginsenosides by acid transformation and their structure-activity relationships against cancer cells. Sci Rep-UK. 2015, 5: 8598.

10. Chong-Zhi Wang, Zhi-Yu Zhang, Jin-Yi Wan, Chun-Feng Zhang, Samantha Anderson, Xin He, Chun-Hao Yu, Tong-Chuan He, Lian-Wen Qi, Chun-Su Yuan*. Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil in an experimental model of colon cancer. Nutrients. 2015, 7: 799-814.

11. Jin-Yi Wan1, Peng Liu1, Huai-You Wang, Lian-Wen Qi*, Chong-Zhi Wang, Ping Li*, Chun-Su Yuan. Biotransformation and metabolic profile of American ginseng saponins with human intestinal microflora by liquid chromatography quadrupole time-of-flight mass spectrometry. J Chromatogr A. 2013, 1286: 83-92.

12. Xiao-Lan Cheng, Jin-Yi Wan, Ping Li*, Lian-Wen Qi*. Ultrasonic/microwave assisted extraction and diagnostic ion filtering strategy by liquid chromatography–quadrupole time-of-flight mass spectrometry for rapid characterization of flavonoids in Spatholobus suberectus. J Chromatogr A. 2011, 1218: 5774-5786.