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周爱华 教授

性别: 男

职称: 教授 (药物化学)

通信地址: 江苏大学药学院,江苏镇江市学府路301号,212013

Mobile:18796002400
Email: zhou_aihua@yahoo.com;ahz@ujs.edu.cn

 Research  Group

 

学习和工作简历:

2010-至今      江苏大学药学院

2008-2010.8     美国University of Wisconsin, Madison, Research Associate.

(从事抗癌药物的合成,筛选,酶催化的天然产物的糖苷化反应,糖化学等研究)

2006-2008.9      美国University of Kansas CMLD药物发现中心, 博士后(从事药用化合物的设计,合成及高通量筛选)

2005                    美国密西西比州立大学化学系, 博士后(从事有机合成方法学和碳纤维等材料方面的研究)

1999.8-2004.12  美国Mississippi State University,获有机化学,博士

(同时还修完该校化学工程博士毕业所需的所有化工理论课,工程数学课).

1995-1999.8     中国石化仪征化纤公司化工厂对苯二甲酸装置工作。

1991.3-1995.8   中国石油辽阳化纤公司化工一厂和芳烃厂工作。

1991.3-1995.8   大连理工大学化工学院化学系,应用化学,硕士学位

1984-1988       大连理工大学化工学院化学工程系,化学工程,工学学士学位.

 

曾在多套石化装置一线工作多年,对连续催化重整再生(UOP工艺),芳烃抽提,歧化及异构化, 二甲苯分离 (旋转吸附分子筛分离),裂解汽油加氢,丙烷/丁烷制氢, PTA精对苯二甲酸装置(BP-AMOCO工艺)有非常丰富的开车,停车,正常操作及事故处理经验。除工艺外, 对多种催化剂,对各种自动化仪表,自动化操作及连锁控制等也有相当的了解。

 

研究领域

1)      药物发现, 抗癌活性天然产物的修饰, 糖化学,酶催化。

2)      有机合成方法学研究, 活性化合物合成,不对称合成,过渡金属催化。

3)      天然化合物的合成、修饰和筛选,磷化合物的合成。

4)      组合化学,多样化合成,固/液相合成, 固/液相化试剂合成

5)      新药、仿制药的合成工艺开发,放大和质量标准的制定,药物申报材料的撰写,精细有机化工。

 

主要代表论文

在江苏大学发表的文章

(1) Generation of thioethers via direct C-H functionalization with sodium benzenesulfinate as a

sulfur source, Org. Biomol. Chem., 2016, (Advance Article, DOI: 10.1039/C5OB02073E).

Yingcai Ding, Wei Wu, Wannian Zhao, Yiwen Li, Ping Xie, Youqin Huang, Yu Liu and Aihua Zhou*

( 2) Regioselective Coupling Reactions of Coumarins with Aldehydes or Di-tert-butyl Peroxide (DTBP) through a C(sp2)-H Functionalization Process, Eur. J. Org. Chem., 2016, (online, DOI:10.1002/ejoc.201501251).

Wannian Zhao, Lei Xu, Yingcai Ding, Ben Niu, Ping Xie, Zhaogang Bian, Denghong Zhang and Aihua Zhou*

 (3) Regioselective C-S Bond Formation between Flavones and Arylsulfonyl Chloride through the Use of Ammonium Iodide, ChemCatChem, 2015, 7, 3464-3467.

Wannian Zhao, Aihua Zhou*

 (4) Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process, J. Org. Chem., 2015, 80, 9167-9175.

Wannian Zhao, Ping Xie, Zhaogang Bian, Aihua Zhou,* Haibo Ge,* Min Zhang, Yingcai Ding, and Lian Zheng

 (5) Synthesis of Nitromethyl-Substituted Oxindole Derivatives via a Desulfonylation Cascade Synlett., 2015, 26, 635-638.

Ben Niu, Ping Xie, Zhaogang Bian, Wannian Zhao, Min Zhang, Yang Zhou, Lei Feng, Charles U. Pittman, Jr., and Aihua Zhou

(6) A Summary of seven- and eight-membered ring sultam syntheses via three Michael addition reactions, Molecular Diversity, 2015, 19, 447-458.

Ben Niu, Ping Xie, Min Wang, Yanjie Wang, Wannian Zhao, Charles U. Pittman Jr., Aihua Zhou

(7) Cascade Couplings of N-Alkyl-N-methacryloyl Benzamides with Ethers and Benzenesulfonohydrazides to Generate Isoquinoline-1,3(2H,4H)-dione Derivatives , J. Org. Chem. 2015, 80, 4176-4183.

Min Zhang, Ping Xie, Wannian Zhao, Ben Niu, Wei Wu, Zhaogang Bian, Charles Pittman, Jr. Aihua Zhou*

(8) Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp3)-H Functionalization, J. Org. Chem. 2015, 80, 7251-7257.

Ben Niu, Wannian Zhao, Yingcai Ding, Zhaogang Bian, Charles U. Pittman Jr., Aihua Zhou* and Haibo Ge 

(9) Generation of ArS-substituted Flavone Derivatives Using Aryl Thiols as Sulfenylating Agents, RSC Advances, 2015, 5, 59861-59864.

Wannian Zhao, Ping Xie, Zhaogang Bian, Haibo Ge, Ben Niu, Yingcai Ding, Aihua Zhou

(10) Metal-free Syntheses of Oxindole Derivatives via a Benzoylation/Substitution /Desulfonylation/Cyclization Cascade, RSC Adv., 2014, 4, 43525-43528

Ben Niu, Ping Xie, Wannian Zhao, Yang Zhou, Zhaogang Bian, Charles U. Pittman,Jr and Aihua Zhou

(11) Synthesis of Isoquinoline-1,3(2H,4H)-dione Derivatives via Cascade Reactions of N-alkyl-N-methacryloyl Benzamide with Aryl Aldehydes, Org. Biomol. Chem., 2014, 12, 7690-7693.

Wannian Zhao, Ping Xie, Min Zhang, Ben Niu, Zhaogang Bian, Charles Pittman Jr. and Aihua Zhou

(12) Diversity-Oriented Syntheses: Coupling Reactions Between Electron-Deficient Olefins and Aryl Aldehydes via C(sp2)-H Functionalization, ACS Comb. Sci. 2014, 16, 454-458.

Ben Niu, Lei Xu, Ping Xie, Min Wang, Wannian Zhao, Charles U. Pittman, Jr., and Aihua Zhou

(13) Copper-catalyzed Oxidative Cascade Coupling of N-alkyl-N-phenylacrylamides with Aryl Aldehydes RSC Adv., 2014, 4, 6854-6857.

Weiwei Gong, Lei Xu, Tao Ji, Ping Xie, Xueyong Qi, Charles U. Pittman, Jr.and Aihua Zhou

(14) Syntheses of Five- and Seven-membered Ring Sultam Derivatives via Michael Addition and Baylis-Hillman Reactions, Tetrahedron, 2013, 69, 2369-2375.

Kun Tong, Jinchang Tu, Xueyong Qi, Min Wang, Yanjie Wang, Haizhen Fu,Charles U. Pittman, Jr., and Aihua Zhou

(15) Parallel Syntheses of Eight-Membered Ring Sultams via Two Cascade Reactions in Water, ACS Comb. Sci. 2013, 15, 595-600.

Tao Ji, Yanjie Wang, Min Wang, Ben Niu, Ping Xie, Charles U. Pittman, Jr., and Aihua Zhou

(16) Selective Synthesis of Seven- and Eight-Membered Ring Sultams via Two Tandem Reaction Protocols from One Starting Material .Org. Lett., 2012, 14 (14), 3700-3703.

Min Wang, Yanjie Wang, Xueyong Qi, Guohua Xia, Kun Tong, Jinchang Tu, Charles,U. Pittman, Jr., and Aihua Zhou

 

在美国期间发表的文章:

(17) Automated Synthesis of a 184-Member Library of Thiadiazepan-1,1-dioxide-4-ones

Erik Fenster, Toby R. Long, Qin Zang, David Hill, Benjamin Neuenswander, Gerald H.

ACS Comb. Sci. 2011, 13, 244-250.

Lushington, Aihua Zhou, Conrad Santini, and Paul R. Hanson, 

(18) Reactions of 2-Methyl- and 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine with Aroyl Chlorides: Diverse Reactivities of Cyclic Ketene N,N-Acetals Generated in situ

Synthesis 2010, 7, 1209-1216.

Guozhong Ye, Sabonie Chatterjee, Aihua Zhou, Bobby Lloyd Barker, et al, Charles U.Pittman, 

(19) Tandem Reactions of 2-Methylimidazoline and 1,2-Dimethylimidazoline with Various Benzoyl Chlorides Synthesis 2010, 1, 141-152.

Guozhong Ye, Chunlong Chen,Sabornie Chatterjee, Collier, Willard E., Zhou Aihua, Yingquan Song, Debbie J. Beard, Charles U. Pittman, 

(20) Push–pull alkenes from cyclic ketene-N,N’-acetals: a wide span of double bond lengths and twist angles Tetrahedron 2010, 66, 2919-2927.

Guozhong Ye, Sabornie Chatterjee, Min Li, Aihua Zhou, Yingquan Song, Bobby Lloyd Barker, Chunlong Chen, Debbie J. Beard, William P. Henry, Charles U. Pittman, 

(21) “Click, Click, Cyclize”: A DOS Approach to Sultams Utilizing Vinyl Sulfonamide Linchipins

Org. Lett. 2009, 11, 531-534.

Aihua Zhou, Paul R. Hanson, 

(22) Push-pull Alkenes by Reacting N,N-dimethyl Cyclic Ketene N,N-Acetals With Isocyanates: Synthesis, Structures and Reactivities Tetrahedron Lett. 2009, 50, 2135-2139.

Guozhong Ye, William P. Henry, Chunlong Chen, Aihua Zhou, Charles U. Pittman, 

(23) a-Haloarylsulfonamides: Multiple Cyclization Pathways to Skeleally Diverse Benzofused Sultams Tetrahedron, 应邀文章, 2009, 65, 3180-3188.

Dinesh Kumar Rayabarapu, Aihua Zhou, Kyu Ok jeon, Thiwanka Samarakoon, Alan Rolfe, Hina Siddiqui and Paul R. Hanson,


(24) Synthesis of Sultam Scaffolds via Intramolecular Oxa-Michael and Diastereoselective Baylis-Hillman Reaction Org. Lett. 2008, 10, 2951-2954.

Aihua Zhou, Paul R. Hanson 

(25) 1,8-NaphthyridinetetraonesfromOne-pot Reactions of 2-Methyllimidazoline or 2-Methyl-1,4,5,6-Tetrahydropyrimidinewith1,3-DiacidChlorides J. Org. Chem. 2008, 73, 5170-5172.

Guozhong Ye, Aihua Zhou, William P. Henry, Yingquan Song, Sabornie Chatterjee, Debbie J. Beard, Charles U. Pittman 

(26) Stereoselective Radical Cyclizations of N-(2-Halobenzoyl)-Cyclic Ketene-N,X (X=O, S)-Acetals”Tetrahedron 2006, 62, 4093-4102.

Aihua Zhou, Moses N. Njogu, Charles U. Pittman 

(27) “Push-Pull” and Spirobicyclic Structures by Reacting N-Methyl Cyclic Ketene-N,X (X =S, O)-acetals with Isocyanates and Isothiocyanates Tetrahedron 2006, 62, 4188-4200.

Aihua Zhou, Charles U. Pittman 

(28) Generation of Cyclic Ketene-N,X-Acetals (X=O,S) from 2-Alkyl-1,3-oxazolines and 2-Alkyl-1,3-thiazolines. Reactions with Acid Chlorides, 1,3-Diacid Chlorides and N-(Chlorocarbonyl) Isocyanate Synthesis 2006, 1, 37-48.

Aihua Zhou, Charles U. Pittman 

(29) Reactions of Cyclic Ketene-N,S-acetals with Isocyanates, Isothiocyanate and Vinylisocyanates Synlett. 2006, 2, 201-206.

Aihua Zhou, Liwei Cao, Haiqing Li, Zhuqing Liu, Charles U. Pittman 

(30) Ring-opening Reactions of Cyclic Ketene-N,X-acetals (X=O, S) with Carboxylic Acids, Phenols and Thiols J. Comb. Chem. 2006, 8, 262-267.

Aihua Zhou, Charles U. Pittman 

(31) Cyclization Reactions of Oxazolines and Thiazolines with Diacid Chlorides”

Tetrahedron Lett. 2005, 46, 2045-2048.

Aihua Zhou, Charles U. Pittman, 

(32) Synthesis of Library of 1,5,2-Dithiazepine-1,1-Dioxide. Part 1: A One-Pot ulfonylation/Thia-Michaelprotocol. Heterocycles. 2012, 86, 1661-1674.

Zang, Q.; Zhou, A.; Javed, S.; Maity, P. K.; Knudtson, C. A.; Bi. D.; Hastings, J. J.; Basha, F. Z.; Hanson, P. R. 

(33) Aryl Radical Cyclization of N-2-Halobenzoyl Cyclic Ketene-N,S-acetals

Tetrahedron Lett. 2005, 46, 3801-3805.

Aihua Zhou, Charles U. Pittman 

(34) Reactions of 2-Methylthiazolines and N-Methyl Cyclic Ketene-N,S-acetals with Acid Chlorides

Tetrahedron Lett. 2004, 45, 8899-8903

Aihua Zhou, Charles U. Pittman 

(35) Multi Capillary Flow Reactor: Synthesis of 1,2,5-thiadiazepane 1,1-dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave- Assisted, Continuous Flow Organic Synthesis (MACOS). J. Flow Chem. 2012, 2, 118-123.

Ullah, F.; Zang, Q.; Javed, S.; Zhou, A.; Knudtson, C. A.; Bi. D.; Hanson, P. R.; Organ, M. G. 

(36) Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’

Strategy: From Bench to Flow, Synthesis 2011, 17, 2743–2750.

Qin Zang, Salim Javed, Farman Ullah, Aihua Zhou, Christopher A. Knudtson, Danse Bi, Fatima Z. Basha, Michael G. Organ, Paul R. Hanson 

(37) Synthesis of Library of 1,5,2-Dithiazepine 1,1-Dioxide. Part 2: Routes to bicyclic Sultams.

Heterocycles. 2012, 86, 1675-1688.

Zang, Q.; Javed, S.; Zhou, A.; Maity, P. K.; Knudtson, C. A.; Bi. D.; Hastings, J. J.; Basha, F. Z.; Hanson, P. R

 

教授过的课程:

(1)药物化学

(2)药物设计和研发过程

(3)化学药物工程和技术

(4)化工原理

(5)光谱

(6)现代药物合成

(7)药学概论

 

其他:

1.  美国化工学会会员 (Member of American Chemical Society).

2. RSC AdvancesTetrahedron, Tetrahedron Lett. Org. Biomol. Chem.等期刊审稿人.