研究专业：药物化学，有机化学，高分子化学，纳米技术与药物制剂。

邮箱：1000004770@ujs.edu.cn or organicboron@ujs.edu.cn

教育与工作简历:

2017.4-至今, 江苏大学, 药学院, 教授

2014.6-2017.2, 韩国圆光大学, 自然科技大学, 研究教授

2011.10-2014.4, 韩国高丽大学, 博士后（研究教授）

2009.7–2011.10,韩国 OCT(株)医药研究所，科研组长

2006.7–2009.7, 韩国圆光大学, 药物化学, 理学博士

2004.7–2006.6, 韩国圆光大学, 药物化学, 理学硕士

2000.9–2004.6, 延边大学, 药学, 药学学士

研究方向：

1.治疗癌症及肿瘤药物的合成设计研究：主要包括1）BNCT新型抗癌药物的设计，2）ODS治疗骨质疏松症新型药物研发，3）HIF-1新型抑制抗肿瘤药物的研发.

2.有机发光材料（Orgainc Light Emitting Diodides, OLED）设计合成与研发：(ETL, HTL, EML and R, G, B dopant materials).

3.BODIPY荧光靶向探针研究：1）构建水溶性动态自主装纳米靶向荧光探针设计，2）表达蛋白靶向探针设计.

4.纳米药物与递送载体的设计合成及应用.

优秀毕业生：

肖福艳 武汉理工大学 （博士）

邵婷玉 校优秀论文奖（2022）金斯瑞生物科技（海外）

刘滢 校优秀论文奖（2024）国家优秀论文奖（2024）金斯瑞生物科技

代表性论文(近3年成果)：

1. Chan, TT; Guofan Jin*. Curcumin/nido-carborane complexes incorporated with crown ether/sodium alginate encapsulated drug delivery strategies exhibit pH-responsive release and enhanced in vitro anti-tumor activity. DYES AND PIGMENTS. (2024), 112428.

2. Liu Y; Guofan Jin*. Rigid symmetric Rhodamine fluorescent dyes as fast selective detection of aluminum and iron ions applied to cell imaging. JOURNAL OF MOLECULAR STRUCTURE. (2024), 1312, 138552.

3. Zhou, M; Guofan Jin*. Design, synthesis, and antitumor activity evaluation of BF3-o, m, p-phenylenediamine bridged with pyrimidine-indole BF3 adduction derivatives. MOLECULAR DIVERSITY. (2024), 07, 28.

4. Chan, TT; Guofan Jin*. A novel pH-sensitive drug carrier system based on 18-crown ether-6/ sodium alginate for curcumin/nido-carborane encapsulation: Studies of release properties, cell imaging and bioactivity evaluation. DYES AND PIGMENTS. (2024), 229.

5. Zhang MT; Guofan Jin*. Polymorphic strategies for encapsulating polyindole@nido-carborane fluorescent polymeric nanocapsules: Their release, imaging, and biological evaluation in the gastrointestinal microenvironment. EUROPEAN POLYMER JOURNAL. (2024), 215.

6. Zhou, M ; Liu, Y ; Wang, S ; Feng, JK ; Ni, HY ; Lu, CC ; Guofan Jin*. Design, synthesis, cell imaging, and bioactivity assessment of novel Rhodamine-Pyrimidine nido-carborane derivatives as fluorescent anticancer agents. JOURNAL OF MOLECULAR STRUCTURE. (2024), 1299, 137211.

7. Liu, Y; Zhou, M; Wang, S; Feng, JK; Lu, CC ; Guofan Jin*. Strategy of eudragit coated curcumin nanoparticles delivery system: Release and cell imaging studies in simulated gastrointestinal microenvironments. BIOORGANIC CHEMISTRY. (2023), 139, 106732.

8. Lian, GC; Liu, Y ; Hu, KB; Zhou, M; Feng, JK; Wang, S; Lu, CC; Guofan Jin*. Multi salt strategy based on curcumin pyrimidine derivatives prodrugs: Synthesis, biological activity, in vitro and in vivo imaging, and drug distribution research. DYES AND PIGMENTS. (2023), 216, 111310.

9. Lue, ZY; Liu, Y; Jin, YC; Zhang, LJ; Wang, X; Lu, CC; Guofan Jin*. A symmetrical carbazole/benzonitrile-based high triplet energy bipolar host designed by a para-linkage strategy for efficient blue and green phosphorescent organic light-emitting diodes. JOURNAL OF LUMINESCENCE. (2023), 261, 119933.

10. Lu, C; Yao, ZD ; Feng, JK; Mao, BE ; Guofan Jin*. Oil-in-water strategy coating Curcumin-nido- Carborane fluorescent complex with acrylic resins for cell imaging. ARABIAN JOURNAL OF CHEMISTRY. (2023), 16, 104876.

11. Zhou, M; Liu, Y ; Wang, S ; Feng, JK; Ni, HY; Lu, CC ;  Guofan Jin*. A novel strategy to bind pyrimidine sulfonamide derivatives with odd even chains: exploration of their design, synthesis and biological activity evaluation. MOLECULAR DIVERSITY. (2023), 12, 23.

12. Lian, Guangchang; Hu, Kaibo; Zhou, Meng; Liu, Ying; Guofan Jin*. Design and bioactivity of Eudragit® encapsulated pH-Sensitive enteric/gastric soluble fluorescent agent. Journal of Polymer Research. (2023), 30, 105.

13. Lian, Guangchang; Hu, Kaibo; Wang, Yuling; Shao, Tingyu; Qi, Xueyong; Zhou, Meng; Liu, Ying; Guofan Jin*. Base on spectroscopic properties response fluorescence probe for rapid, sensitive and selective detection of aluminum ions in wastewater. Inorganic Chemistry Communications (2022), 137, 109171.

14. Liu, Ying; Lian, Guangchang; Wang, Zhenning; Hu, Kaibo; Zhou, Meng; Dou, Yuchen; Li, Siling; Chen, En; Guofan Jin*. Curcumin copolymerized drugs mediated by enteric-coated polymers: Their design, synthesis and biocompatibility cell imaging studies. European Polymer Journal (2022), 180, 111606.

15. Shao, Tingyu; Wang, Yuling; Hu, Kaibo; Lian, Guangchang; Guofan Jin*. Nitrogen-boron eight-ring rigid cis/trans BODIPY-pyrimidine isomers for in vivo and in vitro fluorescence target recognition and evaluation of inhibitory activity. Dyes and Pigments (2022), 201, 110204.

16. Hu, Kaibo; Lian, Guangchang; Wang, Yuling; Shao, Tingyu; Zhou, Meng; Liu, Ying; Guofan Jin*. Rich fluorine trident type rigid donor-acceptor (D-A) tricarbazoles-triazine structures: An effective strong acid affinity fluorescent dye. Dyes and Pigments (2022), 201, 110254.

17. Hu, Jianpeng; Wang, Yuling; shao, Tingyu; Lian, Guangchang; Hu, Kaibo; Liu, Ying; Zhou, Meng; Wang, Xiangpeng; Huang, Lizhuan; Meng, Xinlei; Guofan Jin*. Simple and practical, highly sensitive and responsive recognition of cysteine: Design, synthesis and mechanism study of a novel curcumin fluorescent probe. Arabian Journal of Chemistry (2022), 15(9), 104087.

18. Dai, Dongfang; Lian, Guangchang; He, Xia; Feng, Jifeng; Guofan Jin*. Water-soluble BODIPY-nido-carborane nanoparticles applied to biocompatibility tumor cell imaging. Photochemical & Photobiological Sciences (2022), 21(2), 185-194.

授权国内外专利

1. Guofan Jin; Yoon, Ji Ho; Park, HyeonGyu; Jung, YeongJu; Kim, SeonHui; Kang, Sang Uk; Yoo, Ho Seong; Lee, Jong Dae; Lee, Chae Ho.　Synthesis of 1,3,5-triazin-4-yl-dicarba-closo-dodecaborane derivative for use in anticancer agent for boron-neutron capture radiotherapy.　KRXXA7  KR  2008077801  A  20080826.

2. Guofan Jin; Yoon, Ji Ho; Jung, YeongJu; Kang, Sang Uk; Lee, Jong Dae; Lee, Chae Ho.　1,3,5-triazinylthiocarborane derivatives, their isomers and pharmaceutically acceptable salts, pharmaceutical composition containing the same and preparation method thereof. KRXXA7  KR  2009016794  A  20090218.

3. 金国范; 金峰; 郑兵; 王凯,一种邻碳硼烷苯酚衍生物及其制备方法和应用.中国, 201610325461 .5.

4. 金国范; 金峰; 王凯; 张艳; 张慧; 李柳斌,一种利用邻苯二甲酰亚胺制备双氟磺酰亚胺锂盐的方法,中国, 201610287182 .4.

5. 金国范; 金峰; 王凯; 张艳; 张慧; 李柳斌. 一种利用芳香甲基叠氮制备双氟磺酰亚胺锂盐的方法,中国, 201610286982 .4.

6. 金峰; 王凯; 金国范; 金英兰,邻碳硼烷衍生物、其制备方法和应用及制备该邻碳硼烷衍生物的中间体,中国, 201610286687 .9.

7. 金国范; 金峰; 王凯, 一种双氟磺酰亚胺锂盐的制备方法.中国,201610195308 .5.

8. 金国范;金峰;王凯;张艳;张慧;李柳斌,一种利用联氨制备双氟磺酰亚胺锂盐的方法,201610282164.7.　

9. 金国范;金峰;王凯;张艳;张慧;李柳斌,一种利用羟基氨制备双氟磺酰亚胺锂盐的方法,201610287270.4.