研究专业：药物化学，有机化学，高分子化学，纳米技术与药物制剂。

邮箱：1000004770@ujs.edu.cn or organicboron@ujs.edu.cn

教育与工作简历:

2017.4-至今, 江苏大学, 药学院, 教授

2014.6-2017.2, 韩国圆光大学, 自然科技大学, 研究教授

2011.10-2014.4, 韩国高丽大学, 博士后（研究教授）

2009.7–2011.10,韩国 OCT(株)医药研究所，科研组长

2006.7–2009.7, 韩国圆光大学, 药物化学, 理学博士

2004.7–2006.6, 韩国圆光大学, 药物化学, 理学硕士

2000.9–2004.6, 延边大学, 药学, 药学学士

研究方向：

1. 治疗癌症及肿瘤药物的合成设计研究：主要包括1）BNCT新型抗癌药物的设计，2）嘧啶，喹诺酮等杂环新型抗肿瘤药物研发，3）磺胺类抗肿瘤药物的研发.

2. 有机发光材料（Orgainc Light Emitting Diodides, OLED）设计合成与研发：(ETL, HTL, EML and R, G, B dopant materials).

3. BODIPY荧光靶向探针研究：1）构建水溶性动态自主装纳米靶向荧光探针设计，2）表达蛋白靶向探针设计.

4. 荧光靶向纳米药物与递送系统载体的设计合成及应用.

项目及期刊担任：

1. 基于异质体磁性纳米材料的新型药物传递系统构建及肿瘤标志物检测技术开发

2. 基于药食同源的姜黄素功能提升与可食性递送体系研究

3. 丙烯酸树脂的研发与应用

4. 一种蜂毒肽与天然提取混合型功能性化妆品的研发

中国化妆品期刊：副主编（期刊编辑）

优秀毕业生：

肖福艳： 武汉理工大学 （博士）

邵婷玉： 校优秀论文奖（2022）金斯瑞生物科技（海外）

刘滢 ： 校优秀论文奖（2024）国家优秀论文奖（2024）金斯瑞生物科技

柴田甜，张梦桐： 校优秀论文奖（2026）国家优秀论文奖（2025）

柴田甜： 浙江大学 （博士）

代表性论文(近3年成果：一区及二区)

1. Wang, ZN; Su, P; Guofan Jin*. Photophysical behavior of sulfur-oxidized sulfone and trifluoromethyl-BODIPY: Insight into the relationship between crystal structure and tumor cell imaging. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY. 2026-5-11

2. Chai, TT; Zhang, MT; Su, P; Lu, CC; Guofan Jin*. pH-Triggered and Targeted Delivery of Curcumin: From Dendritic Polymers to Natural and Synthetic Nanocarriers. ADVANCED HEALTHCARE MATERIALS. 2026-04-22

3. Su, P; Chai, TT; Wang, ZN; Lu, CC; Guofan Jin*. Self-assembling nanoscale platforms for curcumin delivery using cerebroprotein hydrolysate/crown ether/quaternary ammonium salts/ phospholipid: pH-responsive release, in vivo targeting real-time monitoring and visualization analysis. EUROPEAN POLYMER JOURNAL. 2026-01-09

4. Su, P; Wang, ZN; Zhang, MT; Guofan Jin*. Oral polymer nanoparticles containing curcumin and berberine hydrochloride based on cerebroprotein hydrolysate-phospholipid crown ether self-assembly: evaluation of nanoparticle properties and in vivo targeting. EUROPEAN POLYMER JOURNAL. 2025-08-11

5. Wang, ZN; Su, P; Lu, CC; Guofan Jin*. A carrier-free rigid fluorescent small molecule CF3/S-containing BODIPY probe: Design and synthesis, tumor cell imaging and biological activity evaluation. DYES AND PIGMENTS. 2025-04-11

6. Su, P; Wang, ZN; Lu, CC; Guofan Jin*. A novel piperazine-linked BODIPY-pyrimidine anti-tumor fluorescent active drug: targeting mechanism, real-time dynamic imaging and delivery effect of DSPC/DPIC nanoparticles. BIOORGANIC CHEMISTRY. 2025-11-03

7. Lü, ZY; Chai, TT; Lu, CC; Guofan Jin*. Asymmetrical carbazole-b enzonitrile-base d TADF emitters designe d by alternate donor-acceptor strategy. CHINESE CHEMICAL LETTERS.2025-04-08

8. Mengtong Zhang; Guofan Jin*. Multi-component driven fluorescence composite nanospheres coating strategy: Spectral properties, release, tumor imaging and bioactivity evaluation in a simulated gastrointestinal microenvironment. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. (2025), 125858.

9. Chan, TT; Guofan Jin*. Based on sodium alginate coatings and dendritic copolymeric modification of curcumin delivery system: pH-sensitive nanospheres and strong tumor cytotoxicity. International Journal of Biological Macromolecules. (2025), 112428. 137962.

10. Chan, TT; Guofan Jin*. Curcumin/nido-carborane complexes incorporated with crown ether/sodium alginate encapsulated drug delivery strategies exhibit pH-responsive release and enhanced in vitro anti-tumor activity. DYES AND PIGMENTS. (2024), 112428.

11. Liu Y; Guofan Jin*. Rigid symmetric Rhodamine fluorescent dyes as fast selective detection of aluminum and iron ions applied to cell imaging. JOURNAL OF MOLECULAR STRUCTURE. (2024), 1312, 138552.

12. Zhou, M; Guofan Jin*. Design, synthesis, and antitumor activity evaluation of BF3-o, m, p-phenylenediamine bridged with pyrimidine-indole BF3 adduction derivatives. MOLECULAR DIVERSITY. (2024), 07, 28.

13. Chan, TT; Guofan Jin*. A novel pH-sensitive drug carrier system based on 18-crown ether-6/ sodium alginate for curcumin/nido-carborane encapsulation: Studies of release properties, cell imaging and bioactivity evaluation. DYES AND PIGMENTS. (2024), 229.

14. Zhang MT; Guofan Jin*. Polymorphic strategies for encapsulating polyindole@nido-carborane fluorescent polymeric nanocapsules: Their release, imaging, and biological evaluation in the gastrointestinal microenvironment. EUROPEAN POLYMER JOURNAL. (2024), 215.

15. Zhou, M ; Liu, Y ; Wang, S ; Feng, JK ; Ni, HY ; Lu, CC ; Guofan Jin*. Design, synthesis, cell imaging, and bioactivity assessment of novel Rhodamine-Pyrimidine nido-carborane derivatives as fluorescent anticancer agents. JOURNAL OF MOLECULAR STRUCTURE. (2024), 1299, 137211.

16. Liu, Y; Zhou, M; Wang, S; Feng, JK; Lu, CC ; Guofan Jin*. Strategy of eudragit coated curcumin nanoparticles delivery system: Release and cell imaging studies in simulated gastrointestinal microenvironments. BIOORGANIC CHEMISTRY. (2023), 139, 106732.

17. Lian, GC; Liu, Y ; Hu, KB; Zhou, M; Feng, JK; Wang, S; Lu, CC; Guofan Jin*. Multi salt strategy based on curcumin pyrimidine derivatives prodrugs: Synthesis, biological activity, in vitro and in vivo imaging, and drug distribution research. DYES AND PIGMENTS. (2023), 216, 111310.

18. Lue, ZY; Liu, Y; Jin, YC; Zhang, LJ; Wang, X; Lu, CC; Guofan Jin*. A symmetrical carbazole/benzonitrile-based high triplet energy bipolar host designed by a para-linkage strategy for efficient blue and green phosphorescent organic light-emitting diodes. JOURNAL OF LUMINESCENCE. (2023), 261, 119933.

19. Lu, C; Yao, ZD ; Feng, JK; Mao, BE ; Guofan Jin*. Oil-in-water strategy coating Curcumin-nido- Carborane fluorescent complex with acrylic resins for cell imaging. ARABIAN JOURNAL OF CHEMISTRY. (2023), 16, 104876.

20. Zhou, M; Liu, Y ; Wang, S ; Feng, JK; Ni, HY; Lu, CC ; Guofan Jin*. A novel strategy to bind pyrimidine sulfonamide derivatives with odd even chains: exploration of their design, synthesis and biological activity evaluation. MOLECULAR DIVERSITY. (2023), 12, 23.

授权专利

1. Guofan Jin; Yoon, Ji Ho; Park, HyeonGyu; Jung, YeongJu; Kim, SeonHui; Kang, Sang Uk; Yoo, Ho Seong; Lee, Jong Dae; Lee, Chae Ho. Synthesis of 1,3,5-triazin-4-yl-dicarba-closo-dodecaborane derivative for use in anticancer agent for boron-neutron capture radiotherapy. KRXXA7 KR 2008077801 A 20080826.

2. Guofan Jin; Yoon, Ji Ho; Jung, YeongJu; Kang, Sang Uk; Lee, Jong Dae; Lee, Chae Ho. 1,3,5-triazinylthiocarborane derivatives, their isomers and pharmaceutically acceptable salts, pharmaceutical composition containing the same and preparation method thereof. KRXXA7 KR 2009016794 A 20090218.

3. 金国范;刘瑞江;肖福燕;于庆梅： 一种二维氮掺杂纳米石墨烯材料及其应用 CN201811277688.2

4. 金国范： 一种咔唑类热激活延迟荧光材料及制备方法 201911267211.0

5. 金国范，戚雪勇：一种甘草酸/甘草次酸-三乙醇胺复合水凝胶及其制备方法和应用 202610158046.9