一、基本信息

姓名：金国范

通讯地址：江苏省镇江市学府路301号 江苏大学药学院（邮编：212013）

电子邮件：1000004770@ujs.edu.cn 或 organicboron@ujs.edu.cn

二、个人简介

金国范，男，江苏大学药学院教授、硕士生导师。长期从事BNCT(硼中子捕获治疗法)新型抗癌药物的设计合成、BODIPY小分子荧光靶向探针、有机发光材料(Orgainc Light Emitting Diodides, OLED)设计合成与研发、天然中药(姜黄素，槲皮素及大黄素等)荧光靶向纳米药物与递送系统的构建与设计合成等研究，主持省部级科研项目5项，在Advances in Colloid and Interface Science(IF=23.7)、Advanced Healthcare Materials(IF=11)、International Journal of Biological Macromolecules(IF=8.7)等国外权威期刊发表论文60多篇。担任《Advances in Colloid and Interface Science》、《Advanced Healthcare Materials》等期刊审稿人、现担任《中国化妆品科学》副主编。

三、教育经历

•2006.09—2009.06 韩国圆光大学，化学专业，博士学位

•2004.09—2006.06 韩国圆光大学，化学专业，硕士学位

•2000.09—2004.06 延边大学，药学专业，学士学位

四、工作经历

•2017.04-至今, 江苏大学, 药学院, 教授

•2014.06-2017.02, 韩国圆光大学, 自然科技学院, 研究教授

•2011.10-2014.04, 韩国高丽大学, 博士后（研究教授）

•2009.07–2011.10,韩国 OCT(株)医药研究所，科研组长

五、研究方向

1.治疗癌症及肿瘤药物的合成设计与研究：主要包括1）BNCT新型抗癌药物的设计，2）嘧啶，喹诺酮等杂环新型抗肿瘤药物研发，3）磺胺类抗肿瘤药物的研发.

2.有机发光材料（Orgainc Light Emitting Diodides, OLED）设计合成与研发：(ETL, HTL, EML and R, G, B dopant materials).

3.BODIPY荧光靶向探针研究：1）构建水溶性动态自主装纳米靶向荧光探针设计，2）表达蛋白靶向探针设计.

4.荧光靶向纳米药物与递送系统载体的设计合成及应用.

六、科研成果

6.1 科研项目

•2025.04-2027.06｜基于药食同源的姜黄素功能提升与可食性递送体系研究｜横向课题｜主持

•2024.09-2029.06｜丙烯酸树脂的研发与应用｜横向课题｜主持

6.2 学术论文

1.Wang, ZN; Su, P; Guofan Jin*. Photophysical behavior of sulfur-oxidized sulfone and trifluoromethyl-BODIPY: Insight into the relationship between crystal structure and tumor cell imaging. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY. 2026-5-11 (中科院二区, IF=4.5)

2.Chai, TT; Zhang, MT; Su, P; Lu, CC; Guofan Jin*. pH-Triggered and Targeted Delivery of Curcumin: From Dendritic Polymers to Natural and Synthetic Nanocarriers. ADVANCED HEALTHCARE MATERIALS. 2026-04-22 (中科院TOP一区, IF=11)

3.Su, P; Chai, TT; Wang, ZN; Lu, CC; Guofan Jin*. Self-assembling nanoscale platforms for curcumin delivery using cerebroprotein hydrolysate/crown ether/quaternary ammonium salts/ phospholipid: pH-responsive release, in vivo targeting real-time monitoring and visualization analysis. EUROPEAN POLYMER JOURNAL. 2026-01-09 (中科院二区, IF=6.8)

4.Su, P; Wang, ZN; Zhang, MT; Guofan Jin*. Oral polymer nanoparticles containing curcumin and berberine hydrochloride based on cerebroprotein hydrolysate-phospholipid crown ether self-assembly: evaluation of nanoparticle properties and in vivo targeting. EUROPEAN POLYMER JOURNAL. 2025-08-11 (中科院二区, IF=6.8)

5.Wang, ZN; Su, P; Lu, CC; Guofan Jin*. A carrier-free rigid fluorescent small molecule CF3/S-containing BODIPY probe: Design and synthesis, tumor cell imaging and biological activity evaluation. DYES AND PIGMENTS. 2025-04-11 (中科院一区, IF=4.2)

6.Su, P; Wang, ZN; Lu, CC; Guofan Jin*. A novel piperazine-linked BODIPY-pyrimidine anti-tumor fluorescent active drug: targeting mechanism, real-time dynamic imaging and delivery effect of DSPC/DPIC nanoparticles. BIOORGANIC CHEMISTRY. 2025-11-03 (中科院一区, IF=5.1)

7.Lü, ZY; Chai, TT; Lu, CC; Guofan Jin*. Asymmetrical carbazole-b enzonitrile-base d TADF emitters designe d by alternate donor-acceptor strategy. CHINESE CHEMICAL LETTERS.2025-04-08 (中科院TOP一区, IF=9.5)

8.Mengtong Zhang; Guofan Jin*. Multi-component driven fluorescence composite nanospheres coating strategy: Spectral properties, release, tumor imaging and bioactivity evaluation in a simulated gastrointestinal microenvironment. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. (2025), 125858. (中科院二区, IF=4.5)

9.Chan, TT; Guofan Jin*. Based on sodium alginate coatings and dendritic copolymeric modification of curcumin delivery system: pH-sensitive nanospheres and strong tumor cytotoxicity. International Journal of Biological Macromolecules. (2025), 112428. 137962 (中科院二区, IF=8.9)

10.Chan, TT; Guofan Jin*. Curcumin/nido-carborane complexes incorporated with crown ether/sodium alginate encapsulated drug delivery strategies exhibit pH-responsive release and enhanced in vitro anti-tumor activity. DYES AND PIGMENTS. (2024), 112428 (中科院一区, IF=4.2)

11.Liu Y; Guofan Jin*. Rigid symmetric Rhodamine fluorescent dyes as fast selective detection of aluminum and iron ions applied to cell imaging. JOURNAL OF MOLECULAR STRUCTURE. (2024), 1312, 138552 (中科院一区, IF=4.2)

12.Zhou, M; Guofan Jin*. Design, synthesis, and antitumor activity evaluation of BF3-o, m, p-phenylenediamine bridged with pyrimidine-indole BF3 adduction derivatives. MOLECULAR DIVERSITY. (2024), 07, 28 (中科院二区, IF=4.3)

13.Chan, TT; Guofan Jin*. A novel pH-sensitive drug carrier system based on 18-crown ether-6/ sodium alginate for curcumin/nido-carborane encapsulation: Studies of release properties, cell imaging and bioactivity evaluation. DYES AND PIGMENTS. (2024), 229 (中科院一区, IF=4.2)

14.Zhang MT; Guofan Jin*. Polymorphic strategies for encapsulating polyindole@nido-carborane fluorescent polymeric nanocapsules: Their release, imaging, and biological evaluation in the gastrointestinal microenvironment. EUROPEAN POLYMER JOURNAL. (2024), 215 (中科院二区, IF=6.8)

15.Zhou, M ; Liu, Y ; Wang, S ; Feng, JK ; Ni, HY ; Lu, CC ; Guofan Jin*. Design, synthesis, cell imaging, and bioactivity assessment of novel Rhodamine-Pyrimidine nido-carborane derivatives as fluorescent anticancer agents. JOURNAL OF MOLECULAR STRUCTURE. (2024), 1299, 137211 (中科院二区, IF=4.9)