E-mail: wmq3415@163.com Tel: 13705283631

【教育经历】

2005.09-2009.06 淮阴师范学院，环境科学专业，获学士学位

2009.09-2014.07 四川大学，有机化学专业，获博士学位

【工作经历】

2011.3-2012.05 中国科学院成都生物研究所，导师：唐卓研究员

2012.06-2013.01 Okayama University（冈山大学），导师：Rrof. Tsutomu Inokuchi

2014.07-至今 江苏大学，药学院，制药工程系

【研究方向】

1、核酸药物化学和核酸化学生物学

2、超分子自组装荧光纳米探针

3、新型光功能有机分子的构建及其应用

【工作业绩】

工作以来，以有机小分子荧光探针的合成为基础，基于组装方式构建功能纳米材料，利用光谱分析及生物成像手段，致力于发展高选择性、高灵敏度和高效的分析检测技术，实现对生物标志物、有毒有害物的分析检测，为疾病的早期诊断与预防和环境污染监测等领域提供新材料和新分析方法。作为负责人先后主持国家自然科学基金，中国博士后基金、江苏省自然科学基金、江苏大学高级人才启动基金等，以第一作者及通讯作者身份在Nucleic Acids Res., Chem. Comm., Talanta, J. Mater. Chem. B., J. Org. Chem., Org. Biomol. Chem., Bioorg. Med. Chem., New J. Chem., Dyes Pigm., Anal. Chim. Acta等国际知名学术期刊上共发表SCI收录学术论文40余篇；授权中国发明专利2项。同时担任国际国内学术刊物的论文评审专家，包括Sensor Actuat B-Chem；Sci Rep-UK、Eur J Med Chem等国际化学领域主流期刊。主讲本科生课程《仪器分析》、《药物波谱学》，研究生课程《现代药物分析技术》。荣获江苏大学“优秀教师”荣誉称号。

【招生方向】

1、药物化学（学硕）

2、生物与医药（专硕）

【科研项目】（项目负责人）

1、基于深红/近红外两亲性BODIPY荧光纳米探针的设计、自组装及G-四链体DNA识别应用，国家自然科学青年基金；

2、肽核酸相关产品的合成及生产工艺研发，企业合作项目；

3、端粒G4-DNA为靶点的喹啉类衍生物结构修饰及机理研究，中国博士后科学基金；

4、端粒DNA识别分子的核酸调控及相关信号转导干预研究，江苏高等学校自然科学研究面上项目；

5、基于深红/近红外两亲性BODIPY荧光分子自组装：分子设计、G-四链体DNA识别与生物应用，江苏省青年科学基金；

6、G-四链体DNA荧光探针分子的设计合成及其抗肿瘤活性研究，江苏大学高级人才启动；

7、一种具有电荷转移特性的荧光探针及其制备方法和用途，成果转化。

【近五年代表性论著】（第一作者和通讯作者论文）

1. Ming-Qi Wang*, Ze-Kai Li, Lu-Yu Li, Xu-Bo Fan, Jing Shu, Qi-Bin Hu, Hai-Jiao Wang, A non-solvatochromic fluorescent probe for imaging of lipid droplets in live cells and tissues. Talanta, 2025, 290, 127805;

2. Hai-Wen Chen, Su'an Tan, Jing-Zhi Li, Lu-Yu Li, Ze-Kai Li, Xiao-Feng Yu, Hai-Jiao Wang, Ming-Qi Wang*. Tuning the push-pull dyes: Construction of polarity insensitive probes for G4 DNA. Dyes and Pigments, 2024, 231,112407；

3. Hai-Wen Chen, Hao-Wen Cao, Jing-Zhi Li, Yan-Song Chen, Lu-Yu Li, Ze-Kai Li, Hai-Jiao Wang, Ming-Qi Wang*. D-π-A type fluorescent dyes: Effect of π-bridge units on optical and G4 DNA binding properties, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 323,124901；

4. Hao-Wen Cao, Yan-Song Chen, Jing-Zhi Li, Hai-Wen Chen, Lu-Yu Li, Ze-Kai Li, Ming-Qi Wang*. Development of D-π-A organic dyes for discriminating HSA from BSA and study on dye-HSA interaction, Bioorganic Chemistry, 2024, 147,107360;

5. Yan-Song Chen, Hao-Wen Cao, Jing-Zhi Li, Hai-Wen Chen, Lu-Yu Li, Ze-Kai Li, Hai-Jiao Wang, Ming-Qi Wang*. Disaggregation-driven far-red BODPIY dye for selective G4 DNA structures detection, Tetrahedron Letters, 2024, 140, 155033;

6. Guang-Feng Liu, Yan-Song Chen, Zhi-Lan Wang, Di Gu, Ming-Qi Wang*. A disaggregation-driven BODPIY-based probe for ratiometric detection of G4 DNA, Dyes and Pigments, 2024, 225, 112107;

7. Hao-Wen Cao, Yan-Song Chen, Hai-Wen Chen, Jing-Zhi Li, Ming-Qi Wang*. Effect of metal coordination in modulating the binding interaction of an arylimidazole-derived organic chromophore with lipase. Dyes and Pigments, 2023, 220, 111674.

8. Jing-Zhi Li, Hong-Lan Lin, Hong-Yao Li, Cao, Hao-Wen Cao, Xue-Xian Lang, Yan-Song Chen, Hai-Wen Chen, Ming-Qi Wang*. Red-emitting Styryl-BODIPY dye with donor-z-acceptor architecture: Selective interaction with serum albumin via disaggregation-induced emission. Dyes and Pigments, 2023, 216, 111357.

9. Xue-Xian Lang, Shu-Hui Sun, Hao-Wen Cao, Yan-Song Chen, Hong-Yao Li, Ming-Qi Wang*. An environmentally insensitive fluorescent probe for G4 DNA detection: Design, synthesis, and mechanism studies. Analytica Chimica Acta, 2023, 1252, 341074.

10. Hao-Wen Cao, Xue-Xian Lang, Yan-Song Chen, Hai-Wen Chen, Jing-Zhi Li, Xiao-Feng Yu, Hai-Jiao Wang, Ming-Qi Wang*. Modulation of G4 DNA sensing behavior by triphenylamine-imidazole based D-D-π-A-type organic fluorophores with subtle structural change. Dyes and Pigments, 2023, 210, 111029.

11. Hong-Yao Li , Hao-Wen Cao, Xue-Xian Lang, Yan-Song Chen , Ming-Qi Wang*. Selective c-MYC G4 DNA recognition based on a fluorescent light-up probe with disaggregation-induced emission characteristics. Journal of Materials Chemistry B, 2022, 10, 7772-7779.

12. Xue-Xian Lang, Hong-Yao Li, Hao-Wen Cao, Yan-Song Chen, Peng-Xiang Zhang, Hai-Jiao Wang^*, Ming-Qi Wang^*. Exploring the binding mechanism of amine-functionalized tetraaryl imidazole fluorescent ligands with lipase: Insights from multi-spectroscopic, thermodynamic and docking approaches. Dyes and Pigments, 2022, 205, 110535.

13. Xue-Xian Lang, Quan-Qi Yu, Hong-Yao Li, Yang Luo, Xiao-Feng Yu, Hai-jiao Wang*, Ming-Qi Wang*. Identification of a non-planar imidazole-cored small molecule for selective telomeric G4 DNA targeting. Dyes and Pigments, 2022, 197, 109901.

14. Quan-Qi Yu, Xue-Xian Lang, Juan-Juan Gao, Hong-Yao Li, Yi-Tong Bai, Hai-jiao Wang*, Ming-Qi Wang*. Zn(II)-DPA Coordinative fluorescent probe for enhancing G4 DNA binding. Dyes and Pigments, 2021, 195, 109707.

15. Juan-Juan Gao, Xue-Xian Lang, Quan-Qi Yu, Hong-Yao Li, Hai-jiao Wang, Ming-Qi Wang*. Amphiphilic BODIPY-based nanoparticles as “light-up” fluorescent probe for PAEs detection by an aggregation/disaggregation approach. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 252, 119492.

16. Yang Luo, Quan-Qi Yu, Juan-Juan Gao, Xue-Xian Lang, Hong-Yao Li, Xiao-Feng Yu, Xue-Yong Qie, Ming-Qi Wang*. Design, synthesis and mechanistic studies of a TICT based fluorogenic probe for lighting up protein HSA. Bioorganic & Medicinal Chemistry Letters, 2021, 53, 128438.

17. Ming-Qi Wang*, Juan-Juan Gao, Quan-Qi Yu, Hong-Bei Liu. An amphiphilic BODIPY-based selective probe for parallel G4 DNA targeting via disaggregation-induced emission. New Journal of Chemistry, 2020, 44: 13557-13564.

18. Quan-Qi Yu, Juan-Juan Gao, Xue-Xian Lang, Hong-Yao Li, Ming-Qi Wang*. Microenvironment-Sensitive Fluorescent Ligand Binds Ascaris Telomere Antiparallel G-Quadruplex DNA with Blue-Shift and Enhanced Emission. ChemBioChem, 2020, 21, 1-8.

19. Quan-Qi Yu, Ming-Qi Wang*. Carbazole-based fluorescent probes for G-quadruplex DNA targeting with superior selectivity and low cytotoxicity. Bioorganic & Medicinal Chemistry, 2020, 28, 115641.

20. Xin-Yue Zeng, Qing-Zhong Zhu,Quan-Qi Yu, Ming-Qi Wang*. Conjugating a groove binder analogue to a styryl-quinolinium scaffold for the light-up detection of duplex and G-Quadruplex DNA with different binding modes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 228, 117705.

21. Ming-Qi Wang*, Yi-Fan Liao, Shu-Hui Zhang, Quan-Qi Yu, Jin-Qiu Huang. Synthesis, G-Quadruplex DNA binding and cytotoxic properties of naphthalimide substituted styryl dyes. Bioorganic & Medicinal Chemistry, 2020, 28, 115325.

【学生培养】

2024年，陈海文（2022级） 获得国家奖学金。

2024年，郎学先（2020级） 获得江苏省优秀专业硕士论文。

2024年，曹浩文（2021级） 获得江苏大学优秀硕士论文。

2023年，郎学先（2020级） 获得江苏大学优秀硕士论文。

【授权发明专利】

[1] 王明齐，唐彩平，刘硕等，一种具有电荷转移特性的荧光探针及其制备方法和用途。

[2] 王明齐，马瑞，于全琦等，一种特异性检测平行构型G-四链体DNA探针的制备方法。