一、基本信息

姓名：曹进

通讯地址：江苏省镇江市学府路301号 江苏大学药学院（邮编：212013）

电子邮件：caoj@ujs.edu.cn

二、个人简介

曹进，女，1983年出生，博士，江苏大学药学院副教授、硕士生导师，药剂学系主任。主要从事生物大分子的药学应用、微/纳米药物递送系统开发及化妆品原料开发与配方研究。主持国家自然科学基金青年项目、中国博士后科学基金面上项目、江苏省高校自然科学研究面上项目等，参与多项国家级、省级科研项目。在Chemical Engineering Journal等国内外期刊发表论文多篇。获江苏省药学会科学技术奖一等奖、江苏大学优秀教师、江苏大学“三全育人”先进个人等荣誉。

三、教育经历

•2008.09—2011.06 中国药科大学，微生物与生化药学专业，博士学位

•2005.09—2008.06 中国药科大学，海洋药学专业，硕士学位

•2001.09—2005.06 中国药科大学，生物制药强化班，学士学位

四、工作经历

•2016.09—至今 江苏大学药学院，副教授、硕士生导师

•2018.12—2019.12 美国明尼苏达大学药学院，访问学者

•2014.10—2018.12 江苏大学，博士后

•2011.07—2016.09 江苏大学药学院，讲师

五、研究方向

1.生物大分子的药学应用

2.微/纳米药物递送系统开发

3.化妆品原料开发与配方研究

六、科研成果

6.1 科研项目

1.2024.11—至今｜校企合作项目“锰-藻蓝蛋白纳米粒复合水凝胶系统在肿瘤局部声动力-化学协同治疗中的应用研究”（项目编号：HX20241098）｜企业合作｜主持

2.2020.01—2023.12｜国家自然科学基金青年项目“基于藻蓝蛋白的声动力-化学抗肿瘤集成纳米系统的研究”（项目编号：82003649）｜国家自然科学基金委员会｜主持

3.2016.09—2018.08｜江苏省高校自然科学研究面上项目“pH稳定的BG-PLGA复合蛋白微球的制备及应用”（项目编号：16KJD350001）｜江苏省教育厅｜主持

4.2015.07—2017.07｜中国博士后科学基金面上项目“微环境调控型BG/PLGA/BMP三元载体的构建及骨修复作用”（项目编号：2015M571706）｜中国博士后科学基金会｜主持

5.2014.07—2017.07｜江苏省自然科学基金青年项目“基于网络和RNAi的抑制Src与PARD6A对卵巢癌的协同杀伤作用研究”（项目编号：BK20140572）｜江苏省科学技术厅｜参与（排名第二）

6.2014.01—2017.12｜国家自然科学基金项目“基于TALEN技术的细胞色素P450基因敲除大鼠模型的构建与应用”（项目编号：81373480）｜国家自然科学基金委员会｜参与（排名第二）

7.2013.06—2018.12｜江苏大学高级专业人才科研启动基金“条斑紫菜活性成分的高效提取及活性研究”（项目编号：1281280019）｜江苏大学｜主持

8.2012.07—2015.06｜江苏省自然科学基金青年项目“五种动物药鉴定中标志蛋白和多肽特征识别物的研究”（项目编号：BK2012290）｜江苏省科学技术厅｜参与（排名第二）

9.2012.01—2015.12｜国家自然科学基金青年项目“载蟾毒灵新型‘触发式’自组装蛋白聚合物纳米载体的设计制备及肝肿瘤靶向研究”（项目编号：81202930）｜国家自然科学基金委员会｜参与（排名第二）

6.2 学术论文

1.Huan Wang, Sijia Lin, Jin Zhou, Jinyue Bi, Yiming Wang, Xinpei Li, Qian Yang, Shuying Wu, Xueyong Qi, Song Shen, Cao Jin*. A natural COX-2 inhibitor-integrated nanoplatform for TNBC immunotherapy: Mn-PC-PTX synergizes chemotherapy and immune activation[J]. Colloids and Surfaces B: Biointerfaces, 2026, 265:115763.

2.Huan Wang, Chenyao Qian, Jinyue Bi, Jin Zhou, Xinpei Li, Xueyong Qi, Song Shen, Cao Jin*. In situ photothermal-chemical dynamics synergistic enhancement of anti-tumor effect based on phycocyanin multifunctional nanosystem[J]. Colloids and Surfaces B: Biointerfaces, 2025, 256(Pt 2):10.

3.Jinyue Bi, Huan Wang, Huan Luo, Chenyao Qian, Jin Zhou, Xinpei Li, Xueyong Qi, Song Shen, Cao Jin*. Self-healing hydrogels loaded with selenium nanoparticles/chitosan/cellulose nanofibers as carriers of mesenchymal stem cells for diabetic wound healing[J]. International Journal of Biological Macromolecules, 2025, 322(Pt 4):146905.

4.Chenyao Qian, Huan Wang, Jinyue Bi, Xiaodan Zheng, Rujia Li, Huan Luo, Xueyong Qi, Song Shen, Cao Jin*. A biomimetic manganese-phycocyanin nanodrug-carrying system and its sonodynamic-immunological anti-tumor therapy[J]. International Journal of Pharmaceutics, 2025, 677.

5.Xiaodan Zheng, Chenyao Qian, Huan Wang, Jinyue Bi, Xueyong Qi, Song Shen, Cao Jin*. Phycocyanin- and Polydopamine-Conjugated Titania Nanoparticles for UV Protection[J]. ACS Applied Nano Materials, 2025, 8(14):6983-6993.

6.Cao Jin, Zhenyan Sun, Chenyao Qian, Huan Wang, Jinyue Bi, Xueyong Qi, Song Shen. Synergetic Sonodynamic-Immunotherapy based on phycocyanin nanoparticles (PCNP) reduces tumor growth and metastasis in mice[J]. Chemical Engineering Journal, 2024, 498:155021.

7.Zhiye Li, Chenyao Qian, Xiaodan Zheng, Xueyong Qi, Jinyue Bi, Huan Wang, Cao Jin*. Collagen/chitosan/genipin hydrogel loaded with phycocyanin nanoparticles and ND-336 for diabetic wound healing[J]. International Journal of Biological Macromolecules, 2024, 266(Pt 1):131220.

8.Cao Jin, Xiaodan Zheng, Zhiye Li, Mingxue Zheng, Chenyao Qian, Song Shen, Xueyong Qi. Exploring marine algae-derived phycocyanin nanoparticles as a safe and effective adjuvant for sunscreen systems[J]. Discover Applied Sciences, 2024, 6(1):24.

9.Cao Jin, Mingxue Zheng, Zhenyan Sun, Zhiye Li, Xueyong Qi, Song Shen. One-Step Fabrication of Multifunctional PLGA-HMME-DTX@MnO2 Nanoparticles for Enhanced Chemo-Sonodynamic Antitumor Treatment[J]. International Journal of Nanomedicine, 2022, 17:2577-2591.

10.Lin Wu, Anran Yuan, Xiangrong Tian, Cao Jin*, Xueyong Qi, Yuan Wei*, Song Shen*. Cell-Membrane-Coated Cationic Nanoparticles Disguised as Macrophages for the Prevention and Treatment of Type 2 Diabetes Mellitus[J]. ACS Applied Materials & Interfaces, 2022, 14(45):50499-50506.

11.Ruan Li, Kai Zhao, Xiangrong Tian, Lin Wu*, Cao Jin*, Xueyong Qi, Song Shen*. Macrophages exosomes-coated Fe3O4 nanoparticles for oxygen independent generation of free radicals and hypoxic cancer therapy[J]. Materials Today Communications, 2022, 33:104672.

12.Cao Jin, Qiwen Pan, Shifang Bei, Mingxue Zheng, Zhenyan Sun, Xueyong Qi, Song Shen. Concise Nanoplatform of Phycocyanin Nanoparticle Loaded with Docetaxel for Synergetic Chemo-sonodynamic Antitumor Therapy[J]. ACS Applied Bio Materials, 2021, 4(9):7176-7185.

13.Cao Jin, Shubhmita Bhatnagar, Jiawei Wang, Xueyong Qi, Swayam Prabha, Jayanth Panyam. Cancer stem cells and strategies for targeted drug delivery[J]. Drug Delivery and Translational Research, 2020, 11(5):1779-1805.

14.Cao Jin, Jin Cheng, Siyu Xi, Xueyong Qi, Song Shen, Yanru Ge. Alginate/chitosan microcapsules for in-situ delivery of the protein, interleukin-1 receptor antagonist (IL-1Ra), for the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2019, 137:112-121.

15.Lin Wu, Ling Zong, Haihua Ni, Xuexue Liu, Wen Wen, Lei Feng, Cao Jin*, Xueyong Qi, Yanru Ge*, Song Shen*. Magnetic Thermosensitive Micelles with Upper Critical Solution Temperature for NIR Triggered Drug Release[J]. Biomaterials Science, 2019, 7(5):2134-2143.

16.Cao Jin, Jin Cheng, Xiaofeng Wang, Yanru Ge. Optimization of the Process for Preparation of Lactococcus lactis NZ9000 Microcapsules by Response Surface Method[J]. Nanoscience and Nanotechnology Letters, 2017, 9(12):2054-2060.

17.Cao Jin, Jianping Wang, Shicheng Wang, Ximing Xu. Porphyra Species: A Mini-review of Its Pharmacological and Nutritional Properties[J]. Journal of Medicinal Food, 2016, 19(2):111-119.

18.Qingtong Yu, Cao Jin, Baoding Chen, Wenwen Deng, Xia Cao, Jingjing Chen, Yan Wang, Shicheng Wang, Jiangnan Yu, Ximing Xu, Xiangdong Gao. Efficient gene delivery to human umbilical cord mesenchymal stem cells by cationized Porphyra yezoensis polysaccharide nanoparticles[J]. International Journal of Nanomedicine, 2015, 10:7097-7107.

19.Cao Jin, Shicheng Wang, Chenwei Yao, Zi Xu, Ximing Xu. Hypolipidemic Effect of Porphyran extracted from Porphyra yezoensis in ICR Mice With High Fatty Diet[J]. Journal of Applied Phycology, 2016, 28(2):1315-1322.

20.Cao Jin, Shicheng Wang, Liuwei Xu, Jiabing He, Ximing Xu. Extraction of porphyran from Porphyra yezoensis for gel formulation preparation[J]. Key Engineering Materials, 2014, 636:133-137.

6.3 专利与软件著作权

1.曹进, 孙箴言, 沈松, 戚雪勇, 马培薇, 李智冶, 钱晨瑶, 郑晓丹. 一种载免疫佐剂藻蓝蛋白纳米系统及其制备方法和应用: CN202310329381.7[P]. 2023-03-30.