一、基本信息

姓名：王明齐

通讯地址：江苏省镇江市学府路301号 江苏大学药学院（邮编：212013）

电子邮件：wmq3415@163.com

二、个人简介

王明齐，1987年5月出生于江苏镇江，2014年毕业于四川大学，师从余孝其教授。博士，副教授，硕士生导师，江苏大学青年英才培育计划优秀青年骨干教师。长期从事发展高选择性、高灵敏度和高效的有机小分子荧光探针，为疾病的早期诊断与预防和环境污染监测等领域提供新材料和新分析方法。作为负责人先后主持国家自然科学基金，中国博士后基金、江苏省自然科学基金等，以第一作者及通讯作者身份在Nucleic Acids Res., Chem. Comm., Talanta等国际知名学术期刊上共发表SCI收录学术论文40余篇；授权中国发明专利2项。荣获江苏大学“优秀教师”荣誉称号。

三、教育经历

•2009.09—2014.06 四川大学，有机化学专业，博士学位

•2005.09—2009.06 淮阴师范学院，环境科学专业，学士学位

四、工作经历

•2014.07—至今 江苏大学药学院，副教授、硕士生导师

•2012.06—2013.01 Okayama University（冈山大学）

•2011.03—2012.06 中国科学院成都生物研究所

五、研究方向

1.核酸药物化学

2.有机小分子荧光探针

3.超分子自组装荧光纳米探针

六、科研成果

6.1 科研项目

•2025.05—2028.12｜一种特异性检测平行构型G－四链体DNA探针的制备方法｜企业合作项目｜主持

•2021.11—2025.04｜肽核酸相关产品的合成及生产工艺研发｜企业合作项目｜主持

•2020.01—2023.12｜基于深红/近红外两亲性BODIPY荧光纳米探针的设计、自组装及G-四链体DNA识别应用｜国家自然科学青年基金｜主持

•2019.05—2021.04｜一种具有电荷转移特性的荧光探针及其制备方法和用途｜企业合作项目｜主持

•2018.07—2021.06｜基于深红/近红外两亲性BODIPY荧光分子自组装：分子设计、G-四链体DNA识别与生物应用｜江苏省青年科学基金｜主持

•2018.07—2019.06｜端粒G4-DNA为靶点的喹啉类衍生物结构修饰及机理研究｜中国博士后科学基金｜主持

•2017.07—2019.06｜端粒DNA识别分子的核酸调控及相关信号转导干预研究｜江苏高等学校自然科学研究面上项目｜主持

6.2 学术论文（近五年）

1.Jing Shu, Hao-Long Sun , Xu-Bo Fan , Si-Hong Zhou , Gui-Chuan Huang, Ming-Qi Wang*, Molecular engineering of a D-A-D-type fluorescent probe for detecting viscosity in environmental and living systems. Analytica Chimica Acta, 2026, 1419, 345925.

2.Xu-Bo Fan, Yi-Ran Zhao, Haoran Guo, Lu-Yu Li, Ze-Kai Li, Jing Shu, Si-Hong Zhou, Gui-Chuan Huang, Fa Yang*, Ming-Qi Wang*, A coumarin-thiazole orange conjugate as a near-infrared ratiometric fluorescent probe for G-quadruplex DNA. Dyes and Pigments, 2026, 247, 113513.

3.Lu-Yu Li, Yi-Ran Zhao, Haoran Guo, Xu-Bo Fan, Ze-Kai Li, Jing Shu, Si-Hong Zhou, Gui-Chuan Huang, Fa Yang*, Ming-Qi Wang*, Alkyl side chain engineering of thiazole orange derivates for improved G-Quadruplex DNA binding selectivity and live-cell fluorescence imaging. Dyes and Pigments, 2026, 246, 113404.

4.Ming-Qi Wang*, Jing-Zhi Li, Hua-Xin Liu, Shuo Li, Fa Yang*, Xu-Bo Fan, Jing Shu, A regioisomer of thiazole orange derivate for selective G-Quadruplex DNA detection and in vivo tumor imaging. Talanta, 2026, 297, 128757;

5.Hai-Wen Chen, Yi-Ran Zhao, Lu-Yu Li, Ze-Kai Li, Xu-Bo Fan, Jing Shu, Guo-Yun Wan, Hai-Jiao Wang*, Ming-Qi Wang*, Engineering a fluorescent probe with symmetric D-π-A-π-D configuration for fluorescence discrimination of HSA from BSA. Bioorganic Chemistry, 2025, 167, 109277.

6.Lu-Yu Li, Ze-Kai Li, Jing Shu, Xu-Bo Fan, Xiao-Feng Yu, Ming-Qi Wang*, A DIE responsive fluorescent probe for phthalate and its application in test paper and hydrogel detection platforms. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 341,126403；

7.Jing-Zhi Li, Luo-Cheng Liu, Hai-Wen Chen, Liang-Fei Gao, Lu-Yu Li, Ze-Kai Li, Ming-Qi Wang*, Molecular engineering of a D-A type fluorescent probe with AIE properties for c-MYC G-quadruplex DNA. Dyes and Pigments, 2025, 239,112814.

8.Lu-Yu Li, Jia-Xuan Yu, Hao-Wen Cao, Ze-Kai Li, Xu-Bo Fan, Jing Shu, Xiao-Feng Yu, Wen-Jing Yi*, Ming-Qi Wang*, Donor-acceptor framework appended with rotators as environment-insensitive probes for the detection of G4 DNA. Dyes and Pigments, 2025, 242,112963.

9.Ming-Qi Wang*, Ze-Kai Li, Lu-Yu Li, Xu-Bo Fan, Jing Shu, Qi-Bin Hu, Hai-Jiao Wang, A non-solvatochromic fluorescent probe for imaging of lipid droplets in live cells and tissues. Talanta, 2025, 290, 127805;

10.Hai-Wen Chen, Su'an Tan, Jing-Zhi Li, Lu-Yu Li, Ze-Kai Li, Xiao-Feng Yu, Hai-Jiao Wang, Ming-Qi Wang*. Tuning the push-pull dyes: Construction of polarity insensitive probes for G4 DNA. Dyes and Pigments, 2024, 231,112407；

11.Hai-Wen Chen, Hao-Wen Cao, Jing-Zhi Li, Yan-Song Chen, Lu-Yu Li, Ze-Kai Li, Hai-Jiao Wang, Ming-Qi Wang*. D-π-A type fluorescent dyes: Effect of π-bridge units on optical and G4 DNA binding properties, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 323,124901；

12.Hao-Wen Cao, Yan-Song Chen, Jing-Zhi Li, Hai-Wen Chen, Lu-Yu Li, Ze-Kai Li, Ming-Qi Wang*. Development of D-π-A organic dyes for discriminating HSA from BSA and study on dye-HSA interaction, Bioorganic Chemistry, 2024, 147,107360;

13.Yan-Song Chen, Hao-Wen Cao, Jing-Zhi Li, Hai-Wen Chen, Lu-Yu Li, Ze-Kai Li, Hai-Jiao Wang, Ming-Qi Wang*. Disaggregation-driven far-red BODPIY dye for selective G4 DNA structures detection, Tetrahedron Letters, 2024, 140, 155033;

14.Guang-Feng Liu, Yan-Song Chen, Zhi-Lan Wang, Di Gu, Ming-Qi Wang*. A disaggregation-driven BODPIY-based probe for ratiometric detection of G4 DNA, Dyes and Pigments, 2024, 225, 112107;

15.Hao-Wen Cao, Yan-Song Chen, Hai-Wen Chen, Jing-Zhi Li, Ming-Qi Wang*. Effect of metal coordination in modulating the binding interaction of an arylimidazole-derived organic chromophore with lipase. Dyes and Pigments, 2023, 220, 111674.

16.Jing-Zhi Li, Hong-Lan Lin, Hong-Yao Li, Cao, Hao-Wen Cao, Xue-Xian Lang, Yan-Song Chen, Hai-Wen Chen, Ming-Qi Wang*. Red-emitting Styryl-BODIPY dye with donor-z-acceptor architecture: Selective interaction with serum albumin via disaggregation-induced emission. Dyes and Pigments, 2023, 216, 111357.

17.Xue-Xian Lang, Shu-Hui Sun, Hao-Wen Cao, Yan-Song Chen, Hong-Yao Li, Ming-Qi Wang*. An environmentally insensitive fluorescent probe for G4 DNA detection: Design, synthesis, and mechanism studies. Analytica Chimica Acta, 2023, 1252, 341074.

18.Hao-Wen Cao, Xue-Xian Lang, Yan-Song Chen, Hai-Wen Chen, Jing-Zhi Li, Xiao-Feng Yu, Hai-Jiao Wang, Ming-Qi Wang*. Modulation of G4 DNA sensing behavior by triphenylamine-imidazole based D-D-π-A-type organic fluorophores with subtle structural change. Dyes and Pigments, 2023, 210, 111029.

19.Hong-Yao Li , Hao-Wen Cao, Xue-Xian Lang, Yan-Song Chen , Ming-Qi Wang*. Selective c-MYC G4 DNA recognition based on a fluorescent light-up probe with disaggregation-induced emission characteristics. Journal of Materials Chemistry B, 2022, 10, 7772-7779.

20.Xue-Xian Lang, Hong-Yao Li, Hao-Wen Cao, Yan-Song Chen, Peng-Xiang Zhang, Hai-Jiao Wang^*, Ming-Qi Wang^*. Exploring the binding mechanism of amine-functionalized tetraaryl imidazole fluorescent ligands with lipase: Insights from multi-spectroscopic, thermodynamic and docking approaches. Dyes and Pigments, 2022, 205, 110535.

21.Xue-Xian Lang, Quan-Qi Yu, Hong-Yao Li, Yang Luo, Xiao-Feng Yu, Hai-jiao Wang*, Ming-Qi Wang*. Identification of a non-planar imidazole-cored small molecule for selective telomeric G4 DNA targeting. Dyes and Pigments, 2022, 197, 109901.

22.Quan-Qi Yu, Xue-Xian Lang, Juan-Juan Gao, Hong-Yao Li, Yi-Tong Bai, Hai-jiao Wang*, Ming-Qi Wang*. Zn(II)-DPA Coordinative fluorescent probe for enhancing G4 DNA binding. Dyes and Pigments, 2021, 195, 109707.

23.Juan-Juan Gao, Xue-Xian Lang, Quan-Qi Yu, Hong-Yao Li, Hai-jiao Wang, Ming-Qi Wang*. Amphiphilic BODIPY-based nanoparticles as “light-up” fluorescent probe for PAEs detection by an aggregation/disaggregation approach. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 252, 119492.

24.Yang Luo, Quan-Qi Yu, Juan-Juan Gao, Xue-Xian Lang, Hong-Yao Li, Xiao-Feng Yu, Xue-Yong Qie, Ming-Qi Wang*. Design, synthesis and mechanistic studies of a TICT based fluorogenic probe for lighting up protein HSA. Bioorganic & Medicinal Chemistry Letters, 2021, 53, 128438.

6.3 专利与软件著作权

•王明齐，唐彩平，刘硕等，一种具有电荷转移特性的荧光探针及其制备方法和用途。ZL 201610209176.7

•王明齐，马瑞，于全琦等，一种特异性检测平行构型G-四链体DNA探针的制备方法。ZL 201911318427.5