一、基本信息

姓名：朱源

通讯地址：江苏省镇江市学府路301号 江苏大学药学院（邮编：212013）

电子邮件：zhuyuanemail@126.com

二、个人简介

朱源，男，江苏大学药学院药剂学系副主任，副教授，硕士生导师，江苏省六大高峰人才，美国德克萨斯大学奥斯汀分校访问学者。2002年进入江苏大学药学院任职教师以来，主要从事药剂学、生物药剂学与药物动力学等理论与实验课程的教学，发表教改论文2篇，获校级教学成果奖二等奖2项，获得江苏大学优秀班主任、江苏大学优秀学业导师和江苏大学京江学院优秀教师称号，2014年获江苏大学优秀教师称号，2019年获江苏大学新长征突击手称号。校级一流课程及国际化专业英语授课精品课程负责人，美国AAPS会员，Food Chemistry、Drug Development and Industrial Pharmacy等SCI期刊审稿人。主要科研方向：药物制剂新剂型与新技术；食源活性成分微囊化及其高效利用研究；难溶性药物增溶及其缓控释制剂研发。近年来，主持国家自然科学基金面上项目1项、江苏省第十六批“六大人才高峰”高层次人才资助项目1项、江苏大学高级人才科研启动基金1项，主持并完成中国博士后基金1项、省高校自然科学研究项目1项、江苏大学博士研究生创新计划项目1项，参与国家自然科学基金项目6项，发表论文50余篇，其中SCI收载40余篇。申请中国发明专利20项，其中16项获授权，申请国际PCT专利4项，3项获美国专利授权。“天然保肝药物及其制剂创新关键技术研究与应用”及“现代药物制剂研发关键技术及其应用”分别获教育部高等学校科学研究优秀成果奖一等奖，获全国商业联合会科技进步奖特等奖、一等奖各1项，江苏省科技进步奖三等奖1项。

三、教育经历

•2009.09—2014.12 江苏大学，临床检验诊断学专业，博士学位

•2004.09—2007.07 江苏大学，药剂学专业，硕士学位

•1998.09—2002.07 中国药科大学，药物制剂专业，学士学位

四、工作经历

•2002.09—至今 江苏大学药学院，助教、讲师、副教授、硕士生导师

五、研究方向

1.药物制剂新剂型与新技术

2.食源活性成分微囊化及其高效利用研究

3.难溶性药物增溶及其缓控释制剂研发

六、科研成果

6.1 科研项目

•2019.01—2022.12｜国家自然科学基金面上项目“超热水性粉体偶联静电喷雾技术构建虾青素复合胶团微囊化体系及其增溶与吸收机制研究”（项目编号：31871810）｜国家自然科学基金委员会｜主持

•2019.09—2022.08｜江苏省第十六批“六大人才高峰”高层次人才资助项目“静电喷雾模式设计基于微环境调控的多晶态药物微/纳米递药体系及其稳定-控释协同作用研究” （项目编号SWYY-163）｜江苏省委组织部、人社厅｜主持

•2015.06—2017.06｜江苏省高校自然科学研究面上项目“羟基磷灰石复合纳米给药系统的构建及其应用研究”（项目编号14KJB350002）｜江苏省教育厅｜主持

•2015.06—2017.06｜中国博士后科学基金面上资助项目“基于静电纺丝的虾青素微囊化技术及其口服吸收机理研究”（项目编号2015M571700）｜中国博士后基金委｜主持

•2020.01—2025.12｜系列医疗器械微球及一类、二类医疗器械产业化开发｜企业合作项目｜主持、参与

•2017.06—2019.06 ｜替格瑞洛片剂（90mg/片）的研究与开发（合同编号：20170200）｜常州制药厂有限公司｜参与

•2014.12—2016.12 ｜尼达尼布软胶囊的研究与开发（合同编号：2014333）｜江苏奥赛康药业股份有限公司｜参与

•2013.03—2015.03｜阿奇霉素分散片的研究与开发（合同编号：2013074）｜沈阳药大药业有限责任公司合作｜参与

•2009.01—2012.12 ｜盐酸坦索罗辛缓释胶囊（合同编号：2008292）｜扬子江药业｜参与

•2010.01—2013.12 HBS缓释片的研制（合同编号：2009310）｜扬子江药业｜参与

•2009.01—2012.12｜高纯度水飞蓟宾原料及其水飞蓟宾自乳化片关键技术开发与产业化（合同编号：CZ2009009）｜江苏中兴药业｜参与

•2007.01—2010.12 正肝宝的研制（合同编号：2006304）｜镇江正东生态农业有限公司｜参与

6.2 学术论文

1.Chengwei Wang#, Haiqiao Wang#, Michael Adu-Frimpong#, Zhihui Zou, Zhou Jin, Peiqi Lu, Zhenrong Liu, Haojie Tian, Ying Xu, Kailun Yang, Jiangnan Yu, Ximing Xu, Yuan Zhu*. Sustained-release Drug Delivery System of Trazodone Hydrochloride Based on Electrospray Technology: Preparation, Characterization, In Vitro and In Vivo Evaluation[J]. AAPS PharmSciTech, 2026, 27(1): 52.

2.Yuan Zhu, Yongqi Lv, Jiaqi Xu, Yingshu Feng, Caleb Kesse Firempong, Runfeng Wang, Haibing He, Guoqing Zhang, Hongfei Liu. Microfluidic-based intra-articular sustained release of triamcinolone acetonide microsphere-gel composite system[J]. Drug Development and Industrial Pharmacy, 2026, 52(4): 720.

3.Yuan Zhu*#, Peiqi Lu#, Youwu Liao#, Michael Adu-Frimpong, Zhihui Zou, Zhou Jin, Chengwei Wang, Min Peng, Houping Peng, Jing Xu, Ying Xu, Jiangnan Yu, Ximing Xu*. Core–shell structural PLGA nanoparticle of astaxanthin fabricated via micelle template for sustained release in vitro and long-term hepatoprotective effect in vivo[J]. Journal of Nanoparticle Research, 2025, 27(4): 1-14.

4.Zhihui Zou#, Yuanyuan Xue#, Michael Adu-Frimpong#, Chengwei Wang, Zhou Jin, Ying Xu, Jiangnan Yu, Ximing Xu, Yuan Zhu*. Formononetin-Loaded Self-Microemulsion Drug Delivery Systems for Improved Solubility and Oral Bioavailability: Fabrication, Characterization, In Vitro and In Vivo Evaluation[J]. AAPS PharmSciTech, 2024, 25(8): 261.

5.Yuan Zhu, Jiaqi Xu, Xiaoyan Chen, Yingshu Feng, Caleb Kesse Firempong, Haibing He, Hongfei Liu. Preparation of core-shell targeted tracer recombinant human interleukin II microspheres via coaxial electrostatic spraying[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(6): 495-510.

6.Yuan Zhu*, Haiqiao Wang, Michael Adu-Frimpong, Zhihui Zou, Zhou Jin, Peiyao Zhang, Yuanyuan Xue, Shuang Li, Ying Xu, Jiangnan Yu, and Ximing Xu. HA/PLA Composite Nanoparticles for Enhanced Oral Bioavailability of Capsaicin: Fabrication, Characterization and in vitro-in vivo Evaluation[J]. ChemistrySelect, 2024, 9(4): e202303080.

7.Youwu Liao, Haiqiao Wang, Shuang Li, Yuanyuan Xue, Yunqiu Chen, Michael Adu-Frimpong, Ying Xu, Jiangnan Yu, Ximing Xu, Hugh D.C. Smyth* and Yuan Zhu*. Preparation of astaxanthin-loaded composite micelles with coaxial electrospray technology for enhanced oral bioavailability and improved antioxidation capability[J]. Journal of the Science of Food and Agriculture, 2023, 104(3): 1408-1419.

8.Yuan Zhu#, Shuang Li#, Haiqiao Wang#, Michael Adu‐Frimpong, Yuanyuan Xue, Zhengqing Gu, Jiangnan Yu, Ximing Xu*. Enhanced oral bioavailability of capsaicin‐loaded microencapsulation complex via electrospray technology: Preparation, in vitro and in vivo evaluation[J]. Biopharmaceutics & Drug Disposition, 2023, 44(2): 137-146.

9.Yuanyuan Xue#, Youwu Liao#, Haiqiao Wang, Shuang Li, Zhengqing Gu, Michael Adu-Frimpong, Jiangnan Yu, Ximing Xu, Hugh D. C Smyth and Yuan Zhu*. Preparation and evaluation of astaxanthin-loaded 2-hydroxypropyl-betacyclodextrin and Soluplus® nanoparticles based on electrospray technology[J]. Journal of the Science of Food and Agriculture, 2023, 103(7): 3628-3637.

10.Zhengqing Gu, Yuanyuan Xue, Shuang Li, Michael Adu‑Frimpong, Ying Xu, Jiangnan Yu, Ximing Xu, Yuan Zhu*. Design, Characterization, and Evaluation of Diosmetin‑Loaded Solid Self‑microemulsifying Drug Delivery System Prepared by Electrospray for Improved Bioavailability[J]. AAPS PharmSciTech, 2022, 23(4): 106.

11.Yuan Zhu#, Zhengqing Gu#, Youwu Liao, Shuang Li, Yuanyuan Xue, Michael Adu Firempong, Ying Xu, Jiangnan Yu, Hugh DC Smyth* and Ximing Xu*. Improved intestinal absorption and oral bioavailability of astaxanthin using poly (ethylene glycol)-graft-chitosan nanoparticles: preparation, in vitro evaluation, and pharmacokinetics in rats[J]. Journal of the Science of Food and Agriculture, 2021, 102(3), 1002-1011.

12.Yuan Zhu#, Jianyin Yu#, Guanghui Zhou#, Zhengqing Gua, Michael Adu-Frimponga,b, Wenwen Denga, Jiangnan Yu, Ximing Xu*. Piperine fast disintegrating tablets comprising sustained-release matrix pellets with enhanced bioavailability: formulation, in vitro and in vivo evaluation[J]. Pharmaceutical Development and Technology, 2020, 25(5): 617-624.

13.Yuan Zhu#, Wen Xu#, Jiajia Zhang#, Youwu Liao, Caleb Kesse Firempong, Michael Adu-Frimpong, Wenwen Deng, Huiyun Zhang, Jiangnan Yu, Ximing Xu*. Self-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation[J]. AAPS PharmSciTech, 2019, 20: 153.

14.Miaomiao Wang, Yuanwen Wang, E. Omari-Siaw, Shengli Wang, Yuan Zhu*, Ximing Xu*. Reduced Burst Release and Enhanced Oral Bioavailability in Shikimic Acid-loaded PLA Submicron Particles by Coaxial-Electrospray[J]. Journal of Pharmaceutical Sciences, 2016, 105: 2427-2436.

15.Yuan Zhu#, Miaomiao Wang#, Ya Zhang, Jin Zeng, E. Omari-Siaw, Jiangnan Yu, Ximing Xu*. In Vitro Release and Bioavailability of Silybin from Micelle Templated Porous Calcium Phosphate Microparticles[J]. AAPS PharmSciTech, 2016, 17(5): 1232-1239.

16.Yuan Zhu, Miaomiao Wang, Jiajia Zhang, Wei Peng, Caleb Kesse Firempong, Wenwen Deng, Qilong Wang, Shicheng Wang, Feng Shi, Jiangnan Yu, Ximing Xu*, Weiming Zhang*. Improved oral bioavailability of capsaicin via liposomal nanoformulation: preparation, in vitro drug release and pharmacokinetics in rats[J]. Archives of Pharmacal Research, 2015, 38(4): 512-521.

17.Yuan Zhu#, Jiajia Zhang#, Qianfeng Zheng#, Miaomiao Wang#, Wenwen Deng, Li Qiang, Caleb Kesse Firempong, Shengli Wang, Shanshan Tong, Ximing Xu*, Jiangnan Yu*. In vitro and in vivo evaluation of capsaicin-loaded microemulsion for enhanced oral bioavailability [J]. Journal of the Science of Food and Agriculture, 2015, 95(13): 2678–2685.

18.Yuan Zhu#, Wei Peng#, Jiajia Zhang#, Miaomiao Wang#, Caleb Kesse Firempong, Chunlai Feng, Hongfei Liu, Ximing Xu*, Jiangnan Yu*. Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation[J]. Journal of Functional Foods, 2014, 8: 358-366.

19.Yuan Zhu#, Jiajia Zhang#, Min Fu#, Jin Zeng#, E. Omari-Siaw, Jiangnan Yu, Xi-ming Xu*. Calcium carbonate nanoparticles templated by mixed polymeric micelles: characterization, in vitro drug release and oral bioavailability in Beagle dogs[J]. Latin American Journal of Pharmacy, 2014, 33(7): 1106-1113.

20.Yuan Zhu, Jiangnan Yu*, Shanshan Tong, Li Wang, Min Peng, Xia Cao, Ximing Xu*. Preparation and In Vitro Evaluation of Povidone-Sodium Cholate-Phospholipid Mixed Micelles for Solubilization of Poorly Soluble Drugs[J]. Archives of Pharmacal Research, 2010, 33(6): 911-917.

6.3 专著与教材

•徐希明主编. 《工业药剂学（第二版）》[M]. 北京: 人民卫生出版社, 2024.（参编，主审，国家卫生健康委员会“十四五”规划教材）

6.4 专利与软件著作权

•Xu Ximing, Yu Jiangnan, Cao Xia, Zhu Yuan. Formulation of Silybinin with High Efficacy and Prolonged Action and the Preparation Method Thereof[P]. United States Patent: US9023388, 20150505

•Xu Ximing, Yu Jiangnan, Tong Shanshan, Zhu Yuan, Cao Xia. Formulation of Silymarin with High Efficacy and Prolonged Action and the Preparation Method Thereof[P]. United States Patent: US8962017, 20150224

•Xu Ximing, Yu Jiangnan, Zhu Yuan, Cao Xia. Highly Efficient and Long-acting Slow-release formulation of Poorly Soluble Drugs and Preparation Method Thereof[P]. United States Patent: US9283190, 20160315

•朱源，顾正清，李双，薛媛媛，徐希明. 静电喷雾法制备的香叶木素固体自微乳纳米粒及制备方法（ZL202111219162.0）2023.08.22

•朱源，廖有武，李双，顾正清，薛媛媛，彭后平. 一种胶束模板法制备的虾青素长效纳米制剂及其制法（ZL202110382269.0）2023.07.18

•朱源，陈韵秋，李双，廖有武，薛媛媛，徐希明. 一种静电喷雾法制备的虾青素非晶固体分散体及其制法（ZL202110602217.X）2022.05.20

•朱源，许雯，廖有武，余剑吟，徐希明. 一种静电喷雾法制备的虾青素纳米制剂及其制法（ZL201811389494.1）2021.05.25