一、基本信息

姓名：邓纹纹

通讯地址：江苏省镇江市学府路301号 江苏大学药学院（邮编：212013）

电子邮件：dengww@ujs.edu.cn

二、个人简介

邓纹纹，女，江苏大学药学院副教授、硕士生导师主持国家自然科学基金（青年项目）1项、中国博士后科学基金面上项目1项，参与国家自然科学基金重点国际合作项目1项，参与国家自然科学基金面上项目3项。于Advanced Materials、Carbohydrate Polymers、Small等学术期刊发表SCI 论文40余篇，获中国授权发明专利5项，申请PCT专利2项。

三、教育经历

•2012.09 —2016.06，江苏大学，医学博士，临床检验诊断学

•2008.09 —2011.06，江苏大学，工学硕士， 药剂学

•2004.09 —2008.06，江苏大学，工学学士，制药工程

四、工作经历

•2021.07至今，江苏大学，副教授， 药学院

•2019.11—2021.06，江苏大学，讲师，药学院

•2016.07—2019.10，江苏大学，脱产博士后，材料科学与工程

五、研究方向

1.基于天然活性材料的纳米基因传递以及干细胞的组织工程；

2.基于小分子化合物的细胞重编程；

3.难溶性药物的控释制剂及药代动力学评价；

4.中药活性成分的筛选与制剂开发。

六、科研成果

6.1 科研项目

•1、 国家自然科学基金委员会，青年项目，81803475，血小板膜-自组装纳米递药系统构建及其诱导星型胶质细胞靶向直接重编程研究，2019-01至2021-12，21万元、已结题、主持；

•2、中国博士后科学基金会，第62批面上项目，2017M621658，姜黄素自组装纳米粒诱导星型胶质细胞直接重编程研究，2017-09至2019-06，5万元、已结题、主持；

•3、国家自然科学基金委员会，国际(地区)合作与交流项目，81720108030，3D仿生打印定位、梯度、长效释药系统及其修复脊髓损伤研究，2018-01至2022-12，233万元、在研、参加；

•4、国家自然科学基金委员会，面上项目，81473172，DNA-阳离子多糖-碳量子点自组装纳米粒介导的体细胞直接重编程研究，2014-01至2018-12，100万元、已结题、参加；

•5、国家自然科学基金项目，面上项目，81273470，microRNA非病毒纳米传递系统构建及其促进体细胞重编程研究，2013-01至2016-12，100万元、已结题，参加；

•6．国家自然科学基金项目，面上项目，81373371，人源iPSC的肝细胞分化及其三维体系中代谢功能研究，2014-01至2017-12，65万元、已结题、参加。

6.2 学术论文

1.Xiaoyi Qian, Ximing Xu*, Wenwen Deng*. Advances in marine polysaccharides for the prevention and treatment of diabetes[J]. Carbohydrate Polymers, 2026, 381: 125189. (SCI，新锐1区，top期刊，IF:13.2)

2.Yuxiang He, Zhe Wang, Zeyu Xu, Huiya Wang, Lili Yuan, Ximing Xu*, Wenwen Deng*. Regulatory effects of natural polysaccharides on skin wound repair through modulation of immune-microbiome interactions[J]. International Journal of Biological Macromolecules, 2026, 359: 151732. (SCI，新锐2区，top期刊，IF:8.7)

3.Wenwen Deng, Xiufen Yang, Jiangnan Yu, Emmanuel Omari-Siaw, Ximing Xu*. Recent advances of physiochemical cues on surfaces for directing cell fates[J]. Colloids and Surfaces B: Biointerfaces, 2025, 250:114550. (SCI，新锐1区，IF:5.9)

4.Peng Fu, Xiufen Yang, Wenwen Deng*, Jiangnan Yu*, Ximing Xu*. Advances in cerebral edema research and targeted drug delivery systems[J]. European Journal of Pharmacology, 2025, 1000: 177744. (SCI，新锐2区，top期刊，IF:5.7)

5.Ximing Xu#, Xinyu Zhang#, Ran Li#, Xiufen Yang, Peng Fu, Ruijie Feng, Xuan Sun, Zhe Wang, Jiangnan Yu, Xia Cao, Qingtong Yu, Qilong Wang, Sitong Liu, Xiaoxia Yang, Yuan Zhu, Wentao Shi, Wenwen Deng*. Platelet Membrane-Coated Curcumin-PLGA Nanoparticles Promote Astrocyte-Neuron Transdifferentiation for Intracerebral Hemorrhage Treatment[J]. Small, 2024, 20(42): 2311128. (SCI，新锐2区，top期刊，IF:11.8)

6.Fengxia Shao#, Xuan Sun#, Qingtong Yu#, Kaili Wang, Congyong Sun, Qilong Wang, Xia Cao, Linzhi Zhang, Peng Fu, Xiufen Yang, Jiangnan Yu*, Ximing Xu*, Wenwen Deng*. Lycium barbarum oligosaccharide-derived carbon quantum dots inhibit glial scar formation while promoting neuronal differentiation of neural stem cells[J]. International Journal of Biological Macromolecules, 2024, 282(6): 137474. (SCI，新锐2区，top期刊，IF:8.7)

7.Wenwen Deng#, Fengxia Shao#, Qinghua He#, Qiang Wang, Wentao Shi, Qingtong Yu, Xia Cao, Chunlai Feng, Shiqi Bi, Jiaxin Chen, Ping Ma, Yang Li, Aihua Gong, Shanshan Tong, Jiangnan Yu, Myron Spector, Ximing Xu*, and Zhijian Zhang*. Ectomesenchymal stem cells build an all-in-one niche for promoted neuronal but suppressed astroglial differentiation of neural stem cells[J]. Advanced Materials, 2019, 31(10): 1806861. (SCI，新锐1区，top期刊，IF:29.1)

8.Wenwen Deng, Xia Yang, Yuan Zhu, Jiangnan Yu, and Ximing Xu*. Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides. Food Science & Nutrition 2019, 7(8): 2674-2683. (SCI，新锐2区，top期刊，IF:5.0)

9.Qilong Wang#, Qiuxuan Yang#, Xia Cao#, Qiuyu Wei, Caleb K. Firempong, Min Guo, Feng Shi, Ximing Xu⁎, Wenwen Deng*, Jiangnan Yu*. Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles[J]. International Journal of Pharmaceutics, 2018, 550: 24–34. (SCI，新锐2区，top期刊，IF:6.0)

10.Yao Xu, Huiyan Jiang, Congyong Sun, Michael Adu-Frimpong, Wenwen Deng*, Jiangnan Yu*, XimingXu*. Antioxidant and hepatoprotective effects of purified Rhodiola rosea polysaccharides[J]. International Journal of Biological Macromolecules, 2018,117:167–178. (SCI，新锐2区，top期刊，IF:8.7)

11.Jiaxin Chen#, Qiang Wang#, Jie Zhou#, Wenwen Deng#, Qingtong Yu, Xia Cao, Jianping Wang, Fengxia Shao, Yang Li, Ping Ma, Myron Spector, Jiangnan Yu, and Ximing Xu*. Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells[J]. Nanoscale, 2017, 9(30): 10820-10831. (SCI，新锐2区，IF:5.2)

12.Wenwen Deng#, Xia Cao#, Yan Wang#, Qingtong Yu, Zhijian Zhang, Rui Qu, Jingjing Chen, Genbao Shao, Xiangdong Gao, Ximing Xu*, Jiangnan Yu*. Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification[J]. Journal of Agricultural and Food Chemistry, 2016, 64(6): 1264-1273. (SCI，新锐1区，top期刊，IF:6.7)

13.Zhou Jie#, Wenwen Deng#, Yan Wang#, Xia Cao, Jingjing Chen, Qiang Wang, Wenqian Xu, Pan Du, Qingtong Yu, Jingjing Chen, Myron Spector, Jiangnan Yu*, Ximing Xu*. Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake[J]. Acta Biomaterialia, 2016, 42:209-219. (SCI，新锐1区，top期刊，IF:10.4)

14.Wenwen Deng#, Xia Cao#, Qiang Wang#, Yan Wang, Jingjing Chen, Qingtong Yu, Zhijian Zhang, Jie Zhou, Wenqian Xu, Pan Du, Jiaxin Chen, Xiangdong Gao, Jiangnan Yu, Ximing Xu*. Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming[J]. ACS Applied Materials & Interfaces, 2016, 8(31): 19916-19927. (SCI，新锐2区，IF:7.8)

15.Zhijian Zhang#, Qinghua He#, Wenwen Deng#, Qian Chen, Xinyuan Hu, Aihua Gong, Xia Cao, Jiangnan Yu, Ximing Xu*. Nasal ectomesenchymal stem cells: Multi-lineage differentiation and transformation effects on fibrin gels[J]. Biomaterials, 2015, 49: 57-67. (SCI，新锐1区，top期刊，IF:13.6)

16.Xia Cao#, Wenwen Deng#, Rui Qu#, Qingtong Yu, Jun Li, Yan Yang, Yue Cao, Xiangdong Gao, Ximing Xu, Jiangnan Yu. Non-Viral Co-Delivery of the Four Yamanaka Factors for Generation of Human Induced Pluripotent Stem Cells via Calcium Phosphate Nanocomposite Particles[J]. Advanced Functional Materials, 2013, 23(43): 5403-5411. (SCI，新锐1区，top期刊，IF:19.9)

17.Wenwen Deng, Min Fu, Yue Cao, Xia Cao, Miao Wang, Yan Yang, Rui Qu, Jun Li, Ximing Xu*, Jiangnan Yu. Angelica sinensis polysaccharide nanoparticles as novel non-viral carriers for gene delivery to mesenchymal stem cells[J]. Nanomedicine: Nanotechnology, Biology and Medicine 2013, 9(8): 1181-1191. (SCI，新锐2区，IF:4.3)

18.Wenwen Deng#, Xia Cao#, Miao Wang#, Yan Yang, Weiyan Su, YaweiWei, Zhen Ou-Yang, Jiangnan Yu*, Ximing Xu*. Efficient Gene Delivery to Mesenchymal Stem Cells by an Ethylenediamine-Modified Polysaccharide from Mulberry Leaves[J]. Small, 2012,8(3): 441-451. (SCI，新锐2区，top期刊，IF:11.8)

19.Wenwen Deng, Xia Cao, Miao Wang, Rui Qu, Weiyan Su, Yan Yang, Yawei Wei, Ximing Xu*, Jiangnan Yu*. Delivery of a transforming growth factor β-1 plasmid to mesenchymal stem cells via cationized Pleurotus eryngii polysaccharide nanoparticles[J]. International Journal of Nanomedicine 2012, 7: 1297-1311. (SCI，新锐1区，top期刊，IF:8.7)

20.Miao Wang#, Wenwen Deng#, Min Fu#, Xia Cao#, Yan Yang, Weiyan Su, Jiangnan Yu*, Ximing Xu*. Efficient gene transfer into rat mesenchymal stem cells with cationized Lycium barbarum polysaccharides nanoparticles[J]. Carbohydrate Polymers, 2011, 86: 1509-1518. (SCI，新锐1区，top期刊，IF:13.2)

6.3 专利

•1.徐希明，邓纹纹，余江南，王淼，曹霞，阳离子化的桑叶多糖纳米粒基因载体及其制法，2014.8.6，中国，ZL201010613484.9

•2.徐希明，邓纹纹，余江南，王淼，曹霞，阳离子化杏鲍菇多糖纳米粒基因传递系统及其制法，2013.3.13，中国，ZL201010613483.4

•3.徐希明，王淼，余江南，邓纹纹，曹霞，阳离子化当归多糖纳米粒基因传递系统及其制法，2012.12.19，中国，ZL201010613603.0

•4.徐希明，王淼，余江南，邓纹纹，曹霞，阳离子化枸杞多糖纳米粒基因传递系统及其制法，2012.8.29，中国，ZL201010613602.6

•5.徐希明，曹霞，余江南，王淼，邓纹纹，阳离子化多糖纳米粒基因传递系统及其制法，2012.11.7，中国，ZL201010614816.5