胡磊，博士，教授，硕士研究生导师。

研究方向

动态组合化学为指导的酶抑制剂研发

酶催化生物活性分子不对称合成

高效表面活性剂研发

医药中间体合成研发

招收药物化学研究方向的学术型研究生以及生物与医药（前制药工程）专业学位研究生，欢迎具有制药工程、药学、化学、生物等相关学习背景的同学报考。

联系方式

办公室：药学楼2413室

实验室：药学楼2404室

微信：36396672

Email：leihu@ujs.edu.cn

教育背景：

2010.10至2014.10 瑞典皇家工学院 KTH-Royal Institute of Technology 有机化学博士 

2007.09至2010.06 暨南大学药学院 药物化学专业硕士

2003.09至2007.06 湖南师范大学制药工程专业学士

工作经历：

2017.04至今    江苏大学药学院教授

2014.12至2016.08 美国俄亥俄州立大学 The Ohio State University 化学系博士后研究员 

代表性科研成果：

Zhang, S., Li, Y.,Hu,L.*, Physical and Biological Evaluation of Glucose Hydrazones as Biodegradable Emulsifiers.J. Mol. Liq., 2022. accepted.

Zhang, S., Li, Y., Han, M., Wu, Y.,Hu,L.*, Comparative Study of Surface-Active and Biological Properties of Lactose-derived Acylhydrazones.J. Mol. Liq., 2021.322. 114989.

Zhao, S., Xu, J., Zhang, S., Han, M., Wu, Y., Li, Y.,Hu,L.*, Multivalent Butyrylcholinesterase Inhibitor Discovered by Exploiting Dynamic Combinatorial Chemistry.Bioorg. Chem., 2021.108. 104565.

Zhao, S., Zhang, S., Xu, J.,Hu,L.*,Synthesis and Comparative Study of Emulsifying and Biological Properties of Triazolated Glucolipids.Tetrahedron, 2020,76, 131517.

Xu, J.¹, Zhao, S.¹, Zhang, S.,Hu,L.*, Development of a Multivalent Acetylcholinesterase Inhibitor via Dynamic Combinatorial Chemistry.Int. J. Biol. Macromol.,2020,150, 1184.

Xu, J., Zhao, S., Zhang, S.,Hu,L.*, Identification and Synthesis of An Efficient MultivalentE.coliHeat Labile Toxin Inhibitor - A Dynamic Combinatorial Chemistry Approach.Bioorgan. Med. Chem.,2020,28, 115436.

Xu, J.,Hu,L.*, Asymmetric One-pot Synthesis of Five- and Six-membered LactonesviaDynamic Covalent Kinetic Resolution: Exploring the Regio- and Stereoselectivities of Lipase.Tetrahedron Lett., 2019,60, 868.

Ren, Y.,Hu, L., Ramström, O.*, Multienzymatic Cascade Synthesis of an Enantiopure (2R,5R)-1,3-Oxathiolane anti-HIV Agent Precursor.Mol. Catal., 2019,468, 52.

Pratumyot, Y.; Chen, S.;Hu, L.; Polen, M. S.; Hadad, M. C.; Badjić, D. B. Assembly and Folding of Twisted Baskets in Organic Solvents,Org. Lett., 2016,18, 4238.

Hu,L.; Polen, S.; Hardin, A.; Pratumyot, Y.; Hadad, C.; Badjić, J. On the Transfer of Chirality, Thermodynamic Stability, and Folding Characteristics of Stereoisomeric Gated Baskets.Eur. J. Org. Chem., 2015,31, 6832.

Hu,L.; Zhang, Y.; Ramström, O. Gelation-driven Dynamic Systemic Resolution:in situGeneration and Self-Selection of an Organogelator.Sci. Rep., 2015,5, 11065.

Hu,L.; Ren, Y., Ramström, O. Chirality Control in Enzyme-Catalyzed Dynamic Kinetic Resolution of 1,3-Oxathiolanes.J. Org. Chem., 2015,80, 8478.

Schaufelberger, F.;Hu, L.; Ramström, O.trans-Symmetric Dynamic Covalent Systems: Connected Transamination and Transimination Reactions.Chem. Eur. J., 2015,21, 9776.

Hu,L.; Ramström, O. Silver-Catalyzed Dynamic Systemic Resolution ofα-Iminonitriles in a 1,3-Dipolar Cycloaddition Process.Chem. Commun., 2014,50, 3792.

Hu,L.; Zhang, Y.; Ramström, O. Lipase-Catalyzed Asymmetric Synthesis of Oxathiazinanones through Dynamic Covalent Kinetic Resolution.Org. Biomol. Chem., 2014,12, 3572.

Hu,L.; Schaufelberger, F.; Timmer, B. J. J.; Abellán Flos, M.; Ramström, O. Dynamic Constitutional Chemistry. In: Kirk-Othmer Encyclopedia of Chemical Technology., John Wiley & Sons, Inc., 2014.DOI: 10.1002/0471238961.consrams.a01

Zhang, Y.;Hu,L.; Ramström, O. Constitutional Dynamic Chemistry for Bioactive Compounds. In: Supramolecular Systems in Biomedical Fields. (Ed.: H.-J. Schneider) RSC, UK, 2013.

Hu,L.; Schaufelberger, F.; Zhang, Y.; Ramström, O. Efficient Asymmetric Synthesis of LamivudineviaEnzymatic Dynamic Kinetic Resolution.Chem. Comm. 2013,49, 10376.

Zhang, Y.;Hu,L.; Ramström, O. Double Parallel Dynamic Resolution through Lipase-Catalyzed Asymmetric Transformation.Chem. Comm. 2013,49, 1805.

Hu,L; Lan, P; Song, Q; Huang, Z; Sun, P; Zhuo, C; Wang, Y; Xiao, S; Chen, WM. Synthesis and Antibacterial Activity of C-12 Pyrazolinyl Spiro Ketolides.Eur. J. Med. Chem., 2010,45, 5943.

Wang, Y-T‡;Hu,L‡; Chen W-M; Hu A-X; Song, Q-L; Guan D. Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-O-methyl-3-oxo-12-(Δ2-pyrazolinyl)-12-dehydroxy-21-demethyl-9-dihydro-erythromycin A.Lett. Org. Chem., 2009,6, 306.

主持项目：

江苏省自然科学基金青年项目在研

江苏省六大人才高峰项目在研

中国博士后面上基金在研

江苏省日常资助博士后项目在研

企业委托项目在研

江苏省双创博士项目结题

江苏大学高级人才启动基金结题

主讲课程

药物化学

波谱解析（留学生）

健康科学导论（留学生）

天然药物化学（留学生）