
胡磊,博士,教授,硕士研究生导师。
研究方向
动态组合化学为指导的酶抑制剂研发
酶催化生物活性分子不对称合成
高效表面活性剂研发
医药中间体合成研发
招收药物化学研究方向的学术型研究生以及生物与医药(前制药工程)专业学位研究生,欢迎具有制药工程、药学、化学、生物等相关学习背景的同学报考。
联系方式
办公室:药学楼2413室
实验室:药学楼2404室
微信:36396672
Email:leihu@ujs.edu.cn
教育背景:
2010.10至2014.10 瑞典皇家工学院 KTH-Royal Institute of Technology 有机化学博士
2007.09至2010.06 暨南大学药学院 药物化学专业硕士
2003.09至2007.06 湖南师范大学制药工程专业学士
工作经历:
2017.04至今 江苏大学药学院教授
2014.12至2016.08 美国俄亥俄州立大学 The Ohio State University 化学系博士后研究员
代表性科研成果:
Zhang, S., Li, Y.,Hu,L.*, Physical and Biological Evaluation of Glucose Hydrazones as Biodegradable Emulsifiers.J. Mol. Liq., 2022. accepted.
Zhang, S., Li, Y., Han, M., Wu, Y.,Hu,L.*, Comparative Study of Surface-Active and Biological Properties of Lactose-derived Acylhydrazones.J. Mol. Liq., 2021.322. 114989.
Zhao, S., Xu, J., Zhang, S., Han, M., Wu, Y., Li, Y.,Hu,L.*, Multivalent Butyrylcholinesterase Inhibitor Discovered by Exploiting Dynamic Combinatorial Chemistry.Bioorg. Chem., 2021.108. 104565.
Zhao, S., Zhang, S., Xu, J.,Hu,L.*,Synthesis and Comparative Study of Emulsifying and Biological Properties of Triazolated Glucolipids.Tetrahedron, 2020,76, 131517.
Xu, J.1, Zhao, S.1, Zhang, S.,Hu,L.*, Development of a Multivalent Acetylcholinesterase Inhibitor via Dynamic Combinatorial Chemistry.Int. J. Biol. Macromol.,2020,150, 1184.
Xu, J., Zhao, S., Zhang, S.,Hu,L.*, Identification and Synthesis of An Efficient MultivalentE.coliHeat Labile Toxin Inhibitor - A Dynamic Combinatorial Chemistry Approach.Bioorgan. Med. Chem.,2020,28, 115436.
Xu, J.,Hu,L.*, Asymmetric One-pot Synthesis of Five- and Six-membered LactonesviaDynamic Covalent Kinetic Resolution: Exploring the Regio- and Stereoselectivities of Lipase.Tetrahedron Lett., 2019,60, 868.
Ren, Y.,Hu, L., Ramström, O.*, Multienzymatic Cascade Synthesis of an Enantiopure (2R,5R)-1,3-Oxathiolane anti-HIV Agent Precursor.Mol. Catal., 2019,468, 52.
Pratumyot, Y.; Chen, S.;Hu, L.; Polen, M. S.; Hadad, M. C.; Badjić, D. B. Assembly and Folding of Twisted Baskets in Organic Solvents,Org. Lett., 2016,18, 4238.
Hu,L.; Polen, S.; Hardin, A.; Pratumyot, Y.; Hadad, C.; Badjić, J. On the Transfer of Chirality, Thermodynamic Stability, and Folding Characteristics of Stereoisomeric Gated Baskets.Eur. J. Org. Chem., 2015,31, 6832.
Hu,L.; Zhang, Y.; Ramström, O. Gelation-driven Dynamic Systemic Resolution:in situGeneration and Self-Selection of an Organogelator.Sci. Rep., 2015,5, 11065.
Hu,L.; Ren, Y., Ramström, O. Chirality Control in Enzyme-Catalyzed Dynamic Kinetic Resolution of 1,3-Oxathiolanes.J. Org. Chem., 2015,80, 8478.
Schaufelberger, F.;Hu, L.; Ramström, O.trans-Symmetric Dynamic Covalent Systems: Connected Transamination and Transimination Reactions.Chem. Eur. J., 2015,21, 9776.
Hu,L.; Ramström, O. Silver-Catalyzed Dynamic Systemic Resolution ofα-Iminonitriles in a 1,3-Dipolar Cycloaddition Process.Chem. Commun., 2014,50, 3792.
Hu,L.; Zhang, Y.; Ramström, O. Lipase-Catalyzed Asymmetric Synthesis of Oxathiazinanones through Dynamic Covalent Kinetic Resolution.Org. Biomol. Chem., 2014,12, 3572.
Hu,L.; Schaufelberger, F.; Timmer, B. J. J.; Abellán Flos, M.; Ramström, O. Dynamic Constitutional Chemistry. In: Kirk-Othmer Encyclopedia of Chemical Technology., John Wiley & Sons, Inc., 2014.DOI: 10.1002/0471238961.consrams.a01
Zhang, Y.;Hu,L.; Ramström, O. Constitutional Dynamic Chemistry for Bioactive Compounds. In: Supramolecular Systems in Biomedical Fields. (Ed.: H.-J. Schneider) RSC, UK, 2013.
Hu,L.; Schaufelberger, F.; Zhang, Y.; Ramström, O. Efficient Asymmetric Synthesis of LamivudineviaEnzymatic Dynamic Kinetic Resolution.Chem. Comm. 2013,49, 10376.
Zhang, Y.;Hu,L.; Ramström, O. Double Parallel Dynamic Resolution through Lipase-Catalyzed Asymmetric Transformation.Chem. Comm. 2013,49, 1805.
Hu,L; Lan, P; Song, Q; Huang, Z; Sun, P; Zhuo, C; Wang, Y; Xiao, S; Chen, WM. Synthesis and Antibacterial Activity of C-12 Pyrazolinyl Spiro Ketolides.Eur. J. Med. Chem., 2010,45, 5943.
Wang, Y-T‡;Hu,L‡; Chen W-M; Hu A-X; Song, Q-L; Guan D. Synthesis and Antibacterial Activities of (9S)-3-O-descladinose-6-O-methyl-3-oxo-12-(Δ2-pyrazolinyl)-12-dehydroxy-21-demethyl-9-dihydro-erythromycin A.Lett. Org. Chem., 2009,6, 306.
主持项目:
江苏省自然科学基金青年项目在研
江苏省六大人才高峰项目在研
中国博士后面上基金在研
江苏省日常资助博士后项目在研
企业委托项目在研
江苏省双创博士项目结题
江苏大学高级人才启动基金结题
主讲课程
药物化学
波谱解析(留学生)
健康科学导论(留学生)
天然药物化学(留学生)