研究专业：药物化学，有机化学，放射药物化学，新能源材料化学，有机金属化学。

邮箱：1000004770@ujs.edu.cn or organicboron@ujs.edu.cn

教育与工作简历:　

2017.4-至今, 江苏大学, 药学院, 教授

2014.6-2017.2, 韩国圆光大学, 自然科技大学, 研究教授

2011.10-2014.4, 韩国高丽大学, 博士后（研究教授）

2009.7–2011.10,韩国 OCT(株)医药研究所，科研组长

2006.7–2009.7, 韩国圆光大学, 药物化学, 理学博士

2004.7–2006.6, 韩国圆光大学, 药物化学, 理学硕士

2000.9–2004.6, 延边大学, 药学, 药学学士

研究方向：

1.治疗癌症及肿瘤药物的合成设计研究：主要包括1）BNCT新型抗癌药物的设计，2）ODS治疗骨质疏松症新型药物研发，3）HIF-1新型抑制抗肿瘤药物的研发.

2.有机发光材料（Orgainc　Light　Emitting　Diodides, OLED）设计合成与研发：(ETL, HTL, EML and R, G, B dopant materials).

3.BODIPY荧光靶向探针研究：1）构建水溶性动态自主装纳米靶向荧光探针设计，2）表达蛋白靶向探针设计.

4.石墨烯锂电池分子构建设计及高效太阳能分子设计研究.

代表性论文：

1.Lian, Guangchang; Hu, Kaibo; Zhou, Meng; Liu, Ying; Jin, Guofan*. Design and bioactivity of Eudragit® encapsulated pH-Sensitive enteric/gastric soluble fluorescent agent. Journal of Polymer Research. (2023), 30, 105.

2.Lian, Guangchang; Hu, Kaibo; Wang, Yuling; Shao, Tingyu; Qi, Xueyong; Zhou, Meng; Liu, Ying; Jin, Guofan*. Base on spectroscopic properties response fluorescence probe for rapid, sensitive and selective detection of aluminum ions in wastewater. Inorganic Chemistry Communications (2022), 137, 109171.

3.Liu Ying; Hu Kaibo; Lian Guangchang; Zhou Meng; Lu Chichong; Jin, Guofan*. Bioactivity and Cell Imaging of Antitumor Fluorescent Agents (Curcumin Derivatives) Coated by Two-Way Embedded Cyclodextrin Strategy. Chemistry & biodiversity (2022), 19(12), e202200644.

4.Hu Kaibo; Lian Guangchang; Zhou Meng; Liu Ying; Lu Chichong; Jin, Guofan*. Blue Emission of Tetrafluorobenzocarbazole Under the Interactions of Nitrogen-oxygen Saturated hydrogen Bonds with Aggregated Proton Acid. Journal of fluorescence (2022).

5.Liu, Ying; Lian, Guangchang; Wang, Zhenning; Hu, Kaibo; Zhou, Meng; Dou, Yuchen; Li, Siling; Chen, En; Jin, Guofan*. Curcumin copolymerized drugs mediated by enteric-coated polymers: Their design, synthesis and biocompatibility cell imaging studies. European Polymer Journal (2022), 180, 111606.

6.Shao, Tingyu; Wang, Yuling; Hu, Kaibo; Lian, Guangchang; Jin, Guofan*. Nitrogen-boron eight-ring rigid cis/trans BODIPY-pyrimidine isomers for in vivo and in vitro fluorescence target recognition and evaluation of inhibitory activity. Dyes and Pigments (2022), 201, 110204.

7.Hu, Kaibo; Lian, Guangchang; Wang, Yuling; Shao, Tingyu; Zhou, Meng; Liu, Ying; Jin, Guofan*. Rich fluorine trident type rigid donor-acceptor (D-A) tricarbazoles-triazine structures: An effective strong acid affinity fluorescent dye. Dyes and Pigments (2022), 201, 110254. 

8.Hu, Jianpeng; Wang, Yuling; shao, Tingyu; Lian, Guangchang; Hu, Kaibo; Liu, Ying; Zhou, Meng; Wang, Xiangpeng; Huang, Lizhuan; Meng, Xinlei; Jin, Guofan*. Simple and practical, highly sensitive and responsive recognition of cysteine: Design, synthesis and mechanism study of a novel curcumin fluorescent probe. Arabian Journal of Chemistry (2022), 15(9), 104087.

9.Dai, Dongfang; Lian, Guangchang; He, Xia; Feng, Jifeng; Jin, Guofan*. Water-soluble BODIPY-nido-carborane nanoparticles applied to biocompatibility tumor cell imaging. Photochemical & Photobiological Sciences (2022), 21(2), 185-194.

10.Guangchang Lian, Fuyan Xiao, Kaibo Hu, Yuling Wang, Tingyu Shao, Guofan Jin*. A simple, efficient, sensitive and practicability：Polyoxyphenylpropeone fluorescent probes for biological imaging. Materials Today Communications. 2021. 20. 1-11.

11.Chen Shao, Guangchang Lian, Guofan Jin*. Nido-carborane encapsulated by BODIPY zwitterionic polymers: Synthesis, photophysical properties and cell imaging. Journal of Saudi Chemical Society. 2021. 25. 1-11.

12.Feng Zhao, Yuling Wang, Guofan Jin*. Sulfamide-substituted-BODIPY based fluorescence drugs: Synthesis, spectral characteristics, molecular docking, and bioactivity. Arabian Journal of Chemistry. 2021. 14. 1-11.

13.Shao, Chen，Wang, Yuling，Guofan Jin*. Design, synthesis and biological activity of bis-sulfonyl-BODIPY probes for tumor cell imaging. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2021. 49. 1-10.

14.Feng Zhao, Kaibo Hu, Chen Shao, Guofan Jin*. Original boron cluster covalent with poly-zwitterionic BODIPYs for boron neutron capture therapy agent. Polymer Testing. 2021. 100. 1-10.

15.Kaibo Hu, Yuling Wang, Guangchang Lian, Fuyan Xiao, Tingyu Shao, Guofan Jin*. A strong acid-resistant flavanthrone with excellent photophysical properties. Journal of Molecular Liquids. 2021. 227. 1-12.

16.Cao, Jia，Lian, Guangchang，Qi, Xueyon，Guofan Jin*. Design synthesis and photophysical properties of a novel antitumor fluorescence agents. Journal of Molecular Structure. 2021. 1243. 1-11

17.Xu Chi，Shao, Tingyu，Shao, Shihe，Guofan Jin*. High activity, high selectivity and high biocompatibility BODIPY-pyrimidine derivatives for fluorescence target recognition and evaluation of inhibitory activity. BIOORGANIC CHEMISTRY. 2021. 114. 1-12.

18.Yuling Wang, Fuyan Xiao, Tingyu Shao, Kaibo Hu, Guangchang Lian, Jiankang Feng, Hao Chen, Guofan Jin*. A multiple acetal chalcone-BODIPY-based fluorescence: synthesis, physical property, and biological studies. Analytical and Bioanalytical Chemistry. 2021. 413. 2529–2541.

19.Peng Deng, Fuyan Xiao, Zhou Wang, Guofan Jin*. A Novel BODIPY Quaternary Ammonium Salt-Based Fluorescent Probe: Synthesis, Physical Properties, and Live-Cell Imaging. Frontiers in Chemistry. 2021. 4. 1-13.

20.ZhixiangLv, YulingWang, JinliangZhang, ZhouWang, Guofan Jin*. Bis-sulfonyl-chalcone-BODIPY molecular probes for in vivo and in vitro imaging. Journal of Molecular Structure. 2021. 1234. 1-15.

21.Su, Guodong, Xiao, Fuyan, Guofan Jin*. Boron Lewis reagent with nitrogen and oxygen adducts: synthesis of aza-belted diazabicyclo[n.n.5.5]alkane derivatives. Journal of the iranian chemical society. 2021. 2. 1-8.

22.Tingyu Shao, Yulin Wang, Fuyan Xiao, Guofan Jin*. Strategies of porous network quinolone polymers: A comprehensive evaluation of their biological activity. Dyes and Pigments. 2021. 1. 26.

23.Yulin Wang, Fuyan Xiao, Guofan Jin*. Structural basis of quinolone derivatives, inhibition of type I and II topoisomerases and inquiry into the relevance of bioactivity in odd or even branches with molecular docking study.　Journal of Molecular Structure. 2020.12. 11.

24.Jianpeng Hu, Fuyan Xiao, Guo Fan Jin.　 Amorphous chalconylurea polymer-doped zirconium metal enhancement of the fluorescence effect applied to cell imaging.　Dyes and Pigments.　2020. 12. 16.

25.Jianpeng Hu, Fuyan Xiao, Guofan Jin*. Zirconium doping level modulation combined with chalconylthiourea organic frameworks induced enhancement of luminescence applied to cell imaging. New Journal of Chemistry. 2020. 44. 10689-10696.

26.Fuyan Xiao, Yuling Wang, Tingyu Shao, Guofan Jin*. Acetonitrilated Unsymmetric BODIPYs having glycine fluorescence responsive quenching: Design, synthesis and spectroscopic properties.　 Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2020. 233. 118211.

27.Yuling Wang, Fuyan Xiao, Tingyu Shao, Guofan Jin*. A near-infrared azadipyrromethene dye: Photophysical properties under different acidity conditions. Inorganic Chemistry Communications. 2020. 116. 107942.

28.Guofan Jin,* Fuyan Xiao, Zhenwang Li, Xueyong Qi, Lei Zhao, and Xianyu Sun.　 Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents. ChemMedChem. 2020. 15. 600–609.

29.Guofan Jin*, Zhenwang Li, Fuyan Xiao, Xueyong Qi, Xianyu Sun. Optimization of activity localization of quinoline derivatives: Design, synthesis, and dual evaluation of biological activity for potential antitumor and antibacterial agents.　Bioorganic Chemistry. 2020. 99. 103837.

30.Guofan Jin*, Hyun Seung Ban, Hiroyuki Nakamura and Jong-Dae Lee. o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity.　Molecules. 2018. 23. 2194.

授权国内外专利

1. Guofan Jin; Yoon, Ji Ho; Park, HyeonGyu; Jung, YeongJu; Kim, SeonHui; Kang, Sang Uk; Yoo, Ho Seong; Lee, Jong Dae; Lee, Chae Ho.　Synthesis of 1,3,5-triazin-4-yl-dicarba-closo-dodecaborane derivative for use in anticancer agent for boron-neutron capture radiotherapy.　KRXXA7  KR  2008077801  A  20080826.

2. Guofan Jin; Yoon, Ji Ho; Jung, YeongJu; Kang, Sang Uk; Lee, Jong Dae; Lee, Chae Ho.　1,3,5-triazinylthiocarborane derivatives, their isomers and pharmaceutically acceptable salts, pharmaceutical composition containing the same and preparation method thereof. KRXXA7  KR  2009016794  A  20090218.

3. 金国范; 金峰; 郑兵; 王凯,一种邻碳硼烷苯酚衍生物及其制备方法和应用.中国, 201610325461 .5.

4. 金国范; 金峰; 王凯; 张艳; 张慧; 李柳斌,一种利用邻苯二甲酰亚胺制备双氟磺酰亚胺锂盐的方法,中国, 201610287182 .4.

5. 金国范; 金峰; 王凯; 张艳; 张慧; 李柳斌. 一种利用芳香甲基叠氮制备双氟磺酰亚胺锂盐的方法,中国, 201610286982 .4.

6. 金峰; 王凯; 金国范; 金英兰,邻碳硼烷衍生物、其制备方法和应用及制备该邻碳硼烷衍生物的中间体,中国, 201610286687 .9.

7. 金国范; 金峰; 王凯, 一种双氟磺酰亚胺锂盐的制备方法.中国,201610195308 .5.

8. 金国范;金峰;王凯;张艳;张慧;李柳斌,一种利用联氨制备双氟磺酰亚胺锂盐的方法,201610282164.7.　

9. 金国范;金峰;王凯;张艳;张慧;李柳斌,一种利用羟基氨制备双氟磺酰亚胺锂盐的方法,201610287270.4.