沈玉萍 副教授

作者: 时间:2020-07-13 点击数:

沈玉萍,女,江苏常州人,博士,副教授,硕士生导师。近年来研究工作主要侧重于HPLC技术在天然药物质量评价中的应用以及蛋白质组学技术在动物药质量评价中的应用。主持国家自然科学基金项目2项,参与并结题多项国家/省级科研项目;近年来以第一作者或通讯作者发表SCI论文20余篇;申请国家专利7项,已授权 2 项;参编来华留学生英文授课精编教材2部。

【教育背景和工作经历】

2017/012018/01,新加坡南洋理工大学,生物科学学院,省公派访问学者

2014.12~至今,江苏大学,药学院,硕士生导师

2014/07~至今,江苏大学,药学院,副教授

2007/082014/06,江苏大学,药学院,讲师

2002/092007/07,江苏大学,药学院,助教

2012/092019/09,江苏大学,临床检验诊断学,博士

2002/092005/06,江苏大学,生药学,硕士

1998/092002/06,江苏大学,药学,学士

【科研项目】

[1] 国家自然科学基金面上项目,构建新型高效酶水解体系以获取中药活性成分的研究(81873196),2019.01-2022.1256万元,在研,主持

[2] 国家自然科学基金面上项目,基于特异蛋白发现的胶类中药专属性鉴定研究(81773855),2018.01-2021.1255万元,在研,参加

[3] 江苏省自然科学基金,基于NanoLC-Orbitrap MSD技术鉴定胶类中药的研究(BK20150463),2015.07-2018.0720万元,已结题,参加

[4] 国家自然科学基金青年项目,MALDI-TOF/TOF-MS解析动物药中标志蛋白质和多肽作为特征识别物的研究(81303174),2014.01-2016.1223万元,已结题,主持

[5] 国家自然科学基金青年项目,共价固定化酶循环利用于高效催化产生中药活性成分的研究(81303313),2014.01-2016.1223万元,已结题,参加

[6] 江苏省自然科学基金青年项目,五种动物药鉴定中标志蛋白和多肽特征识别物的研究(BK2012290),2012.07-2015.0720万元,已结题,参加

[7] 国家自然科学基金青年项目,基于多层次物质基础的三七蒸制机理研究(81102812),2012.01-2014.1222万元,已结题,参加

[8] 国家自然科学基金面上项目,难溶药物新型胶束载体的构建及其增溶机理研究(30472098),2005.01-2007.1220万元,已结题,参加

【代表性SCI论文 2015

[1] Ling Lin, Yajie Zhang, Ye Li, Haizhen Fu, Jianhui Hu, Ying Zhou, Ying Xu, Guohua Xia, Xiaoxiang Sun, Huan Yang*, Yuping Shen*. Identification of signature proteins of processed Bombyx batryticatus by comparative proteomic analysis [J]. International Journal of Biological Macromolecules, 2020, 153: 289-296.

[2] Yaya Yang, Yang Zheng, Beibei Lu, Zhaoqun Jiao, Liqun Chen, Roselyn Tehzee Gblinwon, Xiaobin Jia, Yuping Shen*, Huan Yang*. Rapid identification of Cervus antlers by species-specific PCR assay [J]. Natural Product Research, 2020, 34(9): 1315-1319.

[3] Huan Yang, Ying Zhou, Pingtian Yu, Yaya Yang, Zhaoqun Jiao, James P. Tam, Yuping Shen*, Xiaobin Jia*. A novel PCR-based technology for rapid and non-sequencing authentication of Bombyx batryticatus using species-specific primers [J]. Natural Product Research, 2019, 33(9): 1251-1256.

[4] Changjie Yu, Zihao Li, Huawu Yin, Guohua Xia, Yuping Shen*, Huan Yang*, Jing Gao. Green production of diosgenin from Discorea nipponica Makino based on pressurized biphase acid hydrolysis via response surface methodology optimization [J]. Green Chemistry Letters and Reviews, 2019, 12(1): 79-88.

[5] Yang Zheng, Beibei Lu, Yaya Yang, Zhaoqun Jiao, Liqun Chen, Pingtian Yu, Yuping Shen*, Huan Yang*. Rapid identification of medicinal leech by species-specific PCR technology [J]. Pharmacognosy Magazine, 2019, 15(63): 410-415.

[6] Yuping Shen, Minhui Xu, Yufei Chen, Haiyan Wang, Yiying Zhou, Yeting Zhu, Huan Yang*, Jiangnan Yu*. Integrated extraction and purification of total bioactive flavonoids from Toona sinensis leaves [J]. Natural Product Research, 2019, 33(20): 3025-3028.

[7] Yuping Shen, Yi Lu, Jing Gao, Yeting Zhu, Man Wang, Shunli Jing, Lili Xu, Huan Yang*, Xiaobin Jia*. Efficient preparation of rare Sagittatoside A from Epimedin A, by recyclable aqueous organic two-phase enzymatic hydrolysis [J]. Natural Product Research, 2019, 33(21): 3095-3102.

[8] Yuping Shen, Man Wang, Yufei Chen, Lili Xu, Yi Lu, Yiying Zhou, James P. Tam, Feng Han, Huan Yang*, Xiaobin Jia*. Convenient preparation of sagittatoside B, a rare bioactive secondary flavonol glycoside, by recyclable and integrated biphase enzymatic hydrolysis [J]. Enzyme and Microbial Technology, 2019,121:51-58.

[9] Yuping Shen, Lili Xu, Jiayi Huang, Aida Serra, Huan Yang, James P. Tam*. Potentides: new cysteine-rich peptides with unusual disulfide connectivity from Potentilla anserina [J]. ChemBioChem, 2019, 20(15): 1995-2004.

[10] Liqun Chen, Zhaoqun Jiao, Yufei Chen, Pingtian Yu, Yang Zheng, Yaya Yang, Yuping Shen*, Huan Yang*. Development of a species-specific PCR-based technology for authentication of Asini Corii Colla and Taurus Corii Colla [J]. Pharmacognosy Magazine, 2019, 15(65): 607-612.

[11] Yufei Chen, Yaya Yang, Yinhuan Qian, Roselyn Tehzee Gblinwon, Jiao Zhaoqun, Liqun Chen, Ling Lin, Yang Zheng, Huan Yang*, Yuping Shen*. Harnessing multiplex PCR assay targeting specific mitochondrial DNA elements for simultaneous identification of antelope species in Cornu Saigae Tataricae [J]. Mitochondrial DNA Part B: Resources, 2019, 4(2): 3222-3226.

[12] Yuping Shen+, Man Wang+, Jinwei Zhou+, Yufei Chen, Lili Xu, Mengru Wu, Guohua Xia, James P. Tam, Jiangnan Yu, Xiying Teng, Huan Yang*, Xiaobin Jia*. Eco-efficient Biphasic Enzymatic Hydrolysis for the Green Production of Rare Baohuoside I [J]. Enzyme and Microbial Technology, 2019, 131: 109431.

[13] Huan Yang, Ying Zhou, Pingtian Yu, Yaya Yang, Zhaoqun Jiao, James P. Tam, Yuping Shen*, Xiaobin Jia*. A novel PCR-based technology for rapid and non-sequencing authentication of Bombyx batryticatus using species-specific primers [J]. Natural Product Research, 2019, 33(9): 1251-1256.

[14] Huan Yang, Pingtian Yu, Yi Lu, Zhaoqun Jiao, Liqun Chen, Ying Zhou, Yuping Shen*, Xiaobin Jia*. A novel non-sequencing approach for rapid authentication of Testudinis Carapax et Plastrum and Trionycis Carapax by species-specific primers [J]. Royal Society Open Science, 2018, 5: 172140.

[15] Yuping Shen, Minhui Xu, Peipei Deng, Qinying Gu, Huawu Yin, Guohua Xia, Xiaobin Jia*, Huan Yang*, James Tam. Establishment of a rapid method to quantify eight flavonol glycosides for quality assessment of Red Toon using UPLC [J]. Acta Chromatographica, 2018, 30(1): 31-37.

[16] Yuping Shen#, Haiyan Wang#, Yi Lu#, Lili Xu, Huawu Yin, James P. Tam, Huan Yang*, Xiaobin Jia*. Construction of a novel catalysis system for clean and efficient preparation of Baohuoside I from Icariin based on biphase enzymatic hydrolysis [J]. Journal of Cleaner Production, 2018, 170: 727-734. IF 6.395, Q1)

[17] Huan Yang, Jie Zheng, Haiyan Wang, Nan Li, Yaya Yang, Yuping Shen*. Comparative proteomic analysis of three gelatinous Chinese medicines and their authentications by tryptic-digested peptides profiling using MALDI-TOF/TOF-MS [J]. Pharmacognosy Magazine, 2017, 13(52): 663-667.

[18] Huan Yang, Huawu Yin, Yuping Shen*, Guohua Xia, Bo Zhang, Xiangyang Wu, Baochang Cai*, James P. Tam. A more ecological and efficient approach for producing diosgenin from Dioscorea zingiberensis tubers via pressurized biphase acid hydrolysis [J]. Journal of Cleaner Production, 2016, 131: 10-19.

[19] Huan Yang, Yuping Shen, Ying Xu, Aida Maqueda, Jie Zheng, Qinan Wu*, James P. Tam*. A novel strategy for the discrimination of gelatinous Chinese medicines based on enzymatic digestion followed by nano-flow liquid chromatography in tandem with orbitrap mass spectrum detector [J]. International Journal of Nanomedicine, 2015, 10: 4947-4955. (IF 5.029, Q1)

【国家发明专利】

[1] 杨欢,沈玉萍,顾芹英,周存山,夏国华,孙竞. 一种香椿叶中没食子酸及其甲酯的同时制备及检测方法. 2014.12.24授权ZL201210513809.5

[2] 沈玉萍,杨欢,夏国华,周存山,王海艳,卢艺. 一种双相酶水解获取宝藿苷I的方法. 2020.6.26 授权ZL201611119179.8

[3] 沈玉萍,杨欢,徐莹,余江南,陈慧卿,曹进,夏国华. 一种利用生物质谱技术快速检测僵蚕蛋白质的方法. 2015.12.30公开,CN105203677A

研究生培养

指导生药学研究生6名,重视培养学生的国际化视野,课题组专门设立基金,

承担研究生出国交流、语言培训与考试等费用。

2019 年,指导的两位研究生成功获批CSC全额奖学金资助,分别前往法国皮

埃尔结构生物学研究所、德国亚琛工业大学攻读博士学位。

组织所指导研究生多次赴新加坡、日本参加国际会议,并做墙报展示。

【联系方式】

办公室:药学楼2205

实验室:药学楼2514-2518

Emailsyp131@ujs.edu.cn

2020712日更新

 

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