曹霞 副教授

作者: 时间:2021-03-29 点击数:

曹霞,女,博士,副教授,硕士生导师。主要从事纳米药物/基因传递及组织研究工作。先后主持多项国家及省级科研项目,并参与国家重大专项等多个项目的研究开发工作。发表SCI文章40余篇(最高影响因子16.863);获美国授权发明专利3 项,中国授权发明专利18项;获教育部技术发明二等奖1 项,科学技术进步奖一等奖1项。


联系方式 江苏大学药学院2315室,邮箱:caoxia@ujs.edu.cn


1)主要研究方向


基于微流控芯片技术的纳米颗粒可控合成;


纳米药物递送系统;


非病毒基因传递系统;


3D生物打印及组织工程构建;


2)教育及工作经历


2001.09-2005.06,江苏大学,药学院,药学,学士


2005.09-2008.06,江苏大学,药学院,药剂,硕士


2008.09-2011.12,江苏大学,医学院,临床检验诊断学,博士


2012.04至今,江苏大学,药学院,药剂教研室,副教授


3)留学经历


2016.6-2019.8 美国哈佛医学院,博士后


4)主持的科研项目


国家自然基金委,青年科学基金项目,81503025,荧光碳点介导的纳米基因传递及其诱导脑胶质瘤干细胞分化。

中国博士后面上项目,2014M560410、混杂纳米基因载体构建及干细胞传递研究

江苏省博士后科研资助,1401023B,混杂纳米基因载体构建及干细胞传递研究


5)授权国际专利

[1] A Formulation of Silymarin with High Efficacy and Prolonged Action and the Preparation Method Thereof

[2] Ximing Xu, Jiangnan Yu, Xia Cao, Yuan Zhu. A Formulation of Silybinin with High Efficacy and Prolonged Action and the Preparation Method Thereof, US9023388, Date of Patent: May 5, 2015.

[3] Ximing Xu, Jiangnan Yu, Yuan Zhu, Xia Cao. A Highly Efficient and Long-acting Slow-release formulation of Poorly Soluble Drugs and Preparation Method Thereof, US 9,283,190, Date of Patent:03/15/2016.


6) 授权国内专利

[1] 以脂筏修饰的色谱柱及其制法和在中药抗肿瘤活性部位筛选中的应用

[2] 一种合欢皮抗肿瘤有效组分提取物及其制法和用途

[3] 炒北葶苈子抗肿瘤有效组分提取物及其制法和用途

[4] 北葶苈子抗肿瘤有效组分提取物及其制法和用途

[5] 金针菇抗肿瘤有效组分提取物及其制法和用途

[6] 金针菇中具有抗肿瘤作用的可皂化提取物及其制法和用途

[7] 钙离子化介孔二氧化硅纳米粒基因传递系统及其制法

[8] 一种载有基因的磷酸钙复合纳米粒及其制法与用途

[9] 阳离子化杏鲍菇多糖纳米粒基因传递系统及其制法

[10] 阳离子化当归多糖纳米粒基因传递系统及其制法

[11] 一种基因传递系统的三维纳米支架及其制备与应用

[12] 阳离子化的桑叶多糖纳米粒基因载体及其制法,

[13] 离子化多糖纳米粒基因传递系统及其制法

[14] 阳离子化枸杞多糖纳米粒基因传递系统及其制法

[15] 一种水飞蓟素高效长效制剂及其制法

[16] 难溶性药物高效长效缓释制剂及其制法

[17] 余江南,曹霞,徐希明,朱源. 一种水飞蓟宾高效长效制剂及其制法

[18] 2-氨基-4-羰基-7-3,4-二甲氧苯甲基)-5-乙烯基-6,7-二氢-3H-吡咯并[23-d]嘧啶的制法


7)近5年发表文章

[1] J. Gong, C.C.L. Schuurmans, A.M.V. Genderen, X. Cao, W. Li, F. Cheng, J.J. He, A. Lopez, V. Huerta, J. Manriquez, R. Li, H. Li, C. Delavaux, S. Sebastian, P.E. Capendale, H. Wang, J. Xie, M. Yu, R. Masereeuw, T. Vermonden, Y.S. Zhang, Complexation-induced resolution enhancement of 3D-printed hydrogel constructs, Nat Commun, 2020, 11(1): 1267.

[2] X. Cao, R. Ashfaq, F. Cheng, S. Maharjan, J. Li, G. Ying, S. Hassan, H. Xiao, K. Yue, Y.S. Zhang, Bioprinting: A Tumor-on-a-Chip System with Bioprinted Blood and Lymphatic Vessel Pair (Adv. Funct. Mater. 31/2019), Advanced Functional Materials, 2019, 29(31): 1970217.

[3] Q. Wang, M. Guo, M. Adu-Frimpong, K. Zhang, Q. Yang, E. Toreniyazov, H. Ji, X. Xu, X. Cao, J. Yu; Self-Micro-Emulsifying Controlled Release of Eugenol Pellets: Preparation, In vitro/In vivo Investigation in Beagle Dogs, AAPS PharmSciTech, 2019, 20(7): 284.

[4] A. Polat, S. Hassan, I. Yildirim, L. E. Oliver, M. Mostafaei, S. Kumar, S. Maharjan, L. Bourguet, X. Cao, G. Ying, M. Eyvazi Hesar, Y. S. Zhang; A miniaturized optical tomography platform for volumetric imaging of engineered living systems, Lab Chip, 2019, 19(4): 550-561.

[5] W. Deng, F. Shao, Q. He, Q. Wang, W. Shi, Q. Yu, X. Cao, C. Feng, S. Bi, J. Chen, P. Ma, Y. Li, A. Gong, S. Tong, J. Yu, M. Spector, X. Xu, Z. Zhang; EMSCs Build an All-in-One Niche via Cell-Cell Lipid Raft Assembly for Promoted Neuronal but Suppressed Astroglial Differentiation of Neural Stem Cells, Adv Mater, 2019, 31(10): e1806861.

[6] F. Cheng, X. Cao, H. Li, T. Liu, X. Xie, D. Huang, S. Maharjan, H. P. Bei, A. Gomez, J. Li, H. Zhan, H. Shen, S. Liu, J. He, Y. S. Zhang; Generation of Cost-Effective Paper-Based Tissue Models through Matrix-Assisted Sacrificial 3D Printing, Nano Lett, 2019, 19(6): 3603-3611.

[7] G. L. Ying, N. Jiang, S. Maharjan, Y. X. Yin, R. R. Chai, X. Cao, J. Z. Yang, A. K. Miri, S. Hassan, Y. S. Zhang; Aqueous Two-Phase Emulsion Bioink-Enabled 3D Bioprinting of Porous Hydrogels, Adv Mater, 2018, 30(50): e1805460.

[8] Q. Wang, Q. Yang, X. Cao, Q. Wei, C. K. Firempong, M. Guo, F. Shi, X. Xu, W. Deng, J. Yu; Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles, Int J Pharm, 2018, 550(1-2): 24-34.

[9] Q. Wang, Q. Wei, Q. Yang, X. Cao, Q. Li, F. Shi, S. S. Tong, C. Feng, Q. Yu, J. Yu, X. Xu; A novel formulation of [6]-gingerol: Proliposomes with enhanced oral bioavailability and antitumor effect, Int J Pharm, 2018, 535(1-2): 308-315.

[10] J. Li, Q. Yu, H. Huang, W. Deng, X. Cao, M. Adu-Frimpong, J. Yu, X. Xu; Human chorionic plate-derived mesenchymal stem cells transplantation restores ovarian function in a chemotherapy-induced mouse model of premature ovarian failure, Stem Cell Res Ther, 2018, 9(1): 81.

[11] Q. Yu, J. Chen, W. Deng, X. Cao, Y. Wang, J. Zhou, W. Xu, P. Du, Q. Wang, J. Yu, X. Xu; Direct reprogramming of mouse fibroblasts into neural cells via Porphyra yezoensis polysaccharide based high efficient gene co-delivery, J Nanobiotechnology, 2017, 15(1): 82.

[12] Q. Yu, J. Chen, W. Deng, X. Cao, M. Adu-Frimpong, J. Yu, X. Xu; Neural differentiation of fibroblasts induced by intracellular co-delivery of Ascl1, Brn2 and FoxA1 via a non-viral vector of cationic polysaccharide, Biomed Mater, 2017, 13(1): 015022.

[13] J. Chen, Q. Wang, J. Zhou, W. Deng, Q. Yu, X. Cao, J. Wang, F. Shao, Y. Li, P. Ma, M. Spector, J. Yu, X. Xu; Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells, Nanoscale, 2017, 9(30): 10820-10831.

[14] J. Zhou, W. Deng, Y. Wang, X. Cao, J. Chen, Q. Wang, W. Xu, P. Du, Q. Yu, J. Chen, M. Spector, J. Yu, X. Xu; Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake, Acta Biomater, 2016, 42209-219.

[15] H. Y. Zhang, W. Q. Xu, Y. Y. Zheng, E. Omari-Siaw, Y. Zhu, X. Cao, S. S. Tong, J. N. Yu, X. M. Xu; Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation, Oncotarget, 2016, 7(52): 86326-86338.

[16] H. Y. Zhang, W. Q. Xu, Y. W. Wang, E. Omari-Siaw, Y. Wang, Y. Y. Zheng, X. Cao, S. S. Tong, J. N. Yu, X. M. Xu; Tumor targeted delivery of octreotide-periplogenin conjugate: Synthesis, in vitro and in vivo evaluation, Int J Pharm, 2016, 502(1-2): 98-106.

[17] H. Y. Zhang, C. K. Firempong, Y. W. Wang, W. Q. Xu, M. M. Wang, X. Cao, Y. Zhu, S. S. Tong, J. N. Yu, X. M. Xu; Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability, Acta Pharmacol Sin, 2016, 37(6): 834-844.

[18] E. Omari-Siaw, Y. Zhu, H. Wang, W. Peng, C. K. Firempong, Y. W. Wang, X. Cao, W. Deng, J. Yu, X. Xu; Hypolipidemic potential of perillaldehyde-loaded self-nanoemulsifying delivery system in high-fat diet induced hyperlipidemic mice: Formulation, in vitro and in vivo evaluation, Eur J Pharm Sci, 2016, 85112-122.

[19] E. Omari-Siaw, Q. Wang, C. Sun, Z. Gu, Y. Zhu, X. Cao, C. K. Firempong, R. Agyare, X. Xu, J. Yu; Tissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia, Int J Pharm, 2016, 513(1-2): 68-77.

[20] C. K. Firempong, H. Y. Zhang, Y. Wang, J. Chen, X. Cao, W. Deng, J. Zhou, Q. Wang, S. S. Tong, J. Yu, X. Xu; Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo, Pharmacol Res, 2016, 110101-110.

[21] W. Deng, X. Cao, Y. Wang, Q. Yu, Z. Zhang, R. Qu, J. Chen, G. Shao, X. Gao, X. Xu, J. Yu; Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification, J Agric Food Chem, 2016, 64(6): 1264-1273.

[22] W. Deng, X. Cao, Q. Wang, Y. Wang, J. Chen, Q. Yu, Z. Zhang, J. Zhou, W. Xu, P. Du, J. Chen, X. Gao, J. Yu, X. Xu; Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming, ACS Appl Mater Interfaces, 2016, 8(31): 19916-19927.

           

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