邓纹纹 资格副教授

作者: 时间:2021-03-30 点击数:

江苏大学博士、博士后,资格副教授、硕士生导师。主持国家自然基金(青年项目)1项、中国博士后科学基金面上项目1项,参与国家自然基金重点国际合作项目1项,参与国家自然基金面上项目3项。于Advanced MaterialsSmall等学术期刊发表SCI 论文40篇,其中第一/共同一作论文20篇,共同通讯作者论文6篇;一区论文 12篇,二区论文12篇;影响因子10以上4篇,单篇最高影响因子 25.809,获中国授权发明专利5项,申请PCT专利2项。

【教育背景】

² 2019.10 至今 江苏大学 讲师 药学院

² 2016.07 2019.10 江苏大学 脱产博士后 材料科学与工程

² 2012.09 2016.06 江苏大学 医学博士 临床检验诊断学

² 2008.09 2011.06 江苏大学 工学硕士 药剂学

² 2004.09 2008.06 江苏大学 工学学士 制药工程

【研究方向】

1、非病毒纳米药物/基因传递

2、非病毒细胞重编程、细胞治疗与组织工程

【承担和参与的科研项目】

1 国家自然科学基金委员会,青年项目,81803475,血小板膜-自组装纳米递药系统构建及其诱导星型胶质细胞靶向直接重编程研究,2019-012021-1221万元,在研,主持;

2、中国博士后科学基金会,第62批面上项目,2017M621658,姜黄素自组装纳米粒诱导星型胶质细胞直接重编程研究,2017-092019-065万元、结题、主持;

3、国家自然科学基金委员会,国际(地区)合作与交流项目,817201080303D仿生打印定位、梯度、长效释药系统及其修复脊髓损伤研究,2018-012022-12233万元,在研,参加;

4、国家自然科学基金委员会,面上项目,81473172DNA-阳离子多糖-碳量子点自组装纳米粒介导的体细胞直接重编程研究,2014-012018-12100万元,已结题,参加;

5、国家自然科学基金项目,面上项目,81273470microRNA非病毒纳米传递系统构建及其促进体细胞重编程研究,2013-012016-12100万元,已结题,参加;

6.国家自然科学基金项目,面上项目,81373371,人源iPSC的肝细胞分化及其三维体系中代谢功能研究2014-012017-1265万元,已结题,参加。

【代表性论文】

[1] Wenwen Deng#, Fengxia Shao#, Qinghua He#, Qiang Wang, Wentao Shi, Qingtong Yu, Xia Cao, Chunlai Feng, Shiqi Bi, Jiaxin Chen, Ping Ma, Yang Li, Aihua Gong, Shanshan Tong, Jiangnan Yu, Myron Spector, Ximing Xu*, and Zhijian Zhang*. Ectomesenchymal stem cells build an all-in-one niche for promoted neuronal but suppressed astroglial differentiation of neural stem cells. Advanced Materials, 2019, 31(10): 1806861.(内封面,一区,IF=27.398

[2] Wenwen Deng#, Xia Cao#, Miao Wang#, Yan Yang, Weiyan Su, YaweiWei, Zhen Ou-Yang, Jiangnan Yu*, Ximing Xu*. Efficient Gene Delivery to Mesenchymal Stem Cells by an Ethylenediamine-Modified Polysaccharide from Mulberry Leaves. Small, 2012,8(3): 441-451. (一区,IF=11.459

[3] Wenwen Deng#, Xia Cao#, Qiang Wang#, Yan Wang, Jingjing Chen, Qingtong Yu, Zhijian Zhang, Jie Zhou, Wenqian Xu, Pan Du, Jiaxin Chen, Xiangdong Gao, Jiangnan Yu, Ximing Xu*. Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming. ACS Applied Materials & Interfaces, 2016, 8(31): 19916-19927. (一区,IF= 8.758

[4] Wenwen Deng#, Xia Cao#, Jingjing Chen#, Zhijian Zhang, Qingtong Yu, Yan Wang, Genbao Shao, Jie Zhou, Xiangdong Gao, Jiangnan Yu*, Ximing Xu*. MicroRNA Replacing Oncogenic Klf4 and c-Myc for Generating iPS Cells via Cationized Pleurotus eryngii Polysaccharide-based Nanotransfection. ACS Applied Materials & Interfaces, 2015, 7(34): 18957-18966. (一区,IF= 8.758

[5] Xia Cao#, Wenwen Deng#, Rui Qu#, Qingtong Yu, Jun Li, Yan Yang, Yue Cao, Xiangdong Gao, Ximing Xu*, Jiangnan Yu*. Non-Viral Co-Delivery of the Four Yamanaka Factors for Generation of Human Induced Pluripotent Stem Cells via Calcium Phosphate Nanocomposite Particles. Advanced Functional Materials, 2013, 23(43): 5403-5411. (一区,IF= 16.836

[6] Zhijian Zhang#, Qinghua He#, Wenwen Deng#, Qian Chen, Xinyuan Hu, Aihua Gong, Xia Cao, Jiangnan Yu, Ximing Xu*. Nasal ectomesenchymal stem cells: Multi-lineage differentiation and transformation effects on fibrin gels. Biomaterials, 2015, 49: 57-67. (一区,IF= 10.317

[7] Wenwen Deng#, Xia Cao#, Yan Wang#, Qingtong Yu, Zhijian Zhang, Rui Qu, Jingjing Chen, Genbao Shao, Xiangdong Gao, Ximing Xu*, Jiangnan Yu*. Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification. Journal of Agricultural and Food Chemistry, 2016, 64(6): 1264-1273. (一区,IF= 4.192

[8] Zhou Jie#, Wenwen Deng#, Yan Wang#, Xia Cao, Jingjing Chen, Qiang Wang, Wenqian Xu, Pan Du, Qingtong Yu, Jingjing Chen, Myron Spector, Jiangnan Yu*, Ximing Xu*. Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake. Acta Biomaterialia, 2016, 42:209-219. (一区,IF= 7.242

[9] Jiaxin Chen#, Qiang Wang#, Jie Zhou#, Wenwen Deng#, Qingtong Yu, Xia Cao, Jianping Wang, Fengxia Shao, Yang Li, Ping Ma, Myron Spector, Jiangnan Yu, and Ximing Xu*. Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells. Nanoscale, 2017, 9(30): 10820-10831. (一区,IF= 6.895

[10] Miao Wang#, Wenwen Deng#, Min Fu#, Xia Cao#, Yan Yang, Weiyan Su, Jiangnan Yu*, Ximing Xu*. Efficient gene transfer into rat mesenchymal stem cells with cationized Lycium barbarum polysaccharides nanoparticles. Carbohydrate Polymers, 2011, 86: 1509-1518. (一区,IF= 7.182

[11] Qilong Wang#, Qiuxuan Yang#, Xia Cao#, Qiuyu Wei, Caleb K. Firempong, Min Guo, Feng Shi, Ximing Xu⁎, Wenwen Deng*, Jiangnan Yu*. Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles. International Journal of Pharmaceutics, 2018, 550: 24–34. (一区,IF= 4.485

[12] Yao Xu, Huiyan Jiang, Congyong Sun, Michael Adu-Frimpong, Wenwen Deng*, Jiangnan Yu*, XimingXu*. Antioxidant and hepatoprotective effects of purified Rhodiola rosea polysaccharides. International Journal of Biological Macromolecules, 2018,117:167–178. (一区,IF= 5.162


【授权发明专利】

1.徐希明,邓纹纹,余江南,王淼,曹霞,阳离子化的桑叶多糖纳米粒基因载体及其制法,2014.8.6,中国,ZL201010613484.9

2.徐希明,邓纹纹,余江南,王淼,曹霞,阳离子化杏鲍菇多糖纳米粒基因传递系统及其制法,2013.3.13,中国,ZL201010613483.4

3.徐希明,王淼,余江南,邓纹纹,曹霞,阳离子化当归多糖纳米粒基因传递系统及其制法,2012.12.19,中国,ZL201010613603.0

4.徐希明,王淼,余江南,邓纹纹,曹霞,阳离子化枸杞多糖纳米粒基因传递系统及其制法,2012.8.29,中国,ZL201010613602.6

5.徐希明,曹霞,余江南,王淼,邓纹纹,阳离子化多糖纳米粒基因传递系统及其制法,2012.11.7,中国,ZL201010614816.5



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