蒋俊 副教授

作者: 时间:2020-09-15 点击数:

蒋俊,男,1986年生,中药学博士,出站博士后,副教授,硕士生导师,江苏大学青年英才培育计划优秀青年骨干教师。主持及参与国家自然科学基金3项、江苏省自然科学基金1项、博士后基金3项、市厅级重点研发计划3项、江苏出入境检验检疫系统项目1项、参与制定行业标准(SN标准)1项。在中药学科主流学术期刊发表SCI论文及中文核心论文累计50余篇。获省部级科技进步一等奖1项、江苏中医药科技进步一等奖1项。


联系方式

Tel15252918585

E-mailjiangjuntcm2007@hotmail.com

AddressJiangsu University, 301# Xuefu Road, Zhenjiang 212013, Jiangsu Province, China.

WeChat15252918585


学习/科研经历

1. 2003.9-2007.6,南京中医药大学,中药制剂专业,获学士学位;

2. 2007.9-2010.6,中国中医科学院江苏分院(与江苏大学联合培养),完成硕士论文,获医学硕士学位;

3. 2012.9-2015.6,中国中医科学院江苏分院,完成博士论文,获医学博士学位。


工作经历

2010.7-2012.8,中国海关-国家食品调味品检测重点实验室,从事进出口食品/药品质量控制和安全性评价;

2015.11-至今,江苏大学药学院,从事教研工作。


研究方向

1. 单味中药/中医经方抗骨质疏松药效物质基础及作用机理研究;

2. 中药炮制机理与质量控制研究;

3. 基于药代/毒代动力学的中药安全性、有效性评价;

4. 可植入缓/控释制剂在骨缺损方面的应用与开发。

主讲课程

1. 本科生课程:《天然药物化学》、《中药学》

2. 留学生全英文课程:《Clinical Pharmacotherapeutics》、《Medicinal Chemistry of Natural Products

招生方向

1. 学术型硕士研究生(生药学)

2. 专业型硕士研究生(制药工程)


代表性SCI论文

[1] Jiang J, Xiao S, Yan S, Zhang J, Xu X. The effects of sulfur fumigation processing on Panacis Quinquefolii Radix in chemical profile, immunoregulation and liver and kidney injury. Journal of Ethnopharmacology, 2020, 249: 112377.

[2] Jiang J, Xiao S, Yan S, Xiao J, Xu X. Glycyrrhizae Radix et Rhizoma processed by Sulfur Fumigation damaged the chemical profile accompanied by immunosuppression and liver Injury. Biomed Res Int, 2020: 5439853.

[3] Jiang Jun, Chen Tong, Xu Ximing. Simultaneous determination of 16 phthalate esters in Suet Oil by GC-EIMS Coupled with refrigerant centrifugation and Ethylenediamine-N-propylsilane Depuration. Chromatographia, 2019, 82(11): 1721-1732.

[4] Jiang J, Xiao S, Xu X, Ma H, Feng C, Jia X. Isomeric flavonoid aglycones derived from Epimedii Folium exerted different intensities in anti-osteoporosis through OPG/RANKL protein targets. International Immunopharmacology, 2018, 62: 277-286.

[5] Jiang J, Yin J, Liu X, Wang H, Lu G. Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes. Evidence-based Complementary and Alternative Medicine, 2018, 2018: 1741924.

[6] Liu L, Tao W, Pan W, Li L, Yu Q, Zhang D, Jiang J*. Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis. Biomed Research International, 2018, 2018: 6762146.

[7] Cheng Q, Zhang X, Jiang J*, Zhao G, Wang Y, Xu Y, Xu X, Ma H. Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen. Biomed Research International, 2017, 2017: 1345193.

[8] Jiang J, Feng L, Sun E, Li H, Cui L, Jia X. Metabolic profiling of isomeric aglycones central-icaritin (c-IT) and icaritin (IT) in osteoporotic rats by UPLC-QTOF-MS, Drug Testing and Analysis, 2015, 7(4): 309-319.

[9] Jiang J, Li J, Zhang Z, Sun E, Feng L, Jia X. Mechanism of enhanced antiosteoporosis effect of circinal-icaritin by self-assembled nanomicelles in vivo with suet oil and sodium deoxycholate, International Journal of Nanomedicine, 2015, 10: 2377-2389.

[10] Jiang J, Jia X. Profiling of fatty acids composition in suet oil based on GC-EI-qMS and chemometrics analysis, International Journal of Molecular Sciences, 2015, 16(2): 2864-2878.

[11] Jiang J, Feng L, Li J, Sun E, Ding SM, Jia XB. Multielemental composition of suet oil based on quantification by ultrawave/ICP-MS coupled with chemometric analysis, Molecules, 2014, 19(4): 4452-4465.

[12] Jiang J, Li J, Jia X. The antiosteoporotic activity of central-icaritin (CIT) on bone metabolism of ovariectomized rats. Molecules. 2014, 19(11): 18690-18704.

[13] Zhao BJ, Wang J, Song J, Wang CF, Gu JF, Yuan JR, Zhang L, Jiang J, Feng L, Jia XB. Beneficial Effects of a Flavonoid Fraction of Herba Epimedii on Bone Metabolism in Ovariectomized Rats. Planta Med. 2016, 82(4): 322-9.

[14] Gu JF, Feng L, Zhang MH, Qin D, Jiang J, Cheng XD, Ding SM, Yang SL, Jia XB. New metabolite profiles of Danshensu in rats by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014, 955-956: 20-5.

[15] Zhang MH, Feng L, Zhu MM, Gu JF, Jiang J, Cheng XD, Ding SM, Wu C, Jia XB. The anti-inflammation effect of Moutan Cortex on advanced glycation end products-induced rat mesangial cells dysfunction and High-glucose-fat diet and streptozotocin-induced diabetic nephropathy rats. J Ethnopharmacol. 2014, 151(1): 591-600.

[16] Ding SM, Zhang ZH, Song J, Cheng XD, Jiang J, Jia XB. Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion. Int J Nanomedicine. 2014, 9: 2327-33.

[17] Li Y, Gu JF, Zou X, Wu J, Zhang MH, Jiang J, Qin D, Zhou JY, Liu BX, Zhu YT, Jia XB, Feng L, Wang RP. The anti-lung cancer activities of steroidal saponins of P. polyphylla Smith var. chinensis (Franch.) Hara through enhanced immunostimulation in experimental Lewis tumor-bearing C57BL/6 mice and induction of apoptosis in the A549 cell line. Molecules. 2013, 18(10): 12916-36.

[18] Feng L, Jia XB, Jiang J, Zhu MM, Chen Y, Tan XB, Shi F. Combination of active components enhances the efficacy of Prunella in prevention and treatment of lung cancer. Molecules. 2010, 15(11): 7893-906.


代表性中文核心期刊论文

在已发表的核心期刊中,《药学学报》1篇、《中国药学杂志》1篇、《中国中药杂志》5篇、《中草药》12篇、《中华中医药杂志》7篇、《药物分析》1篇、《中国医院药学杂志》2篇、《南京中医药大学学报》2篇、《分析试验室》2篇、《中国骨质疏松杂志》2篇。5篇代表性论文如下:

[1] 桃红四物汤逆转斑马鱼模型糖皮质激素性骨质疏松的研究. 药学学报, 2019, 54(2): 313 -320.

[2] 淫羊藿素与RANKL蛋白靶点结合抑制破骨细胞分化抗骨质疏松作用研究. 中草药 2017, 48(22): 4707-4712.

[3] 萸黄连饮片反制前后物质基础差异性研究. 药物分析杂志, 2011, 31(1): 43-49.

[4] 雷公藤甲素表观油水分配系数的测定及其对吸收预测的研究. 中国药学杂志, 2009, 44(20): 1560-1563.

[5] 萸黄连炮制研究进展及炮制机制研究思路与方法. 中国中药杂志, 2009, 34(10): 1314-1317.


主持及参与的科研项目

[1] 国家自然科学基金:淫羊藿素通过下调雌激素缺失状态下的铁过载而调节骨type I胶原合成分泌与降解抗绝经后骨质疏松研究(81703773)20万元;

[2] 国家自然科学基金:基于病理网络多靶标的丹皮多组分防治糖尿病肾病的整合调节机制研究(81473394) 75 万元;

[3] 国家自然科学基金:基于多糖球形链构象的黄芩自分散结肠靶向释药系统研究(81403121) 23 万元;

[4] 江苏省自然科学基金:淫羊藿素通过下调雌激素缺失状态下的铁过载而调节骨type I胶原合成分泌与降解抗绝经后骨质疏松研究(BK20170560)20万元;

[5] 江苏省中医药科技发展计划:淫羊藿素通过下调铁过载而调节LncRNAMAR1/Wnt靶点抗绝经后骨骼肌萎缩研究(YB201990)10万元;

[6] 中国博士后科学基金会-特别资助:淫羊藿素下调铁过载干预胶原代谢抗绝经后骨质疏松研究(2018T110461)15万元;

[7] 中国博士后基金:不同糖基数量/种类/位置淫羊藿黄酮口服入骨机制研究(No. 2016M590424)8万元;

[8] 江苏省博士后基金:不同糖基数量/种类/位置淫羊藿黄酮在骨髓间质干细胞的膜转运机制研究,1万元;

[9] 镇江市重点研发计划-社会发展项目:四种中药硫磺熏蒸后QTOF-MS指纹成分筛查及功效和安全性评价(SH2017054)12万元;

[10] 镇江市科技支撑计划-社会发展项目:食品非法加工/处理过程中特异性成分筛查(No. SH2012010)20万元;

[11] 江苏出入境检验检疫局项目:食品中塑料包装迁移物在线检测技术研究(2011KJ48)4万;

学生培养

首批指导的学生于2020年毕业,1名被中国中医科学院录取,1名被推荐至中国药科大学中药制剂专业。


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