一、基本信息

姓名：刘瑞江

通讯地址：江苏省镇江市学府路301号 江苏大学药学院（邮编：212013）

电子邮件：1000003001@ujs.edu.cn

二、个人简介

刘瑞江，男，江苏大学药学院副教授、硕士生导师。长期从事纳米药物构建和评价、电化学纳米生物传感器的构建及肿瘤标志物的检测、磁性纳米功能空间材料的构筑及应用研究。主持和参与各类项目50余项。发表SCI检索文章120余篇，其中第一作者和通讯作者90余篇；授权中国发明专利17项。

三、教育经历

•2010.09—2013.12 江苏大学，材料学专业，博士学位

•2002.09—2004.06 南京工业大学，化学工程专业，硕士学位

•1995.09—1999.07 烟台大学，化学工程专业，学士学位

四、工作经历

•2013.08—至今 江苏大学药学院，副教授、硕士生导师

•2006.08—2013.07 江苏大学药学院，讲师

•2004.07—2006.07 江苏大学生物与环境工程学院，助教

五、研究方向

1.电化学纳米生物传感器的构建及肿瘤标志物的检测；

2.新型双靶向纳米载药系统的构建及其评价研究；

3.生物医药磁性纳米功能空间材料的构筑及其应用研究。

六、科研成果

6.1 科研项目

•2026.01—2028.12｜企业合作项目“基于异质体磁性纳米材料的新型药物传递系统构建及肿瘤标志物检测技术开发”（项目编号：HX20260030）｜主持

•2025.01—2026.10｜企业合作项目“一种用于CYFRA 21-1基因检测的新型免标记磁自组装电化学生物传感器的开发”（项目编号：HX20250099）｜主持

•2023.04—2025.04｜企业合作项目“磁性纳米空间材料的制备和应用新技术开发”（项目编号：HX20230236）｜主持

•2021.11-17—2022.12｜企业合作项目“磁性免标记CYP2C9*3基因电化学生物传感器的开发”（项目编号：HX20210827）｜主持

•2021.06—2023.06｜国家能源项目“一次塑型磁捕集剂试研制及磁回用组件试研制”（项目编号：HX20210452）｜主持

•2020.10—2022.10｜国家能源项目“VOC截流与净化非标组件材料试制/冷态可调磁拦截器样模非标组件试研制/微型柱网回收分离器件试研制”（项目编号：HX20200579/HX20200580/HX20200581）｜主持

•2016.05—2017.05｜中国博士后科研资助项目“磁性F_e3O₄/Fe₂O₃复合纳米管负载siRNA传递系统的构建” （项目编号：2016M591778）｜主持

•2016.03—2018.03｜企业合作项目“磁性纳米空间材料的制备及其污水处理技术的开发” （项目编号：HX20160071）｜主持

•2015.07—2016.12｜江苏省博士后科研资助项目 “磁性氧化铁纳米管的构筑及其负载和传递siRNA系统的构建” （项目编号：1501086C）｜主持

6.2 学术论文

[1]Yixing Li^#, Zhongjun Pan^#, Chen Ling, Jiahao Yuan, Shasha Li*, Ruijiang Liu*. Construction of targeted paclitaxel delivery nanosystem and its apoptosis mechanism on A549 cells. Biomaterials Advances, 2026, 187(10): 214951. (SCI, IF=6.7)

[2]Yuxuan Bai^#, Zhixiang Lv^#, Xuesong Cheng, Yawen Su, Yongjin Li, Dawei He, Ruijiang Liu^*. Magnetic aptamer-functionalized electrochemical nano-biosensor for the detection of circulating tumor DNA. Arabian Journal of Chemistry, 2026, 19(3): 7012025. (SCI, IF=5.3)

[3]Qingxiang Wang^#, Boyi Jiang^#, Liping Wu, Ruiping Chen, Yawen Su, Yongjin Li*, Aolin He*, Ruijiang Liu*. An electrochemical biosensor with indicator-free and magnetically self-assembly for supersensitive determination of PIK3CA gene. Microchemical Journal, 2025, 219(12): 116148. (SCI, IF=5.2)

[4]Mingyi Ma^#, Zhongjun Pan^#, Ziye Zhu, Chen Ling, Jiahao Yuan, Xiangdong Huo*, Shasha Li*, Ruijiang Liu*. Enhanced cancer therapy using modified magnetic α-Fe₂O₃/Fe₃O₄ nanorods: Dual role in curcumin delivery and ferroptosis induction. Colloids and Surfaces B: Biointerfaces, 2025, 252 (8): 114689. (SCI, IF=5.9)

[5]Qingxiang Wang^#, Hezhong Ouyang^#, Jingyi Zhou, Hexiao Zhang, Aolin He*, Ruijiang Liu*. Development and Performance Evaluation of a Magnetic Self-Assembled Electrochemical Biosensor based on α-Fe₂O₃/Fe₃O₄ Heterogeneous Nanorods for Supersensitive Detection of KRAS. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2025, 715(6): 136624. (SCI, IF=5.4)

[6]Zhihao Xu^#, Hezhong Ouyang^#, Sihan Zhao, Xinyu Wang, Xiangdong Huo*, Dawei He*, Ruijiang Liu*. Electroactive Fe₃O₄/α-Fe₂O₃@Au nanocomposites driven label‑free electrochemical aptasensor with magnetic self‑assembly for rapid quantification of alpha‑fetoprotein. Microchimica Acta, 2025, 192: 361. (SCI, IF=5.4)

[7]Haoda Zhang^#, Zhixiang Lv^#, Hexiao Zhang, Yunxiao Zhang, Dawei He*, Ruijiang Liu*. Ultrasensitive detection of PrP^C in human serum using label-free electrochemical biosensor based on α-iron trioxide/ferriferrous oxide magnetic nanocomposites. Microchemical Journal, 2025,212(5): 113369. (SCI, IF=5.2)

[8]Yao Yue^#, Min Liu^#, Mingyi Ma, Zhihao Xu, Haoda Zhang, Qingxiang Wang, Ruijiang Liu*. CRISPR/Cas14a integrated with DNA walker based on magnetic self-assembly for human papillomavirus type 16 oncoprotein E7 ultrasensitive detection. Biosensors & Bioelectronics, 2025, 272(3): 117135. (SCI, IF=11.8)

[9]Qingxiang Wang^#, Min Liu^#, Jihong Zhao, Jiahao Yuan, Shasha Li*, Ruijiang Liu*. Development of a magnetic α‑Fe₂O₃/Fe₃O₄ heterogeneous nanorod-based electrochemical biosensing platform for HPV16 E7 oncoprotein detection. International Journal of Biological Macromolecules, 2025, 284(1): 138085. (SCI, IF=8.7)

[10]Zhihao Xu^#, Hezhong Ouyang^#, Haoda Zhang, Lei Sun, Shasha Li*, Ruijiang Liu*. Ultrafast and Precisely Detection of ProGRP in Human Serum Using Label-Free Electrochemical Biosensor based on α-Fe₂O₃/Fe₃O₄ heterogeneous nanosheets. Ceramics International, 2024, 50(23): 50054-50066. (SCI, IF=5.6)

[11]Jie Wang^#, Min Liu^#, Jiawei Tang, Yaping Yang, Nan He, Shasha Li*, Ruijiang Liu*. Construction of Electrochemical Biosensor Based on Magnetic Fe₃O₄/α-Fe₂O₃ Heterogeneous Nanorods for the Sensitive Detection of MUC1 Mucoprotein. Ceramics International, 2024, 50: 10706-10714. (SCI, IF=5.6)

[12]Yun Ni^#, Xiu Chen^#, Chen Ling, Ziye Zhu, Yao Yue, Jie Wang, Aolin He*, Ruijiang Liu*. Label-Free Electrochemical Biosensor Based on Peptide Nucleic Acid Functionalized α-Fe₂O₃/Fe₃O₄ Nanosheets for Sensitive Detection of CYP2C19*2 Gene. Microchimica Acta, 2023, 190: 189. (SCI, IF=5.3)

[13]Ruijiang Liu^#, Yanling Zhang^#, Peng Deng^#, Wei Huang, Ruitong Yin, Lulu Yu, You Li, Shaoshuai Zhang, Yun Ni, Chen Ling, Ziye Zhu, Shaobo Wu*, Shasha Li*. Construction of targeted delivery system for curcumin loaded on magnetic α-Fe₂O₃/Fe₃O₄ heterogeneous nanotubes and its apoptosis mechanism on MCF-7 cell. Biomaterials Advances, 2022, 136: 212783. (SCI, IF=7.9)

[14]Yanling Zhang^#, Min Liu^#, Shuai Pan, Lulu Yu, Shaoshuai Zhang, Ruijiang Liu*. A magnetically induced self-assembled and label-free electrochemical aptasensor based on magnetic Fe₃O₄/Fe₂O₃@Au nanoparticles for VEGF₁₆₅ protein detection. Applied Surface Science, 2022, 580: 152362. (SCI, IF=6.7)

[15]You Li, Tengchao Wang, Shaoshuai Zhang, Yanling Zhang, Lulu Yu, Ruijiang Liu*. Adsorption and electrochemical behavior investigation of methyl blue onto magnetic Ni_xMg_(1-x)Fe₂O₄ nanoparticles prepared via the rapid combustion process. Journal of Alloys and Compounds, 2021, 885: 160969. (SCI, IF=6.371)

[16]Ruijiang Liu^#, Zhixiang Lv^#, Xiao Liu, Wei Huang, Ruitong Yin, Lulu Yu, You Li, Yanling Zhang, Shaoshuai Zhang, Rongzhu Lu, Yongjin Li*, Shasha Li*. Improved delivery system for celastrol-loaded magnetic Fe₃O₄/Fe₂O₃ heterogeneous nanorods: HIF-1α-related apoptotic effects on SMMC-7721 cell. Materials Science & Engineering C-Materials for Biological Applications, 2021, 125: 112103. (SCI, IF=8.457)

[17]Ruijiang Liu^#, Guoxiang Rong^#, Yanghua Liu, Wei Huang, Dawei He*, Rongzhu Lu*. Delivery of apigenin-loaded magnetic Fe₂O₃/Fe₃O₄@mSiO₂ nanocomposites to A549 cells and their antitumor mechanism. Materials Science & Engineering C-Materials for Biological Applications, 2021, 120: 111719. (SCI, IF=8.457)

[18]Ruijiang Liu*^,#, Shuai Pan^#, Min Liu^#, Wei Huang, Zhixiang Lv, Aolin He^*. A label-free electrochemical biosensor with magnetically induced self-assembly for the detection of CYP2C9*3 gene. Applied Surface Science, 2021, 537: 147868. (SCI, IF=7.392)

[19]Ruijiang Liu*, Wei Huang, Shuai Pan, You Li, Lulu Yu, Dawei He^*. Covalent immobilization and characterization of penicillin G acylase on amino functionalized magnetic Fe₂O₃/Fe₃O₄ heterogeneous nanoparticles prepared via a facile solution-combustion process. International Journal of Biological Macromolecules, 2020, 162: 1587-1596. (SCI, IF=6.953)

[20]Wei Huang, Shuai Pan, You Li, Lulu Yu, Ruijiang Liu*. Immobilization and characterization of cellulase on hydroxy and aldehyde functionalized magnetic Fe₂O₃/Fe₃O₄ nanocomposites prepared via a novel rapid combustion process. International Journal of Biological Macromolecules, 2020, 162: 845-852. (SCI, IF=6.953)

6.3 专著与教材

刘瑞江（副主编），《无机材料制备与合成实验》（“十二∙五”普通高等教育本科规划教材），化学工业出版社，2015-09。

6.4 专利与软件著作权

授权专利：

[1] 一种磁性Fe₃O₄/α-Fe₂O₃纳米棒的构筑方法（ZL202310056316.1）

[2] 一种VEGF₁₆₅蛋白探针及其构建方法和应用（ZL202111027624.9）

[3] 一种自组装免标记磁性纳米CYP2C9*3基因探针及其制备方法（ZL202010716321.7）

[4] 一种磁性异质体纳米材料及其制备（ZL202111175872.8）

[5] 一种Fe₃O₄@Fe₂O₃磁性复合纳米棒的制备方法（ZL202010770537.1）

[6] 一种Fe₃O₄/Fe₂O₃磁性异质体纳米管及其制备方法（ZL202010716294.3）

[7] 用于灵敏检测痕量镍离子的磁诱导自组装电化学生物传感器及其应用（ZL202110659691.6）

[8] 一种喷雾煅烧装置（ZL202122429869.6）

[9] 一种FeOOH纳米纺锤体及其制备方法（ZL201811162387.5）

[10] 一种冰山状ZnO微米材料及其制备方法（ZL201811480962.6）

[11] 一种海胆状FeOOH微米材料的制备方法（ZL201810574611.5）

[12] 一种α-Fe₂O₃磁性纳米棒的制备方法（ZL201611131663.2）

[13] 一种仙人球状磁性Fe₃O₄/Fe₂O₃纳米异质体材料及其制备方法（ZL201610627577.4）

[14] 一种磁性Fe₃O₄/Fe₂O₃复合纳米棒的制备方法（ZL201610229201.8）

[15] 一种圆形磁性锰铁氧体纳米片的制备方法（ZL201610228400.7）

[16] 一种磁性镍铁氧体纳米棒的构筑方法（ZL201510235761.X）

[17] 一种磁性Fe₂O₃/Fe₃O₄纳米异质体颗粒的制备方法（ZL201510235739.5）