一、基本信息

姓名：王丹

通讯地址：江苏省镇江市学府路301号 江苏大学药学院（邮编：212013）

电子邮件：danwang@ujs.edu.cn

二、个人简介

王丹，女，江苏大学药学院副教授，双创博士人才计划入选者。长期从事靶向钙离子通道抑制剂作为镇痛药/抗癌药先导物的新药研发、毒液肽的结构改造等方向的研究，在Marine Drugs、International Journal of Molecular Sciences、BMC Chemistry等国内外权威期刊发表论文23篇。担任《International Journal of Biological Sciences》、《Digital Discovery》、《Pharmaceutics》等领域内重要期刊审稿人等。

三、教育经历

•2015.10—2020.05 澳大利亚昆士兰大学，药理学专业，博士学位

•2012.09—2015.06 四川农业大学，药用植物学专业，硕士学位

•2008.09—2012.06 四川农业大学，中草药栽培与鉴定专业，学士学位

四、工作经历

•2021.07—至今 江苏大学药学院，副教授

•2020.07—2021.06 江苏大学药学院，资格副教授

五、研究方向

1.靶向钙离子通道抑制剂作为镇痛药/抗癌药先导化合物的新药研发

2.非阿片类新型镇痛药物的研发

3.动物毒液活性成分的发现与毒液肽的结构改造

六、科研成果

6.1 科研项目

•2021.08—2023.08｜江苏省双创博士人才项目“靶向T-型钙通道蝎毒多肽抑制剂阻断术后疼痛的研究”（项目编号：JSSCBS20210960）｜江苏省委组织部｜主持

•2021.10—2023.09｜江苏省高等学校自然科学研究面上项目“Ca_V3.2 靶向新型毒液肽抑制剂作为镇痛先导分子的发现与评价”（项目编号：21KJB350023）｜江苏省教育厅｜主持

•2021.10—至今｜江苏大学高级人才科研启动基金“海洋源钙离子通道抑制剂的构效关系解析及止痛活性评价”（项目编号：20JDG075）｜江苏大学｜主持

•2022.01—2025.12｜国家自然科学基金面上项目“中成药中水蛭的新型生物标志物的发现与解析及其专属性鉴定研究”（项目编号：82173937）｜国家自然科学基金委员会｜参与（排名第三）

•2024.09—2027.08｜江苏省自然科学基金面上项目““肺与大肠相表里” 理论指导下天南星炮制调控 “肠道微生态 - 代谢 - 免疫” 网络干预 COPD 的作用及机制”（项目编号：BK20241927）｜江苏省教育厅｜参与（排名第二）

6.2 学术论文

1.Ruike Kang and Dan Wang*, Clinical Advances in Analgesic Drug Development from Ion Channel Modulators[J]. Current Medicinal Chemistry, 2026, DOI:10.2174/0109298673421752260407115756

2.Ruihan Li, Md. Mahadhi Hasan, and Dan Wang*, In Silico Conotoxin Studies: Progress and Prospects[J]. Molecules, 2024, 29(24): 6061.

3.Dan Wang*, Volker Herzig, Zoltan Dekan, K. Johan Rosengren, Colton D. Payne, Md. Mahadhi Hasan, Jiajie Zhuang, Emmanuel Bourinet, Lotten Ragnarsson, Paul F. Alewood and Richard J. Lewis*, Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain[J]. International Journal of Molecular Sciences, 2024, 25(9): 4745.

4.Dan Wang, Pratik Neupane, Lotten Ragnarsson, Robert J. Capon and Richard J. Lewis*, Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels[J]. Membranes, 2022, 12(8): 749.

5.Dan Wang, S.W.A. Himaya, Jean Giacomotto, Md. Mahadhi Hasan, Fernanda C. Cardoso, Lotten Ragnarsson, and Richard J. Lewis*, Characterisation of δ-conotoxin TxVIA as a mammalian T-type calcium channel modulator[J]. Marine drugs, 2020, 18(7): 343.

6.Dan Wang*, Lotten Ragnarsson, Richard J. Lewis, T-type Calcium Channels in Health and Disease[J]. Current Medicinal Chemistry, 2020, 27(19): 3098-3122.

7.Dan Wang, Pratik Neupane, Lotten Ragnarsson, Robert J. Capon* and Richard J. Lewis*, Synthesis of pseudellone analogs and characterization as novel T-type calcium channel blockers[J]. Marine drugs, 2018, 16(12): 475.

8.Dan Wang, Hong-Guan Chen, Xin-Chuan Tian, Xiao-Xia Liang, Feng-Zhen Chen and Feng Gao*, Room-temperature palladium-catalysed Suzuki-Miyaura coupling of arylboric acid with aryl chlorides[J]. RSC Advances, 2015, 5: 107119-107122.

9.Dan Wang, Bi-Bo Zhang, Xiao-Xia Qu, Feng Gao* and Min-Yong Yuan, Microwave-assisted extraction of polysaccharides from Yupingfeng powder and their antioxidant activity[J]. Pharmacognosy Magazine, 2015, 11(43): 546-554.

10.Dan Wang and Feng Gao*, Quinazoline derivatives: synthesis and bioactivities[J]. Chemistry Central Journal, 2013, 7: 95. (杂志于2019年更名为BMC Chemistry)

11. Feng Gao*, Dan Wang, Xing Huang, Synthesis, isolation, stereostructure and cytotoxicity of paclitaxel anologs from cephalomannine[J]. Fitoterapia, 2013, 90: 79-84.

12.Gang Xiang#, Dan Wang#, Gui-Hua Zou, Xing Huang, Meng-Liang Tian*, and Feng Gao*, Optimized Ultrasonic-Assisted Extraction of Polysaccharides from Chinese Traditional Medicinal Plant Paris fargessi Using Orthogonal Design[J]. Journal of Applied Pharmaceutical Science, 2013,3(05):110-113.

13.Ling-Li Zheng, Dan Wang, Yuan-Yuan Li, Hong-Yan Peng, Ming-Yong Yuan, Feng Gao*, Ultrasound-assisted extraction of total flavonoids from Aconitum gymnandrum[J]. Pharmacognosy Magazine, 2014, 10: 141-146.

14.Jiao Wei-Hua, Jing Li, Dan Wang, Meng-Meng Zhang, Li-Yun Liu, Fan Sun, Jing-Ya Li, Robert J. Capon*, and Hou-Wen Lin*, Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea[J]. Journal of Natural Products, 2019, 82(9): 2586-2593.

15.Ya-Nan Cao, Ling-Li Zheng, Dan Wang, Xiao-Xia Liang*, Feng Gao*, Xian-Li Zhou, Recent advances in microtubule-stabilizing agents[J]. European Journal of Medicinal Chemistry, 2018, 143: 806-828.

16.Guan Wen, Xiao-Xia Qu, Dan Wang, Xing-Xiu Chen, Xin-Chuan Tian, Feng Gao*, Xian-Li Zhou*, Recent advances in design, synthesis and bioactivity of paclitaxel-mimics[J]. Fitoterapia, 2016, 110: 26-37.

17.Xin-Chuan Tian, Xing Huang, Dan Wang, and Feng Gao*, Eco-Efficient One-Pot Synthesis of Quinazoline-2,4(1H,3H)-diones at Room Temperature in Water[J]. Chemical & Pharmaceutical Bulletin, 2014, 62(8): 824-829.

18.Feng Gao*, Yuan-yuan Li, Dan Wang, Xing Huang and Qian Liu, Diterpenoid Alkaloids from the Chinese Traditional Herbal “Fuzi” and Their Cytotoxic Activity[J]. Molecules, 2012, 17: 5187-5194.

1.Dan Wang, Volker Herzig, Zoltan Dekan, Lotten Ragnarsson, Fernanda C. Cardoso and Richard J. Lewis, High-throughput Cell-based Assays for Screening Ca_V3.2 Modulators from Venoms[C]. Venoms to Drugs Conference 2017, Noosa Heads, QLD, Australia, 9-14 October 2017.

6.3 专利与软件著作权

王丹,庄嘉杰,沃尔克·赫齐格,佐尔坦·德坎,约翰·罗森格伦,马哈迪·哈桑,洛滕·拉格纳森,理查德·刘易斯. 靶向T-型钙离子通道的蝎毒多肽及其应用. (专利申请号: 202410010696X).