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张彩

信息来源: 发布日期:2026-10-24

一、基本信息

姓名:张彩

通讯地址:江苏省镇江市学府路301号 江苏大学药学院(邮编:212013)

电子邮件:caizhang@ujs.edu.cn

二、个人简介

张彩,女,江苏大学药学院讲师、硕士生导师。长期从事中药安全性评价与肝毒性物质基础及作用机制研究,主持省部级科研项目2项,在Phytomedicine、Journal of Ethnopharmacology、Phytotherapy Research等国内外权威期刊发表论文10余篇。担任《Cell Death & Disease》、《Frontiers in Pharmacology》等期刊审稿人。

三、教育经历

•2017.09—2022.12 中国药科大学,生药学专业,博士学位

•2013.09—2017.07 山东中医药大学,药学专业,学士学位

四、工作经历

•2023.03—至今 江苏大学药学院,讲师、硕士生导师

五、研究方向

1.中药质量控制与安全性评价

2.中药致肝损伤物质基础及作用机制研究

3.天然产物活性成分发现及整合调控作用机制研究

六、科研成果

6.1 科研项目

•2025.09—2028.08|江苏省自然科学基金青年基金项目“调控AhR/CYP1A2通路抑制铁死亡缓解补骨脂致肝损伤的作用机制研究”(BK20250877)|主持

•2025.10—2027.10|江苏省高等学校自然科学研究面上项目“基于AhR/CYP1A2通路探究补骨脂素诱导铁死亡导致肝损伤的机制”(25KJB360001)|主持

•2022.01—2025.12|国家自然科学基金面上项目“中药雌激素样作用物质致胆汁淤积性肝损伤共性作用靶点及机制研究”(82174070)|参与(排名第二)

6.2 学术论文

1.Zhang C, Qian DD, Yu T, Yang H, Li P, Li HJ*. Multi-parametric cellular imaging coupled with multi-component quantitative profiling for screening of hepatotoxic equivalent markers from Psoraleae Fructus. Phytomedicine. 2021, 93:153518. (SCI一区,IF=6.656)

2.Zhang C, Zhao JQ, Sun JX, Li HJ*. Psoralen and isopsoralen from Psoraleae Fructus aroused hepatotoxicity via induction of aryl hydrocarbon receptor-mediated CYP1A2 expression. Journal of Ethnopharmacology. 2022, 297:115577. (SCI一区,IF=5.4)

3.Zhang C, Fan S, Zhao JQ, Jiang Y*, Sun JX, Li HJ*. Transcriptomics and metabolomics reveal the role of CYP1A2 in psoralen/isopsoralen-induced metabolic activation and hepatotoxicity. Phytotherapy Research. 2022, 1-18. (SCI二区,IF=7.2)

4.Chen YD, Yu H, Kai XY, Yin RT, Ouyang Z, Wei Y, Zhang C*. Oxidative stress in metabolic dysfunction-associated steatohepatitis: Mechanisms and emerging therapeutic strategies[J]. Biochemical Pharmacology. 2026, 246:117702. (SCI二区,IF=6.5)

5.Zhang C, Zheng X, Ni H, Li P, Li HJ*. Discovery of quality control markers from traditional Chinese medicines by fingerprint-efficacy modeling: Current status and future perspectives. Journal of Pharmaceutical and Biomedical Analysis. 2018, 159:296-304. (SCI三区,IF=3.4)

6.Zhao JQ#, Zhao Z#, Zhang C, Sun JX, Liu FJ, Yu T, Jiang Y, Li HJ*. Long-term oral administration of Epimedii Folium induced cholestasis in mice by interfering with bile acid transport. Journal of Ethnopharmacology. 2022, 293: 115254. (SCI一区,IF=5.4)

7.Li ZQ, Zhang C, Fan S, Wang LL, Jiang Y, Li HJ*. Evidence for exposure biomarkers in dictamnine-induced liver injury resulting from metabolic activation in vitro and in mice. Journal of Applied Toxicology. 2023, 43 (5): 662-679. (SCI四区,IF=2.7)

8.Jiang Y*, Zhang C, Zheng X, Zhao Z, Li HJ*. Simultaneously screening multiple UGT1A1 inhibitors from Polygonum multiflorum root using ultrafiltration LC-MS. Biomedical Chromatography. 2022, 36 (4): e5300.(SCI四区,IF=1.8)

9.Jiang WZ, Sang RY, Zhang C, Yin RT, Ouyang Z, Wei Y*. Application of small interfering RNA technology in cytochrome P450 gene modulation. Drug Metabolism and Disposition. 2025, 53 (3): 100040. (SCI二区,IF=3.6)

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