一、基本信息

姓名：袁新睿

通讯地址：江苏省镇江市学府路301号 江苏大学药学院（邮编：212013）

电子邮件：xyuan5@ujs.edu.cn

二、个人简介

袁新睿，男，江苏大学药学院讲师、硕士生导师、资格副教授，海外博士后引才计划入选者。长期从事小分子药物的研发工作，主持国家级科研项目1项，参与美国国立卫生研究院（NIH）R01项目和R21项目。近年来共发表学术论文三十余篇，以第一作者及通讯作者在Journal of Medicinal Chemistry、European Journal of Medicinal Chemistry、ACS Medicinal Chemistry Letter等国内外权威期刊发表论文21篇。

三、教育经历

•2016.09—2019.06 中国药科大学，药物化学专业，博士学位

•2013.09—2016.06 南京工业大学，制药工程专业，硕士学位

•2009.09—2013.06 南京工业大学，药物制剂专业，学士学位

四、工作经历

•2024.03—至今 江苏大学药学院，讲师、硕士生导师

•2019.09-2023.09 美国田纳西大学健康科学中心药学院，博士后

五、研究方向

1.小分子药物的发现、结构优化、活性评价；

2.AlphaLISA、HTRF、Hek-Blue等检测方法的开发；

六、科研成果

6.1 科研项目

•2025.01—2027.12｜国家自然科学基金青年项目（项目编号：8111293003）｜国家自然科学基金委员会｜主持

•2024.08—2027.08｜江苏大学高级人才科研启动基金｜主持

•2025.09—2026.03｜去甲托品醇等产品的合成工艺研究与开发｜企业横向｜主持

6.2 学术论文

1.Qingru Wang, Ziliang Liu, Jindong Li, Wei Luo, Xinrui Yuan, Lei Hu. Natural Active Ingredient Nanomicelles for Synergistic Treatment of Wound Bacterial Infections [J]. ACS Applied Polymer Materials, 2026, 8 (17): 15244–15255.

2.Xinrui Yuan, Eun Bee Cho, Amol D Patil, Md Aktaruzzaman, Andhavaram Ramaraju, Chenyao Jiang, Meilin Wang, Miao He, Aaron Robida, Bo Wen, Duxin Sun, Jason C Rech, Jianxiong Jiang, Chao-Yie Yang. Development of 2-Methyl-5-phenylpyrrolidine-Based ST2 Inhibitors for Neuroinflammatory Conditions [J]. ACS Medicinal Chemistry Letters, 2026, 17 (8): 1915–1922.

3.Xinrui Yuan, Chao-Yie Yang. Recent Advances in Targeting RNA Splicing Factors with Small Molecules [J]. Journal of Medicinal Chemistry, 2026, 69 (13): 15009–15044.

4.Ziliang Liu, Qingru Wang, Wei Luo, Xinrui Yuan, Lei Hu. pH-Responsive Chalcone-Polyglycidol Prodrugs: Self-Assembling Micelles for Synergistic Anticancer and Antibacterial Therapy [J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 747: 140869.

5.Xinrui Yuan, Hongyan Xu, Yifeng Pei, Dezhong Guan, Lei Hu, Huibin Zhang. Recent progress in small-molecule targeted therapies for melanoma treatment [J]. Bioorganic & Medicinal Chemistry, 2026, 139: 118699.

6.Xinrui Yuan, Zeru Wang, Xihan Cui, Wenjing Xia, Yiming Liu, Zijie Sun, Yifeng Pei, Dezhong Guan, Hongyan Xu, Lei Hu, Chao-Yie Yang, Huibin Zhang. Design, synthesis, and evaluation of furo [3, 2-c] pyridine-based MNK1/2 inhibitors for the treatment of colorectal cancer [J]. European Journal of Medicinal Chemistry, 2026, 311: 118853.

7.Jingyu Jiang, Xinrui Yuan, Lei Hu. Recent Advances of Azobenzene-Based Photoresponsive Molecular Switches for Protein-Targeted Photopharmacology. Molecules, 2026, 31(7): 1205.

8.Ziliang Liu, Yue Dai, Xinyu Zhang, Tianxiang Fanglu, Jia Xu, Jianghua Wang, Qingru Wang, Xinrui Yuan, Lei Hu. Rational design of AIE fluorescence probe-drug conjugate encapsulated amphiphilic linear polyglycidol nanoplatforms for precision anti-cancer drug delivery and cell imaging [J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2025, 726: 137900.

9.Xinrui Yuan, Jason C Rech, Andhavaram Ramaraju, Amol D Patil, Krishani Rajanayake, Hebao Yuan, Mona Kazemi Sabzvar, Mousumi Mandal, Eun Bee Cho, Bo Wen, Jianxiong Jiang, M Dennis Leo, Udai P Singh, Duxin Sun, Chao-Yie Yang. Studies of Structure–Activity Relationship of 2‑(Pyrrolidin-1ylmethyl)‑1H‑pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation [J]. ACS Medicinal Chemistry Letters, 2025, 15 (11): 2053-2059.

10.Xinrui Yuan, Mona Kazemi Sabzvar, Amol D Patil, Arda Durmaz, Jaroslaw Maciejewski, Valeria Visconte, Chao-Yie Yang. Targeting Poly (U) Binding Splicing Factor 60 (PUF60): A Small-Molecule Inhibitor Shows Anti-Leukemic Activity and Impacts Cell Cycle in Leukemia Models [J]. Blood, 144: 7470.

11.Xinrui Yuan, Mona Kazemi Sabzvar, Amol D Patil, Krishnapriya Chinnaswamy, Kathryn L Howie, Ramaraju Andhavaram, Borwyn Wang, Maxime A Siegler, Arda Dumaz, Jeanne A Stuckey, Seth J Corey, Jaroslaw P Maciejewski, Valeria Visconte, Chao-Yie Yang. Comprehensive Analyses of the Effects of the Small-Molecule Inhibitor of the UHM Domain in the Splicing Factor U2AF1 in Leukemia Cells [J]. Research Square, 2024, rs.3.rs-4477663.

12.Xinrui Yuan, Dezhong Guan, Chao Chen, Shi Guo, Hanshu Wu, Hong Bu, Chao-Yie Yang, Mian Wang, Jinpei Zhou, Huibin Zhang. Development of an Imidazopyridazine-based MNK1/2 inhibitor for the treatment of lymphoma [J]. Journal of Medicinal Chemistry, 2024, 67(7): 5437-5457.

13.Xinrui Yuan, Hua Jiang, Denggang Fu, Jason C Rech, Aaron Robida, Krishani Rajanayake, Hebao Yuan, Miao He, Bo Wen, Duxin Sun, Chen Liu, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Sophie Paczesny, Chao-Yie Yang. Prophylactic mitigation of acute graft versus host disease by novel 2-(Pyrrolidin-1-ylmethyl) pyrrole-based stimulation-2 (ST2) inhibitors [J]. ACS Pharmacology & Translational Science, 2023, 6(9): 1275.

14.Xinrui Yuan, Kathryn L Howie, Mona Kazemi Sabzvar, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Chao-Yie Yang. Profiling the binding activities of peptides and inhibitors to the U2 auxiliary factor homology motif (UHM) domains [J]. ACS Medicinal Chemistry Letters, 2023, 14(4): 450-457.

15.Xinrui Yuan, Hua Jiang, Denggang Fu, Aaron Robida, Krishani Rajanayake, Hebao Yuan, Bo Wen, Duxin Sun, Brennan T Watch, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Sophie Paczesny, Jason C Rech, Chao-Yie Yang. Structure-Activity relationship of 1-(Furan-2ylmethyl) Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease [J]. Bioorganic & Medicinal Chemistry, 2022, 71: 116942.

16.Xinrui Yuan, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Chao-Yie Yang. Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding [J]. The Journal of Physical Chemistry B, 2022, 126 (12): 2394–2406.

17.Xinrui Yuan, Hong Bu, Jinpei Zhou, Chao-Yie Yang, Huibin Zhang. Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application [J]. Journal of Medicinal Chemistry, 63(20): 11368-11396.

18.Xinrui Yuan, Hanshu Wu, Hong Bu, Peiyuan Zheng, Jinpei Zhou, Huibin Zhang. Design, synthesis and biological evaluation of pyridone–aminal derivatives as MNK1/2 inhibitors [J]. Bioorganic & Medicinal Chemistry, 2019, 27(7): 1211-1225.

19.Xinrui Yuan, Hanshu Wu, Hong Bu, Jinpei Zhou, Huibin Zhang. Targeting the immunity protein kinases for immuno-oncology [J]. European Journal of Medicinal Chemistry, 2019, 163: 413-427.

6.3 专利与软件著作权

•陈春麟, 张惠斌, 袁新睿, 周金培, 洪菊. 咪唑并哒嗪类MNK1/MNK2激酶抑制剂及其制备方法和应用: CN111978325B [P].