Ph.D., Associate Professor

• Education:

2008.9-2010.8, Postdoc,Konkuk University, Republic of Korea

2002.09 ~ 2006.03, Ph.D.,East China University of Science and Technology

1997.09 ~ 2000.06, M.S.,Dalian University of Technology

1993.09 ~ 1997.06, B.S.,Wuhan Institute of Chemical Technology

• Research Interests:

Biocatalysis and Biotransformation, Pharmaceutical Process Engineering. Mainly including (1) Establish novel biocatalytic technology for production of important medicine or intermediates; (2) Screening and modification of some interested biocatalysts; (3) Integrated technology for pharmaceutical process.

• Selected Publications:

1. Ye-Wang Zhang, Manish Kumar Tiwarri, Marimuthu Jeya, Jung-kul Lee*. Covalent immobilization of recombinant Rhizobium etli CFN42 xylitol dehydrogenase onto modified silica nanoparticles.Applied Microbiology and Biotechnology. 2011, 90: 499-507.

2. Ye-Wang Zhang, Marimuthu Jeya, Jung-Kul Lee*. Enhanced activity and stability of L-arabinose isomerase by immobilization on aminopropyl glass.Applied Microbiology and Biotechnology. 2011, 89: 1435-1442.

3. Ye-Wang Zhang*, Rui-Jiang Liu, Xi-Ming Xu*. One-pot, two-step enzymatic synthesis of amoxicillin by complexing with Zn²⁺.Applied Microbiology and Biotechnology, 2010, 88:49-55.

4. Ye-Wang Zhang, Marimuthu Jeya, Jung-Kul Lee*.L-Ribulose production by anEscherichia coliharboring L-arabinose isomerase fromBacillus licheniformis.Applied Microbiology and Biotechnology, 2010, 87: 1993-1999..

5. Ye-Wang Zhang, Ponnandy Prabhu, Jung-Kul Lee*.Alginate immobilization of recombinant Escherichia coliwhole cells harboring L-arabinose isomerase for L-ribulose production.Bioprocess and Biosystem Eingeering, 2010, 33: 741-748..

6. Ye-Wang Zhang, Ponnandy Prabhu, Jung-kul Lee*. Immobilization ofBacillus licheniformisL-arabinose isomerase for semi-continuous L-ribulose production.Bioscience, Biotechnology and Biochemistry.2009,73: 2234-2239..

7. Yewang. Zhang, Dongzhi Wei*, Dengchao Li, Shulai Liu, Qingxun Song. Optimisation of enzymatic synthesis of cefaclor within situproduct removal and continuous acyl donor feeding.Biocatalysis and Biotransformation.2007, 25: 59-64.

8. Yewang Zhang,Dongzhi Wei*. Enzymatic preparation of cefaclor with immobilized penicillin acylase.Preparative Biochemistry and Biotechnology. 2008, 38: 136-145.

9. Yewang Zhang, Shulai Liu, Dongzhi Wei*, Ruijiang Liu, Ximing Xu. Kinetically controlled synthesis of cefaclor with immobilized penicillin acylase in the presence of organic cosolvents.Chemical and Biochemical Engineering Quarterly.2008, 22: 349-354.

10. Yewang. Zhang, Dongzhi Wei*, Dengchao Li, Shulai Liu, Qingxun Song. Optimisation of enzymatic synthesis of cefaclor within situproduct removal and continuous acyl donor feeding.Biocatalysis and Biotransformation.2007, 25: 59-64.

11. Yewang Zhang*,Ruijiang Liu, Xiaoyu Wu. The proteolytic systems and heterologous proteins degradation in the methylotrophic yeastPichia pastoris.Annals of Microbiology. 2007, 37, 553-560.

12. Shu-Guang Fang, Tan Qiang, Rui-Jiang Liu, Xi-Ming Xu,Ye-Wang Zhang*. Enhanced production of 6-aminopenicillanic acid in aqueous-methyl isobutyl ketone system with immobilized penicillin G acylase.Preparative Biochemistry and Biotechnology. 2010, 40(1):38-45.

13. Qiang Tan, Yewang Zhang,Qingxun Song, Dongzhi Wei.Single-pot conversion of cephalosporin C to 7-aminocephalosporanic acid in the absence of hydrogen peroxide.World Jounal of Microbiology and Biotechnology.2010, 26: 145-152.

14. Marimuthu Jeya,Ye-Wang Zhang, In-Won Kim, Jung-Kul Lee*. Enhanced saccharification of alkali treated rice straw by cellulase ofTrametes hirsutaand statistical optimization of hydrolysis condition by RSM.Bioresource Technology, 2009, 100 (21): 5155-5161.

15. Dengchao Li,Yewang Zhang, Dongzhi Wei*, Qingxun Song, Shiwei Cheng. Enzymatic synthesis cephalexin at high substrates concentration within situproduct removal.Food Technology and Biotechnology. 2008, 46: 461-466.

16. Rui Han,Yewang Zhang, Xiuling Dong, Hongwei Gai*and Edward S. Yeung.Spectral imaging of single molecules by transmission grating based epi-fluorescence microscopy.Analytica Chimica Acta.2008,619: 209-214.

• Contact Information :

Room 2413, School of Pharmacy, Jiangsu University, Zhenjiang, 212013, P.R. China

Tel (office): +86-511-8503-8201

Email: zhangyewang

ujs.edu.cn