XIMING XU, PH.D.

Professor, School pf Pharmacy, Jiangsu University

Director, Center for Nano Drug/Gene Delivery and Tissue Engineering

Director, Jiangsu Engineering Center of "Development of Medicinal

Functions of New Food Resources" and Key Laboratory of "Drug

Delivery and Tissue Regeneration (Zhenjiang)"

301Xuefu Road, Jingkou District, Zhenjiang 212013, Jiangsu, China

Phone: +86-13861358338

Email: xmxu@ujs.edu.cn

Education and Experience

2001.11- 2020.6    Dean, Professor, School of Pharmacy, Jiangsu University

       2006.1-2006.8     Research Fellow, Lab of Gene Transfer and Tissue Repair, Harvard Medical School

       2004.3-2005.12   Visiting Associate Professor/Research Fellow, Harvard Medical School. Tissue Engineering Laboratories, VA Boston Healthcare System.

       1996.9-1999.6     Ph.D., Pharmaceutics/Drug Delivery, China Pharmaceutical University

       1993.9-1996.6     Master in Medicine, Peking University (original Beijing Medical University)

       1983.9-1987.6     B.Sc., Chemistry and Chemical Engineering, Soochow University

RESEARCH FOCUS

1.Natural biomaterials for nano gene transfer and stem cell-based tissue engineering;

2.Cell reprogramming by small chemical molecules;

3.Controlled release preparations and Pharmacokinetic evaluation of poorly soluble drugs;

4.Screening and formulation development of active components from Traditional Chinese Medicine

Projects

The innovative research and development of active ingredients in Liquorice. National Key Research and Development Project of China (PI, No.2018YFE0208600, 10.41 million RMB)

Bio-mimic 3D printed self-crosslinking gels for local, gradient, and long-term drug delivery and spinal cord regeneration. Project supported by the National Natural Science Foundation of China (PI, 2018-2022, No. 81720108030, 2.74 million RMB)

Direct reprogramming with CDs modified self-assembly nanoparticles. National Natural Science Foundation of China (PI, 2015-2018, No. 81473172, one million RMB)

PS generation via micro-RNA non-viral delivery strategy. National Natural Science Foundation of China (PI, 2013-2016, No. 81273470, one million RMB)

Non-viral nanoparticle gene delivery systems for the generation of induced pluripotent stem Cells. National Natural Science Foundation of China (PI, No. 81072586); Special funds for 333 and 331 project (PI, No. BRA2013198)

Pharmaceutical biotechnology and translational medicine. A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions. (Project leader, 2014-2017, 40 million RMB)

Screening of new active components from edible fungi. National "Twelfth Five-Year" Plan for Science & Technology Support (2013BAD16B07-1); Special funds for Industry-University-Research Institution Cooperation (PI, JHB2012-37, GY2012049).

Poorly soluble drug formulations for controlled release (PI, supported from Yangzi River Pharmaceutical Group, one of the most famous pharmaceutical company in China)

High efficiency hepatic protective preparations from Traditional Chinese Medicine (PI, supported from the Center of Zhendong Ecological Biotech Development)

HONORS AND AWARDS

2021          “Industrial pharmacy”. Chief editor of national planning textbooks.

2018          “The key technology and application of modern pharmaceutical preparation research and development”. The first prize of Science and Technology Progress (issued by the Ministry of Education of China) 

2018          “Key technologies and applications of slow-release intelligent drug delivery system”. The first prize of Science and Technology of Jiangsu Province;

2017          The outstanding prize of Science and Technology Progress (issued by China Federation of Commerce);2017          Expert enjoying the special allowance of State Council;

2015          “Research and application of natural hepatoprotective drugs and key technologies in pharmaceutical innovation”. The first prize of Science and Technology Progress (issued by the Ministry of Education of China);

2015          National Millions of Talents Project; 

2015          National Young- and Middle-aged Expert with Outstanding Contributions;

2014          “Biotechnology and Translational Medicine”. Leader of Priority Academic Program Development of Jiangsu Higher Education Institutions (approved with 40 million RMB);

2013          “DNA-Polysaccharide nanoparticles -- a novel non-viral vector for stem cell gene therapy”. Excellent instructor for the outstanding winner of "Challenge Cup" National College Student Curricular Academic Science and Technology Works Competition;

2012~now      Expert in evaluating the Major/Key/General Program of National Natural Science          Foundation of China, the National Science and Technology Award, Key Research and Development Projects, National Science Foundation for Distinguished Young Scholars of China, and Cheung Kong Scholars Programme of China

SELECTED PUBLICATIONS (*: corresponding author; †: equal contribution)

2023

1. Zheng Lu, Yue Xu, Ze Wen, Changhong Xie, Chengyue Xie, Mengqian Yu, Lingyun Gao, Yongqing Yang*, Ximing Xu*. A Visible-Light-Driven Approach to Free Alcohol from Esters of Quinone Propionic Acid. Synthesis-Stuttgart. (n.d.). 2023,55（03）：473-480

2. Xiaoxiao Li†, Xiaoli Xia†, Jian Zhang, Michael Adu-Frimpong, Xinyi Shen, Wenxiong Yin, Qing He, Wanjing Rong, Feng Shi, Xia Cao, Hao Ji, Elmurat Toreniyazov, Qilong Wang*, Jiangnan Yu*, Ximing Xu*. Preparation, Physical Characterization, Pharmacokinetics and Anti-Hyperglycemic Activity of Esculetin-Loaded Mixed Micelles. Journal of Pharmaceutical Sciences. 2023, 112(1): 148–157.

2022

1. Mingchun Liao†, Congyong Sun†, Ran Li, Wenjing Li, Zhumei Ge, Michael Adu-Frimpong, Ximing Xu*, Jiangnan Yu*. Amelioration action of gastrodigenin rhamno-pyranoside from Moringa seeds on non-alcoholic fatty liver disease. Food Chemistry. 2022, 379: 132087.

3. Chunmei Wei†, Qilong Wang†, Wen Weng, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Ximing Xu*, Jiangnan Yu*. Enhanced oral bioavailability and anti-hyperuricemic activity of liquiritin via a self-nanoemulsifying drug delivery system. Journal Of the Science of Food and Agriculture. 2022, 102(5): 2032–2040.

4. Feng Shi†, Lin Chen†, Yaping Wang, Jing Liu, Michael Adu-Frimpong, Hao Ji, Elmurat Toreniyazov, Qilong Wang, Jiangnan Yu, Ximing Xu*. Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus (R)-glycyrrhizic acid mixed micelle system. Drug Delivery and Translational Research. 2022, 12(3): 603–614.

5. Wenwan Shi, Xia Cao*, Qi Liu, Qin Zhu, Kai Liu, Tianwen Deng, Qingtong Yu, Wenwen Deng, Jiangnan Yu, Qilong Wang*, Ximing Xu*. Hybrid Membrane-Derived Nanoparticles for Isoliquiritin Enhanced Glioma Therapy. Pharmaceuticals. 2022, 15(9): 1059.

6. Xiaoli Xia†, Jian Zhang†, Michael Adu-Frimpong, Xiaoxiao Li, Xinyi Shen, Qing He, Wanjing Rong, Hao Ji, Elmurat Toreniyazov, Ximing Xu*, Jiangnan Yu*, Qilong Wang*. Hyperoside-loaded TPGs/mPEG-PDLLA self-assembled polymeric micelles: preparation, characterization and in vitro/in vivo evaluation. Pharmaceutical Development and Technology. 2022, 27(7): 829–841.

7. Yuan Zhu†, Zhengqing Gu†, Youwu Liao, Shuang Li, Yuanyuan Xue, Michael Adu Firempong, Ying Xu, Jiangnan Yu, Hugh D. C. Smyth*, Ximing Xu*. Improved intestinal absorption and oral bioavailability of astaxanthin using poly (ethylene glycol)-graft-chitosan nanoparticles: preparation, in vitro evaluation, and pharmacokinetics in rats. Journal of the Science of Food and Agriculture. 2022, 102(3): 1002–1011.

8. Qilong Wang†, Kangyi Zhang†, Wen Weng†, Lin Chen, Chunmei Wei, Rui Bao, Michael Adu-Frimpong, Xia Cao, Qingtong Yu, Feng Shi, Elmurat Toreniyazov, Hao Ji, Ximing Xu*, Jiangnan Yu*. Liquiritin-Hydroxypropyl-Beta-Cyclodextrin Inclusion Complex: Preparation, Characterization, Bioavailability and Antitumor Activity Evaluation. Journal of Pharmaceutical Sciences. 2022, 111(7): 2083–2092.

9. Yuhang Yang†, Zhongan Zhu†, Michael Adu-Frimpong, Jing Liu, Yaping Wang, Lin Chen, Elmurat Toreniyazov, Hao Ji, Xia Cao, Feng Shi, Qilong Wang, Jiangnan Yu, Ximing Xu*. Micelles of Licorice chalcone A for oral administration: preparation, in vitro, in vivo, and hepatoprotective activity evaluation. Journal of Nanoparticle Research. 2022, 24(6): 110.

10. Wanjing Rong†, Xinyi Shen†, Michael Adu-Frimpong, Qing He, Jian Zhang, Xiaoxiao Li, Xiaoli Xia, Feng Shi, Xia Cao, Hao Ji, Elmurat Toreniyazov, Qilong Wang*, Jiangnan Yu*, Ximing Xu*. Pinocembrin polymeric micellar drug delivery system: preparation, characterisation and anti-hyperuricemic activity evaluation. Journal of Microencapsulation. 2022, 39(5): 419–432.

11. Xia Cao†, Qing He†, Michael Adu-Frimpong, Xinyi Shen, Wanjing Rong, Xiaoxiao Li, Jian Zhang, Xiaoli Xia, Feng Shi, Hao Ji, Elmurat Toreniyazov, Qilong Wang*, Jiangnan Yu*, Ximing Xu*. Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity. AAPS Pharmscitech. 2022, 23(7): 276.

12. Jing Liu†, Zhongan Zhu†, Yuhang Yang, Michael Adu-Frimpong, Lin Chen, Hao Ji, Elmurat Toreniyazov, Qilong Wang*, Jiangnan Yu*, Ximing Xu*. Preparation, characterization, pharmacokinetics, and antirenal injury activity studies of Licochalcone A-loaded liposomes. Journal of Food Biochemistry. 2022, 46(1): e14007.

13. Xinyi Shen†, Wanjing Rong†, Michael Adu-Frimpong, Qing He, Xiaoxiao Li, Feng Shi, Hao Ji, Elmurat Toreniyazov, Xiaoli Xia, Jian Zhang, Qilong Wang*, Jiangnan Yu*, Ximing Xu*. Preparation, in vitro and in vivo evaluation of pinocembrin-loaded TPGS modified liposomes with enhanced bioavailability and antihyperglycemic activity. Drug Development and Industrial Pharmacy. 2022, 48(11): 623–634.

2021

1. Qilong Wang†, Jing Liu†, Jian Liu, Yaminn Thant, Wen Weng, Chunmei Wei, Rui Bao, Michael Adu-Frimpong, Qingtong Yu, Wenwen Deng, Xia Cao, Elmurat Toreniyazov, Hao Ji, Ximing Xu*, Jiangnan Yu*. Bisdemethoxycurcumin-conjugated vitamin E TPGS liposomes ameliorate poor bioavailability of free form and evaluation of its analgesic and hypouricemic activity in oxonate-treated rats. Journal of Nanoparticle Research. 2021, 23(6): 122.

2. Yaminn Thant†, Qilong Wang†, Chunmei Wei, Jian Liu, Kangyi Zhang, Rui Bao, Qin Zhu, Wen Weng, Qingtong Yu, Yuan Zhu, Ximing Xu*, Jiangnan Yu*. TPGS conjugated pro-liposomal nano-drug delivery system potentiate the antioxidant and hepatoprotective activity of Myricetin. Journal of Drug Delivery Science and Technology. 2021, 66: 102808.

3. Qilong Wang, Chunmei Wei, Wen Weng, Rui Bao, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Ximing Xu*, Jiangnan Yu. Enhancement of oral bioavailability and hypoglycemic activity of liquiritin-loaded precursor liposome. International Journal of Pharmaceutics. 2021, 592: 120036.

4. Congyong Sun†, Wenjing Li†, Huiyun Zhang, Michael Adu-Frimpong, Ping Ma, Yuan Zhu, Wenwen Deng, Jiangnan Yu*, Ximing Xu*. Improved Oral Bioavailability and Hypolipidemic Effect of Syringic Acid via a Self-microemulsifying Drug Delivery System. AAPS Pharmscitech. 2021, 22(1): 45

5. Zhumei Ge, Qilong Wang, Qin Zhu, Mukhtar Yusif, Jiangnan Yu, Ximing Xu*. Improved oral bioavailability, cellular uptake, and cytotoxic activity of zingerone via nano-micelles drug delivery system. Journal of Microencapsulation. 2021, 38(6): 394–404.

6. Xia Cao†, Qin Zhu†, Qilong Wang†, Michael Adu-Frimpong, Chunmei Wei, Wenweng, Rui Bao, Yaping Wang, Jiangnan Yu*, Ximing Xu*. Improvement of Oral Bioavailability and Anti-Tumor Effect of Zingerone Self-Microemulsion Drug Delivery System. Journal of Pharmaceutical Sciences. 2021, 110(7): 2718–2727.

7. Qingtong Yu†, Mingchun Liao†, Congyong Sun, Qijian Zhang, Wenwen Deng, Xia Cao, Qilong Wang, Emmanuel Omari-Siaw, Shiqi Bi, Zhijian Zhang, Jiangnan Yu*, Ximing Xu*. LBO-EMSC Hydrogel Serves a Dual Function in Spinal Cord Injury Restoration via the PI3K-Akt-mTOR Pathway. ACS Applied Materials & Interfaces. 2021, 13(41): 48365–48377.

8. Wen Weng†, Qilong Wang*†, Chunmei Wei, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu*, Ximing Xu*. Mixed micelles for enhanced oral bioavailability and hypolipidemic effect of liquiritin: preparation, in vitro and in vivo evaluation. Drug Development and Industrial Pharmacy. 2021, 47(2): 308–318.

9. Qilong Wang†, Yaping Wang†, Yujiao Xie, Michael Adu-Frimpong, Chunmei Wei, Xia Yang, Xia Cao, Wenwen Deng, Elmurat Toreniyazov, Hao Ji, Ximing Xu*, Jiangnan Yu*. Nonionic surfactant vesicles as a novel drug delivery system for increasing the oral bioavailability of Ginsenoside Rb-1. Food Bioscience. 2021, 42: 101064.

10. Zhongan Zhu†, Jing Liu†, Yuhang Yang, Michael Adu-Frimpong, Hao Ji, Elmurat Toreniyazov, Qilong Wang*, Jiangnan Yu*, Ximing Xu*. SMEDDS for improved oral bioavailability and anti-hyperuricemic activity of licochalcone A. Journal of Microencapsulation. 2021, 38(7–8): 459–471.

2020

1. Yuan Zhu†, Jianyin Yu†, Guanghui Zhou†, Zhengqing Gu, Michael Adu-Frimpong, Wenwen Deng, Jiangnan Yu, Ximing Xu*. Piperine fast disintegrating tablets comprising sustained-release matrix pellets with enhanced bioavailability: formulation, and evaluation. Pharmaceutical Development and Technology. 2020, 25(5): 617-624.

2. Lijun Zhen, Qiuyu Wei, Qilong Wang, Huiyun Zhang, Michael Adu-Frimpong, Caleb Kesse Firempong, Ximing Xu*. Jiangnan Yu*. Preparation and evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles. Pharmaceutical Development and Technology. 2020, 25(1): 1-8.

3. Huiyun Zhang, Yuan Zhu, Congyong Sun, Yujiao Xie, Michael Adu-Frimpong, Wenwen Deng, Jiangnan Yu*, Ximing Xu*. Zhongfei Han, Gang Qi*. GSH responsive nanomedicines self-assembled from small molecule prodrug alleviate the toxicity of cardiac glycosides as potent cancer drugs. International Journal of Pharmaceutics. 2020, 575 118980.

4. Na Man†, Qilong Wang†, Huihua Li, Michael Adu-Frimpong, Congyong Sun, Kangyi Zhang, Qiuxuan Yang, Qiuyu Wei, Hao Ji, Elmurat Toreniyazov, Jiangnan Yu*, Ximing Xu*. Improved oral bioavailability of myricitrin by liquid self-microemulsifying drug delivery systems. Drug Delivery Science and Technology 2019, 52 597-606.

5. Yingkun Liu, Congyong Sun, Wenjing Li, Michael Adu-Frimpong, Qilong Wang, Jiangnan Yu*, Ximing Xu*. Preparation and Characterization of Syringic Acid-Loaded TPGS Liposome with Enhanced Oral Bioavailability and In Vivo Antioxidant Efficiency. AAPS PharmSciTech 2019, 20(3): 98.

6. Jian Liu, Qilong Wang, Michael Adu-Frimpong, Qiuyu Wei, Yujiao Xie, Kangyi Zhang, Chunmei Wei, Wen Weng, Hao Ji, Elmurat Toreniyazov, Ximing Xu*, Jiangnan Yu*. Preparation, in vitro and in vivo evaluation of isoliquiritigenin-loaded TPGS modified proliposomes. International Journal of Pharmaceutics 2019, 563 53-62.

7.Wenjing Li†, Congyong Sun†, Wenwen Deng, Yingkun Liu, Michael Adu-Frimpong, Jiangnan Yu*, Ximing Xu*. Pharmacokinetic of gastrodigenin rhamnopyranoside from Moringa seeds in rodents. Fitoterapia 2019, 138 104348.

8. Wenwen Deng, Xia Yang, Yuan Zhu, Jiangnan Yu*, Ximing Xu*. Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides. Food Science & Nutrition 2019, 7(8): 2674-2683.

9. Bao Ding Chen†, Zheng Zhang†, Ke Ke Wang, Meng Yuan Shang, Shuang Shuang Zhao, Wen Bo Ding, Rui Du, Zhuan Yu, Ximing Xu*. A multivariable model of BRAF and ultrasonographic features for predicting the risk of central lymph node metastasis in cN0 papillary thyroid microcarcinoma. Cancer Management and Research 2019, 11 7211-7217.

10. Michael Adu-Frimpong, Wei Qiuyu, Caleb Kesse Firempong, Yusif Mohammed Mukhtar, Qiuxuan Yang, Emmanuel Omari-Siaw, Zhen Lijun, Ximing Xu*, Jiangnan Yu*. Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice. Journal of Pharmacy and Pharmacology 2019, 71(8): 1324-1338.

11. Michael Adu-Frimpong, Caleb Kesse Firempong, Emmanuel Omari-Siaw, Qilong Wang, Yusif Mohammed Mukhtar, Wenwen Deng, Qingtong Yu, Ximing Xu*, Jiangnan Yu*. Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol-bound punicic acid for increased antihepatotoxic activity, Drug Development Research 2019, 80(2): 230-245.

2019

1. Wenwen Deng†, Fengxia Shao†, Qinghua He†, Qiang Wang, Wentao Shi, Qingtong Yu, Xia Cao, Chunlai Feng, Shiqi Bi, Jiaxin Chen, Ping Ma, Yang Li, Aihua Gong, Shanshan Tong, Jiangnan Yu, Myron Spector, Ximing Xu*, Zhijian Zhang*. EMSCs Build an All-in-One Niche via Cell-Cell Lipid Raft Assembly for Promoted Neuronal but Suppressed Astroglial Differentiation of Neural Stem Cells. Advanced Materials 2019, 31(10): e1806861.

2. Yuan Zhu†, Wen Xu†, Jiajia Zhang†, Youwu Liao, Caleb Kesse Firempong, Michael Adu-Frimpong,Wenwen Deng, Huiyun Zhang, Jiangnan Yu*, Ximing Xu*.Self-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation. AAPS PharmSciTech 2019, 20(4): 153.

3. Kangyi Zhang†, Qilong Wang†, Qiuxuan Yang, Qiuyu Wei, Na Man, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu*, Ximing Xu*. Enhancement of Oral Bioavailability and Anti-hyperuricemic Activity of Isoliquiritigenin via Self-Microemulsifying Drug Delivery System. AAPS PharmSciTech 2019, 20(5): 218.

4. Huiyun Zhang, Cong yong Sun, Michael Adu Frimpong, Jiangnan Yu*, Ximing Xu*. Glutathione-sensitive PEGylated curcumin prodrug nanomicelles: Preparation, characterization, cellular uptake and bioavailability evaluation. International Journal of Pharmaceutics 2019, 555 270-279.

5. Huiyun Zhang†, Qilong Wang†, Congyong Sun†, Yuan Zhu, Qiuxuan Yang, Qiuyu Wei, Jiaxin Chen, Wenwen Deng, Michael Adu-Frimpong, Jiangnan Yu*, Ximing Xu*. Enhanced Oral Bioavailability, Anti-Tumor Activity and Hepatoprotective Effect of 6-Shogaol Loaded in a Type of Novel Micelles of Polyethylene Glycol and Linoleic Acid Conjugate. Pharmaceutics 2019, 11(3).

6. Qingtong Yu†, Yan Wang†, Xia Cao, Wenwen Deng, Michael Adu Frimpong, Jiangnan Yu*, Ximing Xu*. One-Step Formation of Chondrocytes through Direct Reprogramming via Polysaccharide-Based Gene Delivery. Advances in Polymer Technology 2019.

7. Qiuxuan Yang, Qilong Wang, Yingshu Feng, Qiuyu Wei, Congyong Sun, Caleb Kesse Firempong, Michael Adu-Frimpong, Ran Li, Rui Bao, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu*, Ximing Xu*. Anti-hyperuricemic property of 6-shogaol via self-micro emulsifying drug delivery system in model rats: formulation design, and evaluation. Drug Development and Industrial Pharmacy 2019, 45(8): 1265-1276.

8. Wen Wen†, Qilong Wang†, Chunmei Wei, Na Man, Kangyi Zhang, Qiuyu Wei, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu*, Ximing Xu*. Preparation, characterization, pharmacokinetics and anti-hyperuricemia activity studies of myricitrin-loaded proliposomes. International Journal of Pharmaceutics 2019, 572 118735.

9.Chunmei Wei, Qilong Wang, Wen Weng, Qiuyu Wei, Yujiao Xie, Michael AduFrimpong, Elmurat Toreniyazov, Hao Ji, Ximing Xu*, Jiangnan Yu*. The characterisation, pharmacokinetic and tissue distribution studies of TPGS modified myricetrin mixed micelles in rats. Journal of Microencapsulation 2019, 36(3): 278-290.

10. Qilong Wang†, Min Guo†, Michael Adu-Frimpong, Kangyi Zhang, Qiuxuan Yang, Elmurat Toreniyazov, Hao Ji, Ximing Xu*, Xia Cao*, Jiangnan Yu*. Self-Micro-Emulsifying Controlled Release of Eugenol Pellets: Preparation, In vitro/In vivo Investigation in Beagle Dogs. AAPS PharmSciTech 2019, 20(7): 284.

11. Shanshan Tong, Yuchu Chen, Michael Adu-Frimpong, Lu Zhao, Li Wang, Ximing Xu*, Jiangnan Yu*. Simultaneous Determination and Assessment of Antioxidant Activities of 2,3-Dehydrosilycristin and 2,3-Dehydrosilybin in Dehydro Silymarin. Latin American Journal of Pharmacy. 2019, 38(5): 931-937.

12. Congyong Sun†, Wenjing Li†, Yingkun Liu, Wenwen Deng, Michael Adu-Frimpong, Huiyun Zhang, Qilong Wang, Jiangnan Yu*, Ximing Xu*. In vitro/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury. Food and chemical toxicology 2019, 131 110531.

2018

1. Qilong Wang, Qiuxuan Yang, Xia Cao, Qiuyu Wei, Caleb K. Firempong, Min Guo, Feng Shi, Ximing Xu*, Wenwen Deng*, Jiangnan Yu*. Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles. International Journal of Pharmaceutics. 2018.550:24-34.

2. Yao Xu, Huiyan Jiang, Congyong Sun, Michael Adu-Frimpong, Wenwen Deng*, Jiangnan Yu*, Ximing Xu*. Antioxidant and hepatoprotective effects of purified, Rhodiola rosea, polysaccharides. International Journal of Biological Macromolecules. 2018.117:167-178.

3. Xing Jin, Qilong Wang, Xia Yang, Min Guo, Wenjing Li, Jixiang Shi, Michael Adu-Frimpong, Ximing Xu*, Wenwen Deng*, Jiangnan Yu*. Chemical characterisation and hypolipidaemic effects of two purified Pleurotus eryngii polysaccharides. International Journal of Food Science and Technology. 2018,53:2298-2307.

4. Jun Jiang, Shichang Xiao, Ximing Xu*, Haile Ma, Chunlai Feng, Xiaobin Jia. Isomeric flavonoid aglycones derived from Epimedii Folium exerted different intensities in anti-osteoporosis through OPG/RANKL protein targets. International Immunopharmacology. 2018,62:277-286.

5. Jing Zhu, Qilong Wang, Huihua Li, Huiyun Zhang, Yuan Zhu, Emmanuel Omari-Siaw, Congyong Sun, Qiuyu Wei, Wenwen Deng*, Jiangnan Yu*, Ximing Xu*. Galangin-loaded, liver targeting liposomes: Optimization and hepatoprotective efficacy. Journal of Drug Delivery Science and Technology. 2018,46:339-347.

6. Xia Cao, Jianping Wang, Wenwen Deng, Jingjing Chen, Yan Wang, Jie Zhou, Pan Du, Wenqian Xu, Qiang Wang, Qilong Wang, Qingtong Yu, Myron Spector, Jiangnan Yu, Ximing Xu*. Photoluminescent Cationic Carbon Dots as efficient Non-Viral Delivery of Plasmid SOX9 and Chondrogenesis of Fibroblasts. Scientific Reports. 2018,8.

7. Yingshu Feng, Yuan Zhu, Jinyi Wan, Xia Yang, Caleb Kesse Firempong, Jiangnan Yu*, Ximing Xu*. Enhanced oral bioavailability, reduced irritation and increasedhypolipidemic activity of self-assembled capsaicin prodrug nanoparticles. Journal of Functional Foods.2018,44:137-145.

8. Jun Li†, Qingtong Yu†, Haisen Huang†, Wenwen Deng, Xia Cao, Michael Adu-Frimpong, Jiangnan Yu, Ximing Xu*. Human chorionic plate-derived mesenchymal stem cells transplantation restores ovarian function in a chemotherapy-induced mouse model of premature ovarian failure. Stem Cell Research & Therapy.2018,9:81.

9. Qilong Wang, Qiuyu Wei, Qiuxuan Yang, Xia Cao, Qiang Li, Feng Shi, Shan Shan Tong, Chunlai Feng, Qingtong Yu, Jiangnan Yu*, Ximing Xu*. A novel formulation of [6]-gingerol: Proliposomes with enhanced oral bioavailability and antitumor effect. International Journal of Pharmaceutics. 2018,535:308-315.

10. Qingtong Yu†, Jingjing Chen†, Wenwen Deng, Xia Cao, Michael Adu-Frimpong, Jiangnan Yu, Ximing Xu*. Neural differentiation of fibroblasts induced by intracellular co-delivery of Ascl1, Brn2 and FoxA1 via a non-viral vector of cationic polysaccharide. Biomedical Materials. 2018, 13:015022.

11. Jing Zhu, Qilong Wang, Yuan Zhu, Michael Adu-Frimpong, Huihua Li, Emmanuel Omari-Siaw, Xing Jin, Qiuxuan Yang,Wenwen Deng*, Ximing Xu*, Jiangnan Yu*. Enhanced Oral Bioavailability and In Vivo Hypouricemic Activity of Galangin Via Polymeric Micelles. Latin American Journal of Pharmacy. 2018,37:1818-1827.

12. Congyong Sun†, Yangyang Yuan†, Emmanuel Omari-Siaw, Shanshan Tong, Yuan Zhu, Qilong Wang, Yuanwen Wang, Qiuyu Wei, Jiangnan Yu*, Ximing Xu*. An Efficient HPLC Method for Determination of Syringic Acid Liposome in Rats Plasma and Mice Tissue: Pharmacokinetic and Biodistribution Application. Current Pharmaceutical Analysis. 2018,14:41-52.

13. Huiyan Jiang, Yao Xu, Congyong Sun, Michael Adu-Frimpong, Jiangnan Yu*, Wenwen Deng*, Ximing Xu*. Physicochemical properties and antidiabetic effects of apolysaccharide obtained from Polygonatum odoratum. International Journal of Food Science and Technology 2018, doi:10.1111/ijfs.13896.

14. Huiyun Zhang, Congyong Sun, M. Adu-Frimpong, Jiangnan Yu*, Ximing Xu*, Glutathione-sensitive PEGylated curcumin prodrug nanomicelles: preparation, characterization, cellular uptake and bioavailability evaluation, International Journal of Pharmaceutics (2018), doi: https://doi.org/10.1016/j.ijpharm.2018.11.049.

15. Qiuxuan Yang, Qilong Wang, Wenwen Deng, Congyong Sun, Qiuyu Wei, Michael Adu-Frimpong, Jixiang Shi, Jiangnan Yu*, Ximing Xu*, Antihyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica in model rats. Biomac (2018), https://doi.org/10.1016/j.ijbiomac.2018.11.077.

16. Qiuyu Wei, Qiuxuan Yang, Qilong Wang, Congyong Sun, Yuan Zhu, Ya Niu, Jiangnan Yu*, Ximing Xu*. Formulation, Characterization, and Pharmacokinetic Studies of 6-Gingerol-Loaded Nanostructured Lipid Carriers. AAPS PharmSciTech 2018, DOI: 10.1208/s12249-018-1165-2.

2017

1. Qingtong Yu†, Jingjing Chen†, Wenwen Deng, Xia Cao, Yan Wang, Jie Zhou, Wenqian Xu, Pan Du, Qiang Wang, Jiangnan Yu and Ximing Xu*. Direct reprogramming of mouse fibroblasts into neural cells via Porphyrayezoensis polysaccharide based high efficient gene co-delivery. Journal of Nanobiotechnology. 2017,15.

2. Huiyun Zhang, Wenqian Xu, Emmanuel Omari-Siaw, Yingkun Liu, Baoding Chen, Deyu Chen, Jiangnan Yu*, Ximing Xu*. Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfide bond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy. Drug Delivery. 2017,24:1170-1178.

3. Jiaxin Chen†, Qiang Wang†, Jie Zhou†, Wenwen Deng†, Qingtong Yu, Xia Cao, Jianping Wang, Fengxia Shao, Yang Li, Ping Ma, Myron Spector, Jiangnan Yu, Ximing Xu*. Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells. Nanoscale.2017;9:10820-10831.

4. Chunlai Feng*, Mengjie Rui, Haijun Shen, Yuanrong Xin, Jie Zhang, Jun Li, Lixiang Yue, Wenlong Lai, Ximing Xu*. Tumor-specific delivery of doxorubicin through conjugation of pH-responsive peptide for overcoming drug resistance in cancer. International Journal of Pharmaceutics. 2017,528:322-333.

5. Jun Li*, Haisen Huang, Ximing Xu*. Biological characteristics and karyotiping of a new isolation method for human adipose mesenchymal stem cells in vitro. Tissue and Cell. 2017,49:376-382.

6. Yuanwen Wang, Shicheng Wang, Caleb Kesse Firempong, Huiyun Zhang, Miaomiao Wang, Ya Zhang, Yuan Zhu, Jiangnan Yu, Ximing Xu*. Enhanced solubility and bioavailability of naringenin via liposomal nanoformulation: preparation and in vitro and in vivo evaluations. AAPS PharmSciTech. 2017,18:586-594.

7. Zengquan Gu, Xiaolei Shi, Emmanuel Omari-Siaw, Yuan Zhu, Huihua Li, Min Guo, Xia Yang, Jiangnan Yu*, Ximing Xu*. Self-microemulsifying sustained-release pellet of Ginkgo biloba extract: Preparation, invitro drug release and pharmacokinetics study in beagle dogs. Journal of Drug Delivery Science & Technology. 2017,37:184-193.

8. Jun Li*, Haisen Huang, Ximing Xu*. Biological and genetic characteristics of mesenchymal stem cells in vitro derived from human adipose, umbilical cord and placenta. International Journal of Clinical and Experimental Medicine. 2017,10:16310-16318.

9. Hongfei Liu, Pengyue Bao, Yihong Xu, Shuangshuang Shi, Yuanrong Xin, Lijun Ji, Yixiang Dong*, Ximing Xu*. Bioactive Glass and PLGA Composite Microspheres, a Promising Efficient Carrier for Exenatide Delivery. Latin American Journal of Pharmacy. 2017,36:135-141.

10. Mengjie Rui, Yang Qu, Tong Gao, Yanru Ge, Chunlai Feng*, Ximing Xu*. Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells. International Journal of Nanomedicine. 2017,12:217-37.

2016

1. Mengjie Rui, Yuanrong Xin, Ran Li, Yanru Ge, Chunlai Feng,* Ximing Xu*. Targeted Biomimetic Nanoparticles for Synergistic Combination Chemotherapy of Paclitaxel and Doxorubicin. Molecular Pharmaceutics. 2016,14:107-123.

2. Yang Xu, Qilong Wang, Yingshu Feng, Caleb Kesse Firempong, Yuan Zhu, Emmanuel Omari-Siaw, Yuanyuan Zheng, Zunqin Pu, Ximing Xu*, Jiangnan Yu*. Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation. Journal of Functional Foods.2016,27:703-710.

3. Zhijian Zhang†, Zhengnan Li†, Wenwen Deng†, Qinghua He, QiangWang, Wentao Shi, Qian Chen, Wenjing Yang, Myron Spector, Aihua Gong, Jiangnan Yu, Ximing Xu*. Ectoderm mesenchymal stem cells promote differentiation and maturation of oligodendrocyte precursor cells. Biochemical and Biophysical Research Communications. 2016,80:727-33.

4. Emmanuel Omari-Siawa, Qilong Wang, Congyong Sun, Zengquan Gu, Yuan Zhu, Xia Cao, Caleb Kesse Firempong, Rita Agyared, Ximing Xu*, Jiangnan Yu. Tissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia. International Journal of Pharmaceutics. 2016,513:68-77.

5. Yuan Zhu†, Miaomiao Wang†, Ya Zhang, Jin Zeng, E. Omari-Siaw, Jiangnan Yu, Ximing Xu*. In Vitro Release and Bioavailability of Silybin from Micelle-Templated Porous Calcium Phosphate Microparticles. AAPS PharmSciTech. 2016,17:1232-1239.

6. Jie Zhou†, Wenwen Deng†, Yan Wang†, Xia Cao, Jingjing Chen, Qiang Wang, Wenqian Xu, Pan Du, Qingtong Yu, Jiaxin Chen, Myron Spector, Jiangnan Yu*, Ximing Xu*. Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake. Acta Biomaterialia.2016,42:209-19.

7. Wenwen Deng†, Xia Cao†, Qiang Wang†, Yan Wang, Jingjing Chen, Qingtong Yu, Zhijian Zhang, Jie Zhou, Wenqian Xu, Pan Du, Jiaxin Chen, Xiangdong Gao, Jiangnan Yu, and Ximing Xu*. Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming. ACS Applied Materials & Interfaces. 2016,8:19916-27.

8. Miaomiao Wang, Yuanwen Wang, Emmanuel Omari-Siaw, Shengli Wang, Yuan Zhu*, Ximing Xu*. Reduced Burst Release and Enhanced Oral Bioavailability in Shikimic Acid–Loaded Polylactic Acid Submicron Particles by Coaxial Electrospray. Journal of Pharmaceutical Sciences. 2016,105:2427-36.

9. Caleb Kesse Firempong, Hui Yun Zhang, Yan Wang, Jingjing Chen, Xia Cao, Wenwen Deng, Jie Zhou, Qiang Wang, ShanShan Tong, Jiangnan Yu, Ximing Xu∗. Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo. Pharmacological Research. 2016,110:101-110.

10. Feng Shi, Zheng Wei, Yingying Zhao, Ximing Xu*. Nanostructured Lipid Carriers Loaded with Baicalin: An Efficient Carrier for Enhanced Antidiabetic Effects. Pharmacognosy Magazine. 2016,12:198-202.

11. Dongmei Jiang, Jin Zeng, Yuan Zhu, Guanghui Zhou, Wenwen Deng, Ximing Xu*, and Jiangnan Yu*. Sustained-release of Cyclosporin A pellets: preparation, in vitro release, pharmacokinetic studies and in vitro–in vivo correlation in beagle dogs. Drug Development and Industrial Pharmacy. 2016,42:1174-1182.

12. Huiyun Zhang, Caleb Kesse Firempong, Yuanwen Wang, Wenqian Xu, Miaomiao Wang, Xia Cao, Yuan Zhu, Shanshan Tong, Jiangnan Yu*, Ximing Xu*. Ergosterol-loaded poly（lactide-co-glycolide） nanoparticles with enhanced in vitro antitumor activity and oral bioavailability. Acta Pharmacologica Sinica. 2016,37:834-844.

13. Jin Cao, Shicheng Wang, Chenwei Yao, Zi Xu, Ximing Xu*. Hypolipidemic effect of porphyran extracted from Pyropia yezoensis in ICR mice with high fatty diet. Journal of Applied Phycology. 2016,28:1315-1322.

14. Ya Zhang, Zhimin Huang, E. Omari-Siaw, Shuang Lu, Yuan Zhu, Dongmei Jiang, Miaomiao Wang, Jiangnan Yu, Ximing Xu*, Weiming Zhang*. Preparation and In Vitro-In Vivo Evaluation of Sustained-Release Matrix Pellets of Capsaicin to Enhance the Oral Bioavailability. AAPS PharmSciTech. 2016,17:339-349.

15. Emmanuel Omari-Siawa, Yuan Zhu, Houyong Wang, Wei Peng, Caleb Kesse Firempong, Yuanwen Wang, Xia Cao, Wenwen Deng, Jiangnan Yu, Ximing Xu*. Hypolipidemic potential of perillaldehyde-loaded self-nanoemulsifying delivery system in high-fat diet induced hyperlipidemic mice: Formulation, in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences. 2016,85:112-22.

16. Yingshu Feng†, Congyong Sun†, Yangyang Yuan†, Yuan Zhu, Jinyi Wan, Caleb Kesse Firempong, Emmanuel Omari-Siaw, Yang Xu, Zunqin Pu, Jiangnan Yu*, Ximing Xu*. Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation. International Journal of Pharmaceutics. 2016,501:342-349.

17. Yingshu Feng, Congyong Sun, Emmanuel Omari-Siaw, Yuan Zhu, Shanshan Tong, Jinyi Wan, Jiangnan Yu* and Ximing Xu*. An efficient in vitro and in vivo HPLC method for hydnocarpin in nanomicelles formulation. Biomedical Chromatography. 2016,30:432-439.

18. Wenwen Deng†, Xia Cao†, Yan Wang†, Qingtong Yu, Zhijian Zhang, Rui Qu, Jingjing Chen, Genbao Shao, Xiangdong Gao, Ximing Xu*, Jiangnan Yu*. Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification. Journal of Agricultural and Food Chemistry. 2016,64:1264-73.

19. Jin Cao, Jianping Wang, Shicheng Wang, Ximing Xu*. A Mini-Review of Its Pharmacological and Nutritional Properties. Journal of Medicinal Food. 2016,19:111-119.

20. Yingying Zhao, Chaonan Sun, Feng Shi, Caleb Kesse Firempong, Jiangnan Yu, Ximing Xu*, Weiming Zhang*. Preparation, characterization, and pharmacokinetics study of capsaicin via hydroxypropyl-beta-cyclodextrin encapsulation. Pharmaceutical Biology. 2016,54:130-138.

21. Feng Shi, Yingying Zhao, Caleb Kesse Firempong and Ximing Xu*. Preparation, characterization and pharmacokinetic studies of linalool-loaded nanostructured lipid carriers. Pharmaceutical Biology. 2016,54:2320-2328.

22. Huiyun Zhang, Wenqian Xu, Yuanyuan Zheng, Emmanuel Omari-Siaw, Yuan Zhu, Xia Cao, Shanshan Tong, Jiangnan Yu*, Ximing Xu*. Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation. Oncotarget. 2016,7:86326-38.

23. Hui-Yun Zhang, Wenqian Xu, Yuanwen Wang, Emmanuel Omari-Siaw, Yan Wang, Yuanyuan Zheng, Xia Cao, Shanshan Tong, Jiangnan Yu*, Ximing Xu*. Tumor targeted delivery of octreotide-periplogenin conjugate: Synthesis, in vitro and in vivo evaluation. International Journal of Pharmaceutics. 2016, 502:98-106.

2015

1. Yuan Zhu†, Jiajia Zhang†, Qianfeng Zheng†, Miaomiao Wang†, Wenwen Deng, Qiang Li, Caleb Kesse Firempong, Shengli Wang, Shanshan Tong, Ximing Xu*, Jiangnan Yu*.  In vitro and in vivo evaluation of capsaicin-loaded microemulsion for enhanced oral bioavailability. Journal of the Science of Food and Agriculture. 2015,95:2678-2685.

2. Wenwen Deng†, Xia Cao†, Jingjing Chen†, Zhijian Zhang, Qingtong Yu, Yan Wang, Genbao Shao, Jie Zhou, Xiangdong Gao, Jiangnan Yu*, and Ximing Xu*. MicroRNA Replacing Oncogenic Klf4 and c-Myc for Generating iPS Cells via Cationized Pleurotus eryngii Polysaccharide-based Nanotransfection. ACS Applied Materials & Interfaces. 2015,7:18957-18966.

3. Caleb Kesse Firempong, Huiyun Zhang, Jiajia Zhang, Yan Wang, Xia Cao, Emmmanuel Omari-Siawa, Shanshan Tong, Jiangnan Yu*, Ximing Xu*. Lipid raft biomaterial as a mass screening affinity tool for rapid identification of potential antitumor Chinese herbal medicine. European Journal of Integrative Medicine. 2015,7:365-371.

4. Zhijian Zhang†, Qinghua He†, Wenwen Deng†, Qian Chen, Xinyuan Hu, Aihua Gong, Xia Cao, Jiangnan Yu, Ximing Xu*. Nasal ectomesenchymal stem cells: Multi-lineage differentiation and transformation effects on fibrin gels. Biomaterials. 2015,49:57-67.

5. Yuan Zhu, Miaomiao Wang, Jiajia Zhang, Wei Peng, Caleb Kesse Firempong, Wenwen Deng, Qilong Wang, Shicheng Wang, Feng Shi, Jiangnan Yu, Ximing Xu*, Weiming Zhang*. Improved oral bioavailability of capsaicin via liposomal nanoformulation: preparation, in vitro drug release and pharmacokinetics in rats. Archives of Pharmacal Research. 2015,38: 512-21.

6. Houyong Wang, Qiang Li, Wenwen Deng, E. Omari-siaw, Qilong Wang, Shicheng Wang, Shengli Wang, Xia Cao, Ximing Xu*, Jiangnan Yu*. Self-Nanoemulsifying Drug Delivery System of trans-Cinnamic acid: Formulation Development and Pharmacodynamic Evaluation in Alloxan-induced Type 2 Diabetic Rat Model. Drug Development Research.2015, 76:82-93.

7. Qingtong Yu, Jin Cao, Baoding Chen, Wenwen Deng, Xia Cao, Jingjing Chen, Yan Wang, Shicheng Wang, Jiangnan Yu, Ximing Xu*, and Xiangdong Gao*. Efficient gene delivery to human umbilical cord mesenchymal stem cells by cationized Porphyra yezoensis polysaccharide nanoparticles. International Journal of Nanomedicine. 2015,10:7097-107.

8. Caleb Kesse Firempong, Xia Cao, Shanshan Tong, Jiangnan Yua and Ximing Xu*. Prospects for multitarget lipid-raft-coated silica beads: a remarkable online biomaterial for discovering multitarget antitumor lead compounds. RSC ADVANCES. 2015,5:49330-49342.

9. Wei Peng, Xinyi Jiang, Yuan Zhu, E Omari-Siaw, Wenwen Deng, Jiangnan Yu, Ximing Xu*, and Weiming Zhang*. Oral delivery of capsaicin using MPEG-PCL nanoparticles. Acta Pharmacologica Sinica.2015,36:139-148.

10. Hanqing Liu, Zhigang Tu*, Fan Feng, Haifeng Shi, Keping Chen, Ximing Xu. Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment. Acta Pharm. 65 (2015) 105–116

2014

1. Shanshan Tong†, Chaonan Sun†, Xia Cao†, Qianfeng Zheng, Huiyun Zhang, Caleb Kesse Firempong, Yingshu Feng, Yan Yang, Jiangnan Yu, Ximing Xu*. Development and thermodynamic evaluation of novel lipid raft stationary phase chromatography for screening potential antitumor agents. Biomedical Chromatography, 2014. 28: 1615-1623.

2. Yuan Zhu†, Wei Peng†, Jiajia Zhang†, Miaomiao Wang†, Caleb Kesse Firempong, Chunlai Feng, Hongfei Liu, Ximing Xu*, Jiangnan Yu*. Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation. Journal of Functional Foods, 2014, 8: 358-366.

3. Shanshan Tong†, Min Fu†, Xia Cao†, Caleb Kesse Firempong, Chengxue Yi, Qianfeng Zhen, Hui Zhong, Jiangnan Yu*, Ximing Xu*. Lipid Raft Stationary Phase Chromatography for Screening Anti-tumor Components from Galla chinensis. Chromatographia, 2014,77(5-6): 419-429.

4. Li Wang, Min Peng, Yuan Zhu, Shan-shan Tong, Xia Cao, Xi-ming Xu, Jiang-nan Yu*. Preparation of Pluronic/Bile salt/Phospholipid Mixed Micelles as Drug Solubility Enhancer and Study the Effect of the PPO Block Size on the Solubility of Pyrene. Iranian Journal of Pharmaceutical Research.2014,13:1157-1163.

5. Li Yue, Wang Xiang-Yu, Zhang Rui-Zhuo, Zhang Xiao-Yun, Liu Wei, Xu Xi-Ming, Zhang Ye-Wang. Molecular Imprinting and Immobilization of Cellulase Onto Magnetic Fe3O4@SiO2 Nanoparticles. Journal of Nanoscience and Nanotechnology. 2014, 14(4):2931-2936.

6. Liu Wei, Zhou Fang, Zhang Xiao-Yun, Li Yue, Wang Xiang-Yu, Xu Xi-Ming, Zhang Ye-Wang. Preparation of Magnetic Fe3O4@SiO2 Nanoparticles for Immobilization of Lipase. Journal of Nanoscience and Nanotechnology. 2014, 14(4):3068-3072.

7. Yuan Zhu, Jiajia Zhang, Min Fu, Jin Zeng, E. Omari-Siaw, Xi-ming Xu*. Calcium carbonate nanoparticles templated by mixed polymeric micelles: characterization, in vitro drug release and oral bioavailability in Beagle dogs. Latin American Journal of Pharmacy, 2014, 33(7): 1106-1113.

8. Shanshan Tong†, Hui Zhong†, Chengxue Yi†, Xia Cao†, Caleb Kesse Firempong, Qianfeng Zheng, Yingshu Feng, Jiangnan Yu*, Ximing Xu*. Simultaneous HPLC determination of ergosterol and 22,23-dihydroergosterol in Flammulina velutipes sterol-loaded microemulsion. Biomedical Chromatography, 2014, 28(2): 247-254.

2013

1. Xia Cao†, Wenwen Deng†, Rui Qu, Yan Yang, Jun Li, Yue Cao, Ximing Xu*, Jiangnan Yu*. Non-viral co-delivery of the four Yamanaka factors for generation of human induced pluripotent stem cells via calcium phosphate nanocomposite particles. Advanced Functional Materials, 2013, 23(43): 5403-5411.

2. Wenwen Deng†, Min Fu†, Yue Cao†, Xia Cao†, Miao Wang, Yan Yang, Rui Qu, Jun Li, Ximing Xu*, Jiangnan Yu. Angelica sinensis polysaccharide nanoparticles as novel non-viral carriers for gene delivery to mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 2013, 9: 1181-1191.

3. Lin Mei†, LiangWang†, Qianqian Li, Jiangnan Yu and Ximing Xu∗. Comparison of acid degumming and enzymatic degumming process for Silybum marianum seed oil.  Journal of the Science of Food and Agriculture. 2013 93(11):2822-2828.

4. Chengxue Yi†, Min Fu†, Xia Cao†, Shanshan Tong†, Qianfeng Zheng, Caleb Kesse Firempong, Xinyi Jiang, Ximing Xu, Jiangnan Yu. Enhanced oral bioavailability and tissue distribution of a new potential anticancer agent, Flammulina velutipes sterols, through liposomal encapsulation. Journal of Agricultural and Food Chemistry, 2013, 61: 5961-5971.

5. Chengxue Yi†, Chaonan Sun†, Shanshan Tong†, Xia Cao†, Yingshu Feng, Caleb Kesse Firempong, Xinyi Jiang, Ximing Xu*, Jiangnan Yu*, Cytotoxic effect of novel Flammulina velutipes sterols and its oral bioavailability via mixed micellar nanoformulation. International Journal of Pharmaceutics, 2013, 448: 44-50.

6. Xinyi Jiang, Xianyi Sha, Hongliang Xin, Ximing Xu, Jijin Gu, Weiyi Xia, Shuo Chen,Yike Xie, Liangcen Chen, Yanzuo Chen, Xiaoling Fang*. Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel. Biomaterials, 2013, 34: 2969-2979.

7. Xinyi Jiang, Hongliang Xin, Jijin Gu, Ximing Xu, Weiyi Xia, Shuo Chen, Yike Xie,Liangcen Chen, Yanzuo Chen, Xianyi Sha, Xiaoling Fang*. Solid tumor penetration by integrin-mediated pegylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel Biomaterials. Biomaterials, 2013, 34: 1739-1746.

8. Xia Cao, Wenwen Deng, Min Fu, Yuan Zhu, Hongfei Liu, Li Wang, Jin Zeng, Yawei Wei, XimingXu, Jiangnan Yu. Seventy-two-hour release formulation of the poorly soluble drug silybin based on porous silica nanoparticles: In vitro release kinetics and in vitro/in vivo correlations in beagle dogs. European Journal of Pharmaceutical Sciences, 2013, 48:64-71

9. Li Hui, Dong Wen-feng, Zhou Jian-yuan, Xu Xi-ming, Li Feng-qian. Triggering effect of N-acetylglucosamine on retarded drug release from a lectin-anchored chitosan nanoparticles-in-microparticles system. International Journal of Pharmaceutics. 2013, 449(1-2):37-43.

10. Wang Li†, Wang Yan-song†, Chen Rong-ying†, Feng Chun-lai, Wang Hao, Zhu Xi-wen, Yu Jiang-nan, Xu Xi-ming*. PLGA microspheres as a delivery vehicle for sustained release of tetracycline: biodistribution in mice after subcutaneous administration. Journal of Drug Delivery Science and Technology. 2013, 23(6):547-553.

2012

1. Xia Cao†, Min Fu†, Liang Wang†, Hongfei Liu†, Wenwen Deng, Rui Qu, Weiyan Su, Yawei Wei, Jiangnan Yu*, Ximing Xu*. Oral Bioavailability of Silymarin Formulated as a Novel 3-day Delivery System Based on Porous Silica Nanoparticles. Acta Biomaterialia. 2012, 8:2104-2112.

2. Chengxue Yi†, Hui Zhong†, Shanshan Tong†, Xia Cao†, Caleb K Firempong, Hongfei Liu, Min Fu, Yan Yang, Yingshu Feng, Huiyun Zhang, Ximing Xu*, Jiangnan Yu*. Enhanced oral bioavailability of a sterol-loaded microemulsion formulation of Flammulina velutipes, a potential antitumor drug. International Journal of Nanomedicine. 2012, 7:5067-78.

3. Xia Cao†, Wenwen Deng†, Yuan Wei†, Yan Yang†, Weiyan Su, Yawei Wei, Jiangnan Yu*, Ximing Xu*. Incorporating pTGF-β1/calcium phosphate nanoparticles with fibronectin into 3-dimensional collagen/chitosan scaffolds: efficient, sustained gene delivery to stem cells and chondrogenic differentiation. European Cells & Materials. 2012, 23:81-93.

4. Wenwen Deng†, Miao Wang†, Xia Cao†, Yan Yang, Wei-Yan Su, Ya-Wei Wei, Zhen Ou-Yang, Jiangnan Yu*, Ximing Xu*. Efficient Gene Delivery to Mesenchymal Stem Cells by Ethylenediamine-modified Polysaccharide from Mulberry Leaves. Small. 2012, 8(3):441-451.

5. Xia Cao†, Wen-Wen Deng†, Min Fu†, Liang Wang, Shan-Shan Tong, Ya-Wei Wei, Ying Xu, Wei-Yan Su, Xi-ming Xu*, Jiang-Nan Yu*. In vitro release and in vitro-in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles. International Journal of Nanomedicine. 2012,7:753-762.

6. Wenwen Deng, Xia Cao, Miao Wang, Rui Qu, Weiyan Su, Yan Yang, Yawei Wei, Jiangnan Yu*, Ximing Xu*. Delivery of a Transforming Growth Factor Beta-1 Plasmid to Mesenchymal Stem Cells via Cationized Pleurotus eryngii Polysaccharide Nanoparticles. International Journal of Nanomedicine. 2012, 7:1297-1311.

Before 2012

1. Miao Wang†, Wenwen Deng†, Min Fu†, Xia Cao†, Yan Yang, Weiyan Su, Jiangnan Yu*, Ximing Xu*. Efficient gene transfer into rat mesenchymal stem cells with cationized Lycium barbarum polysaccharides nanoparticles. Carbohydrate Polymers, 2011, 86:1509–1518.

2. Chang Chu, Shanshan Tong, Ying Xu, Min Fu, Yanru Ge, Jiangnan Yu*, Ximing Xu*. Proliposomes for the oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo. Acta Pharmacologica Sinica, 2011, 32: 973-980.

3. Shanshan Tong, Chang Chu, Yuan Wei, Li Wang, Xizhe Gao, Ximing Xu*, Jiangnan Yu*. Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger. Journal of Pharmacy and Pharmacology, 2011, 63(2): 238-44.

4. Xia Cao†, Wenwen Deng†, Yuan Wei†, Weiyan Su, Yan Yang, Yawei Wei, Jiangnan Yu*, Ximing Xu*. Encapsulation of Plasmid DNA in Calcium Phosphate Nanoparticles: Stem Cell Uptake and Gene Transfer Efficiency. International Journal of Nanomedicine, 2011, 6:3335-3349.

5. Xi-ming XU*, Yan-song WANG, Rong-ying CHEN, Chun-lai FENG, Feng YAO, Shan-shan TONG, Li WANG, Fumiyoshi YAMASHITA, Jiang-nan YU*. Formulation and pharmacokinetic evaluation of tetracycline-loaded solid lipid nanoparticles (Tet-SLN) for subcutaneous injection in mice. Chemical & Pharmaceutical Bulletin, 2011, 59(2): 260-265.

6. Jiangnan Yu, Yuan Zhu, Li Wang, Min Peng, Shanshan Tong, Xia Cao, Hui Qiu, Ximing Xu*. Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles. Acta Pharmacologica Sinica, 2010, 31(6): 759-764.

7. Yuan Zhu, Jiangnan Yu*, Shanshan Tong, Li Wang, Min Peng, Xia Cao, Ximing Xu*. Preparation and In Vitro Evaluation of Povidone-Sodium Cholate-Phospholipid Mixed Micelles for the Solubilization of Poorly Soluble Drugs. Archives of Pharmacal Research, 2010, 33(6): 911-917.

8. Ye-Wang Zhang*, Rui-Jiang Liu, Xi-Ming Xu. One-pot, two-step enzymatic synthesis of amoxicillin by complexing with Zn₂⁺. Applied Microbiology and Biotechnology, 2010, 88(1): 49-55.

9. Shu-Guang Fang; Tan Qiang; Rui-Jiang Liuad; Xi-Ming Xu; Ye-Wang Zhang*. Enhanced Production of 6-Aminopenicillanic Acid in Aqueous Methyl Isobutyl Ketone System with Immobilized Penicillin G Acylase. Prep Biochem Biotechnol, 2010, 40(1): 38-45.

10. Feng Yao, Nao Murakami, Oliver Bleiziffer, Pengwei Zhang, Natali V. Akhrameyeva, Ximing Xu*, Richard Brans. Development of a Regulatable Oncolytic Herpes Simplex Virus Type 1 Recombinant Virus for Tumor Therapy. Journal of Virology. 2010, 84(16): 8163-8171.

11. Zheming Lu, Richard Brans, Natali V. Akhrameyeva, Nao Murakami, Ximing Xu, Feng Yao. High-level expression of glycoprotein D by a dominant-negative HSV-1 virus augments its efficacy as a vaccine against HSV-1iInfection. J Invest Derma 2009; 129(5): 1174-1184.

12. Ximing Xu, Ramille M. Capito, Myron Spector*. Plasmid size influences chitosan nanoparticle mediated gene transfer to chondrocytes. Journal of Biomedical Materials Research Part A, 2008, 84A(4): 1038-1048.

13. Ximing Xu, Ramille M. Capito, Myron Spector*. Delivery of plasmid IGF-1 to chondrocytes via cationized gelatin nanoparticles. Journal of Biomedical Materials Research Part A, 2008, 84A(1): 73-82.

14. Ye-Wang Zhang, Shu-Lai Liu, Dong-Zhi Wei, Rui-Jiang Liu, Xi-Ming Xu. Kinetically Controlled Synthesis of Cefaclor with Immobilized Penicillin Acylase in the Presence of Organic Cosolvents. Chem Biochem Eng Q, 2008, 22 (3): 349-354.

15. Weiyan Su, Ximing Xu*, Jiangnan Yu. Advances in research progress of drug metabolism for primary cultured rat hepatocytes. Pharmaceutical Biotechnology, 2010, (6): 534-537.

16. Xi-ming XU*, Yan-song WANG, Rong-ying CHEN, Chun-lai FENG, Feng YAO, Shan-shan TONG, Li WANG, Fumiyoshi YAMASHITA, Jiang-nan YU. Formulation and pharmacokinetic evaluation of tetracycline-loaded solid lipid nanoparticles (Tet-SLN) for subcutaneous injection in mice. Chem Pharm Bull, 2011, 59(2): 260-265.

17. Hui Li, Juan Bi, Ximing Xu, Fengqian Li. Wheat germ agglutinin anchored chitosan nanoparticles and its conjugation with N-acetylglucosamine. Acta Pharmaceutica Sinica, 2012, (1): 131-134.

18. Zhen fang Yan, Ximing Xu*, Jiangnan Yu. Advances in Research of Targeting Drug Delivery Systems Mediated by Receptors. Pharmaceutical Biotechnology, 2009, (5): 481-485.

CONFERENCE ABSTRACTS    

1.Ximing Xu, One of the hosts of China Pharmaceutical Congress, 2022, Shanghai, sub-conference host.

2.Ximing Xu, One of the hosts of China Pharmaceutical Congress, 2021, Shenyang, sub-conference host.

3.Ximing Xu, Nanoparticle-mediated cell reprogramming and epigenetic modification, Frontiers Forum of “Acta Pharmaceutica Sinica”, 2019, Guangzhou, Oral presentation.

4.Ximing Xu, One of the hosts of China Pharmaceutical Congress, 2019, Yantai, Shandong, sub-conference host.

5.Ximing Xu, Nano gene delivery based on cationized polysaccharides from traditional Chinese medicine, China Pharmaceutical Congress, 2018, Guangzhou, Oral presentation.  

6.Ximing Xu, Non-viral Strategies for Cell Reprogramming, China Pharmaceutical Congress, 2015, Hangzhou, Oral presentation.

PATENTS  

(1) Xu Ximing, Jiangnan Yu, Shanshan Tong, Yuan Zhu,A Formulation of Silymarin with High Efficacy and Prolonged Action and the Preparation Method Thereof, February 24, 2015, USA, US8962017

(2) Xu Ximing, Jiangnan Yu, Xia Cao, Yuan Zhu,A Formulation of Silybinin with High Efficacy and Prolonged Action and the Preparation Method Thereof, May 05, 2015, USA, US9023388

(3) Xu Ximing, Jiangnan Yu, Yuan Zhu, Xia Cao,A Highly Efficient and Long-acting Slow-release Formulation of Poorly Soluble Drugs and Preparation Method Thereof, A highly efficient and long -acting slow -release formulation of poorly soluble drugs and preparation method thereof,2016.02.08, USA, US20110250269A1

(4) Xu Ximing, Cao Xia, Su Weiyan, Yu Jiangnan, Preparation and Application of three-dimensional nano-scaffold for gene delivery System, 2009.12.30, China, ZL 200910264113.1

(5) Xu Ximing, Cao Xia, Su Weiyan, Yu Jiangnan, Calcium ionized mesoporous silica Nanoparticles Gene delivery System and preparation method, 2008.12.31, China, ZL 200810242995.7

(6) Xu Ximing, Deng Wenwen, Yu Jiangnan, Wang Miao, Cao Xia, Cationized Mulberry leaf Polysaccharide nanoparticle gene Carrier and its preparation method, 2014.8.6, China, ZL201010613484.9

(7) Xu Ximing, Deng Wenwen, Yu Jiangnan, Wang Miao, Cao Xia, Gene delivery system and preparation method of cationized Pleuroplein Eryngium Polysaccharide nanoparticles, 2013.3.13, China, ZL201010613483.4

(8) Xu Ximing, Wang Miao, Yu Jiangnan, Deng Wenwen, Cao Xia, Gene Delivery System and preparation method of cationized Angelica Polysaccharide nanoparticle, 2012.12.19, ZL201010613603.0, China

(9) Xu Ximing, Wang Miao, Yu Jiangnan, Deng Wenwen, Cao Xia, Gene Delivery System and preparation method of cationized Lycium polysaccharide nanoparticles, 2012.8.29, ZL201010613602.6, China

(10) Xu Ximing, Deng Wenwen, Yu Jiangnan, Wang Miao, Cao Xia, Cationized Mulberry Leaf Polysaccharide nanoparticle gene Carrier and its preparation method, 2010.12.30, China, ZL 201010613484.9

(11) Xu Ximing, Zhu Yuan, Yu Jiangnan, Cao Xia, Preparation of highly effective long-acting sustained-release formulation of insoluble drugs, 2008.12.31, China, ZL200810242994.2

(12) Xu Ximing, Yi Chengxue, Yu Jiangnan, Cao Xia, Qu Rui, Preparation and application of saponifiable extracts from Flammulina Velutifolia with antitumor effects, 2011, ZL201110361029, China

(13) Xu Ximing, Wen Xiaoguang, Liang Lei, Zhang Zhenggen, Liu Hongfei, Yu Jiangnan, Oral preparation of Cyclosporine A sustained-release preparation, April 25, 2011, ZL201110103797, China

(14) Xu Ximing, Yu Jiangnan, Zhu Yuan, Zhang Zhenggen, You Mingxia, Jin Xia, Gu Xiaohong, Sun Tianjiang, Lu Hongguo, Tamsulosin hydrochloride sustained release pellet preparation and preparation method, 2009.10.23, China, ZL200910233724.X

(16) Yu Jiangnan, Cao Xia, Xu Ximing, Zhu Yuan, A long-acting preparation of Silybin and its preparation method, 2008.12.31, China, ZL200810242993.8

(17) Yu Jiangnan, Tong Shanshan, Zhu Yuan, Cao Xia, Xu Ximing, a long-acting preparation of silymarin and its preparation method, 2008.12.31, China, ZL200810242988.7

(18) Yu Jiangnan, Yi Chengxue, Xu Ximing, Cao Xia, Qu Rui, Preparation and application of Flammulina velutifolia antitumor extracts, 2011.11.17, China, ZL 201110364099.X

(19) Xu Ximing, Silybin precursor Polyphase liposome Preparation and Preparation Method, 2010.6.2, China, 200710191464.5(Authorized)

(20) Xu Ximing, Silybin dimer Self-emulsifying Microemulsion Preparation and Preparation Method, 2010.6.16, China, 200710191353.4(Authorized)

(21) Yu Jiangnan, Cao Xia, Xu Ximing, Su Weiyan, Synthesis and application of Gene-containing calcium phosphate composite Nanoparticles, 2009.12.30, China, ZL200910264114.6

(22) Yu Jiangnan, Tong Shanshan, Xu Ximing, Deng Qian, Determination of β-sitosterol content in supercritical fluid extraction of pine pollen, 2011.11.22, China, ZL 201110373574

(24) Yu Jiangnan, Feng Yingshu, Xu Ximing, Tong Shanshan, Liu Hongfei, Yang Yan, Preparation and application of an antitumor component extract from Hainanensis, 2012.11.29, China, ZL 201210498924.X

(25) Yu Jiangnan, Tong Shanshan, Xu Ximing, Yi Chengxue, Cao Xia, Fu Min, Preparation and application of an antitumor active component extract from Albizia albizia bark, 2012.11.19, ZL 201210467197.0, China

(26) Yu Jiangnan, Guo Linfeng, Xu Ximing, Tong Shanshan, Zhang Huiyun, Preparation and application of an antitumor active component extract from the root of Bean root, 2012.12.6, ZL201210520857.7, China

(27) Xu Ximing, Sun Congyong, Yu Jiangnan, A Traditional Chinese medicine composition with protective effect against chemical liver injury, preparation method and application, 2022.09.23, China, ZL 202110835147.2

(28) Xu Ximing, Yu Jiangnan, Zhu Yuan, Povidone-phosphate-cholate terpolymer used as an insoluble drug carrier, 2008.07.09, China, ZL200510037848.2

(29) Xu Ximing, Yu Jiangnan, Zhu Yuan, Tong Shanshan, Preparation of Silybin nanoparticle, 2007.12.26, China, ZL200510094008.X

(30) Yu Jiangnan, Huang Zhimin, Zhu Yuan, Xu Ximing, Cao Xia, a double-coated silybin sustained-release pellets and preparation method, 2017.09.26, China, ZL 201410295059.8

(31) Xu Ximing, Zhu Yuan, Wang Miaomiao, Yu Jiangnan, Preparation and Application of capsaicine nano micelles, 2016.04.13, China, ZL201410141437.7

(32) Yu Jiangnan, Sun Chaonan, Zhu Yuan, Xu Ximing, Tong Shanshan, Preparation of Ph-sensitive gel microspheres containing capsaicine, 2016.08.17, China, ZL 201410292559.6

(33) Yuan Zhu, Yunqiu Chen, Shuang Li, Youwu Liao, Yuanyuan Xue, Xu Ximing, Preparation of astaxanthin amorphous solid dispersions by electrostatic spray method, 2022.05.20, China, ZL 202110602217.X

(34) Xu Ximing, Jiang Dongmei, Yu Jiangnan, Zhu Yuan, Wang Qiang, an oral preparation of sustained-release cyclosporine A pellets and its preparation method, 2017.06.30, China, ZL201410514157.6

(35) Xu Ximing, Zheng Qianfeng, Zhu Yuan, Yu Jiangnan, Shi Feng, Preparation of Nano-sized Hollow silica containing capsaicine and its preparation method, 2016.08.10, China, ZL201410291386.6

(36) Xu Ximing, Jiang Dongmei, Yu Jiangnan, Zhu Yuan, A double-coated sustained release pellet preparation of Cyclosporine A and its preparation method, 2016.12.14, China, ZL201480001191.1

(37) Xu Ximing, Zhu Yuan, Wang Miaomiao, Lu Shuang, Yu Jiangnan, Preparation of shikimic acid core-shell nanopreparation, 2020.10.20, China, ZL201610312911

(38) Xu Ximing, Yu Jiangnan, Shen Song, Zhu Yuan, Effective oral silybin sustained-release preparation and preparation method, 2010.08.25, China, ZL200610096780

(39) Xu Ximing, Shi Xiaolei, Zhu Yuan, Yu Jiangnan, Shen Yuping, Ginkgo Ester solid self-emulsion sustained release pellets and preparation method, 2017.09.22, ZL201410291439, China

(40) Yu Jiangnan, Tong Shanshan, Xu Ximing, Cao Xia, Yi Chengxue, Fu Min, Preparation of a lipid raft modified column and its application in the screening of antitumor active sites of traditional Chinese Medicine, 2016.01.13, China, ZL201210467778

(41) Yu Jiangnan, Feng Yingshu, Xu Ximing, Zhang Weiming, Preparation and Application of capsaicin-Vitamin E predrug self-assembled Nanoparticles, 2021.12.28, China, ZL201680001930

(42) Yu Jiangnan, Tong Shanshan, Xu Ximing, Fu Min, Yang Yan, Feng Yingshu, Preparation and Application of extracts from Gallnut, 06.10, 2015, ZL201210474797, China

(43) Xu Ximing, Wang Qilong, Yu Jiangnan, Ding Lixia, Cao Xia, Qu Rui, Tong Shanshan, Screening method and application of a multi-target antitumor Chinese medicine Active component, 2017.09.26, China, ZL201480001270

(44) Yuan Zhu, Wen Xu, Youwu Liao, Jianyin Yu, Ximing Xu, Preparation of astaxanthin nanoparticle by electrostatic spray, 2021.05.25, China, ZL201811389494

(45) Xu Ximing, Yu Jiangnan, Zhu Yuan, Prannico-Phosphate-cholate ternary composition used as an insoluble drug carrier, 2006.08, China, ZL200410065983.3

(46) Xu Ximing, Preparation of 2-amino-4-carbonyl -7-(3, 4-dimethoxy-phenylmethyl) -5-vinyl-6, 7-dihydro-3h-pyrrole [2, 3-D] pyrimidine, April 2015, ZL201210299670.9, China

PROFESSIONAL MEMBERSHIPS

Vice-chairman, Pharmaceutical Science Committee of Jiangsu Pharmaceutical Association;

Editorial board member of Acta Pharmaceutica Sinica, China Journal of Chinese Materia Medica, Chinese Journal of Pharmaceutical Analysis

JOURNAL PAPER REVIEWER

Advanced Materials

Advanced Functional Materials

ACS Applied Materials & Interfaces

Acta Biomaterialia

Biomaterials

International Journal of Pharmaceutics

Journal of Controlled Release

Molecular Pharmaceutics