Part 1 Basic Information

Name: Yuan Wei

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Tel: 0511-85038750

Email: ywei@ujs.edu.cn

Part 2 Personal Profile

Dr. Yuan Wei is a Professor and Dean of the School of Pharmacy, Jiangsu University, and a young core teacher of Jiangsu Province's 'Qinglan Project'. He received his Ph.D. in Environmental Health Sciences (Toxicology) from the School of Public Health, University at Albany, State University of New York. His research focuses on cytochrome P450-related drug metabolism and toxicology, and molecular pharmacognosy. He has led research projects funded by the National Key R&D Program of China (intergovernmental international cooperation project), the National Natural Science Foundation of China (General and Young Scientist programs), and the Jiangsu Provincial Natural Science Foundation. He has published over 70 papers in peer-reviewed journals, including Acta Pharmaceutica Sinica B, Drug Metabolism and Disposition, Journal of Ethnopharmacology, and Chinese Medicine, and holds one authorized Chinese invention patent. He is a member of the International Society for the Study of Xenobiotics (ISSX), and serves as a committee member of the Toxicology and Safety Evaluation Branch of the China Association of Chinese Medicine and the Molecular Pharmacognosy Committee of the Chinese Association of Integrative Medicine.

Part 3 Education

2003.09–2010.02, University at Albany, State University of New York, Environmental Health Sciences (Toxicology), Ph.D.

1999.09–2003.07, Nanjing University, Biochemistry, B.S.

Part 4 Work Experience

2020.05–Present, School of Pharmacy, Jiangsu University, Dean, Professor

2019.05–2020.05, School of Pharmacy, Jiangsu University, Party Secretary, Professor

2014.05–2019.05, School of Pharmacy, Jiangsu University, Party Secretary, Associate Professor

2011.05–2014.05, School of Pharmacy, Jiangsu University, Vice Dean, Associate Professor

2010.03–2011.05, School of Pharmacy, Jiangsu University, Associate Professor

2004.05–2010.02, Wadsworth Center, New York State Department of Health, Research Assistant (Ph.D. student)

Part 5 Research Interests

1. Cytochrome P450 enzymes in drug/xenobiotic metabolism and drug-induced liver injury

2. RNAi- and genome-editing-based modulation of drug-metabolizing enzymes for liver disease intervention

3. Metabolism and toxicology of active ingredients from traditional Chinese medicine (triptolide, pulegone, Houttuynia cordata injection, etc.)

4. Molecular pharmacognosy and quality formation mechanisms of geo-herbal medicines

Part 6 Research Achievements

6.1 Research Projects

2024.10–2027.12 | “Construction of TCM Life-Omics Big Data Foundation” under the Key project at central government level/The ability establishment of sustainable use for valuable Chinese medicine resources. | Central Government Budget | Principal Investigator (4.5 million CNY)

2021.01–2023.12 | National Key R&D Program of China (Intergovernmental International Cooperation Project, sub-project) "Construction of the China–Austria Joint Laboratory on Prevention and Treatment of Major Infectious Diseases with Traditional Chinese Medicine (Belt and Road)" (No. 2020YFE0205100) | Ministry of Science and Technology | Principal Investigator (0.35 million CNY)

2020.11–2023.12 | “Molecular Mechanism of Chemotype Formation of Geo-herbal Mentha haplocalyx” under the Key project at central government level/The ability establishment of sustainable use for valuable Chinese medicine resources. | Central Government Budget | Principal Investigator (0.27 million CNY)

2014.01–2017.12 | NSFC General Program "Construction and Application of CYP450 Gene Knockout Rat Models Based on TALEN Technology" (No. 81373480) | National Natural Science Foundation of China | Principal Investigator (0.65 million CNY)

2012.01–2016.12 | Jiangsu "Qinglan Project" Young Core Teacher Fund | Jiangsu Provincial Department of Education | Principal Investigator

2012.01–2014.12 | NSFC Young Scientists Fund "Extrahepatic Metabolism and Toxicology of Triptolide Based on XH-CL Gene Knockout Mouse Models" (No. 81102522) | National Natural Science Foundation of China | Principal Investigator (0.22 million CNY)

2012.01–2014.12 | Jiangsu Provincial Natural Science Foundation "Role of Extrahepatic CYP450 Metabolism in Triptolide-Induced Multi-System Toxicity" (No. BK2011473) | Jiangsu Provincial Department of Science and Technology | Principal Investigator (0.10 million CNY)

Jiangsu Postdoctoral Research Funding Program (No. 1201081C) | Jiangsu Provincial Department of Human Resources and Social Security | Principal Investigator

Jiangsu University Advanced Talent Fund | Jiangsu University | Principal Investigator

6.2 Publications

1. Zhang Z, Jiang W, Sang R, Ouyang Z, Wu Q, Wei Y. Liver-directed Cyp2e1 RNA interference attenuates hepatotoxicity induced by triptolide, a bioactive diterpenoid from Tripterygium wilfordii Hook. f. [J]. Pharmaceuticals, 2026, 19(7): 1087.

2. Liu W, Huan L, Zhang C, Yin R, Ouyang Z, Wei Y. Amelioration of acetaminophen-induced hepatic oxidative stress and inflammation by RNAi targeting Cyp2e1 in vivo [J]. Current Issues in Molecular Biology, 2025, 47(5): 372.

3. Jiang W, Sang R, Zhang C, Yin R, Ouyang Z, Wei Y. Application of small interfering RNA technology in cytochrome P450 gene modulation [J]. Drug Metabolism and Disposition, 2025. DOI: 10.1016/j.dmd.2025.100040.

4. Huan L, Zhang Y, Liu W, Lu H, Zhang C, Yin R, Ouyang Z, Wei Y. In vivo inhibition of CYP2E1 fails to reduce pulegone-induced liver injury in mice [J]. Xenobiotica, 2025. DOI: 10.1080/00498254.2025.2493620.

5. Zhang Q, Wu S, Chen Q, Zhang Y, Zhang C, Yin R, Ouyang Z, Wei Y. Reducing oxidative stress-mediated alcoholic liver injury by multiplexed RNAi of Cyp2e1, Cyp4a10, and Cyp4a14 [J]. Biomedicines, 2024, 12(7): 1505.

6. Chen Q, Wang T, Wu X, Yuan H, Wei Y, et al. The role of the cytochrome P450 superfamily in the skin [J]. Expert Reviews in Molecular Medicine, 2024.

7. Wang Y, Chen Q, Wu S, Sun X, Yin R, Ouyang Z, Yin H, Wei Y. Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1 [J]. Acta Pharmaceutica Sinica B, 2023, 13(9): 3906-3918.

8. Sun X, Lv W, Wang Y, Zhang X, Ouyang Z, Yin R, Wei Y. Mrgprb2 gene plays a role in the anaphylactoid reactions induced by Houttuynia cordata injection [J]. Journal of Ethnopharmacology, 2022, 289: 115021.

9. Fan X, Chen J, Zhang Y, et al. Alpinetin promotes hair regeneration via activating hair follicle stem cells [J]. Chinese Medicine, 2022, 17(1): 63.

10. Zhou H, Yang L, Wang C, Li Z, Ouyang Z, Shan M, Gu J, Wei Y. CYP2D1 gene knockout reduces the metabolism and efficacy of venlafaxine in rats [J]. Drug Metabolism and Disposition, 2019, 47(12): 1425-1432.

11. Wei Y, Yang L, Zhang X, Sui D, Wang C, Wang K, et al. Generation and characterization of a CYP2C11-null rat model by using the CRISPR/Cas9 method [J]. Drug Metabolism and Disposition, 2018, 46(8): 1126-1134.

12. Wei Y, Wang D, Chen M, Ouyang Z, Wang S, Gu J. Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity [J]. Chinese Medicine, 2018, 13: 20.

6.3 Monographs and Textbooks

(To be updated)

6.4 Patents and Software Copyrights

Wei Y, et al. Cytochrome P450 gene detection chip for lung cancer risk in smokers: ZL 2011 1 0123137.2 [P]. Granted.