Part 1 Basic Information

Name: Yuan Zhu

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: zhuyuanemail@126.com

Part 2 Personal Profile

Yuan Zhu, male, is Deputy Director of the Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Associate Professor, and Master’s Supervisor. He is a recipient of the Jiangsu Province “Six Talent Peaks” High-level Talent Program and a Visiting Scholar at the University of Texas at Austin, USA. Since joining the School of Pharmacy of Jiangsu University as a faculty member in 2002, he has mainly been engaged in the teaching of theoretical and experimental courses in pharmaceutics, biopharmaceutics, and pharmacokinetics. He has published 2 teaching reform papers, received 2 second prizes for university-level teaching achievement awards, and was awarded the titles of Outstanding Class Advisor of Jiangsu University, Outstanding Academic Mentor of Jiangsu University, and Outstanding Teacher of Jingjiang College of Jiangsu University. In 2014, he was awarded the title of Outstanding Teacher of Jiangsu University, and in 2019, the title of “New Long March Pacesetter” of Jiangsu University. He is the leader of university-level first-class courses and internationalized professional English-taught excellent courses, a member of the American Association of Pharmaceutical Scientists (AAPS), and a reviewer for SCI journals such as Food Chemistry and Drug Development and Industrial Pharmacy. His main research directions include novel dosage forms and technologies of pharmaceutical preparations; microencapsulation of food-derived bioactive components and their efficient utilization; and solubilization of poorly soluble drugs and the R&D of sustained- and controlled-release preparations. In recent years, he has led 1 General Program of the National Natural Science Foundation of China, 1 project under the 16th batch of the Jiangsu Province “Six Talent Peaks” High-level Talent Support Program, and 1 Jiangsu University Senior Talent Research Startup Fund. He has led and completed 1 China Postdoctoral Science Foundation project, 1 Natural Science Research Project for Higher Education Institutions of Jiangsu Province, and 1 Jiangsu University Doctoral Innovation Program project, and has participated in 6 NSFC projects. He has published more than 50 papers, including more than 40 SCI-indexed papers. He has applied for 20 Chinese invention patents, of which 16 have been authorized, and 4 international PCT patents, of which 3 have been granted as US patents. The projects “Innovative Key Technology Research and Application of Natural Hepatoprotective Drugs and Their Preparations” and “Key Technologies for Modern Pharmaceutical Preparation R&D and Their Applications” received First Prize of the Outstanding Scientific Research Achievement Award of Higher Education Institutions, Ministry of Education; he also received one Special Prize and one First Prize of the Science and Technology Progress Award of the China General Chamber of Commerce, and one Third Prize of the Jiangsu Provincial Science and Technology Progress Award.

Part 3 Education

•2009.09—2014.12，Jiangsu University，Clinical Laboratory Diagnostics，ph.D

•2004.09—2007.07， Jiangsu University，Pharmaceutics，M.S.

•1998.09—2002.07，China Pharmaceutical University，Pharmaceutics，B.S.

Part 4 Work Experience

•2002.09–Present, School of Pharmacy, Jiangsu University, Assistant Lecturer, Lecturer, Associate Professor and Master's Supervisor

Part 5 Research Interests

1. Novel dosage forms and emerging technologies for pharmaceutical preparations

2. Microencapsulation and efficient utilization of food-derived bioactive ingredients

3. Solubilization of poorly soluble drugs and development of sustained- and controlled-release formulations

Part 6 Research Achievements

6.1 Research Projects

•2019.01—2022.12｜General Program of the National Natural Science Foundation of China “Research on the Construction of an Astaxanthin Composite Micelle Microencapsulation System via Superheated Water Powder Coupled with Electrospray Technology and Its Solubilization and Absorption Mechanisms” (Project No.: 31871810)｜National Natural Science Foundation of China｜Principal Investigator

•2019.09—2022.08｜The 16th Batch of Jiangsu Province “Six Talent Peaks” High-level Talent Support Program “Research on Electrospray Mode Design of Polymorphic Drug Micro/Nano Delivery Systems Based on Microenvironment Regulation and Their Stability-Controlled Release Synergistic Effect” (Project No.: SWYY-163)｜Organization Department of Jiangsu Provincial Party Committee and Department of Human Resources and Social Security of Jiangsu Province｜Principal Investigator

•2015.06—2017.06｜Natural Science Research General Program for Higher Education Institutions of Jiangsu Province “Construction and Application Research of Hydroxyapatite Composite Nano Drug Delivery System” (Project No.: 14KJB350002)｜Jiangsu Provincial Department of Education｜Principal Investigator

•2015.06—2017.06｜General Financial Grant from the China Postdoctoral Science Foundation “Research on Astaxanthin Microencapsulation Technology Based on Electrospinning and Its Oral Absorption Mechanism” (Project No.: 2015M571700)｜China Postdoctoral Science Foundation｜Principal Investigator

•2020.01—2025.12｜Industrialization Development of a Series of Medical Device Microspheres and Class I and Class II Medical Devices｜Enterprise Collaborative Project｜Principal Investigator, Participant

• 2017.06—2019.06｜Research and Development of Ticagrelor Tablets (90 mg/tablet) (Contract No.: 20170200)｜Changzhou Pharmaceutical Factory Co., Ltd.｜Participant

•2014.12—2016.12｜Research and Development of Nintedanib Soft Capsules (Contract No.: 2014333)｜Jiangsu Aosaikang Pharmaceutical Co., Ltd.｜Participant

• 2013.03—2015.03｜Research and Development of Azithromycin Dispersible Tablets (Contract No.: 2013074)｜Shenyang Pharmaceutical University Pharmaceutical Co., Ltd. (Cooperation)｜Participant

•2009.01—2012.12｜Tamsulosin Hydrochloride Sustained-release Capsules (Contract No.: 2008292)｜Yangtze River Pharmaceutical Group｜Participant

•2010.01—2013.12｜Development of HBS Sustained-release Tablets (Contract No.: 2009310)｜Yangtze River Pharmaceutical Group｜Participant

• 2009.01—2012.12｜Key Technology Development and Industrialization of High-purity Silibinin Raw Material and Silibinin Self-emulsifying Tablets (Contract No.: CZ2009009)｜Jiangsu Zhongxing Pharmaceutical Co., Ltd.｜Participant

•2007.01—2010.12｜Development of Zhengganbao (Contract No.: 2006304)｜Zhenjiang Zhengdong Ecological Agriculture Co., Ltd.｜Participant

6.2 Publications

1.Chengwei Wang#, Haiqiao Wang#, Michael Adu-Frimpong#, Zhihui Zou, Zhou Jin, Peiqi Lu, Zhenrong Liu, Haojie Tian, Ying Xu, Kailun Yang, Jiangnan Yu, Ximing Xu, Yuan Zhu*. Sustained-release Drug Delivery System of Trazodone Hydrochloride Based on Electrospray Technology: Preparation, Characterization, In Vitro and In Vivo Evaluation[J]. AAPS PharmSciTech, 2026, 27(1): 52.

2.Yuan Zhu, Yongqi Lv, Jiaqi Xu, Yingshu Feng, Caleb Kesse Firempong, Runfeng Wang, Haibing He, Guoqing Zhang, Hongfei Liu. Microfluidic-based intra-articular sustained release of triamcinolone acetonide microsphere-gel composite system[J]. Drug Development and Industrial Pharmacy, 2026, 52(4): 720.

3.Yuan Zhu*#, Peiqi Lu#, Youwu Liao#, Michael Adu-Frimpong, Zhihui Zou, Zhou Jin, Chengwei Wang, Min Peng, Houping Peng, Jing Xu, Ying Xu, Jiangnan Yu, Ximing Xu*. Core–shell structural PLGA nanoparticle of astaxanthin fabricated via micelle template for sustained release in vitro and long-term hepatoprotective effect in vivo[J]. Journal of Nanoparticle Research, 2025, 27(4): 1-14.

4.Zhihui Zou#, Yuanyuan Xue#, Michael Adu-Frimpong#, Chengwei Wang, Zhou Jin, Ying Xu, Jiangnan Yu, Ximing Xu, Yuan Zhu*. Formononetin-Loaded Self-Microemulsion Drug Delivery Systems for Improved Solubility and Oral Bioavailability: Fabrication, Characterization, In Vitro and In Vivo Evaluation[J]. AAPS PharmSciTech, 2024, 25(8): 261.

5.Yuan Zhu, Jiaqi Xu, Xiaoyan Chen, Yingshu Feng, Caleb Kesse Firempong, Haibing He, Hongfei Liu. Preparation of core-shell targeted tracer recombinant human interleukin II microspheres via coaxial electrostatic spraying[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(6): 495-510.

6.Yuan Zhu*, Haiqiao Wang, Michael Adu-Frimpong, Zhihui Zou, Zhou Jin, Peiyao Zhang, Yuanyuan Xue, Shuang Li, Ying Xu, Jiangnan Yu, and Ximing Xu. HA/PLA Composite Nanoparticles for Enhanced Oral Bioavailability of Capsaicin: Fabrication, Characterization and in vitro-in vivo Evaluation[J]. ChemistrySelect, 2024, 9(4): e202303080.

7.Youwu Liao, Haiqiao Wang, Shuang Li, Yuanyuan Xue, Yunqiu Chen, Michael Adu-Frimpong, Ying Xu, Jiangnan Yu, Ximing Xu, Hugh D.C. Smyth* and Yuan Zhu*. Preparation of astaxanthin-loaded composite micelles with coaxial electrospray technology for enhanced oral bioavailability and improved antioxidation capability[J]. Journal of the Science of Food and Agriculture, 2023, 104(3): 1408-1419.

8.Yuan Zhu#, Shuang Li#, Haiqiao Wang#, Michael Adu‐Frimpong, Yuanyuan Xue, Zhengqing Gu, Jiangnan Yu, Ximing Xu*. Enhanced oral bioavailability of capsaicin‐loaded microencapsulation complex via electrospray technology: Preparation, in vitro and in vivo evaluation[J]. Biopharmaceutics & Drug Disposition, 2023, 44(2): 137-146.

9.Yuanyuan Xue#, Youwu Liao#, Haiqiao Wang, Shuang Li, Zhengqing Gu, Michael Adu-Frimpong, Jiangnan Yu, Ximing Xu, Hugh D. C Smyth and Yuan Zhu*. Preparation and evaluation of astaxanthin-loaded 2-hydroxypropyl-betacyclodextrin and Soluplus® nanoparticles based on electrospray technology[J]. Journal of the Science of Food and Agriculture, 2023, 103(7): 3628-3637.

10.Zhengqing Gu, Yuanyuan Xue, Shuang Li, Michael Adu‑Frimpong, Ying Xu, Jiangnan Yu, Ximing Xu, Yuan Zhu*. Design, Characterization, and Evaluation of Diosmetin‑Loaded Solid Self‑microemulsifying Drug Delivery System Prepared by Electrospray for Improved Bioavailability[J]. AAPS PharmSciTech, 2022, 23(4): 106.

11.Yuan Zhu#, Zhengqing Gu#, Youwu Liao, Shuang Li, Yuanyuan Xue, Michael Adu Firempong, Ying Xu, Jiangnan Yu, Hugh DC Smyth* and Ximing Xu*. Improved intestinal absorption and oral bioavailability of astaxanthin using poly (ethylene glycol)-graft-chitosan nanoparticles: preparation, in vitro evaluation, and pharmacokinetics in rats[J]. Journal of the Science of Food and Agriculture, 2021, 102(3), 1002-1011.

12.Yuan Zhu#, Jianyin Yu#, Guanghui Zhou#, Zhengqing Gua, Michael Adu-Frimponga,b, Wenwen Denga, Jiangnan Yu, Ximing Xu*. Piperine fast disintegrating tablets comprising sustained-release matrix pellets with enhanced bioavailability: formulation, in vitro and in vivo evaluation[J]. Pharmaceutical Development and Technology, 2020, 25(5): 617-624.

13.Yuan Zhu#, Wen Xu#, Jiajia Zhang#, Youwu Liao, Caleb Kesse Firempong, Michael Adu-Frimpong, Wenwen Deng, Huiyun Zhang, Jiangnan Yu, Ximing Xu*. Self-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation[J]. AAPS PharmSciTech, 2019, 20: 153.

14.Miaomiao Wang, Yuanwen Wang, E. Omari-Siaw, Shengli Wang, Yuan Zhu*, Ximing Xu*. Reduced Burst Release and Enhanced Oral Bioavailability in Shikimic Acid-loaded PLA Submicron Particles by Coaxial-Electrospray[J]. Journal of Pharmaceutical Sciences, 2016, 105: 2427-2436.

15.Yuan Zhu#, Miaomiao Wang#, Ya Zhang, Jin Zeng, E. Omari-Siaw, Jiangnan Yu, Ximing Xu*. In Vitro Release and Bioavailability of Silybin from Micelle Templated Porous Calcium Phosphate Microparticles[J]. AAPS PharmSciTech, 2016, 17(5): 1232-1239.

16.Yuan Zhu, Miaomiao Wang, Jiajia Zhang, Wei Peng, Caleb Kesse Firempong, Wenwen Deng, Qilong Wang, Shicheng Wang, Feng Shi, Jiangnan Yu, Ximing Xu*, Weiming Zhang*. Improved oral bioavailability of capsaicin via liposomal nanoformulation: preparation, in vitro drug release and pharmacokinetics in rats[J]. Archives of Pharmacal Research, 2015, 38(4): 512-521.

17.Yuan Zhu#, Jiajia Zhang#, Qianfeng Zheng#, Miaomiao Wang#, Wenwen Deng, Li Qiang, Caleb Kesse Firempong, Shengli Wang, Shanshan Tong, Ximing Xu*, Jiangnan Yu*. In vitro and in vivo evaluation of capsaicin-loaded microemulsion for enhanced oral bioavailability [J]. Journal of the Science of Food and Agriculture, 2015, 95(13): 2678–2685.

18.Yuan Zhu#, Wei Peng#, Jiajia Zhang#, Miaomiao Wang#, Caleb Kesse Firempong, Chunlai Feng, Hongfei Liu, Ximing Xu*, Jiangnan Yu*. Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation[J]. Journal of Functional Foods, 2014, 8: 358-366.

19.Yuan Zhu#, Jiajia Zhang#, Min Fu#, Jin Zeng#, E. Omari-Siaw, Jiangnan Yu, Xi-ming Xu*. Calcium carbonate nanoparticles templated by mixed polymeric micelles: characterization, in vitro drug release and oral bioavailability in Beagle dogs[J]. Latin American Journal of Pharmacy, 2014, 33(7): 1106-1113.

20.Yuan Zhu, Jiangnan Yu*, Shanshan Tong, Li Wang, Min Peng, Xia Cao, Ximing Xu*. Preparation and In Vitro Evaluation of Povidone-Sodium Cholate-Phospholipid Mixed Micelles for Solubilization of Poorly Soluble Drugs[J]. Archives of Pharmacal Research, 2010, 33(6): 911-917.

6.3 Monographs and Textbooks

[Format] Author | Title | Publisher | Year | ISBN (indicate sole author / editor / associate editor / contributor).

•Xu Ximing, Editor-in-Chief. 《Industrial Pharmaceutics（Second Editio）》[M]. Beijing: People's Medical Publishing House, 2024. (Contributing Author, Chief Reviewer, National Health Commission "14th Five-Year Plan" Textbook)

6.4 Patents and Software Copyrights

•Xu Ximing, Yu Jiangnan, Cao Xia, Zhu Yuan. Formulation of Silybinin with High Efficacy and Prolonged Action and the Preparation Method Thereof[P]. United States Patent: US9023388, 20150505

•Xu Ximing, Yu Jiangnan, Tong Shanshan, Zhu Yuan, Cao Xia. Formulation of Silymarin with High Efficacy and Prolonged Action and the Preparation Method Thereof[P]. United States Patent: US8962017, 20150224

•Xu Ximing, Yu Jiangnan, Zhu Yuan, Cao Xia. Highly Efficient and Long-acting Slow-release formulation of Poorly Soluble Drugs and Preparation Method Thereof[P]. United States Patent: US9283190, 20160315

•Yuan Zhu, Zhengqing Gu, Shuang Li, Yuanyuan Xue, Ximing Xu. Diosmetin solid self-microemulsifying nanoparticles prepared by electrospray method and preparation method thereof (ZL202111219162.0) 2023.08.22

•Yuan Zhu, Youwu Liao, Shuang Li, Zhengqing Gu, Yuanyuan Xue, Houping Peng. A long-acting astaxanthin nanoformulation prepared by micelle template method and preparation method thereof (ZL202110382269.0) 2023.07.18

•Yuan Zhu, Yunqiu Chen, Shuang Li, Youwu Liao, Yuanyuan Xue, Ximing Xu. An astaxanthin amorphous solid dispersion prepared by electrospray method and preparation method thereof (ZL202110602217.X) 2022.05.20

•Yuan Zhu, Wen Xu, Youwu Liao, Jianyin Yu, Ximing Xu. An astaxanthin nanoformulation prepared by electrospray method and preparation method thereof (ZL201811389494.1) 2021.05.25