Part 1 Basic Information

Name: Wenwen Deng

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: dengww@ujs.edu.cn

Part 2 Personal Profile

Deng Wenwen, female, is an Associate Professor and Master’s Supervisor at the School of Pharmacy, Jiangsu University. She has led one Young Scientists Fund project of the National Natural Science Foundation of China (NSFC) and one General Program project of the China Postdoctoral Science Foundation, participated in one NSFC Key International Cooperation Program project, and participated in three NSFC General Program projects. She has published more than 40 SCI papers in academic journals such as Advanced Materials, Carbohydrate Polymers, and Small, obtained 5 authorized invention patents in China, and filed 2 PCT patent applications.

Part 3 Education

•2012.09 - 2016.06 Jiangsu University, Clinical Laboratory Diagnostics, Ph.D.

•2008.09 - 2011.06 Jiangsu University, Pharmaceutics, M.S.

•2004.09 - 2008.06 Jiangsu University, Pharmaceutical Engineering, B.S.

Part 4 Work Experience

•2022.07 till now Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Associate Professor

•2019.11 - 2022.07 Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Lecture

•2016.06 - 2019.11 Materials Science and Engineering School of Pharmacy, Jiangsu University, Post-doctor

Part 5 Research Interests

1.Natural biomaterials for nano gene transfer and stem cell-based tissue engineering;

2.Cell reprogramming by small chemical molecules;

3.Controlled release preparations and Pharmacokinetic evaluation of poorly soluble drugs;

4.Screening and formulation development of active components from Traditional Chinese Medicine

Part 6 Research Achievements

6.1 Research Projects

•1. National Natural Science Foundation of China, Youth Project (PI, No.:81803475), Construction of Platelet membrane-Self-assembled Nanodrug Delivery System and Its Direct reprogramming Induced astrocyte Targeting, 2019-01 to 2021-12, 0. 21 million RMB;

•2. China Postdoctoral Science Foundation, the 62nd batch of surface project (PI, No.:2017M621658) curcumin Self-assembly Nanoparticles induced Direct reprogramming of astrocytes, 2017-09 to 2019-06, 0.05 million RMB;

•3. National Natural Science Foundation of China, International (regional) Cooperation and Exchange Project, 81720108030, Research on 3D Bionic Printing Positioning, Gradient, Long-term Drug Release System and its Repair of Spinal cord Injury, 2018-01 to 2022-12, 2.33 million RMB, participate;

•4. National Natural Science Foundation of China, Surface Project, 81473172, Research on Somatic cell direct reprogramming mediated by DNA-Cationic Polysaccharides and carbon quantum Dots Self-Assembly Nanoparticles, 2014-01 to 2018-12, one million RMB, Participate;

•5. National Natural Science Foundation of China, Surface Project, 81273470, Construction of microRNA non-viral nanodelivery System and Its Promotion of Somatic Cell Reprogramming, 2013-01 to 2016-121 million RMB, participated;

•6.Project of National Natural Science Foundation of China, Surface Project, 81373371, Hepatocyte Differentiation and Metabolic Function in human iPSC three-dimensional system, 2014-01 to 2017-12,650 RMB, participate.

6.2 Publications

1.Xiaoyi Qian, Ximing Xu*, Wenwen Deng*. Advances in marine polysaccharides for the prevention and treatment of diabetes[J]. Carbohydrate Polymers, 2026, 381: 125189. (SCI，XinRui Ranking Tier 1，top journal，IF:13.2)

2.Yuxiang He, Zhe Wang, Zeyu Xu, Huiya Wang, Lili Yuan, Ximing Xu*, Wenwen Deng*. Regulatory effects of natural polysaccharides on skin wound repair through modulation of immune-microbiome interactions[J]. International Journal of Biological Macromolecules, 2026, 359: 151732. (SCI，XinRui Ranking Tier 2，top journal，IF:8.7)

3.Wenwen Deng, Xiufen Yang, Jiangnan Yu, Emmanuel Omari-Siaw, Ximing Xu*. Recent advances of physiochemical cues on surfaces for directing cell fates[J]. Colloids and Surfaces B: Biointerfaces, 2025, 250:114550. (SCI，XinRui Ranking Tier 1，IF:5.9)

4.Peng Fu, Xiufen Yang, Wenwen Deng*, Jiangnan Yu*, Ximing Xu*. Advances in cerebral edema research and targeted drug delivery systems[J]. European Journal of Pharmacology, 2025, 1000: 177744. (SCI，XinRui Ranking Tier 2，top journal，IF:5.7)

5.Ximing Xu#, Xinyu Zhang#, Ran Li#, Xiufen Yang, Peng Fu, Ruijie Feng, Xuan Sun, Zhe Wang, Jiangnan Yu, Xia Cao, Qingtong Yu, Qilong Wang, Sitong Liu, Xiaoxia Yang, Yuan Zhu, Wentao Shi, Wenwen Deng*. Platelet Membrane-Coated Curcumin-PLGA Nanoparticles Promote Astrocyte-Neuron Transdifferentiation for Intracerebral Hemorrhage Treatment[J]. Small, 2024, 20(42): 2311128. (SCI，XinRui Ranking Tier 2，top journal，IF:11.8)

6.Fengxia Shao#, Xuan Sun#, Qingtong Yu#, Kaili Wang, Congyong Sun, Qilong Wang, Xia Cao, Linzhi Zhang, Peng Fu, Xiufen Yang, Jiangnan Yu*, Ximing Xu*, Wenwen Deng*. Lycium barbarum oligosaccharide-derived carbon quantum dots inhibit glial scar formation while promoting neuronal differentiation of neural stem cells[J]. International Journal of Biological Macromolecules, 2024, 282(6): 137474. (SCI，XinRui Ranking Tier 2，top journal，IF:8.7)

7.Wenwen Deng#, Fengxia Shao#, Qinghua He#, Qiang Wang, Wentao Shi, Qingtong Yu, Xia Cao, Chunlai Feng, Shiqi Bi, Jiaxin Chen, Ping Ma, Yang Li, Aihua Gong, Shanshan Tong, Jiangnan Yu, Myron Spector, Ximing Xu*, and Zhijian Zhang*. Ectomesenchymal stem cells build an all-in-one niche for promoted neuronal but suppressed astroglial differentiation of neural stem cells[J]. Advanced Materials, 2019, 31(10): 1806861. (SCI，XinRui Ranking Tier 1，top journal，IF:29.1)

8.Wenwen Deng, Xia Yang, Yuan Zhu, Jiangnan Yu, and Ximing Xu*. Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides. Food Science & Nutrition 2019, 7(8): 2674-2683. (SCI，XinRui Ranking Tier 2，top journal，IF:5.0)

9.Qilong Wang#, Qiuxuan Yang#, Xia Cao#, Qiuyu Wei, Caleb K. Firempong, Min Guo, Feng Shi, Ximing Xu⁎, Wenwen Deng*, Jiangnan Yu*. Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles[J]. International Journal of Pharmaceutics, 2018, 550: 24–34. (SCI，XinRui Ranking Tier 2，top journal，IF:6.0)

10.Yao Xu, Huiyan Jiang, Congyong Sun, Michael Adu-Frimpong, Wenwen Deng*, Jiangnan Yu*, XimingXu*. Antioxidant and hepatoprotective effects of purified Rhodiola rosea polysaccharides[J]. International Journal of Biological Macromolecules, 2018,117:167–178. (SCI，XinRui Ranking Tier 2，top journal，IF:8.7)

11.Jiaxin Chen#, Qiang Wang#, Jie Zhou#, Wenwen Deng#, Qingtong Yu, Xia Cao, Jianping Wang, Fengxia Shao, Yang Li, Ping Ma, Myron Spector, Jiangnan Yu, and Ximing Xu*. Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells[J]. Nanoscale, 2017, 9(30): 10820-10831. (SCI，XinRui Ranking Tier 2，IF:5.2)

12.Wenwen Deng#, Xia Cao#, Yan Wang#, Qingtong Yu, Zhijian Zhang, Rui Qu, Jingjing Chen, Genbao Shao, Xiangdong Gao, Ximing Xu*, Jiangnan Yu*. Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification[J]. Journal of Agricultural and Food Chemistry, 2016, 64(6): 1264-1273. (SCI，XinRui Ranking Tier 1，top journal，IF:6.7)

13.Zhou Jie#, Wenwen Deng#, Yan Wang#, Xia Cao, Jingjing Chen, Qiang Wang, Wenqian Xu, Pan Du, Qingtong Yu, Jingjing Chen, Myron Spector, Jiangnan Yu*, Ximing Xu*. Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake[J]. Acta Biomaterialia, 2016, 42:209-219. (SCI，XinRui Ranking Tier 1，top journal，IF:10.4)

14.Wenwen Deng#, Xia Cao#, Qiang Wang#, Yan Wang, Jingjing Chen, Qingtong Yu, Zhijian Zhang, Jie Zhou, Wenqian Xu, Pan Du, Jiaxin Chen, Xiangdong Gao, Jiangnan Yu, Ximing Xu*. Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming[J]. ACS Applied Materials & Interfaces, 2016, 8(31): 19916-19927. (SCI，XinRui Ranking Tier 2，IF:7.8)

15.Zhijian Zhang#, Qinghua He#, Wenwen Deng#, Qian Chen, Xinyuan Hu, Aihua Gong, Xia Cao, Jiangnan Yu, Ximing Xu*. Nasal ectomesenchymal stem cells: Multi-lineage differentiation and transformation effects on fibrin gels[J]. Biomaterials, 2015, 49: 57-67 (SCI，XinRui Ranking Tier 1，top journal，IF:13.6)

16.Xia Cao#, Wenwen Deng#, Rui Qu#, Qingtong Yu, Jun Li, Yan Yang, Yue Cao, Xiangdong Gao, Ximing Xu, Jiangnan Yu. Non-Viral Co-Delivery of the Four Yamanaka Factors for Generation of Human Induced Pluripotent Stem Cells via Calcium Phosphate Nanocomposite Particles[J]. Advanced Functional Materials, 2013, 23(43): 5403-5411. (SCI，XinRui Ranking Tier 1，top journal，IF:19.9)

17.Wenwen Deng, Min Fu, Yue Cao, Xia Cao, Miao Wang, Yan Yang, Rui Qu, Jun Li, Ximing Xu*, Jiangnan Yu. Angelica sinensis polysaccharide nanoparticles as novel non-viral carriers for gene delivery to mesenchymal stem cells[J]. Nanomedicine: Nanotechnology, Biology and Medicine 2013, 9(8): 1181-1191. (SCI，XinRui Ranking Tier 2，IF:4.3)

18.Wenwen Deng#, Xia Cao#, Miao Wang#, Yan Yang, Weiyan Su, YaweiWei, Zhen Ou-Yang, Jiangnan Yu*, Ximing Xu*. Efficient Gene Delivery to Mesenchymal Stem Cells by an Ethylenediamine-Modified Polysaccharide from Mulberry Leaves[J]. Small, 2012,8(3): 441-451. (SCI，XinRui Ranking Tier 2，top journal，IF:11.8)

19.Wenwen Deng, Xia Cao, Miao Wang, Rui Qu, Weiyan Su, Yan Yang, Yawei Wei, Ximing Xu*, Jiangnan Yu*. Delivery of a transforming growth factor β-1 plasmid to mesenchymal stem cells via cationized Pleurotus eryngii polysaccharide nanoparticles[J]. International Journal of Nanomedicine 2012, 7: 1297-1311. (SCI，XinRui Ranking Tier 1，top journal，IF:8.7)

20.Miao Wang#, Wenwen Deng#, Min Fu#, Xia Cao#, Yan Yang, Weiyan Su, Jiangnan Yu*, Ximing Xu*. Efficient gene transfer into rat mesenchymal stem cells with cationized Lycium barbarum polysaccharides nanoparticles[J]. Carbohydrate Polymers, 2011, 86: 1509-1518. (SCI，XinRui Ranking Tier 1，top journal，IF:13.2)

6.3 Patents

• Xu Ximing, Deng Wenwen, Yu Jiangnan, Wang Miao, Cao Xia, Cationized mulberry leaf polysaccharide nanoparticle gene vector and preparation method thereof, 2014.8.6, China, ZL201010613484.9

•Xu Ximing, Deng Wenwen, Yu Jiangnan, Wang Miao, Cao Xia, Cationized Pleurotus eryngii polysaccharide nanoparticle gene delivery system and preparation method thereof, 2013.3.13, China, ZL201010613483.4

•Xu Ximing, Wang Miao, Yu Jiangnan, Deng Wenwen, Cao Xia, Cationized Angelica polysaccharide nanoparticle gene delivery system and preparation method thereof, 2012.12.19, China, ZL201010613603.0

•Xu Ximing, Wang Miao, Yu Jiangnan, Deng Wenwen, Cao Xia, Cationized Lycium barbarum polysaccharide nanoparticle gene delivery system and preparation method thereof, 2012.8.29, China, ZL201010613602.6

•Xu Ximing, Cao Xia, Yu Jiangnan, Wang Miao, Deng Wenwen, Cationized polysaccharide nanoparticle gene delivery system and preparation method thereof, 2012.11.7, China, ZL201010614816.5