Part 1 Basic Information

Name: Zhen Chen

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: chenzhen@ujs.edu.cn

Part 2 Personal Profile

Dr. Zhen Chen is a Professor (university-qualified) and Master's Supervisor at the School of Pharmacy, Jiangsu University. He received his doctorate in Pharmacognosy from Ocean University of China and previously held research and teaching positions at Hokkaido University, Japan. His research focuses on marine natural products, marine glycochemistry and glycobiology, and their relationships with lipid metabolism and health. Combining mass spectrometry, nuclear magnetic resonance and lipidomics, he investigates bioactive components from seaweeds, lipid oxidation and the regulation of lipid metabolism. He has led Early-Career Scientists projects funded by the Japan Society for the Promotion of Science and a research start-up project at Jiangsu University. His work has appeared in journals including Analytical Chemistry and Food Chemistry. He has served as a guest editor for Nutrients and as a reviewer for international journals in related fields. He teaches and supervises undergraduate, postgraduate and international students, and received third prize in Jiangsu University's English-medium teaching competition. He currently serves as Deputy Head of the Department of Traditional Chinese Pharmacy and Pharmacy.

Part 3 Education

2011.08–2016.06 | Ocean University of China | Pharmacognosy | Integrated postgraduate and doctoral studies; doctorate in medicine.

2007.09–2011.06 | Ocean University of China | Pharmacy | Bachelor’s degree.

Part 4 Work Experience

2022.10–Present | School of Pharmacy, Jiangsu University | Professor (university-qualified); approved as a master’s supervisor in 2023.12; Deputy Head of the Department of Traditional Chinese Pharmacy and Pharmacy since 2024.04.

2020.10–2022.08 | Faculty of Health Sciences, Hokkaido University, Japan | Lecturer.

2017.04–2020.09 | Faculty of Health Sciences, Hokkaido University, Japan | Assistant Professor.

2016.07–2017.03 | Hokkaido University, Japan | Postdoctoral Researcher.

Part 5 Research Interests

1. Isolation, identification, quantitative analysis and biological activities of marine natural products.

2. Marine glycochemistry and glycobiology, with a focus on alginate oligosaccharides, gut microbiota and lipid metabolism.

3. Lipidomics and oxidized lipid analysis in metabolic dysregulation and nutritional interventions.

4. Analytical methods for natural bioactive compounds using liquid chromatography–mass spectrometry and quantitative nuclear magnetic resonance.

Part 6 Research Achievements

6.1 Research Projects

2023.03–2026.03 | Neuroprotective Bioactive Lipids from Seaweeds (5501290015) | Research Start-up Fund for High-level Talent, Jiangsu University | Principal Investigator.

2021.04–2023.03 | Study on anti-AD functional marine phytosterols and their sources in dietary seaweeds (21K14799) | Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Early-Career Scientists | Principal Investigator.

2019.04–2021.03 | Studies on the association of lipid hydroperoxides and Alzheimer’s disease by LC/MS (19K16531) | JSPS, Grant-in-Aid for Early-Career Scientists | Principal Investigator.

2022.04–2025.03 | Mitochondria-targeted action of vitamin K mediated by the muscle-kidney axis (22K11746) | JSPS, Grant-in-Aid for Scientific Research (C) | Co-Investigator (2nd of 2).

6.2 Publications

Selected SCI journal articles in reverse chronological order of publication

[1] CHEN Z, JIA J P, WU Y, CHIBA H, HUI S P. LC/MS Analysis of Storage-Induced Plasmalogen Loss in Ready-to-Eat Fish[J]. Food Chemistry, 2022, 383: 132320. DOI: 10.1016/j.foodchem.2022.132320. (2022.07)

[2] QIAO L, CHEN Z, TAKADA C, CHIBA H, INOUE K I, HUI S P, YE S. Quantitative Evaluation on the Degradation Process of the Pulmonary Surfactant Monolayer When Exposed to Low-Level Ozone of Ambient Environment[J]. Analytical Chemistry, 2022, 94(24): 8651–8658. DOI: 10.1021/acs.analchem.2c00576. (2022.06)

[3] WU Y, CHEN Z, CHIBA H, HUI S P. Plasmalogen Fingerprint Alteration and Content Reduction in Beef During Boiling, Roasting, and Frying[J]. Food Chemistry, 2020, 322: 126764. DOI: 10.1016/j.foodchem.2020.126764. (2020.08)

[4] TSUKUI T, CHEN Z, FUDA H, FURUKAWA T, OURA K, SAKURAI T, HUI S P, CHIBA H. Novel Fluorescence-Based Method To Characterize the Antioxidative Effects of Food Metabolites on Lipid Droplets in Cultured Hepatocytes[J]. Journal of Agricultural and Food Chemistry, 2019, 67(35): 9934–9941. DOI: 10.1021/acs.jafc.9b02081. (2019.09)

[5] ZHAO Y Y, CHEN Z, WU Y, TSUKUI T, MA X X, ZHANG X R, CHIBA H, HUI S P. Separating and Profiling Phosphatidylcholines and Triglycerides from Single Cellular Lipid Droplet by In-Tip Solvent Microextraction Mass Spectrometry[J]. Analytical Chemistry, 2019, 91(7): 4466–4471. DOI: 10.1021/acs.analchem.8b05122. (2019.04)

[6] MA A C, CHEN Z, WANG T, SONG N, YAN Q, FANG Y C, GUAN H S, LIU H B. Isolation of the Molecular Species of Monogalactosyldiacylglycerols from Brown Edible Seaweed Sargassum horneri and Their Inhibitory Effects on Triglyceride Accumulation in 3T3-L1 Adipocytes[J]. Journal of Agricultural and Food Chemistry, 2014, 62(46): 11157–11162. DOI: 10.1021/jf503068n. (2014.11)

[7] CHEN Z, LIU J, FU Z F, YE C, ZHANG R S, SONG Y Y, ZHANG Y, LI H H, YING H, LIU H B. 24(S)-Saringosterol from Edible Marine Seaweed Sargassum fusiforme Is a Novel Selective LXRβ Agonist[J]. Journal of Agricultural and Food Chemistry, 2014, 62(26): 6130–6137. DOI: 10.1021/jf500083r. (2014.07)

6.3 Patents and Software Copyrights

CHEN Z. Use of Phytosterols to Improve Neuronal Lipid Metabolism[P]. China, Application No. 202410219955.X. Applicant: Jiangsu University. Filed: 2024.02; published: 2024.06. Published invention patent application.

CHEN Z. Computational Software for Mass Spectrometry-Based Lipidomics Analysis, V1.0.0. Software Copyright Registration No. 2023SR0670644. Registration date: 2023.06.