Part 1 Basic Information

Name: Xinrui Yuan

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: xyuan5@ujs.edu.cn

Part 2 Personal Profile

Dr. Xinrui Yuan, male, Lecturer, Master's Supervisor, Associate Professor (qualification) at the School of Pharmacy, Jiangsu University, and recipient of the Overseas Postdoctoral Talent Recruitment Program. His research focuses on the discovery and development of small-molecule drugs. He has led 1 national-level research project and participated in NIH R01 and R21 projects. In recent years, he has published over 30 academic papers in peer-reviewed journals, including 21 papers as first author or corresponding author in authoritative domestic and international journals such as Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, and ACS Medicinal Chemistry Letters.

Part 3 Education

•2016.09–2019.06, China Pharmaceutical University, Medicinal Chemistry, Ph.D.

•2013.09–2016.06, Nanjing Tech University, Pharmaceutical Engineering, M.S.

•2009.09–2013.06, Nanjing Tech University, Pharmaceutics, B.S.

Part 4 Work Experience

•2024.03–Present, School of Pharmacy, Jiangsu University, Lecturer and Master's Supervisor

•2019.09-2023.09, College of Pharmacy, University of Tennessee Health Science Center, Postdoctoral fellow

Part 5 Research Interests

1.Discovery, structural optimization, and activity evaluation of small-molecule drugs

2.Development of AlphaLISA, HTRF, and Hek-Blue assays

Part 6 Research Achievements

6.1 Research Projects

•2025.01—2027.12 | the Young Scientists Fund of the National Natural Science Foundation of China | NSFC | Principal Investigator

•2024.08–2027.08 | Senior Talent Foundation of Jiangsu University | Principal Investigator

•2025.09–2026.03 | Research and development of synthetic processes for products such as nortropanol | Industry collaboration | Principal Investigator

6.2 Publications

1.Qingru Wang, Ziliang Liu, Jindong Li, Wei Luo, Xinrui Yuan, Lei Hu. Natural Active Ingredient Nanomicelles for Synergistic Treatment of Wound Bacterial Infections [J]. ACS Applied Polymer Materials, 2026, 8 (17): 15244–15255.

2.Xinrui Yuan, Eun Bee Cho, Amol D Patil, Md Aktaruzzaman, Andhavaram Ramaraju, Chenyao Jiang, Meilin Wang, Miao He, Aaron Robida, Bo Wen, Duxin Sun, Jason C Rech, Jianxiong Jiang, Chao-Yie Yang. Development of 2-Methyl-5-phenylpyrrolidine-Based ST2 Inhibitors for Neuroinflammatory Conditions [J]. ACS Medicinal Chemistry Letters, 2026, 17 (8): 1915–1922.

3.Xinrui Yuan, Chao-Yie Yang. Recent Advances in Targeting RNA Splicing Factors with Small Molecules [J]. Journal of Medicinal Chemistry, 2026, 69 (13): 15009–15044.

4.Ziliang Liu, Qingru Wang, Wei Luo, Xinrui Yuan, Lei Hu. pH-Responsive Chalcone-Polyglycidol Prodrugs: Self-Assembling Micelles for Synergistic Anticancer and Antibacterial Therapy [J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 747: 140869.

5.Xinrui Yuan, Hongyan Xu, Yifeng Pei, Dezhong Guan, Lei Hu, Huibin Zhang. Recent progress in small-molecule targeted therapies for melanoma treatment [J]. Bioorganic & Medicinal Chemistry, 2026, 139: 118699.

6.Xinrui Yuan, Zeru Wang, Xihan Cui, Wenjing Xia, Yiming Liu, Zijie Sun, Yifeng Pei, Dezhong Guan, Hongyan Xu, Lei Hu, Chao-Yie Yang, Huibin Zhang. Design, synthesis, and evaluation of furo [3, 2-c] pyridine-based MNK1/2 inhibitors for the treatment of colorectal cancer [J]. European Journal of Medicinal Chemistry, 2026, 311: 118853.

7.Jingyu Jiang, Xinrui Yuan, Lei Hu. Recent Advances of Azobenzene-Based Photoresponsive Molecular Switches for Protein-Targeted Photopharmacology. Molecules, 2026, 31(7): 1205.

8.Ziliang Liu, Yue Dai, Xinyu Zhang, Tianxiang Fanglu, Jia Xu, Jianghua Wang, Qingru Wang, Xinrui Yuan, Lei Hu. Rational design of AIE fluorescence probe-drug conjugate encapsulated amphiphilic linear polyglycidol nanoplatforms for precision anti-cancer drug delivery and cell imaging [J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2025, 726: 137900.

9.Xinrui Yuan, Jason C Rech, Andhavaram Ramaraju, Amol D Patil, Krishani Rajanayake, Hebao Yuan, Mona Kazemi Sabzvar, Mousumi Mandal, Eun Bee Cho, Bo Wen, Jianxiong Jiang, M Dennis Leo, Udai P Singh, Duxin Sun, Chao-Yie Yang. Studies of Structure–Activity Relationship of 2‑(Pyrrolidin-1ylmethyl)‑1H‑pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation [J]. ACS Medicinal Chemistry Letters, 2025, 15 (11): 2053-2059.

10.Xinrui Yuan, Mona Kazemi Sabzvar, Amol D Patil, Arda Durmaz, Jaroslaw Maciejewski, Valeria Visconte, Chao-Yie Yang. Targeting Poly (U) Binding Splicing Factor 60 (PUF60): A Small-Molecule Inhibitor Shows Anti-Leukemic Activity and Impacts Cell Cycle in Leukemia Models [J]. Blood, 144: 7470.

11.Xinrui Yuan, Mona Kazemi Sabzvar, Amol D Patil, Krishnapriya Chinnaswamy, Kathryn L Howie, Ramaraju Andhavaram, Borwyn Wang, Maxime A Siegler, Arda Dumaz, Jeanne A Stuckey, Seth J Corey, Jaroslaw P Maciejewski, Valeria Visconte, Chao-Yie Yang. Comprehensive Analyses of the Effects of the Small-Molecule Inhibitor of the UHM Domain in the Splicing Factor U2AF1 in Leukemia Cells [J]. Research Square, 2024, rs.3.rs-4477663.

12.Xinrui Yuan, Dezhong Guan, Chao Chen, Shi Guo, Hanshu Wu, Hong Bu, Chao-Yie Yang, Mian Wang, Jinpei Zhou, Huibin Zhang. Development of an Imidazopyridazine-based MNK1/2 inhibitor for the treatment of lymphoma [J]. Journal of Medicinal Chemistry, 2024, 67(7): 5437-5457.

13.Xinrui Yuan, Hua Jiang, Denggang Fu, Jason C Rech, Aaron Robida, Krishani Rajanayake, Hebao Yuan, Miao He, Bo Wen, Duxin Sun, Chen Liu, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Sophie Paczesny, Chao-Yie Yang. Prophylactic mitigation of acute graft versus host disease by novel 2-(Pyrrolidin-1-ylmethyl) pyrrole-based stimulation-2 (ST2) inhibitors [J]. ACS Pharmacology & Translational Science, 2023, 6(9): 1275.

14.Xinrui Yuan, Kathryn L Howie, Mona Kazemi Sabzvar, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Chao-Yie Yang. Profiling the binding activities of peptides and inhibitors to the U2 auxiliary factor homology motif (UHM) domains [J]. ACS Medicinal Chemistry Letters, 2023, 14(4): 450-457.

15.Xinrui Yuan, Hua Jiang, Denggang Fu, Aaron Robida, Krishani Rajanayake, Hebao Yuan, Bo Wen, Duxin Sun, Brennan T Watch, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Sophie Paczesny, Jason C Rech, Chao-Yie Yang. Structure-Activity relationship of 1-(Furan-2ylmethyl) Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease [J]. Bioorganic & Medicinal Chemistry, 2022, 71: 116942.

16.Xinrui Yuan, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Chao-Yie Yang. Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding [J]. The Journal of Physical Chemistry B, 2022, 126 (12): 2394–2406.

17.Xinrui Yuan, Hong Bu, Jinpei Zhou, Chao-Yie Yang, Huibin Zhang. Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application [J]. Journal of Medicinal Chemistry, 63(20): 11368-11396.

18.Xinrui Yuan, Hanshu Wu, Hong Bu, Peiyuan Zheng, Jinpei Zhou, Huibin Zhang. Design, synthesis and biological evaluation of pyridone–aminal derivatives as MNK1/2 inhibitors [J]. Bioorganic & Medicinal Chemistry, 2019, 27(7): 1211-1225.

19.Xinrui Yuan, Hanshu Wu, Hong Bu, Jinpei Zhou, Huibin Zhang. Targeting the immunity protein kinases for immuno-oncology [J]. European Journal of Medicinal Chemistry, 2019, 163: 413-427.

6.3 Patents and Software Copyrights

•Chunlin Chen, Huibin Zhang, Xinrui Yuan, Jinpei Zhou, Ju Hong. Imidazopyridazine MNK1/MNK2 kinase inhibitors and preparation methods and applications thereof: CN111978325B [P].