Part 1 Basic Information
Name: Zhen Ouyang
Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China
Email: zhenouyang@ujs.edu.cn
Part 2 Personal Profile
Dr. Zhen Ouyang is a Professor and Doctoral Supervisor, and the former Vice Dean of the School of Pharmacy at Jiangsu University and a leader of the Traditional Chinese Medicine discipline. She has been selected for Jiangsu Province's "Six Major Talent Peaks" program and was named one of the Top Ten Outstanding Figures in Traditional Chinese Medicine in Jiangsu Province's Third "Tianjiang Cup." She serves as a standing council member of the Specialty Committee on Identification of Chinese Materia Medica of the World Federation of Chinese Medicine Societies, Standing Committee Member of the Molecular Pharmacognosy Branch of the Chinese Association of Integrative Medicine, and Committee Member of the Natural Medicinal Resources Branch of the China Society of Natural Resources. Her research focuses primarily on Chinese medicine resources and quality evaluation, molecular pharmacognosy, and bioactive constituents and new drug development of traditional Chinese medicine. She has served as Principal Investigator on more than 30 research projects, including those funded by the National Natural Science Foundation of China, key research and development projects on the modernization of traditional Chinese medicine, major projects of the National Major Science and Technology Program for New Drug Development, and key projects of the 863 Program. As the first contributor, she has received two First Prizes for National Commercial Science and Technology Progress from the China General Chamber of Commerce, one Second Prize for Science and Technology Progress from Jiangsu Province, and four science and technology awards at the municipal and departmental levels. She has obtained one new drug certificate and 15 authorized invention patents. She has contributed to more than 10 monographs and nationally unified textbooks and has published over 300 academic papers in journals such as the Journal of Agricultural and Food Chemistry, International Journal of Molecular Sciences, Food Science and Human Wellness, and Frontiers in Plant Science.
Part 3 Education
•2001.09–2005.12, Jiangsu University, Agricultural Product Processing and Storage Engineering, Ph.D.
•1981.09–1985.07, Nanjing University of Chinese Medicine, Chinese Pharmacy, B.S.
Part 4 Work Experience
•1998.12–Present, Jiangsu University, successively served as Vice Dean of the School of Pharmacy, Director of the Department of Pharmaceutical Engineering of the School of Biological and Environmental Engineering, Director of the Department of Pharmaceutical Engineering of the School of Pharmacy, and Director of the Department of Traditional Chinese Medicine and Pharmacy
•1985.07–1998.12, Pharmaceutical factory of Traditional Chinese Medicine, Zhenjiang, Jiangsu province, Minister of department of Quality Monitoring
Part 5 Research Interests
1.Development and quality evaluation of traditional Chinese medicine resources
2.Development of new traditional Chinese medicines
3.Extraction, separation, and bioactivity research of active ingredients from natural products
4.Chemistry of medicinal and edible resources and development of functional foods
5.Molecular pharmacognosy
Part 6 Research Achievements
6.1 Research Projects
•2025.11–2027.12 | The Key project at central government level " Study on the Catalytic Mechanism of CYP450s Hydroxylases in DNJ Biosynthesis in Mulberry Leaves and Synthetic Biology" (No.: 2060302-2504-03) | The Key project at central government level | Principal Investigator (500,000 CNY)
•2026.09–2027.12 | Enterprise-commissioned project "Feasibility Study on Cobalt-60 Irradiation Sterilization of Decoction Pieces in the Wuzi Yanzong Pill Prescription" (No.: HX20260908) | Principal Investigator (80,000 CNY)
•2023.01–2026.12 | General Program of NSFC "Analysis of the Key Hydroxylation Processes in the Biosynthetic Pathway of DNJ Polyhydroxy Alkaloids in Mulberry Leaves" (No.: 82274040) | National Natural Science Foundation of China | Principal Investigator (604,000 CNY)
•2022.01–2023.01｜Enterprise-commissioned project "Research and Development on the Feasibility of Cobalt-60 Irradiation Sterilization of Decoction Pieces in the Stomach Medicine Capsule Prescription" (No.: HX20220204) | Principal Investigator (140,000 CNY)
•2020.10–2024.12 | The Key project at central government level "Study on the Genome of Thesium chinense and the Formation Mechanism of the Parasitic Relationship of Santalaceae Plants" (No.: 2060302-2003-02) | The Key project at central government level | Principal Investigator (1500,000 CNY)
•2019.01–2022.12 | General Program of NSFC "Discovery and Functional Study of Key Enzymes in DNJ Polyhydroxy Alkaloids Biosynthesis Pathway of Mulberry Leaves" (No.: 81872961) | National Natural Science Foundation of China | Principal Investigator (678,000 CNY)
•2019.10–2023.06 | The Key project at central government level "Development of Specification and Grade Standards for Rubus chingii, Panax japonicus, and Viscum coloratum" (Nos.: 2060302-1906-12, 13) | The Key project at central government level | Principal Investigator (150,000 CNY)
•2018.12–2023.06 | The Key project at central government level "Research on Ethnic/Folk New Traditional Chinese Medicines" (No.: 2018YFC1706105) | Ministry of Science and Technology | Principal Investigator (2,700,000 CNY)
•2016.01–2019.12 | General Program of NSFC "Study on the Mechanism of Quality Changes in Mulberry Leaves after Frost" (Project No.: 81573529) | National Natural Science Foundation of China | Principal Investigator (684,000 CNY)
•2016.01–2019.12 | General Program of NSFC "Revealing the Scientific Connotation of 'Identifying Quality by Appearance' of Dao-di Astragalus membranaceus Based on the Correlation of 'Organ Traits–Tissue Structure–Chemical Components'" (No.: 81573543) | National Natural Science Foundation of China | Participant (110,000 CNY)
•2016.10–2023.12 | The Key project at central government level "Research and Development of Cordyceps cicadae as a New Food Raw Material" (Project No.: 2060302-1604-03) | The Key project at central government level | Principal Investigator (500,000 CNY)
• 2015.12–2016.06 | The Key project at central government level "Development of Commodity Specification and Grade Standards for Mulberry-Type Chinese Medicinal Materials" (No.: 2060302-1509-23) | The Key project at central government level | Principal Investigator (80,000 CNY)
•2013.01–2015.08 | The Key project at central government level "Research on Production Regionalization of Chinese Medicinal Materials – National Production Regionalization of Mentha haplocalyx" (No.: 20603020121) | The Key project at central government level | Principal Investigator (150,000 CNY)
•2013.01–2015.08 | The Key project at central government level "Research on Regional Quality Characteristics and Commodity Specifications of Chinese Medicine Resources – Quality Characteristics and Commodity Specifications of Mentha haplocalyx" (No.: 20603020121) | The Key project at central government level | Principal Investigator (120,000 CNY)
•2012.07–2014.06 | Jiangsu Province Industry-University-Research Joint Innovation Fund – Prospective Research Project "Preclinical Study of a Novel Pure Natural Hypoglycemic Drug 'Sangtongjian Capsule'" (No.: BY2012171) | Jiangsu Provincial Department of Science and Technology | Principal Investigator (400,000 CNY)
•2011.06–2013.06 | Jiangsu Province Six Major Talent Peaks Project "Preclinical Study of the Novel Hypoglycemic Drug 'Sangtongjian Capsule'" | Jiangsu Provincial Department of Science and Technology | Principal Investigator (30,000 CNY)
•2011.01–2019.12 | Horizontal Collaborative New Drug Development Project "Research and Development of Mulberry Leaf Extract and Its New Anti-Diabetic Drug" (No.: 2011016) | Principal Investigator (4,500,000 CNY)
•2011.01–2014.12 | General Program of NSFC "Mechanism Study on Efficient Enrichment of 1-Deoxynojirimycin by Silkworm" (No.: 81053961) | National Natural Science Foundation of China | Principal Investigator (330,000 CNY)
•2011.06–2013.6 | Jiangsu Province Northern Jiangsu Science and Technology Development Special Project: Efficient Extraction and Product Development of Hypoglycemic Active Substances from Mulberry Leaves (No.: BC2011461) | Jiangsu Provincial Department of Science and Technology | Principal Investigator (250,000 CNY)
•2005.01–2007.12 | Jiangsu Provincial Natural Science Fund "Collection of Germplasm Resources and Quality Evaluation of Atractylodes lancea" (No.: BK2004062) | Jiangsu Provincial Department of Science and Technology | Principal Investigator (75,000 CNY)
•2004.01–2006.01 | Jiangsu Provincial Agricultural Key Project "Technical Breakthrough and Development for Efficient Extraction and Purification of Silkworm and Mulberry Active Substances" (No.: BE2004352) | Jiangsu Provincial Department of Science and Technology | Principal Investigator (180,000 CNY)
6.2 Publications
1. Longfei Wang, Feixuan Wang, Jiahe Fan, Wenfang Li, Jingqiong Wan, Yuan Wei, Zhen Ouyang*, Xia Deng*. The active components in Cordyceps cicadae alleviate 4-HNE-induced neural cell ferroptosis and D‑galactose‑induced cognitive impairment via regulating the EGFR/AKT/GPX4 pathway [J]. Food Science and Human Wellness, 2026. (SCI Q1，IF5 years=7.5)
2. Jiahe Fan, Liyuan He, Yue Gao, Jingqiong Wan, Zhongyi Hua, Qishuang Li, Yuan Wei, Juan Guo, Zhen Ouyang*. Elucidation of the hydroxylation sequence in 1-DNJ biosynthesis through stable isotope tracing and enzymatic characterization[J]. Journal of Agricultural and Food Chemistry, 2026, 74 (36): 28558–28569. (SCI Q1，IF5 years=6.9)
3. Jiahe Fan, Yangzhen Liao, Yaqin Zhao, Jingqiong Wan, Yuan Wei, Zhen Ouyang*. A CYP450 monooxygenase MaCYP82C169 discovered from mulberry leaves catalyzes the methyl oxidation reaction in 1-deoxynojirimycin biosynthesis[J]. Food bioscience, 2025, 66, 106177. (SCI Q1，IF5 years=6.3)
4. Yangzhen Liao, Wenmin Du, Jingqiong Wan, Jiahe Fan, Jilan Pi, Min Wu, Yuan Wei, Zhen Ouyang*. Mining and functional characterization of NADPH-cytochrome P450 reductases of the DNJ biosynthetic pathway in mulberry leaves[J]. BMC Plant Biology. 2024, 24, 133. (SCI Q2，IF5 years=6.0)
5. Yangzhen Liao, Min Wu, Jiahe Fan, Jingqiong Wan, Xin An, Xiaolan Li, Yuan Wei, Zhen Ouyang*. Mining and characterization of a novel cytochrome P450 MaCYP71BG22 involved in the C4-stereoselective hydroxylation of 1-deoxynojirimycin biosynthesis in mulberry leaves[J]. International journal of biological macromolecules, 2024, 282:136941. (SCI Q2，IF5 years=8.7)
6. Xin An, Yangzhen Liao, Yifan Yu, Jiahe Fan, Jingqiong Wan, Yuan Wei, Zhen Ouyang. Effects of MhMYB1 and MhMYB2 transcription factors on the monoterpenoid biosynthesis pathway in L-menthol chemotype of Mentha haplocalyx Briq[J]. Planta. 2024, 260(1):3. (SCI Q2，IF5 years=4.7)
7. Maryam Fatima, Mudasir A Dar, Maruti J Dhanavade, Syed Zaghum Abbas, Mohd Nadeem Bukhari, Abdullah Arsalan, Yangzhen Liao, Jingqiong Wan, Jehangir Shah Syed Bukhari, Zhen Ouyang*. Biosynthesis and Pharmacological Activities of the Bioactive Compounds of White Mulberry (Morus alba): Current Paradigms and Future Challenges [J]. Biology-Basel. 2024, 13(7):506. (SCI Q2，IF5 years=4.6)
8. Feixuan Wang, Jingqiong Wan, Shangyu Liu, Yangzhen Liao, Yuan Wei, Zhen Ouyang*. Energy homeostasis regulation: neuroprotection of nutraceuticals Dendrobium species on neurodegenerative diseases [J]. Food Science and Human Wellness, 2023, 6(12): 2151-2174. (SCI Q1, IF5 years=7.5)
9. Jingqiong Wan, Yangzhen Liao, Jia Liu, Wenmin Du, Chang Liu, Yuan Wei, Zhen Ouyang. Screening, cloning and functional characterization of key methyltransferases involved in the methylation step of 1-deoxynojirimycin alkaloids biosynthesis in mulberry leaves [J]. Planta, 2022, 255: 121. (SCI Q2, IF5 years=4.7)
10. Jia Liu, Jingqiong Wan, Wenmin Du,Wang Dujun Wang, Chongwei Wen, Yuan Wei, Zhen Ouyang*. In vivo Functional verification of four related genes involved in the 1-deoxynojirimycin biosynthetic pathway in mulberry leaves [J]. Journal of Agricultural and Food Chemistry, 2021, 69 (37), 10989–10998. (SCI Q1, IF5 years=6.9)
11. Jia Liu, Jingqiong Wan, Dujun Wang, Chongwei Wen, Yuan Wei, and Zhen Ouyang*. Comparative Transcriptome analysis of key reductase genes involved in the 1-deoxynojirimycin biosynthetic pathway in mulberry leaves and cloning, prokaryotic expression, and functional analysis of MaSDR1 and MaSDR2 [J]. Journal of Agricultural and Food Chemistry, 2020, 68 (44), 12345-12357. (SCI Q1, IF5 years=6.9)
12. Yiling Zhu, Xiaofeng Yu, Qi Ge, Jun Li, Dujun Wang, Yuan Wei, Zhen Ouyang*. Antioxidant and anti-aging activities of polysaccharides from Cordyceps cicadae [J], International Journal of Biological Macromolecules, 2020, 157: 394-400.（SCI Q2，IF5 years=8.7）
6.3 Monographs and Textbooks
•Huang Luqi, Yuan Yuan, Liu Chunsheng (Ed.). Molecular Pharmacognosy [M]. Beijing: Science Press, 2024. (Associate Editor)
•Liu Chunsheng, Yuan Yuan (Ed.). Molecular Pharmacognosy [M]. Beijing: China Press of Traditional Chinese Medicine, 2024. (Associate Editor)
•Li Ping (Ed.). Pharmacognosy (5th Edition) [M]. Beijing: China Medical Science Press, 2024. (Contributor)
•Li Ping (Ed.). Pharmacognosy (4th Edition) [M]. Beijing: China Medical Science Press, 2022. (Contributor)
•Yuan Yuan (Ed.). Molecular Pharmacognosy [M]. Beijing: People's Medical Publishing House, 2021. (Contributor)
•Liu Chunsheng, Yuan Yuan (Ed.). Molecular Pharmacognosy [M]. Beijing: China Press of Traditional Chinese Medicine, 2017. (Associate Editor)
•Jia Jingming, Liu Chunsheng (Ed.). Monographs on Molecular Pharmacognosy [M]. Beijing: People's Medical Publishing House, 2017. (Contributor)
•Peng Guoping (Ed.). Pharmaceutical Chemistry of Traditional Chinese Medicine [M]. Beijing: China Medical Science Press, 2016. (Editorial Board Member)
•Duan Jin'ao (Ed.). Resource Chemistry of Traditional Chinese Medicine: Theoretical Basis and Resource Recycling [M]. Beijing: Science Press, 2015. (Contributor)
•Chao Jianguo, Pei Jin (Ed.). Science of Chinese Medicine Resources [M]. Beijing: China Medical Science Press, 2014. (Contributor)
•Guo Lanping, Huang Luqi (Ed.). Dao-di Medicinal Materials of China: Atractylodes lancea [M]. Shanghai: Shanghai Scientific and Technical Publishers, 2014. (Contributor)
•Luo Guangming, Liu Hegang (Ed.). Cultivation of Medicinal Plants [M]. Shanghai: Shanghai Scientific and Technical Publishers, 2013. (Contributor)
•Zhou Ronghan, Duan Jin'ao (Ed.). Phytochemical Taxonomy [M]. Beijing: China Medical Science Press, 2013. (Contributor)
6.4 Patents and Software Copyrights
•Ouyang Zhen et al. An active fraction of Cordyceps cicadae and its application in the preparation of neuroprotective and anti-aging drugs. ZL201410046301.8[P]. 2016-01-20
•Ouyang Zhen et al. An extract of Cordyceps cicadae and its application in the preparation of neuroprotective and anti-aging drugs. ZL201410046249.6[P]. 2016-04-06
•Ouyang Zhen et al. Cordyceps cicadae polysaccharides and their application in the preparation of neuroprotective and anti-aging drugs. ZL201410046558.3[P]. 2016-05-25
•Ouyang Zhen et al. An active fraction of Cordyceps cicadae and its application in the preparation of neuroprotective and anti-aging drugs. ZL201410046280.X[P]. 2016-06-25
•Ouyang Zhen et al. Method for manufacturing compound lipid-lowering dropping pills. ZL200510123010.5[P]. 2006-11-22
•Ouyang Zhen et al. Composition of effective hypoglycemic fractions from mulberry leaves and preparation method thereof. ZL200610038713.2[P]. 2009-03-04
•Ouyang Zhen et al. A method for separating 1-deoxynojirimycin monomer from total alkaloids of mulberry leaves. ZL200810122998.7[P]. 2012-07-02
•Ouyang Zhen et al. A compound lipid-lowering pellet formulation and preparation method thereof. 200810122997.2[P]. 2008-12-03
•Ouyang Zhen et al. A pharmaceutical composition for treating diabetes or diabetic complications and preparation method thereof. ZL201110178678.5[P]. 2013-04-17
•Ouyang Zhen et al. A mosquito repellent containing Sedum sarmentosum and peppermint oil and preparation method thereof. ZL 201210047300.6[P]. 2013-06-12
