Part 1 Basic Information

Name: Cao Jin

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: caoj@ujs.edu.cn

Part 2 Personal Profile

Dr. Cao Jin (b. 1983) is an Associate Professor and Master’s Supervisor at the School of Pharmacy, Jiangsu University, and serves as Director of the Pharmaceutics Department. Her research focuses on the pharmaceutical applications of biomacromolecules, the development of micro/nano drug delivery systems, and the development and formulation of cosmetic raw materials. She has led projects funded by the National Natural Science Foundation of China, the China Postdoctoral Science Foundation, and the Jiangsu Provincial University Natural Science Research Program, and has participated in multiple national and provincial projects. She has published papers in journals such as Chemical Engineering Journal and International Journal of Biological Macromolecules, and has received the First Prize of the Science and Technology Award of Jiangsu Pharmaceutical Association, the Excellent Teacher Award of Jiangsu University, and the Advanced Individual of "Three-Wide Education" at Jiangsu University.

Part 3 Education

•2008.09–2011.06, China Pharmaceutical University, Microbiology and Biochemical Pharmacy, Ph.D.

•2005.09–2008.06, China Pharmaceutical University, Marine Pharmacy, M.S.

•2001.09–2005.06, China Pharmaceutical University, Biopharmaceutical Program, B.S.

Part 4 Work Experience

•2016.09–Present, School of Pharmacy, Jiangsu University, Associate Professor and Master's Supervisor

•2018.12–2019.12, College of Pharmacy, University of Minnesota, USA, Visiting Scholar

•2014.10–2018.12, Jiangsu University, Postdoctoral Research Fellow

•2011.07–2016.09, School of Pharmacy, Jiangsu University, Lecturer

Part 5 Research Interests

1.Pharmaceutical applications of biological macromolecules

2.Development of micro/nano drug delivery systems

3.Development and formulation research of cosmetic raw materials

Part 6 Research Achievements

6.1 Research Projects

1.2024.11–Present | Enterprise collaboration project "Manganese-phycocyanin nanoparticle composite hydrogel system for local sono-chemo synergistic antitumor therapy" (No. HX20241098) | Enterprise Cooperation | Principal Investigator

2.2020.01–2023.12 | National Natural Science Foundation of China (Youth Program) "Integrated sono-chemo antitumor nanosystem based on phycocyanin" (Grant No. 82003649) | NSFC | Principal Investigator

3.2016.09–2018.08 | Jiangsu Provincial University Natural Science Research General Program "pH-stable BG-PLGA composite protein microspheres" (No. 16KJD350001) | Jiangsu Provincial Department of Education | Principal Investigator

4.2015.07–2017.07 | China Postdoctoral Science Foundation General Program "Microenvironment-modulated BG/PLGA/BMP ternary carriers for bone repair" (No. 2015M571706) | China Postdoctoral Science Foundation | Principal Investigator

5.2014.07–2017.07 | Jiangsu Provincial Natural Science Foundation (Youth, No. BK20140572) "Network- and RNAi-based synergistic killing of ovarian cancer by inhibiting Src and PARD6A" | Jiangsu Provincial Department of Science and Technology | Participant (2nd)

6.2014.01–2017.12 | National Natural Science Foundation of China "Construction and application of cytochrome P450 knockout rat model based on TALEN" (No. 81373480) | NSFC | Participant (2nd)

7.2013.06–2018.12 | Jiangsu University High-level Talent Research Fund "Efficient extraction and activity of active components from Porphyra yezoensis" (No. 1281280019) | Jiangsu University | Principal Investigator

8.2012.07–2015.06 | Jiangsu Provincial Natural Science Foundation (Youth, No. BK2012290) "Identification of marker proteins and peptides for authentication of five animal medicines" | Jiangsu Provincial Department of Science and Technology | Participant (2nd)

9.2012.01–2015.12 | National Natural Science Foundation of China (Youth, No. 81202930) "Design and preparation of novel triggered self-assembled protein polymer nanocarriers loaded with bufalin for liver tumor targeting" | NSFC | Participant (2nd)

6.2 Publications

1.Huan Wang, Sijia Lin, Jin Zhou, Jinyue Bi, Yiming Wang, Xinpei Li, Qian Yang, Shuying Wu, Xueyong Qi, Song Shen, Cao Jin*. A natural COX-2 inhibitor-integrated nanoplatform for TNBC immunotherapy: Mn-PC-PTX synergizes chemotherapy and immune activation[J]. Colloids and Surfaces B: Biointerfaces, 2026, 265:115763.

2.Huan Wang, Chenyao Qian, Jinyue Bi, Jin Zhou, Xinpei Li, Xueyong Qi, Song Shen, Cao Jin*. In situ photothermal-chemical dynamics synergistic enhancement of anti-tumor effect based on phycocyanin multifunctional nanosystem[J]. Colloids and Surfaces B: Biointerfaces, 2025, 256(Pt 2):10.

3.Jinyue Bi, Huan Wang, Huan Luo, Chenyao Qian, Jin Zhou, Xinpei Li, Xueyong Qi, Song Shen, Cao Jin*. Self-healing hydrogels loaded with selenium nanoparticles/chitosan/cellulose nanofibers as carriers of mesenchymal stem cells for diabetic wound healing[J]. International Journal of Biological Macromolecules, 2025, 322(Pt 4):146905.

4.Chenyao Qian, Huan Wang, Jinyue Bi, Xiaodan Zheng, Rujia Li, Huan Luo, Xueyong Qi, Song Shen, Cao Jin*. A biomimetic manganese-phycocyanin nanodrug-carrying system and its sonodynamic-immunological anti-tumor therapy[J]. International Journal of Pharmaceutics, 2025, 677.

5.Xiaodan Zheng, Chenyao Qian, Huan Wang, Jinyue Bi, Xueyong Qi, Song Shen, Cao Jin*. Phycocyanin- and Polydopamine-Conjugated Titania Nanoparticles for UV Protection[J]. ACS Applied Nano Materials, 2025, 8(14):6983-6993.

6.Cao Jin, Zhenyan Sun, Chenyao Qian, Huan Wang, Jinyue Bi, Xueyong Qi, Song Shen. Synergetic Sonodynamic-Immunotherapy based on phycocyanin nanoparticles (PCNP) reduces tumor growth and metastasis in mice[J]. Chemical Engineering Journal, 2024, 498:155021.

7.Zhiye Li, Chenyao Qian, Xiaodan Zheng, Xueyong Qi, Jinyue Bi, Huan Wang, Cao Jin*. Collagen/chitosan/genipin hydrogel loaded with phycocyanin nanoparticles and ND-336 for diabetic wound healing[J]. International Journal of Biological Macromolecules, 2024, 266(Pt 1):131220.

8.Cao Jin, Xiaodan Zheng, Zhiye Li, Mingxue Zheng, Chenyao Qian, Song Shen, Xueyong Qi. Exploring marine algae-derived phycocyanin nanoparticles as a safe and effective adjuvant for sunscreen systems[J]. Discover Applied Sciences, 2024, 6(1):24.

9.Cao Jin, Mingxue Zheng, Zhenyan Sun, Zhiye Li, Xueyong Qi, Song Shen. One-Step Fabrication of Multifunctional PLGA-HMME-DTX@MnO2 Nanoparticles for Enhanced Chemo-Sonodynamic Antitumor Treatment[J]. International Journal of Nanomedicine, 2022, 17:2577-2591.

10.Lin Wu, Anran Yuan, Xiangrong Tian, Cao Jin*, Xueyong Qi, Yuan Wei*, Song Shen*. Cell-Membrane-Coated Cationic Nanoparticles Disguised as Macrophages for the Prevention and Treatment of Type 2 Diabetes Mellitus[J]. ACS Applied Materials & Interfaces, 2022, 14(45):50499-50506.

11.Ruan Li, Kai Zhao, Xiangrong Tian, Lin Wu*, Cao Jin*, Xueyong Qi, Song Shen*. Macrophages exosomes-coated Fe3O4 nanoparticles for oxygen independent generation of free radicals and hypoxic cancer therapy[J]. Materials Today Communications, 2022, 33:104672.

12.Cao Jin, Qiwen Pan, Shifang Bei, Mingxue Zheng, Zhenyan Sun, Xueyong Qi, Song Shen. Concise Nanoplatform of Phycocyanin Nanoparticle Loaded with Docetaxel for Synergetic Chemo-sonodynamic Antitumor Therapy[J]. ACS Applied Bio Materials, 2021, 4(9):7176-7185.

13.Cao Jin, Shubhmita Bhatnagar, Jiawei Wang, Xueyong Qi, Swayam Prabha, Jayanth Panyam. Cancer stem cells and strategies for targeted drug delivery[J]. Drug Delivery and Translational Research, 2020, 11(5):1779-1805.

14.Cao Jin, Jin Cheng, Siyu Xi, Xueyong Qi, Song Shen, Yanru Ge. Alginate/chitosan microcapsules for in-situ delivery of the protein, interleukin-1 receptor antagonist (IL-1Ra), for the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2019, 137:112-121.

15.Lin Wu, Ling Zong, Haihua Ni, Xuexue Liu, Wen Wen, Lei Feng, Cao Jin*, Xueyong Qi, Yanru Ge*, Song Shen*. Magnetic Thermosensitive Micelles with Upper Critical Solution Temperature for NIR Triggered Drug Release[J]. Biomaterials Science, 2019, 7(5):2134-2143.

16.Cao Jin, Jin Cheng, Xiaofeng Wang, Yanru Ge. Optimization of the Process for Preparation of Lactococcus lactis NZ9000 Microcapsules by Response Surface Method[J]. Nanoscience and Nanotechnology Letters, 2017, 9(12):2054-2060.

17.Cao Jin, Jianping Wang, Shicheng Wang, Ximing Xu. Porphyra Species: A Mini-review of Its Pharmacological and Nutritional Properties[J]. Journal of Medicinal Food, 2016, 19(2):111-119.

18.Qingtong Yu, Cao Jin, Baoding Chen, Wenwen Deng, Xia Cao, Jingjing Chen, Yan Wang, Shicheng Wang, Jiangnan Yu, Ximing Xu, Xiangdong Gao. Efficient gene delivery to human umbilical cord mesenchymal stem cells by cationized Porphyra yezoensis polysaccharide nanoparticles[J]. International Journal of Nanomedicine, 2015, 10:7097-7107.

19.Cao Jin, Shicheng Wang, Chenwei Yao, Zi Xu, Ximing Xu. Hypolipidemic Effect of Porphyran extracted from Porphyra yezoensis in ICR Mice With High Fatty Diet[J]. Journal of Applied Phycology, 2016, 28(2):1315-1322.

20.Cao Jin, Shicheng Wang, Liuwei Xu, Jiabing He, Ximing Xu. Extraction of porphyran from Porphyra yezoensis for gel formulation preparation[J]. Key Engineering Materials, 2014, 636:133-137.

6.3 Patents and Software Copyrights

1.Cao Jin, Zhenyan Sun, Song Shen, Xueyong Qi, Peiwei Ma, Zhiye Li, Chenyao Qian, Xiaodan Zheng. A phycocyanin nanosystem loaded with immune adjuvant and its preparation method and application: CN202310329381.7[P]. 2023-03-30.