Part 1 Basic Information

Name: Cao Xia

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: caoxia@ujs.edu.cn

Part 2 Personal Profile

Dr. Cao Xia is an Associate Professor and Master's Supervisor at the School of Pharmacy, Jiangsu University, and a postdoctoral fellow of Harvard Medical School. Her research focuses on microfluidic nano drug/gene delivery systems and 3D-printed tissue engineering. She has led multiple national and provincial research projects and participated in several national key R&D programs. She holds 16 authorized invention patents (3 US patents and 13 Chinese patents), and has received one Second Prize of Technological Invention Award from the Ministry of Education and one First Prize of Science and Technology Progress Award.

Part 3 Education

•2008.09 - 2011.12, School of Pharmacy, Jiangsu University, Clinical Laboratory Diagnostics, Ph.D.

Part 4 Work Experience

•2012.04 - Present, School of Pharmacy, Jiangsu University, Associate Professor and Master's Supervisor

•2016.06 - 2018.09, Harvard Medical School, Postdoctoral Fellow

Part 5 Research Interests

1.Microfluidic nano drug/gene delivery systems

2.3D-printed tissue engineering and regenerative medicine

3.Organoids and organ-on-a-chip

4.Nanomedicine for spinal cord injury repair and antitumor therapy

Part 6 Research Achievements

6.1 Research Projects

•National Natural Science Foundation of China, Young Scientists Fund, Fluorescent carbon dots-mediated nano-gene delivery and induction of glioma stem cell differentiation, No. 81503025, RMB 300,000, 2016-01 to 2018-12, Completed, PI.

•Basic Research Project of Zhenjiang, Construction of vascularized kidney organoid injury chip and screening of active components from traditional Chinese medicine, No. SH2021024, RMB 50,000, 2021-07 to 2023-07, Completed, PI.

•National Natural Science Foundation of China, International (Regional) Cooperation and Exchange Program, 3D biomimetic printed drug delivery system with positioning, gradient and long-term release for spinal cord injury repair, No. 81720108030, RMB 2,330,000, 2018-01 to 2022-12, Ongoing, Participant.

•National Natural Science Foundation of China, General Program, Somatic cell direct reprogramming mediated by DNA-cationic polysaccharide-carbon quantum dot self-assembled nanoparticles, No. 81473172, RMB 1,000,000, 2015-01 to 2018-12, Completed, Participant.

•National Natural Science Foundation of China, General Program, Construction of 3D nano-gene delivery system for Yamanaka factors and induction of pluripotent stem cells, No. 81072586, RMB 400,000, 2011-01 to 2013-12, Completed, Participant.

•National Natural Science Foundation of China, General Program, TrkA lipid raft chromatography and its application in screening anti-tumor active components from traditional Chinese medicine, No. 30973677, RMB 330,000, 2010-01 to 2012-12, Completed, Participant.

6.2 Publications

1.J. Yu, M. Ni, K. Liu, P. Pan, X. Li, J. Zhang, T. Deng, Q. Wang, X. Xu, X. Cao*. Electrospinning of microspheres with ectodermal mesenchymal stem cells for vascular regeneration[J]. European Polymer Journal, 2025, 224: 113716.(SCI)

2.X. Cao*, X. Li, W. Shi, M. Adu-Frimpong, J. Li, H. Huang, J. Liang, Y. Dong, J. Yu, Q. Wang, X. Xu. 3D-Bioprinted Scaffolds with Precise Factor Delivery for Spinal Cord Injury Repair[J]. ACS Appl. Mater. Interfaces, 2025, 17(30): 42586-42601.(SCI)

3.Q. Wang, K. Liu, X. Cao*, W. Rong, W. Shi, Q. Yu, W. Deng, J. Yu, X. Xu. Plant-derived exosomes extracted from Lycium barbarum L. loaded with isoliquiritigenin to promote spinal cord injury repair based on 3D printed bionic scaffold[J]. Bioeng Transl Med, 2024, 9(4): e10646.(SCI)

4.Y. Tao, C. Lu, X. Wang, Z. Xin, X. Cao*, Y. Ren. Monolayer heterojunction interactive hydrogels for high-freedom 4D shape reconfiguration by two-photon polymerization[J]. Int J Bioprint, 2023, 9(3): 678.(SCI)

5.X. Cao*, Q. Liu, W. Shi, K. Liu, T. Deng, X. Weng, S. Pan, Q. Yu, W. Deng, J. Yu, Q. Wang, G. Xiao, X. Xu. Microfluidic fabricated bisdemethoxycurcumin thermosensitive liposome with enhanced antitumor effect[J]. Int J Pharm, 2023, 641: 123039.(SCI)

6.X. Cao*, Q. Liu, M. Adu-Frimpong, W. Shi, K. Liu, T. Deng, H. Yuan, X. Weng, Y. Gao, Q. Yu, W. Deng, J. Yu, Q. Wang, G. Xiao, X. Xu. Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy[J]. AAPS PharmSciTech, 2023, 24(4): 82.(SCI)

7.X. Cao*, Q. Li, X. Li, Q. Liu, K. Liu, T. Deng, X. Weng, Q. Yu, W. Deng, J. Yu, Q. Wang, G. Xiao, X. Xu. Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication[J]. AAPS PharmSciTech, 2023, 24(8): 241.(SCI)

8.D. Wu, Z. Wang, J. Li, Y. Song, M.E.M. Perez, Z. Wang, X. Cao, C. Cao, S. Maharjan, K.C. Anderson, D. Chauhan, Y.S. Zhang. A 3D-Bioprinted Multiple Myeloma Model[J]. Adv Healthc Mater, 2022, 11(7): e2100884.(SCI)

9.D. Wang, S. Maharjan, X. Kuang, Z. Wang, L.S. Mille, M. Tao, P. Yu, X. Cao, L. Lian, L. Lv, J.J. He, G. Tang, H. Yuk, C.K. Ozaki, X. Zhao, Y.S. Zhang. Microfluidic bioprinting of tough hydrogel-based vascular conduits for functional blood vessels[J]. Sci Adv, 2022, 8(43): eabq6900.(SCI)

10.H. Li, F. Cheng, W. Li, X. Cao, Z. Wang, M. Wang, J.A. Robledo-Lara, J. Liao, C. Chavez-Madero, S. Hassan, J. Xie, G. Trujillo-de Santiago, M.M. Alvarez, J. He, Y.S. Zhang. Expanding sacrificially printed microfluidic channel-embedded paper devices for construction of volumetric tissue models in vitro[J]. Biofabrication, 2020, 12(4): 045027.(SCI)

11.J. Gong, C.C.L. Schuurmans, A.M.V. Genderen, X. Cao, W. Li, F. Cheng, J.J. He, A. Lopez, V. Huerta, J. Manriquez, R. Li, H. Li, C. Delavaux, S. Sebastian, P.E. Capendale, H. Wang, J. Xie, M. Yu, R. Masereeuw, T. Vermonden, Y.S. Zhang. Complexation-induced resolution enhancement of 3D-printed hydrogel constructs[J]. Nat Commun, 2020, 11(1): 1267.(SCI)

12.A. Polat, S. Hassan, I. Yildirim, L.E. Oliver, M. Mostafaei, S. Kumar, S. Maharjan, L. Bourguet, X. Cao, G. Ying, M. Eyvazi Hesar, Y.S. Zhang. A miniaturized optical tomography platform for volumetric imaging of engineered living systems[J]. Lab Chip, 2019, 19(4): 550-561.(SCI)

13.F. Cheng, X. Cao, H. Li, T. Liu, X. Xie, D. Huang, S. Maharjan, H.P. Bei, A. Gomez, J. Li, H. Zhan, H. Shen, S. Liu, J. He, Y.S. Zhang. Generation of Cost-Effective Paper-Based Tissue Models through Matrix-Assisted Sacrificial 3D Printing[J]. Nano Lett, 2019, 19(6): 3603-3611.(SCI)

14.X. Cao, R. Ashfaq, F. Cheng, S. Maharjan, J. Li, G. Ying, S. Hassan, H. Xiao, K. Yue, Y.S. Zhang. A Tumor-on-a-Chip System with Bioprinted Blood and Lymphatic Vessel Pair[J]. Adv Funct Mater, 2019, 29(31).(SCI)

15.G.L. Ying, N. Jiang, S. Maharjan, Y.X. Yin, R.R. Chai, X. Cao, J.Z. Yang, A.K. Miri, S. Hassan, Y.S. Zhang. Aqueous Two-Phase Emulsion Bioink-Enabled 3D Bioprinting of Porous Hydrogels[J]. Adv Mater, 2018, 30(50): e1805460.(SCI)

6.3 Patents and Software Copyrights

•International Patents (3)

1.A Formulation of Silymarin with High Efficacy and Prolonged Action and the Preparation Method Thereof

2.Ximing Xu, Jiangnan Yu, Xia Cao, Yuan Zhu. A Formulation of Silybinin with High Efficacy and Prolonged Action and the Preparation Method Thereof, US9023388, Date of Patent: May 5, 2015.

3.Ximing Xu, Jiangnan Yu, Yuan Zhu, Xia Cao. A Highly Efficient and Long-acting Slow-release formulation of Poorly Soluble Drugs and Preparation Method Thereof, US 9,283,190, Date of Patent:03/15/2016.

•Domestic Patents (13)

14.Lipid raft-modified chromatographic column, its preparation method and application in screening anti-tumor active fractions from traditional Chinese medicine (Inventors: Jiangnan Yu, Shanshan Tong, Ximing Xu, Xia Cao, Chengxue Yi, Min Fu; Patent No.: CN103134880B; Date of Patent: January 13, 2016)

15.An anti-tumor active fraction extract of stir-fried Tinglizi (northern Descurainia sophia), its preparation method and use (Inventors: Jiangnan Yu, Chaoqun Xi, Ximing Xu, Shanshan Tong, Chengxue Yi, Xia Cao; Patent No.: CN103120710B; Date of Patent: November 5, 2014)

16.An anti-tumor active fraction extract of Tinglizi (northern Descurainia sophia), its preparation method and use (Inventors: Jiangnan Yu, Chaoqun Xi, Ximing Xu, Shanshan Tong, Chengxue Yi, Xia Cao; Patent No.: CN103006741B; Date of Patent: May 7, 2014)

17.An anti-tumor active fraction extract of enoki mushroom (Flammulina velutipes), its preparation method and use (Inventors: Jiangnan Yu, Chengxue Yi, Ximing Xu, Xia Cao, Rui Qu; Patent No.: CN102416025B; Date of Patent: December 11, 2013)

18.Cationized Angelica sinensis polysaccharide nanoparticle gene delivery system and its preparation method (Inventors: Ximing Xu, Miao Wang, Jiangnan Yu, Wenwen Deng, Xia Cao; Patent No.: CN102154351B; Date of Patent: December 19, 2012)

19.A three-dimensional nano-scaffold for gene delivery system, its preparation and application (Inventors: Ximing Xu, Xia Cao, Weiyan Su, Jiangnan Yu; Patent No.: CN101829367B; Date of Patent: May 8, 2013)

20.Cationized mulberry leaf polysaccharide nanoparticle gene carrier and its preparation method (Inventors: Ximing Xu, Wenwen Deng, Jiangnan Yu, Miao Wang, Xia Cao; Patent No.: CN102154349B; Date of Patent: August 6, 2014)

21.Ionized polysaccharide nanoparticle gene delivery system and its preparation method (Inventors: Ximing Xu, Xia Cao, Jiangnan Yu, Miao Wang, Wenwen Deng; Patent No.: CN102154352B; Date of Patent: November 7, 2012)

22.Cationized wolfberry (Lycium barbarum) polysaccharide nanoparticle gene delivery system and its preparation method (Inventors: Ximing Xu, Miao Wang, Jiangnan Yu, Wenwen Deng, Xia Cao; Patent No.: CN102154350B; Date of Patent: August 29, 2012)

23.A highly efficient and long-acting formulation of silymarin and its preparation method (Inventors: Jiangnan Yu, Shanshan Tong, Yuan Zhu, Xia Cao, Ximing Xu; Patent No.: CN101439025B; Date of Patent: May 11, 2011)

24.A highly efficient and long-acting sustained-release formulation of poorly soluble drugs and its preparation method (Inventors: Jiangnan Yu, Ximing Xu, Xia Cao, Yuan Zhu; Patent No.: CN101444494B; Date of Patent: March 30, 2011)

25.A highly efficient and long-acting formulation of silybinin and its preparation method (Inventors: Jiangnan Yu, Xia Cao, Ximing Xu, Yuan Zhu; Patent No.: CN101444503B; Date of Patent: February 2, 2011)

26.Preparation method of 2-amino-4-oxo-7-(3,4-dimethoxybenzyl)-5-vinyl-6,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine (Inventors: Huiming Cai, Ximing Xu, Qilong Wang, Xia Cao, Jiangnan Yu; Patent No.: CN102911175B; Date of Patent: April 15, 2015)