Part 1 Basic Information

Name: Dan Wang

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: danwang@ujs.edu.cn

Part 2 Personal Profile

Dr. Dan Wang is an Associate Professor at the School of Pharmacy, Jiangsu University, and a recipient of the Innovative and Entrepreneurial Program_Doctor (PhD) Talent Program. Her research focuses on the discovery and development of voltage-gated calcium channel blockers as analgesic/anticancer drug leads and the structural engineering of venom peptides. She has led 2 provincial research projects and published over 23 papers in peer-reviewed journals, including Marine Drugs and BMC Chemistry. She serves as a reviewer for International Journal of Biological Sciences, Digital Discovery, Pharmaceutics, etc.

Part 3 Education

•2015.10–2020.05, The University of Queensland, Pharmacology, Ph.D.

•2012.09–2015.06, Sichuan Agricultural University, Pharmaceutical botany, M.S.

•2008.09–2012.06, Sichuan Agricultural University, Traditional Chinese Medicine Cultivation and Authentication, B.S.

Part 4 Work Experience

•2021.07–Present, School of Pharmacy, Jiangsu University, Associate Professor

•2020.07–2021.06, School of Pharmacy, Jiangsu University, Probationary Associate Professor

Part 5 Research Interests

1.Discovery and development of voltage-gated calcium channel blockers as analgesic/anticancer drug leads

2.Discovery and development of novel non-opioid analgesics

3.Discovery of bioactive components from animal venoms and structural engineering of venom peptides

Part 6 Research Achievements

6.1 Research Projects

•2021.08–2023.08 | The Innovative and Entrepreneurial Program_Doctor (PhD) (Grant No. JSSCBS20210960) | Organization Department of the CPC Jiangsu Provincial Committee | Principal Investigator

•2021.10–2023.09 | The Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grant No. 21KJB350023) | Jiangsu Provincial Department of Education | Principal Investigator

•2021.10– | Senior Talent Foundation of Jiangsu University (Grant No. 20JDG075) | Jiangsu University | Principal Investigator

•2022.01–2025.12 | National Natural Science Foundation of China General Program (Grant No. 82173937) | NSFC | Participant (3rd)

•2024.09–2027.08 | Jiangsu Provincial Natural Science Foundation (General Program) (Grant No. BK20241927) | Jiangsu Provincial Department of Education | Participant (2nd)

6.2 Publications

1.Ruike Kang and Dan Wang*, Clinical Advances in Analgesic Drug Development from Ion Channel Modulators, Current Medicinal Chemistry 2026, DOI:10.2174/0109298673421752260407115756

2.Ruihan Li, Md. Mahadhi Hasan, and Dan Wang*, In Silico Conotoxin Studies: Progress and Prospects, Molecules 2024, 29(24): 6061.

3.Dan Wang*, Volker Herzig, Zoltan Dekan, K. Johan Rosengren, Colton D. Payne, Md. Mahadhi Hasan, Jiajie Zhuang, Emmanuel Bourinet, Lotten Ragnarsson, Paul F. Alewood and Richard J. Lewis*, Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via Ca_V3.3 and Ca_V3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain, International Journal of Molecular Sciences 2024, 25(9): 4745.

4.Dan Wang, Pratik Neupane, Lotten Ragnarsson, Robert J. Capon and Richard J. Lewis*, Diindolylmethane Derivatives: New Selective Blockers forT-Type Calcium Channels, Membranes 2022, 12(8): 749.

5.Dan Wang, S.W.A. Himaya, Jean Giacomotto, Md. Mahadhi Hasan, Fernanda C. Cardoso, Lotten Ragnarsson, and Richard J. Lewis*, Characterisation of δ-conotoxin TxVIA as a mammalian T-type calcium channel modulator, Marine drugs 2020, 18(7): 343.

6.Dan Wang*, Lotten Ragnarsson, Richard J. Lewis, T-type Calcium Channels in Health and Disease, Current Medicinal Chemistry 2020, 27(19): 3098-3122.

7.Dan Wang, Pratik Neupane, Lotten Ragnarsson, Robert J. Capon* and Richard J. Lewis*, Synthesis of pseudellone analogs and characterization as novel T-type calcium channel blockers, Marine drugs 2018, 16(12): 475.

8.Dan Wang, Hong-Guan Chen, Xin-Chuan Tian, Xiao-Xia Liang, Feng-Zhen Chen and Feng Gao*, Room-temperature palladium-catalysed Suzuki-Miyaura coupling of arylboric acid with aryl chlorides, RSC Advances 2015, 5: 107119-107122.

9.Dan Wang, Bi-Bo Zhang, Xiao-Xia Qu, Feng Gao* and Min-Yong Yuan, Microwave-assisted extraction of polysaccharides from Yupingfeng powder and their antioxidant activity, Pharmacognosy Magazine 2015, 11(43): 546-554.

10.Dan Wang and Feng Gao*, Quinazoline derivatives: synthesis and bioactivities, Chemistry Central Journal 2013, 7: 95. (This journal was renamed as BMC Chemistry in 2019)

11.Feng Gao*, Dan Wang, Xing Huang, Synthesis, isolation, stereostructure and cytotoxicity of paclitaxel anologs from cephalomannine, Fitoterapia 2013, 90: 79-84.

12.Gang Xiang^#, Dan Wang^#, Gui-Hua Zou, Xing Huang, Meng-Liang Tian*, and Feng Gao*, Optimized Ultrasonic-Assisted Extraction of Polysaccharides from Chinese Traditional Medicinal Plant Paris fargessi Using Orthogonal Design, Journal of Applied Pharmaceutical Science 2013,3(05):110-113.

13.Ling-Li Zheng, Dan Wang, Yuan-Yuan Li, Hong-Yan Peng, Ming-Yong Yuan, Feng Gao*, Ultrasound-assisted extraction of total flavonoids from Aconitum gymnandrum, Pharmacognosy Magazine 2014, 10: 141-146.

14.Jiao Wei-Hua, Jing Li, Dan Wang, Meng-Meng Zhang, Li-Yun Liu, Fan Sun, Jing-Ya Li, Robert J. Capon*, and Hou-Wen Lin*, Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea, Journal of Natural Products 2019, 82(9): 2586-2593.

15.Ya-Nan Cao, Ling-Li Zheng, Dan Wang, Xiao-Xia Liang*, Feng Gao*, Xian-Li Zhou, Recent advances in microtubule-stabilizing agents, European Journal of Medicinal Chemistry 2018, 143: 806-828.

16.Guan Wen, Xiao-Xia Qu, Dan Wang, Xing-Xiu Chen, Xin-Chuan Tian, Feng Gao*, Xian-Li Zhou*, Recent advances in design, synthesis and bioactivity of paclitaxel-mimics, Fitoterapia 2016, 110: 26-37.

17.Xin-Chuan Tian, Xing Huang, Dan Wang, and Feng Gao*, Eco-Efficient One-Pot Synthesis of Quinazoline-2,4(1H,3H)-diones at Room Temperature in Water, Chemical & Pharmaceutical Bulletin 2014, 62(8): 824-829.

18.Feng Gao*, Yuan-yuan Li, Dan Wang, Xing Huang and Qian Liu, Diterpenoid Alkaloids from the Chinese Traditional Herbal “Fuzi” and Their Cytotoxic Activity, Molecules 2012, 17: 5187-5194.

Conference Paper:

1.Dan Wang, Volker Herzig, Zoltan Dekan, Lotten Ragnarsson, Fernanda C. Cardoso and Richard J. Lewis, High-throughput Cell-based Assays for Screening Ca_V3.2 Modulators from Venoms. Venoms to Drugs Conference 2017, Noosa Heads, QLD, Australia, 9-14 October 2017.