Part 1 Basic Information

Name: Chengqian Pan

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: cqpan@ujs.edu.cn

Part 2 Personal Profile

Pan Chengqian, male, born in 1992, a native of Changxing, Zhejiang Province, is a member of the Revolutionary Committee of the Chinese Kuomintang. He is a tenure-track associate professor‌ and master's supervisor at the School of Pharmacy, Jiangsu University, and a recipient of the Jiangsu Provincial "Double Innovation Doctor" talent program. For a long time, he has been engaged in the research of ‌microorganism-derived natural product chemistry‌. He has presided over 2 national and provincial/ministerial scientific research projects and participated in 1 related project. He has published more than 20 papers in authoritative domestic and international journals including Organic Letters, Journal of Organic Chemistry, Journal of Natural Products, and European Journal of Medicinal Chemistry. He also serves as a special issue editor for SCI journals ‌《Frontiers in Marine Science》‌ and ‌《Letters in Organic Chemistry》‌, among other academic positions.

Part 3 Education

•2017.4–2020.9, Kyoto University, Pharmaceutical Innovation Informatics, Ph.D.

•2014.9–2017.3, Zhengjiang University, Marine Science, M.S.

•2010.9–2014.6, Zhejiang University, Chemical Engineering and Technology‌, B.S.

Part 4 Work Experience

•2023.8–Present, School of Pharmacy, Jiangsu University, Tenure-track Associate Professor and Master's Supervisor

•2022.1–2023.7, Natural Medicine Institute of YST, Phytochemistry Researcher

•2020.10–2021.9, Hansoh Pharmaceutical Group Company Limited., Analytical Researcher

Part 5 Research Interests

1.Discovery of novel bioactive secondary metabolites from microorganisms

2.Research on cryptic secondary metabolites of microorganisms based on co-culture strategy

3.Structural modification and structure-activity relationship study of bioactive natural products

Part 6 Research Achievements

6.1 Research Projects

•2025.1–2027.12 | National Natural Science Foundation of China Youth Program (Grant No. 82404465) | NSFC | Principal Investigator

•2025.7–2027.6 | Jiangsu Provincial "Double Innovation Doctor" Program (Grant No. JSSCBS0623) | Jiangsu Provincial Department of Science and Technology | Principal Investigator

•2024.1–2026.12 | The Senior Talent Foundation of Jiangsu University (Grant No. 5501290012) | Jiangsu University | Principal Investigator

•2026.1–2029.12 | National Natural Science Foundation of China General Program (Grant No. 82574882) | NSFC | Participant

6.2 Publications

21. Zou Y, Gong C, Pan C*. Neuroprotective effects of natural products: Innovative therapeutic strategies for preventing the progression of neurodegenerative diseases. Mini-Rev. Med. Chem. 2026

20. Pan C, Yang K, Li Z, et al. An overview of novel compounds from marine invertebrates: Sources, structures, and bioactivities. Curr. Med. Chem. 2026.

19. Pan C, Tang Z, Kakeya H. Mushroom-derived metabolites: A promising sourceof novel lead compounds for pharmaceutical and functional food applications. Med. Chem. Res. 2026.

18. Tang W, Hu L, Pan C*. Bioactive compounds from cyanobacteria: A mini review. Curr. Top. Med. Chem. 2026.

17. Pan C, Kurimura M, Taniguchi M, et al. Piperapeptins A and B, cyclic hexapeptides containing the rare amino acid piperazic acid, produced by a combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis. J. Nat. Prod. 2026

16. Pan C, Zhang L, Kuranaga T, et al. Combination of combined-culture of Amycolatopsis sp. with Tsukamurella pulmonis and GNPS molecular networking reveals novel sulfur-containing cyclic lipopeptides thioamycolamides F–I. J. Antibiot. 2026, 79(5): 293-300.

15. Pan C, Ni H, Li Z, et al. Recent advances in bioactive natural products from plant fruits: structures, activities, and future prospects. Plant Food Hum. Nutr. 2025, 80(4): 191.

14. Pan C, Kakeya H. Recent progress in chemistrty and bioactivity of novel enzyme inhibitors from natural products: a comprehensive review. Eur. J. Med. Chem. 2025, 289, 117481.

13. Pan C, Hassan S S, Ishaq M, et al. Marine actinomycetes: a hidden treasure trove for antibacterial discovery. Front. Mar. Sci. 2025, 12: 1558320.

12. Yi R, Shi Y, Cao X, Pan C*. Actinomycetes: treasure trove for discovering novel antibiotic candidates. Eur. J. Med. Chem. 2025, 117317.

11. Pan C#*, Hassan SS#, Muhammad I, Jin H*. Marine fungi as a goldmine for novel antibiotics: a 2024 perspective. Front. Mar. Sci. 2025. (# co-first author‌)

10. Pan C#, Ikeda H#, Minote M, Tokuda T, Kuranaga T, Taniguchi T, Shinzato N, Onaka H, Kakeya H. Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis. J. Antibiot. 2024, 77, 66-70.(# co-first author‌)

9. Pan C, Kuranaga T, Cao X, Suzuki T, Dohmae N, Shinzato N, Onaka H, Kakeya H. Amycolapeptins A and B, Cyclic nonadepsipeptides produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis. J. Org. Chem. 2021, 86, 1843-1849.

8. Pan C, Kuranaga T, Kakeya H. Application of the highly sensitive labeling reagent to the structural confirmation of readily isomerizable peptides. J. Nat. Med. 2021, 75, 339-343.

7. Pan C, Kuranaga T, Kakeya H. Total synthesis of thioamycolamide A via a biomimetic route. Org. Biomol. Chem. 2020, 18, 8366-8370.

6. Pan C, Kuranaga T, Liu C, Lu S, Shinzato N, Kakeya H. Thioamycolamides A-E, sulfur-containing cycliclipopeptides produced by the rare actinomycete Amycolatopsis sp. Org. Lett. 2020, 22, 3014-3017.

5. Pan C, Shi Y, Auckloo B N, Chen C T A, Chen X, Wu X, Wu B. Four verrucosidin derivatives isolated from the hydrothermal vent sulfur-derived fungus Penicillium sp. Y-50-10. Chem. Nat. Compd. 2018, 54, 253-256.

4. Pan C, Shi Y, Auckloo B N, Hassan S S, Akhter N, Wang K, Ye Y, Chen C T A, Tao X, Wu B. Isolation and antibiotic screening of fungi from a hydrothermal vent site and characterization of secondary metabolites from a Penicillium isolate. Mar. Biotechnol. 2017, 19, 469-479.

3. Pan C, Shi Y, Chen X, Chen C T A, Tao X, Wu B. New compounds from a hydrothermal vent crab-associated fungus Aspergillus versicolor XZ-4. Org. Biomol. Chem. 2017, 15, 1155-1163.

2. Pan C, Lu J, Wu B, Wu L, Li B. Effect of monomer structure on crystallization and glass transition of flexible copolyesters. J. Polym. Environ. 2017, 25, 1051-1061.

1. Pan C, Shi Y, Auckloo B N, Chen X, Chen C T A, Tao X, Wu B. An Unusual conformational isomer of verrucosidin backbone from a hydrothermal vent fungus, Penicillium sp. Y-50-10. Mar. Drugs 2016, 14, 156.

Collaboration‌：

10. Mao D, Lu S, Su X, Pan C, et al. Mannodaidzein, a rare daidzein mannoside isolated froma rare actinomycete Saccharothrix sp. JS2. Rec. Nat. Prod. 2025, 1: 12-12.

9. ul Hassan S S, Ahmad N, Rehman A, Pan C, et al. A cinderella story in antimicrobials: CDPDP’s perfect fit for multiple-pathway bacterial inhibition. Eur. J. Med. Chem. 2025: 117967.

8. Tokuda T, Kuranaga T, Minote M, Minote M, Ikeda H, Pan C, Kakeya H. Structural elucidation using highly sensitive labeling reagents and total synthesis of a new anoikis inducer amoxetamide A. Chem. Eur. J. 31, e202500357, 2025.

7. Kanoh N, Terashima R, Nishiyama H, Terajima Y, Nagasawa S, Sasano Y, Iwabuchi Y, Saito H, Egoshi S, Dodo K, Sodeoka M, Pan C, Ikeuchi Y, Nishimura S, Kakeya H. Design, synthesis, and antifungal activity of 16,17-dihydroheronamide C and ent-heronamide C. J. Org. Chem. 2021, 86, 16249-16258.

6. Kuranaga T, Minote M, Morimoto R, Pan C, Ogawa H, Kakeya H. Highly sensitive labeling reagents for scarce natural products. ACS Chem. Biol. 2020, 15, 2499-2506.

5. Shi Y, Pan C, Cen S, Fu L, Cao X, Wang H, Wang K, Wu B. Comparative metabolomics reveals defence-related modification of citrinin by Penicillium citrinum within a synthetic Penicillium-Pseudomonas community. Environ. Microbiol. 2019, 21, 496-510.

4. Akhter N, Pan C, Liu Y, Shi Y, Wu B. Isolation and structure determination of a new indene derivative from endophytic fungus Aspergillus flavipes Y-62. Nat. Prod. Res. 2019, 33, 2939-2944.

3. Auckloo BN, Pan C, Akhter A, Wu B, Wu X, He S. Stress-driven Discovery of Novel Cryptic Antibiotics from a Marine Fungus Penicillium sp. BB1122. Front. Microbiol. 2017, 8, 1450.

2. Shi Y, Pan C, Chen C-T A, Wu B. Synthetic multispecies microbial communities reveals shifts in secondary metabolism and facilitates cryptic natural product discovery. Environ. Microbiol. 2017, 19, 3606-3618.

1. Shi Y, Pan C, Auckloo BN, Chen X, Chen C-T A, Wang K, Wu X, Ye Y, Wu B. Stress-driven discovery of a cryptic antibiotic produced by Streptomyces sp. WU20 from Kueishantao hydrothermal vent with an integrated metabolomics strategy. Appl. Microbiol. Biotech. 2017, 101, 1395-1408.