Part 1 Basic Information

Name: Meng Xie

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: xiemeng@ujs.edu.cn

Part 2 Personal Profile

Dr. MengXie is an Associate Professor and Master’s Supervisor at the School of Pharmacy, Jiangsu University. Her research focuses on nano-drug delivery and biosensing. She has presided over 4 national and provincial research projects and has been listed among the World’s Top 2% Scientists by Elsevier for three consecutive years (2024–2026). She has published more than 40 papers in authoritative journals including Angewandte Chemie-International Edition, Nature Communications, Chemical Engineering Journal, Journal of Controlled Release, Journal of Colloid and Interface Science, etc.

Part 3 Education

• 2008.09–2013.06, Zhejiang University, Pharmaceutics, Doctor of Philosophy

• 2004.09–2008.06, School of Pharmacy, Soochow University, Pharmacy, Bachelor of Science

Part 4 Work Experience

• 2016.06–Present, School of Pharmacy, Jiangsu University, Associate Professor, Master’s Supervisor

• 2013.06–2016.06, School of Pharmacy, Jiangsu University, Lecturer

• (2018.03–2019.04, Columbia University, USA, Visiting Scholar)

Part 5 Research Interests

1.Fabrication of functional nano-biomaterials and targeted drug delivery

2. Multi-targeted therapy for Alzheimer’s disease and inflammatory diseases

3. Biosensing

Part 6 Research Achievements

6.1 Research Projects

2025.09–2027.06 | Social Development General Program of Zhenjiang Science and Technology Plan, Design and Synergistic Regulation Mechanism of Dandelion-Based Nano-Drugs for Intranasal Delivery against Alzheimer’s Disease (Grant No. SH2025034) | Zhenjiang Science and Technology Bureau | Principal Investigator

• 2021.09–2023.06 | China Postdoctoral Science Foundation General Program, Light-Controlled Self-Targeted Therapeutic System with “Dual-Disassembly and Dual-Clearance” for Alzheimer’s Disease Based on Black g-C₃N₄ (Grant No. 2021M701502) | China Postdoctoral Science Foundation | Principal Investigator

• 2020.09–2023.06 | Natural Science Foundation of Jiangsu Province (General Program), Biomimetic Camouflage of Two-Dimensional TMDs and Imaging-Guided Precision Tumor Therapy (Grant No. BK20201419) | Jiangsu Provincial Department of Science and Technology | Principal Investigator

• 2016.01–2018.12 | National Natural Science Foundation of China (Young Scientists Fund), Construction of Graphene-Based Light-Controlled Biomimetic Drug Delivery System and Its Application in Multimodal Therapy of Hepatocellular Carcinoma (Grant No. 21506079) | National Natural Science Foundation of China | Principal Investigator

• 2014.09–2016.06 | China Postdoctoral Science Foundation General Program, Design and Performance Evaluation of Graphene/Lipid Photothermally Responsive Biomimetic Drug Carriers (Grant No. 2014M560399) | China Postdoctoral Science Foundation | Principal Investigator

6.2 Publications

[1] Wang Yan, Li Lianxin, Zhou Puyang, Gan Yu, Liu Weipeng, Wang Yiwen, Deng Yilin, Li Hongping; Xie Meng*, Xu Yuanguo. Aeration-Free Photo-Fenton-Like Reaction Mediated by Heterojunction Photocatalyst toward Efficient Degradation of Organic Pollutants, Angew. Chem. Int. Ed. 2025, 64, e202419680.

[2] Yuewen Zhang, Yancheng Hong, Fengmei Yang, Yujiao Yan, Ruixin Zhao, Meng Xie*. TGN peptide and erythrocyte membrane dual-modified selenium-doped carbon quantum dots for multifaceted treatment of Alzheimers's disease. Chem. Eng. J., 2025, 514, 163340

[3] Lianxin Li, Yu Xiong, Yuewen Zhang, Yujiao Yan, Ruixin Zhao, Fengmei Yang, Meng Xie*. Biofilm-camouflaged Prussian blue synergistic mitochondrial mass enhancement for Alzheimer's disease based on Cu²⁺ chelation and photothermal therapy. J. Controlled Release, 2024, 375, 269-284.

[4] Yujiao Yan, Yutong Chen, Fengmei Yang, Ruixin Zhao, Die Tian, Liran Deng, Meng Xie*. In-situ engineering of a covalent organic framework-based biomimetic nanoplatform for multi-target therapy of Alzheimer’s disease, Biomaterials Advances, 2026, 182, 214728

[5] Fengmei Yang, Yutong Chen, Yujiao Yan, Ruixin Zhao, Liran Deng, Die Tian, Meng Xie*, Biomimetic red blood cell membran-coated cerium metal-organic framework for multi-target synergistic therapy of Alzheimer’s disease, Colloids and Surfaces B: Biointerfaces, 2026, 262, 115464

[6] Ruixin Zhao, Mengrong Guo, Fengmei Yang, Yujiao Yan, Die Tian, Liran Deng, Qi Wang* and Meng Xie*. A Microglia membrane biomimetic platinum-based MOF-loaded quercetin nanodrug delivery system for the treatment of Alzheimer's disease. Journal of Materials Chemistry B, 2026, 14, 6034-6049

[7] Lianxin Li, Jiayang Zhang, Yuewen Zhang, Ruixin Zhao , Fengmei Yang, Yujiao Yan, Qi Wang*, Meng Xie*. Biofilm-modified Prussian blue improves memory function in late-stage Alzheimer’s disease mice with triple therapy. Inter. J. Pharm. 2025, 670,125112

[8] Xiating Qi, Lianxin Li, Pengkun Ye, Meng Xie*. Macrophage Membrane-Modified MoS₂ Quantum Dots as a Nanodrug for Combined Multi-Targeting of Alzheimer's Disease, Adv. Healthc. Mater., 2024, 13: 2023211

[9] Mingyuan Chi, Jichun Liu, Lianxin Li, Yuewen Zhang, and Meng Xie*. CeO₂ In Situ Growth on Red Blood Cell Membranes: CQD Coating and Multipathway Alzheimer’s Disease Therapy under NIR. ACS Appl. Mater. Interfaces 2024, 16, 35898−35911

[10] Mingyuan Chi , Jichun Liu, Lianxin Li, Yuewen Zhang, Meng Xie. In-situ growth of CeO₂ on biofilms: Innovative nanoparticles for photothermal therapy & multi-pronged attack on Alzheimer’s disease. Colloids and Surfaces B: Biointerfaces 2024, 238, 113887.

[11] Jichun Liu, Mingyuan Chi, Lianxin Li, Yuewen Zhang, Meng Xie*. Erythrocyte membrane coated with nitrogen-doped quantum dots and polydopamine composite nano-system combined with photothermal treatment of Alzheimer's disease, J. Colloid Interf. Sci., 2024, 663:856-868

[12] Pengkun Ye, Lei Li, Xiating Qi, Mingyuan Chi, Jichun Liu, Meng Xie*. Macrophage membrane-encapsulated nitrogen-doped carbon quantum dot nanosystem for targeted treatment of Alzheimer’s disease: Regulating metal ion homeostasis and photothermal removal of β-amyloid. J. Colloid Interf. Sci., 2023, 650, 1749–1761.

[13] Xiating Qi, Pengkun Ye, Meng Xie*. MoS₂ quantum dots based on lipid drug delivery system for combined therapy against Alzheimer’s disease. J. Drug Deliv. Sci. Tec. 2023, 82, 104324.

[14] Jiaqian Li, Xiating Qi, Pengkun Ye, Mei Yang, Meng Xie*. Construction of WS₂/Au-lipid drug delivery system for multiple combined therapy of tumor. J. Drug Deliv. Sci. Tec. 2023, 76, 103747.

[15] Jia-Qian Li, Rui-Xin Zhao, Feng-Mei Yang, Xia-Ting Qi, Peng-Kun Ye, Meng Xie*. An erythrocyte membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of breast cancer. J. Mater. Chem. B, 2022, 10, 2047.

[16] Jiaqian Li, Na Yang, Mei Yang, Chao Lu*, Meng Xie*. Development of a magnetic MoS₂ system camouflaged by lipid for chemo/ phototherapy of cancer. Colloids Surf., B 2022, 213,112389.

6.3 Patents and Software Copyrights

•[1] Zhao Ruixin, Xie Meng. Preparation method and application of layered WS₂/Au@tumor cell membrane composite material, 2022-04-19, China, ZL 2022 1 0407111.9

•[2] Xie Meng, Zhang Feng, Xu Yuanguo, Yang Mei, Yang Na, Zhang Yanan. Preparation method and application of magnetic graphene oxide-chitosan/dextran composite, 2020-05-05, China, ZL 201711173539.7

•[3] Xie Meng, Zhang Yanan, Xu Yuanguo, Yang Na, Yang Mei, Zhang Feng. Preparation method and application of graphene oxide-lipid nanocomposite, 2020-06-09, China, ZL 201711178589.4

•[4] Xie Meng, Yang Mei, Xu Yuanguo, Zhang Yanan, Yang Na, Zhang Feng. Preparation method and application of lipid-modified magnetic graphene oxide composite material, 2020-07-31, China, ZL 201711178607.9

•[5] Xie Meng, Liu Caihong, Xu Yuanguo, Zhang Yanan, Zhang Feng, Lei Hailin, Yang Na. Preparation method and application of graphene oxide-protamine/sodium alginate composite, 2020-01-24, China, ZL 201710227407.1