Part 1 Basic Information

Name: Xia Guohua

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Tel: 0511-85038451

Email: xgh78131@ujs.edu.cn

Part 2 Personal Profile

Guohua Xia, male, Senior Experimentalist and Master’s Supervisor at the School of Pharmacy, Jiangsu University, and Science and Technology Vice-General of Jiangsu Province. His research focuses on key technologies for quality control of traditional Chinese medicines (TCMs), as well as physical field sterilization technologies for medicinal and edible TCM materials. He has published more than 30 papers in domestic and international authoritative journals including Food Research International and Journal of Applied Research on Medicinal and Aromatic Plants. He has won four science and technology awards such as the China General Chamber of Commerce Science and Technology Award and the Jiangsu Traditional Chinese Medicine Science and Technology Award. He serves as a director of the 3rd Council of the Professional Committee for Quality of Chinese Herbal Decoction Pieces, World Federation of Chinese Medicine Societies; a member of the Chinese Pharmaceutical Association; a member of the Diet and Nutrition Professional Committee of Jiangsu Health Management Association; and a member of the Professional Committee of Chinese Materia Medica and Natural Medicines under the 6th Council of Zhenjiang Pharmaceutical Association.

Part 3 Education

•2016.09–2022.06: Jiangsu University, Food Science, Ph.D.

•2007.09–2010.12: Jiangsu University, Pharmaceutics, M.S.

•2002.09–2005.07: Nanjing University of Chinese Medicine, Chinese Materia Medica, B.S.

Part 4 Work Experience

•2018.04- Present: School of Pharmacy, Jiangsu University, Senior Experimentalist, Master’s Supervisor

•2007.11-2018.04：School of Pharmacy, Jiangsu University, Experimentalist

•2001.01-2007.10：School of Pharmacy, Jiangsu University, Assistant Experimentalist

•1997.08-2000.12：Department of Pharmacy, Zhenjiang Medical College, Laboratory Technician

Part 5 Research Interests

1.Key technologies of physical field decontamination for medicinal and edible traditional Chinese medicines

2.Stress response mechanisms of microorganisms

3.Key technologies for quality control of traditional Chinese medicines

Part 6 Research Achievements

6.1 Research Projects

•2024.05-2033.05, Industry-University-Research Cooperation Agreement (HX240053#), Principal Investigator

•2023.06-2025.06, Enterprise-commissioned Technology Development, Development of Preparation Technology for Hydrophilic Antibacterial Medical Device Coatings (HX20230517, 2022321102001169), Principal Investigator

•2021.05-2023.04, Jiangsu Industry-University-Research Cooperation Project, Development of Key Preparation Technologies for Fluorescent Quantitative Rapid Detection Strips of Aflatoxin B1 (BY2021178), Principal Investigator

•2021.08-202307, Jiangsu Provincial Science and Technology Vice-General Program, Principal Investigator

•2018.05-2019.04, Enterprise-commissioned Technical Service Project, Research and Development of CDV Antigen Rapid Detection Test Strips (20180321), Principal Investigator

•2016.06-2017.12, Enterprise-commissioned Technical Service Project, Research and Development of Dispersible Tablets A and B for Detection (20160410), Principal Investigator

•2021.01-2025.12, General Program of National Natural Science Foundation of China (NSFC), Discovery, Characterization and Specific Identification of Novel Markers for Hirudo in Chinese Patent Medicines (82173937), Participant (5/9)

•2018.01-2021.12, General Program of NSFC, Construction of a Novel and Efficient Enzymatic Hydrolysis System for Obtaining Active Ingredients from Traditional Chinese Medicines (81873196), Participant (5/10)

•2017.01-2020.12, General Program of NSFC, Specific Identification Research of Glue-Type Chinese Materia Medica Based on Specific Proteins (81773855), Participant (5/10)

•2016.01-2019.12, General Program of NSFC, Construction of Multi-target Lipid Raft Chromatography Related to P-gp Regulation, Screening of Active Component Groups of TCMs and Their Mechanism of Action (81673574), Participant (3/9)

•2013.01-2015.12, Young Scientists Fund of NSFC, Recyclable Covalently Immobilized Enzymes for Efficient Catalytic Production of TCM Active Ingredients (81303313), Participant (3/13)

•2013.01-2015.12, Young Scientists Fund of NSFC, Characterization of Marker Proteins and Peptides in Animal Medicines by MALDI-TOF/TOF-MS for Specific Identification (81303174), Participant (7/14)

•2015.07-2018.06, Young Scientists Fund of Jiangsu Natural Science Foundation, Identification of Glue-Type Chinese Materia Medica Based on NanoLC-Orbitrap MSD (BK20150463), Participant (4nd)

•2013.07-2016.06, Young Scientists Fund of Jiangsu Natural Science Foundation, Construction and Mechanism Study of HDL Nanoparticles as Targeted Co-delivery Carriers for Liver Cancer (BK20130541), Participant (2/8)

•2012/07-2015/06, Young Scientists Fund of Jiangsu Natural Science Foundation, Study on Characteristic Recognition Markers of Marker Proteins and Peptides for Identification of Five Kinds of Animal Medicines (BK2012290), Participant (3/11)

•2013.02-2014.12, Jiangsu University Fund for Medical Clinical Science and Technology Development, Screening of Anti-Mycobacterium tuberculosis Active Compounds from Silybum marianum Seed Kernel Oil (JLY20120171), Participant (4/6)

•2011.09-2014.12, Research Startup Fund for Senior Professionals of Jiangsu University, Study on Anti-Mycobacterium tuberculosis Active Compounds in Silybum marianum Seed Kernel Oil and Its Extraction Technology (11JDG073), Participant (5/7)

•2011.09-2013.08, Open Fund of Key Laboratory of TCM Drug Delivery System, National Administration of Traditional Chinese Medicine, Research on Construction and Bioavailability Evaluation Technology of Multi-component Release System of Tongmai Pellets (2011NDDCM01002), Participant (3/8)

•2009/09-2013/12, Natural Science Research Project of Jiangsu Universities, Study on a New Two-step Tandem Enzymatic Synthesis Process of Amoxicillin (09KLB530001), Participant (3/3)

•2009.11-2012.12, Science and Technology Project of Jiangsu Administration of Traditional Chinese Medicine, Release Behavior and Pharmacokinetics of Pueraria Flavonoids and Salvianolic Acids in Multi-component Release System of Tongmai Pellets (LZ09061), Participant (3/7)

•2024.07-2026.06, Zhenjiang Science and Technology Development Program, Research on Key Identification Technologies for Carapax Trionycis Medicinal Materials, Decoction Pieces and Its Contained Chinese Patent Medicines (SH2024055), Campus Principal Investigator (3nd)

•2023.07-2025.06, Zhenjiang Science and Technology Development Program, Establishment of On-site Rapid Identification Method for Hirudo in Blood-activating and Stasis-resolving TCMs Based on LAMP (SH2023014), Campus Principal Investigator (2nd)

•2022.10-2024.10, Applied Basic Research Program of Changzhou Science and Technology Program, Study on Immobilized Enzyme Technology for Efficient Catalytic Production of TCM Active Ingredient Diosgenin (CJ20220161), Campus Principal Investigator (5nd)

•2022.07-2024.06, Nantong Basic Scientific Research Program, Specific Identification Research of Animal Medicine Components (Gallus Gigerii Endothelium Corneum, Bombyx Batryticatus, Carapax Trionycis) in Commonly Used Pediatric Chinese Patent Medicines, Campus Principal Investigator (3nd)

•2017.11-2019.12, Zhenjiang Key Research and Development Program, Material Basis of Toona sinensis Leaves in the Treatment of Diabetic Nephropathy Based on Component Structure Theory (SH2017035), Campus Principal Investigator (2/8)

6.2 Publications

1.Guohua Xia, Haixia Li, Minjun Wang, Lei Zhang, Cunshan Zhou, Yuping Shen*, Huan Yang*. Bactericidal mechanisms of intense pulsed light against Salmonella Enteritidis on green Sichuan pepper. Food Research International, 2025, 219: 117042. （Q1，IF=8.0）

2.Guohua Xia, Haixia Li, Minjun Wang, Siying Fu, Pushuo Wang, Huan Yang*, Cunshan Zhou*, Lei Zhang*. Catalytic infrared promoted the decontamination of intense pulsed light on green Sichuan pepper (Zanthoxylum schinifolium). Journal of Food Safety, 2025, 45(1): e70005.

3.Guohua Xia, Yangguang Dai, Jinwei Zhou, Mingjing Zhang, Minjun Wang, Huan Yang*, Yuping Shen*, Pengfei Yang*. Diosgenin production from Dioscorea zingiberensis tubers by novel pressurized hydrolysis in acidic ionic liquids. Journal of Applied Research on Medicinal and Aromatic Plants, 2024, 43: 100596. （Q2）

4.Yeting Zhu, Jiangsong Peng, Yaqin Zhao, Mengru Wu, Suping Chen, Jiali Shao, Xubo Wang, Guohua Xia*, Yuping Shen. Obtaining acid-sensitive prosaikogenin F by enzymatic hydrolysis of saikosaponin A. Pharmacognosy Magazine, 2023, 19(3): 689-699.

5.Jiangsong Peng, Ye Li, Xiaoli Deng, Mengyao Lu, Chunbin Yang, Yuping Shen, Guohua Xia*, Huan Yang*. Loop‑mediated isothermal amplification for on‑site visual identification of Leech species. Food Analytical Methods, 2024, 17: 618-627.

6.Guohua Xia, Minjun Wang, Haixia Li, Manni Ren, Hafida Wahia, Cunshan Zhou*, Huan Yang*. Synergistic principle of catalytic infrared and intense pulsed light for bacteriostasis on green Sichuan pepper (Zanthoxylum schinifolium). Food Bioscience, 2023, 56(22): 103177. （Q1）

7.Guohua Xia, Ye Li, Huihui Tao, Long Zhang, Jin Zhang, Huan Yang, Abdullateef Taiye Mustapha, Cunshan Zhou*. Inactivation mechanism of catalytic infrared against Pseudomonas aeruginosa and its decontamination application on dry green Sichuan pepper (Zanthoxylum schinifolium), Food Control, 2022, 132, 108483. （Q1）

8.Hao-Feng Wu, Yan-Hong Chao*, Guo-Hua Xia*, Jing Luo, Duan-Jian Tao, Lin-Hua Zhu, Gui-Ling Luo, Yan Huang, Ming-Qing Hua, Wen-Shuai Zhu*. Enhanced adsorption performance for antibiotics by alcohol-solvent mediated boron nitride nanosheets. RARE METALS, 2022, 41(1): 342-352. （Q1）

9.Xia Guohua, Ruirong Pan, Rui Bao, Yanru Ge, Cunshan Zhou*, Yuping Shen. Rapid Quantitative Analysis of Naringenin in the Fruit Bodies of Inonotus vaninii by Two-phase Acid Hydrolysis Followed by RP-HPLC-UV [J]. Pharmacognosy Magazine, 2017, 13(52): 659-662.

10. Guo-Hua Xia, Wei Liu, Xiao-Ping Jiang, Xiang-Yu Wang, Ye-Wang Zhang, and Jianyong Guo. Surface Modification of Fe3O4@SiO2 Magnetic Nanoparticles for Immobilization of Lipase. Journal of Nanoscience and Nanotechnology, 2017, 17: 370-376.

11.Caihong Tan; Xianrong Xu, Jun Chen, Xianli Fu; Guohua Xia*, Huan Yang*. A novel approach for the efficient extraction of silybin from milk thistle fruits, Pharmacognosy Magazine, 2014, 40(10): 536-540.

12.Guo Lu-Yue, Yang Cheng-Yu, Fu Si-Ying, Zhou Jin-Wei, Song Xiao-Bing, Liu Rong-Sheng, Xia Guo-Hua*, Yang Huan*. Preparation of nitrogen-doped carbon quantum dots from turmeric cellulose and its application for ferric ion detection. Chinese Traditional Patent Medicine, 2025, 47(07): 2184–2189.

13.Deng Xiao-Li, Li Ye, Lu Meng-Yao, Ge Chong-Yu, Zheng Han-Xue, Shen Yu-Ping, Yang Chun-Bin, Sun Xiao-Xiang, Xia Guo-Hua*, Yang Huan*. Rapid identification of Hirudo components in Maixuekang Capsules based on loop-mediated isothermal amplification. Chinese Traditional Patent Medicine, 2025, 47(07): 2441–2445.

14.Chen Xiang, Han Jing, Wang Jia-Qi, Peng Jiang-Song, Cao Shao-Yang, Ning Yi-Ke, Xia Guo-Hua*, Yang Huan*. Study on authenticity identification of vinegar-processed Carapax Testudinis in Dabuiyin Pills. Chinese Traditional Patent Medicine, 2025, 47(03): 1031–1035.

15.Han Jing, Chen Xiang, Li Ye, Shen Yu-Ping, Sun Xiao-Xiang, Xia Guo-Hua*, Yang Huan*. Identification of vinegar-processed Carapax Trionycis in Gejie Dingchuan Pills by fluorescent quantitative PCR. Chinese Traditional Patent Medicine, 2024, 46(04): 1209–1213.

16.Xu Tian-Zhen, Wu Meng-Ru, Shao Jia-Li, Chang Yue, Zhu Ye-Ting, Chen Ji-Xuan, Chen Lu-Yang, Chen Deng-Yan, Yang Huan, Xia Guo-Hua*. Preparation of rare protobupleurosaponin A via enzymatic hydrolysis of saikosaponin B1. Chinese Traditional Patent Medicine, 2023, 45(12): 4156–4160.

17.Yang Huan, Roselyn Tehzee Gblinwon, Yang Ya-Ya, Wang Qiang, Chen Xiang, Lu Meng-Yao, Zheng Han-Xue, Wu Yuan-Zhen, Xia Guo-Hua*, Shen Yu-Ping. Protein identification of Cornu Cervi and Cornu Cervi Pantotrichum. Chinese Traditional Patent Medicine, 2022, 44(06): 1859–1864.

18.Xia Guo-Hua, Shen Yu-Ping, Yang Huan, Jia Xiao-Bin*. Determination of catecholamine compounds in rat urine by HPLC-FD. Chinese Journal of Experimental Traditional Medical Formulae, 2014, 20(23): 76–79.

19.Xia Guo-Hua, Yin Hua-Wu, Wang Xu-Bo, Yuan Zhen, Yang Huan*, Jia Xiao-Bin. Determination of diosgenin in Dioscorea zingiberensis by biphasic combined acid hydrolysis-HPLC. Natural Product Research and Development, 2013, 25(12): 1699–1703.

20.Xia Guo-Hua, Qi Xue-Yong, Fu Hai-Zhen, Ge Yan-Ru*. Determination of total flavonoids in Phellinus igniarius extract by charge-transfer UV spectrophotometry. Spectroscopy Laboratory, 2013, 30(3): 1362–1367.

21.Xia Guo-Hua, Ge Yan-Ru*, Qi Xue-Yong, Zheng Zhao-Lei, Ren Meng. Determination of naringenin in Phellinus vaninii by reversed-phase high-performance liquid chromatography. Acta Edulis Fungi, 2012, 19(2): 84–86.

22.Xia Guo-Hua, Qi Xue-Yong, Fu Hai-Zhen, Ge Yan-Ru*. Determination of total flavonoids in fruiting bodies of Phellinus igniarius by charge-transfer fluorescence spectrometry. Spectroscopy Laboratory, 2012, 29(4): 2425–2428.

23.Xia Guo-Hua, Tong Xin-Wei, Ding Yan, Yang Huan*. Determination of rutin in Toona sinensis leaves by reversed-phase high-performance liquid chromatography. Journal of Nanjing University of Chinese Medicine, 2011, 27(6): 41–42.

24.Xia Guo-Hua, Ge Yan-Ru, Fu Hai-Zhen, Qi Xue-Yong. Optimization of ultrasonic extraction process for total flavonoids from Phellinus igniarius. Journal of Jiangsu University (Medicine Edition), 2010, 20(1): 40–41, 55.

6.3 Monographs and Textbooks

•Qi Xueyong (Ed.). Experiment of Pharmaceutical Analysis [M]. Zhenjiang: Jiangsu University Press, 2018.

6.4 Patents and Software Copyrights

•[1] Xia Guohua, Fu Haizhen, He Peng, Yang Huan, Tong Shanshan. A low-temperature condensed water circulation pipeline for undergraduate laboratories [P]. Authorized on Jun. 23, 2020, Patent No. ZL201921426819.X

•[2] Yang Huan, Shen Yuping, Gu Qinying, Zhou Cunshan, Xia Guohua, Sun Jing. A method for simultaneous preparation and detection of gallic acid and its methyl ester from Toona sinensis leaves [P]. Authorized on Dec. 24, 2014, China, Patent No. ZL201210513809.5

•[3] Yang Huan, Gu Qinying, Xia Guohua. A rapid separation method for catalpol from Rehmannia glutinosa using triple-column chromatography [P]. Authorized on Sep. 02, 2015, China, Patent No. ZL201310476980.8. Assigned to Chengdu Pufei De Reference Substance Technology Co., Ltd.

•[4] Yang Huan, Gu Qinying, Xia Guohua. A method for extracting diosgenin via pressurized two-phase acid hydrolysis [P]. Authorized on Oct. 28, 2015, China, Patent No. ZL201310726629.X

•[5] Shen Yuping, Yang Huan, Xia Guohua, Zhou Cunshan, Wang Haiyan, Lu Yi. A method for obtaining baohuoside I by biphasic enzymatic hydrolysis [P]. Authorized on Jun. 26, 2020, China, Patent No. ZL201611119179.8

•[6] Yang Huan, Zhou Ying, Shen Yuping, Yang Yaya, Wu Qinan, Xia Guohua, Chen Yufei, Lu Beibei. A set of specific primers for identifying Bombyx Batryticatus and its identification method [P]. Authorized on Sep. 25, 2020, China, Patent No. ZL201711487245.1