Part 1 Basic Information

Name: Chen Wang

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: chenwang@ujs.edu.cn

Part 2 Personal Profile

Dr. Chen Wang is a Professor and Master's Supervisor at the School of Pharmacy, Jiangsu University. Her research focuses on non-coding RNA and host-microbe interactions. She has led two national and provincial research projects and published papers in prestigious journals, including Cell Reports Medicine, Cancer Research, Protein Cell, Nat. Cell Biol., Cell Res., and Nat. Commun. She serves as a reviewer for SCI-indexed journals (Int J Cancer, J Cell Physiol, Plos One) and a young editorial board member of Journal of Jiangsu University (Medicine Edition) and ExRNA.

Teaching: Pharmacology, Clinical Pharmacotherapeutics.

Graduate admission programs: 1007 Pharmacy–Pharmacology (academic master), 0860 Biology and Medicine (Pharmaceutical Engineering, professional master), 1055 Pharmaceutical Science (professional master).

Part 3 Education

•2010.03–2012.04, Yale University, School of Medicine, Visiting Scholar.

•2007.09–2013.09, Nanjing University, School of Life Sciences, Ph.D.

•2003.09–2007.06, Nanjing University, School of Life Sciences, B.S.

Part 4 Work Experience

•2021.11–Present, School of Pharmacy, Jiangsu University, Professor and Master's Supervisor

•2013.10–2021.10, School of Life Sciences, Nanjing University, Associate Research Fellow

Part 5 Research Interests

1.Roles of non-coding RNA in cancer

2.Host-microbe interaction mechanisms and development of novel anti-bacterial therapeutics

3.Characterization of small nucleic acids from traditional Chinese medicine

Part 6 Research Achievements

6.1 Research Projects

•2017.01–2019.12 | National Natural Science Foundation of China Young Scientists Fund “Exosome-mediated delivery of siRNA for cross-kingdom regulation in bacteria” | NSFC | Principal Investigator

•2014.07–2017.06 | Natural Science Foundation of Jiangsu Province Young Scientists Fund “Mechanistic study of miR-203-mediated suppression of lung cancer progression by targeting SRC” | JSKJ | Principal Investigator

•2022.01–2024.12 | Senior Talent Foundation of Jiangsu University | Principal Investigator

•2017.01–2019.12 | National Natural Science Foundation of China Major Research Plan | Biogenesis and functional characterization of bacterial miRNA-like small RNAs in bacterial–host interactions | NSFC | Participant (2nd)

6.2 Publications

1.Li G, Li M, Liu S, Wei Y*, Wang C*. Plant-Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy. Phytother Res. 2026 Sep 21. doi: 10.1002/ptr.70456. (SCI Q1, IF = 8.1)

2.Wang C*, Li M, Li G, Zhang H, Wang C*, Zhang CY*. The HCMV-encoded miR-UL36-3p promotes angiogenesis of endothelial cells by downregulating FOXO3. Animal Model Exp Med. 2026 May;9(5):980-990. (SCI Q2, IF = 4.4)

3.Wang C#, Sheng W#, Zhou Y#, Hang X#, Zhao J#, Gu Y, Meng X, Bai Y, Li W, Zhang Y, Zhang L, Yu J, Zhou Z, Li X, Sun H, Xue Y, Xu T, Zen K, Ling H*, Zhang CY*, Bi H*, Wang H*. siRNA-AGO2 complex inhibits bacterial gene translation: A promising therapeutic strategy for superbug infection. Cell Rep Med. 2025 Mar 18;6(3):101997. (SCI Q1, IF = 14)

4.Wang C#*, Meng X#, Zhou Y#, Yu J, Li Q, Liao Z, Gu Y, Han J, Linghu S, Jiao Z, Wang T, Zhang CY*, Chen X*. Long Noncoding RNA CTD-2245E15.3 Promotes Anabolic Enzymes ACC1 and PC to Support Non-Small Cell Lung Cancer Growth. Cancer Res. 2021 Jul 1;81(13):3509-3524. (SCI Q1, IF = 22.6)

5.Meng X#, Sun W#, Yu J#, Zhou Y, Gu Y, Han J, Zhou L, Jiang X, Wang C*. LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer. Mol Ther Nucleic Acids. 2020 Oct 15;22:1004-1015. (SCI Q2, IF = 6.5)

6.Zhou Y#, Yuan Y#, Li L#, Wang X, Quan Y, Liu C, Yu M, Hu X, Meng X, Zhou Z, Zhang CY, Chen X, Liu M*, Wang C*. HER2-intronic miR-4728-5p facilitates HER2 expression and accelerates cell proliferation and migration by targeting EBP1 in breast cancer. PLoS One. 2021 Feb 2;16(2): e0245832.

7.Gu Y, Yu J, Zhang J*, Wang C*. Suppressing the secretion of exosomal miR-19b by gw4869 could regulate oxaliplatin sensitivity in colorectal cancer. Neoplasma. 2019 Jan 15;66(1):39-45.

8.Wang C#, Wang X#, Liang H#, Wang T#, Yan X, Cao M, Wang N, Zhang S, Zen K, Zhang C*, Chen X*. miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα. PLoS One. 2013 Sep 10;8(9):e73985.

9.Wang C#, Sun G#, Chen K, Lv Z, Peng S, Jiang X*, Xiang Y*, Zhang C*. Molecular cloning of lamprey uncoupling protein and assessment of its uncoupling activity using a yeast heterologous expression system. Mitochondrion. 2010 Jan;10(1):54-61.

10.Gu Y#, Liu S#, Zhang X, Chen G, Liang H, Yu M, Liao Z, Zhou Y, Zhang CY, Wang T*, Wang C*, Zhang J*, Chen X*. Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer. Protein Cell. 2017 Jun;8(6):455-466.

11.Wang N#, Liang H#, Zhou Y#, Wang C#, Zhang S, Pan Y, Wang Y, Yan X, Zhang J, Zhang CY, Zen K, Li D*, Chen X*. miR-203 Suppresses the Proliferation and Migration and Promotes the Apoptosis of Lung Cancer Cells by Targeting SRC. PLoS One. 2014 Aug 20;9(8):e105570.

12.Li W#, Ding J#, Chen S#, Chen J, Wang C, Li J, Shi H, Yin X, Wang J, Liu J, Song H, Zhou Z, Jiang X, Jiang W, Jiang Y, Cao M, Li B, Li J*, Li L*, Zhang Y*. Alleviation of colitis by honeysuckle MIR2911 via direct regulation of gut microbiota. J Control Release. 2024 Dec;376:123-137.

13.Yan W#, Wang S#*, Hao H#, Lin H, Wang C, Xie S, Zhang X, Lu Y, Ding X, Chen X, Liu H, Zhang G, Wei D, Ma C, Tang C, Li X, Yu B, Hu J, Gu Z, Yu EY*, Li W*, Xia J*, Zhang H*. Extracellular vesicle engineering using a small scaffold protein. Extracellular vesicle engineering using a small scaffold protein. Nat Commun. 2026 Mar 10;17(1):3726.

14.Chen Q#, Zhang F#, Dong L#, Wu H#, Xu J#, Li H#, Wang J, Zhou Z, Liu C, Wang Y, Liu Y, Lu L, Wang C, Liu M, Chen X, Wang C, Zhang C, Li D, Zen K, Wang F*, Zhang Q*, Zhang CY*. SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs. Cell Res. 2020 Aug 17. doi: 10.1038/s41422-020-0389-3.

15.Gan X, Wang C, Patel M, Kreutz B, Zhou M, Kozasa T, Wu D*. Different Raf protein kinases mediate different signaling pathways to stimulate E3 ligase RFFL gene expression in cell migration regulation. J Biol Chem. 2013 Nov 22;288(47):33978-84.

16.Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D*. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nat Cell Biol. 2012 May 20;14(7):686-96.

6.3 Patents and Software Copyrights

•Chen Wang, Xi Chen, Yu Zhou. A causative gene in non-small cell lung cancer and its applications: ZL 2021 1 0400139.5 [P]. 2022-05-13.

•Chen-Yu Zhang, Chen Wang, Huan Wang. Exosome formulation for treating drug-resistant bacterial infections: PCT/CN2020/133392.