Part 1 Basic Information

Name: Hanqing Liu

Address: School of Pharmacy, Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China

Email: hanqing@ujs.edu.cn

Part 2 Personal Profile

Dr. Hanqing Liu is a Professor and Doctoral Supervisor at the School of Pharmacy, Jiangsu University. She has been selected for Top Talent of Innovative Research Team of Jiangsu Province, the Second-tier Candidate of Jiangsu Province’s “333 High-level Talents Training Project,” Jiangsu Recruitment Program of Leading Creative and Entrepreneurial Talents, and the Jiangsu Specially-Appointed Professor Program. She has long been engaged in research on tumor target screening and the molecular mechanisms of aging. She has led multiple national and provincial/ministerial research projects and has published over 50 papers in authoritative domestic and international journals such as Nature Reviews Cancer, Molecular Cancer, PNAS, Clinical Cancer Research, Aging Cell, Chemistry & Biology, RNA, Cell Death & Disease, and Journal of Molecular Biology. She has received multiple science and technology awards, including the First Jiangsu Provincial Innovation and Excellence Award Medal, the Third Prize of the Jiangsu Provincial Science and Technology Award, the Second Prize of the Natural Science Award of the Chinese Association of Maternal and Child Health Studies, and the Second Prize of the Science and Technology Award of the Jiangsu Preventive Medicine Association. She also serves as a reviewer for journals such as Journal of Molecular Cell Biology, Journal of Cell Science, and Biochimie, and as a Council Member of the Jiangsu Pharmacological Society, among other academic positions.

Part 3 Education

•2004.07–2010.10, University of Pennsylvania, USA, Biochemistry, Ph.D.

•2001.09–2004.MM, 07, UShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Analytical Chemistry, M.S.

•1997.09–2001.07, Nanjing University and China Pharmaceutical University, Pharmaceutical Bioengineering (Intensive Class), B.S.

Part 4 Work Experience

•2013.10–Present, School of Pharmacy, Jiangsu University, School of Pharmacy, Jiangsu University, Professor and Doctoral Supervisor

•2010.11–2013.10 Department of Developmental Therapeutics, Fox Chase Cancer Center, USA, Postdoctoral Fellow

Part 5 Research Interests

1.Cancer target screening

2.Molecular mechanisms of aging associated diseases

3.Cancer pharmacology

Part 6 Research Achievements

6.1 Research Projects

• 2017.01–2020.12 | General Program of the National Natural Science Foundation of China, “Mechanism of Action of OCT1 at the Center of Signaling Pathways in Ovarian Cancer and Related Targeted Drugs” (Project No.: 81672582) | National Natural Science Foundation of China | Principal Investigator

•2016.07–2019.06 | Jiangsu Provincial Distinguished Young Scholars Program, “Research on Novel Targets and Targeted Drugs for Lung Cancer Based on RNA Interference and Signaling Network Construction” (Project No.: BK20160013) | Jiangsu Provincial Department of Science and Technology | Principal Investigator

•2015.10–2018.10 | Jiangsu Province “Six Talent Peaks” Project (Category B), “Identification and Study of Core Regulatory Genes in Lung Cancer Based on Network Construction and RNA Interference” | Jiangsu Provincial Department of Human Resources and Social Security | Principal Investigator

•2015.01–2017.12 | Youth Program of the National Natural Science Foundation of China, “Mechanistic Study of the PARD6A Gene Cluster Identified by Network Screening in Ovarian Cancer” (Project No.: 81402145) | National Natural Science Foundation of China | Principal Investigator

• 2014.07–2017.06 | Youth Program of the Natural Science Foundation of Jiangsu Province, “Study on the Synergistic Killing Effect of Inhibiting Src and PARD6A on Ovarian Cancer Based on Network and RNAi” (Project No.: BK20140572) | Jiangsu Provincial Department of Science and Technology | Principal Investigator

6.2 Publications

1.Liu H, Kiseleva AA, Golemis EA*. Ciliary signalling in cancer. Nat Rev Cancer. 2018, 18(8):511-524. （SCI Q1，IF=60.7）

2.Shi C, Lan T, Gao Y, Liang Z, Zhang Y, Tu Y, Liu H*, Tu Z*. Targeting CD30L in B-cell non-Hodgkin lymphoma: novel peptide conjugates and their therapeutic potential. Mol Cancer. 2025, 24(1):189. （SCI Q1，IF=42.2）

3.Liu H, Xiao F, Serebriiskii IG, O'Brien SW, Maglaty MA, Astsaturov I, Litwin S, Martin LP, Proia DA, Golemis EA*, Connolly DC*. Network analysis identifies an HSP90-central hub susceptible in ovarian cancer. Clin Cancer Res. 2013, 19(18):5053-67. （SCI Q1，IF=10.9）

4.Liu H, Chen C, Zhang H, Kaur J, Goldman YE, Cooperman BS*. The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis. Proc Natl Acad Sci U S A. 2011, 108(39):16223-8. （SCI Q1，IF=9.5）

5.Lu Z, Yuan S, Ruan L, Tu Z*, Liu H*. Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer. Cell Death Dis. 2022, 13(4):304. （SCI Q1，IF=12.1）

6.3 Monographs and Textbooks

•1. Hanqing Liu, Jennifer R. Cracchiolob, Tim M. Beck, Ilya G. Serebriiskiia, and Erica A. Golemis*. EGFR inhibitors as therapeutic agents in head and neck cancer. in Molecular Determinants of Head and Neck Cancer, eds, Burtness B. and Golemis E.A., Current Cancer Research, Springer Press, pp 55-90, 2014.

•2. Hanqing Liu, Tim M. Beck, Erica A. Golemis, and Ilya G. Serebriiskii*. Integrating in silico resources to map a signaling network. Methods in Mol Biol. 1101:197-245, 2014.

•3. Barry S. Cooperman*, Yale E. Goldman, Chunlai Chen, Ian Farrell, Jaskarin Kaur, Hanqing Liu, Wei Liu, Gabriel Rosenblum, Zeev Smilansky, Benjamin Stevens, and Haibo Zhang, (2011). Mechanism and dynamics of the elongation cycle. In Ribosomes: Structure, Function and Dynamics, Marina Rodnina, Wolfgang Wintermeyer, Rachel Green, eds. (Springer Press), pp. 339-348

•4. Yinlong Guo, Hanqing Liu, and Chongtian Yu. Application of biological mass spectrometry in the study of non-covalent interactions between biomolecules. In Applications of Organic Mass Spectrometry in Biomedical and Pharmaceutical Research, eds, Songcheng Yang et al., Chemical Industry Press, Beijing, pp 37-59, 2009.

•5. Yun Feng and Hanqing Liu, eds. Pharmacology. 2016, Jiangsu University Press.